[Hub]/) : Traits : Trunk fat-free mass :

chr2:171,087,015-173,555,880

Best TWAS P=1.07e-31 · Best GWAS P=5.06e-35 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CYBRD1 0.33 0.18 lasso 7 0.27 5.2e-33 5.6 9.4 7.7e-21 -0.69 1.00 0.00 TRUE
2 CommonMind Brain Pre-frontal Cortex METTL8 0.07 0.05 lasso 4 0.06 1.0e-07 6.6 -7.5 8.2e-14 0.29 0.99 0.00 FALSE
3 GTEx Adipose Subcutaneous CYBRD1 0.35 0.19 lasso 6 0.24 7.3e-20 -9.0 9.8 7.3e-23 -0.77 0.00 1.00 FALSE
4 GTEx Adipose Subcutaneous DYNC1I2 0.13 0.11 enet 13 0.11 4.1e-09 -5.4 5.8 7.9e-09 -0.29 1.00 0.00 FALSE
5 GTEx Adipose Visceral Omentum CYBRD1 0.33 0.10 lasso 10 0.26 4.6e-14 -7.2 10.6 2.7e-26 -0.71 0.03 0.97 TRUE
6 GTEx Artery Aorta CYBRD1 0.52 0.30 lasso 10 0.41 6.0e-24 5.6 9.4 3.9e-21 -0.66 0.96 0.04 FALSE
7 GTEx Artery Coronary CYBRD1 0.29 0.01 enet 44 0.11 2.0e-04 -7.2 11.2 5.9e-29 -0.68 0.04 0.61 TRUE
8 GTEx Artery Tibial CYBRD1 0.37 0.08 lasso 9 0.21 3.0e-16 -8.1 10.0 1.9e-23 -0.75 0.00 1.00 FALSE
9 GTEx Artery Tibial DYNC1I2 0.10 0.06 enet 17 0.06 2.2e-05 -6.0 5.1 3.0e-07 -0.23 0.94 0.01 FALSE
10 GTEx Artery Tibial SLC25A12 0.11 0.09 lasso 8 0.06 8.4e-06 -5.4 -5.6 2.3e-08 0.28 1.00 0.00 FALSE
11 GTEx Brain Cerebellum SLC25A12 0.24 0.22 lasso 7 0.17 1.3e-05 -5.8 -5.2 1.9e-07 0.28 0.90 0.01 FALSE
12 GTEx Breast Mammary Tissue CYBRD1 0.32 0.21 enet 16 0.27 2.0e-14 -9.0 10.7 7.6e-27 -0.74 0.00 1.00 FALSE
13 GTEx Breast Mammary Tissue (Male) CYBRD1 0.35 0.24 lasso 6 0.20 2.4e-05 -9.0 9.8 1.7e-22 -0.72 0.00 0.98 FALSE
14 GTEx Breast Mammary Tissue (Female) CYBRD1 0.20 0.07 lasso 2 0.14 4.5e-05 -9.0 9.9 3.2e-23 -0.78 0.00 0.98 FALSE
15 GTEx Cells Transformed fibroblasts CYBRD1 0.34 0.16 enet 27 0.26 6.3e-20 -7.2 9.1 1.3e-19 -0.57 1.00 0.00 FALSE
16 GTEx Cells Transformed fibroblasts DYNC1I2 0.12 0.14 lasso 3 0.14 1.4e-10 -5.9 5.9 3.0e-09 -0.29 1.00 0.00 FALSE
17 GTEx Esophagus Muscularis CYBRD1 0.33 0.07 lasso 9 0.22 1.3e-13 -8.1 11.2 3.3e-29 -0.75 0.06 0.94 FALSE
18 GTEx Lung CYBRD1 0.14 0.05 enet 8 0.10 5.6e-08 4.7 7.8 4.4e-15 -0.45 0.98 0.01 FALSE
19 GTEx Muscle Skeletal CYBRD1 0.10 0.00 enet 9 0.01 1.5e-02 -9.0 9.3 1.5e-20 -0.71 0.00 0.99 FALSE
20 GTEx Muscle Skeletal DYNC1I2 0.11 0.12 lasso 2 0.12 6.5e-12 -6.0 6.1 8.4e-10 -0.30 1.00 0.00 FALSE
21 GTEx Nerve Tibial CYBRD1 0.36 0.07 lasso 10 0.20 2.3e-14 -9.0 9.9 3.2e-23 -0.73 0.00 1.00 FALSE
