Best TWAS P=5.97e-16 · Best GWAS P=2.79e-15 conditioned to 0.00277
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | FRZB | 0.14 | 0.04 | enet | 16 | 0.05 | 9.6e-05 | -2.718 | -5.4 | 5.3e-08 | -0.22 | 0.92 | 0.01 | FALSE |
| 2 | GTEx | Brain Hypothalamus | PDE1A | 0.24 | -0.01 | enet | 21 | -0.01 | 7.6e-01 | 6.691 | 8.1 | 6.0e-16 | 0.59 | 0.08 | 0.22 | TRUE |
| 3 | GTEx | Liver | NCKAP1 | 0.50 | -0.01 | lasso | 10 | 0.01 | 1.4e-01 | 4.934 | 6.4 | 1.5e-10 | 0.12 | 0.05 | 0.08 | TRUE |
| 4 | GTEx | Skin Sun Exposed Lower leg | PDE1A | 0.11 | 0.07 | lasso | 4 | 0.04 | 6.0e-04 | 5.963 | -6.5 | 8.6e-11 | -0.69 | 0.13 | 0.85 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PDE1A | 0.03 | 0.01 | blup | 209 | 0.02 | 1.3e-05 | 0.068 | 5.1 | 2.8e-07 | 0.34 | 0.48 | 0.02 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | FRZB | 0.05 | 0.02 | lasso | 4 | 0.04 | 1.5e-05 | 4.107 | -5.3 | 1.4e-07 | -0.10 | 0.01 | 0.22 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PDE1A | 0.05 | 0.04 | blup | 206 | 0.04 | 5.0e-05 | -4.397 | 5.2 | 1.5e-07 | 0.42 | 0.65 | 0.02 | FALSE |