Best TWAS P=8.11e-27 · Best GWAS P=2.49e-31 conditioned to 4.56e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PPA2 | 0.08 | 0.03 | bslmm | 429 | 0.04 | 2.2e-05 | -7.1 | -7.7 | 1.3e-14 | 0.61 | 0.08 | 0.88 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | PPA2 | 0.15 | 0.02 | enet | 36 | 0.06 | 7.0e-06 | 4.7 | -5.6 | 2.7e-08 | 0.38 | 0.27 | 0.09 | FALSE |
| 3 | GTEx | Artery Aorta | PPA2 | 0.11 | -0.01 | enet | 24 | 0.01 | 1.6e-01 | -11.2 | -8.4 | 4.5e-17 | 0.58 | 0.07 | 0.35 | FALSE |
| 4 | GTEx | Brain Cerebellum | PPA2 | 0.22 | 0.01 | lasso | 4 | 0.03 | 3.7e-02 | -7.7 | -6.2 | 4.0e-10 | 0.55 | 0.09 | 0.15 | FALSE |
| 5 | GTEx | Brain Cortex | PPA2 | 0.14 | 0.09 | lasso | 9 | 0.09 | 1.6e-03 | -9.0 | -9.1 | 7.6e-20 | 0.79 | 0.06 | 0.58 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | PPA2 | 0.11 | 0.03 | lasso | 3 | 0.01 | 6.5e-02 | -7.0 | -7.6 | 2.1e-14 | 0.59 | 0.41 | 0.11 | FALSE |
| 7 | GTEx | Esophagus Gastroesophageal Junction | PPA2 | 0.29 | 0.15 | lasso | 5 | 0.14 | 8.8e-06 | -11.2 | -10.7 | 8.1e-27 | 0.81 | 0.05 | 0.91 | TRUE |
| 8 | GTEx | Esophagus Mucosa | PPA2 | 0.18 | 0.06 | enet | 14 | 0.12 | 2.5e-08 | 8.8 | -9.7 | 2.3e-22 | 0.68 | 0.12 | 0.87 | FALSE |
| 9 | GTEx | Heart Atrial Appendage | PPA2 | 0.15 | 0.05 | lasso | 7 | 0.06 | 7.4e-04 | -9.3 | -7.3 | 2.2e-13 | 0.70 | 0.24 | 0.38 | FALSE |
| 10 | GTEx | Muscle Skeletal | PPA2 | 0.19 | 0.06 | enet | 28 | 0.11 | 8.7e-11 | -9.0 | -6.5 | 7.3e-11 | 0.67 | 0.80 | 0.19 | FALSE |
| 11 | GTEx | Nerve Tibial | PPA2 | 0.13 | 0.07 | enet | 23 | 0.07 | 2.1e-05 | -7.7 | -7.5 | 9.6e-14 | 0.63 | 0.48 | 0.28 | FALSE |
| 12 | GTEx | Ovary | PPA2 | 0.18 | 0.10 | lasso | 3 | 0.14 | 2.2e-04 | -7.7 | -9.0 | 3.3e-19 | 0.72 | 0.06 | 0.67 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | TET2 | 0.09 | 0.01 | enet | 18 | 0.02 | 3.6e-03 | -11.5 | -7.3 | 3.1e-13 | 0.58 | 0.02 | 0.89 | FALSE |
| 14 | GTEx | Thyroid | PPA2 | 0.22 | 0.01 | enet | 18 | 0.12 | 2.9e-09 | 6.0 | -5.8 | 6.0e-09 | 0.50 | 0.75 | 0.05 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | PPA2 | 0.32 | 0.38 | lasso | 2 | 0.38 | 1.1e-51 | 4.6 | -5.2 | 1.8e-07 | 0.42 | 1.00 | 0.00 | FALSE |
| 16 | YFS | Blood | PPA2 | 0.22 | 0.05 | lasso | 19 | 0.12 | 9.7e-38 | -3.4 | 5.5 | 4.8e-08 | -0.40 | 1.00 | 0.00 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PPA2 | 0.29 | 0.01 | blup | 84 | 0.10 | 4.3e-06 | -5.9 | -5.1 | 2.8e-07 | 0.42 | 0.13 | 0.12 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | PPA2 | 0.04 | 0.02 | blup | 84 | 0.04 | 6.1e-05 | -9.0 | -8.3 | 1.1e-16 | 0.74 | 0.14 | 0.65 | FALSE |