Best TWAS P=5.77e-10 · Best GWAS P=9.24e-08 conditioned to 0.094
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FEZ2 | 0.16 | 0.24 | lasso | 2 | 0.22 | 1.3e-26 | 5.2 | -5.2 | 2.0e-07 | -0.97 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | AC007401.1 | 0.10 | 0.02 | lasso | 4 | 0.02 | 5.4e-03 | 4.6 | 5.2 | 2.5e-07 | 0.87 | 0.03 | 0.92 | FALSE |
| 3 | GTEx | Artery Tibial | CRIM1 | 0.10 | 0.04 | lasso | 4 | 0.05 | 1.4e-04 | 4.6 | -5.4 | 7.1e-08 | -0.86 | 0.03 | 0.95 | FALSE |
| 4 | GTEx | Artery Tibial | RP11-78I14.1 | 0.10 | 0.08 | enet | 16 | 0.07 | 4.2e-06 | 4.6 | -5.3 | 9.2e-08 | -0.71 | 0.09 | 0.84 | FALSE |
| 5 | GTEx | Spleen | FEZ2 | 0.42 | 0.16 | enet | 25 | 0.17 | 3.9e-05 | 4.4 | 6.2 | 5.8e-10 | 0.66 | 0.06 | 0.81 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FEZ2 | 0.01 | 0.01 | blup | 85 | 0.01 | 1.0e-03 | 4.3 | -5.5 | 4.3e-08 | -0.90 | 0.02 | 0.94 | FALSE |