22 GTEx Skin Sun Exposed Lower leg DYNC1I2 0.11 0.16 lasso 1 0.15 8.9e-13 -5.9 5.9 3.3e-09 -0.29 1.00 0.00 FALSE
23 GTEx Spleen METTL8 0.39 0.34 lasso 2 0.29 4.4e-08 7.0 -7.0 3.2e-12 0.25 0.89 0.01 FALSE
24 GTEx Testis DYNC1I2 0.13 0.02 lasso 4 0.01 1.1e-01 -6.0 5.8 6.9e-09 -0.29 0.17 0.09 FALSE
25 GTEx Testis GORASP2 0.17 0.12 lasso 3 0.11 1.5e-05 -5.4 5.4 7.2e-08 -0.16 0.94 0.00 TRUE
26 GTEx Thyroid CYBRD1 0.26 0.08 enet 26 0.12 1.4e-09 -9.0 9.0 3.3e-19 -0.72 0.00 1.00 FALSE
27 GTEx Uterus CYBRD1 0.54 0.04 lasso 6 0.19 1.1e-04 7.4 8.0 1.2e-15 -0.49 0.05 0.44 FALSE
28 GTEx Whole Blood CYBRD1 0.25 0.14 enet 19 0.15 1.4e-13 4.9 7.1 1.1e-12 -0.52 1.00 0.00 FALSE
29 METSIM Adipose CYBRD1 0.08 0.06 lasso 6 0.06 8.0e-09 5.9 7.8 4.3e-15 -0.48 0.92 0.08 FALSE
30 METSIM Adipose SLC25A12 0.05 0.03 blup 544 0.04 8.2e-07 -6.0 -5.9 3.2e-09 0.33 1.00 0.00 FALSE
31 NTR Blood METTL8 0.03 0.02 lasso 7 0.02 1.7e-08 6.6 -8.3 1.1e-16 0.37 1.00 0.00 FALSE
32 ROSMAP Brain Pre-frontal Cortex CYBRD1 0.37 0.16 lasso 9 0.30 3.0e-39 -7.2 10.1 4.4e-24 -0.77 0.30 0.70 FALSE
33 ROSMAP Brain Pre-frontal Cortex SLC25A12 0.13 0.08 lasso 6 0.11 1.8e-13 -5.9 -5.4 6.4e-08 0.28 1.00 0.00 FALSE
34 ROSMAP Brain Pre-frontal Cortex AC068039.4 0.43 0.64 enet 35 0.65 1.6e-110 -5.9 -5.9 4.0e-09 0.29 1.00 0.00 FALSE
35 YFS Blood METTL8 0.04 0.03 lasso 9 0.03 4.4e-11 7.0 -7.1 1.5e-12 0.27 1.00 0.00 FALSE
36 YFS Blood SLC25A12 0.09 0.15 lasso 7 0.15 1.3e-45 -5.9 -5.8 5.8e-09 0.29 1.00 0.00 FALSE
37 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CYBRD1 0.14 0.04 enet 12 0.09 2.2e-05 -12.3 -10.5 1.1e-25 0.78 0.00 0.96 FALSE
38 The Cancer Genome Atlas Colon Adenocarcinoma CYBRD1 0.14 0.06 blup 69 0.05 6.4e-04 5.7 -6.2 4.3e-10 0.52 0.16 0.48 TRUE
39 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DYNC1I2 0.05 0.06 lasso 4 0.05 6.3e-06 -6.1 5.9 3.2e-09 -0.26 0.03 0.97 FALSE
40 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma METTL8 0.06 0.01 enet 15 0.04 4.4e-05 7.3 -6.5 7.8e-11 0.17 0.22 0.61 TRUE
41 The Cancer Genome Atlas Brain Lower Grade Glioma CYBRD1 0.03 0.02 lasso 3 0.03 4.5e-04 5.6 7.0 3.0e-12 -0.46 0.18 0.21 FALSE
42 The Cancer Genome Atlas Prostate Adenocarcinoma CYBRD1 0.08 0.06 blup 68 0.08 1.5e-08 -7.2 6.3 2.1e-10 -0.51 0.94 0.06 FALSE
43 The Cancer Genome Atlas Thyroid Carcinoma CYBRD1 0.10 0.06 lasso 4 0.06 6.2e-07 -9.0 11.7 1.1e-31 -0.86 0.00 1.00 TRUE