Best TWAS P=4.56e-20 · Best GWAS P=4.11e-19 conditioned to 0.035
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Pituitary | LHFPL2 | 0.38 | 0.02 | lasso | 9 | 0.04 | 4.0e-02 | 0.98 | -5.3 | 1.3e-07 | 0.50 | 0.04 | 0.48 | FALSE |
| 2 | GTEx | Testis | LHFPL2 | 0.18 | -0.01 | enet | 21 | 0.10 | 2.1e-05 | 4.35 | 5.7 | 1.0e-08 | -0.26 | 0.11 | 0.14 | FALSE |
| 3 | METSIM | Adipose | AP3B1 | 0.07 | 0.01 | blup | 556 | 0.02 | 2.4e-04 | 4.47 | -6.2 | 4.3e-10 | 0.54 | 0.10 | 0.78 | FALSE |
| 4 | YFS | Blood | AP3B1 | 0.25 | 0.22 | lasso | 9 | 0.23 | 2.6e-74 | 5.97 | -6.0 | 1.7e-09 | 0.30 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP3B1 | 0.02 | 0.00 | blup | 126 | 0.01 | 1.8e-02 | -8.93 | -9.2 | 4.6e-20 | 0.85 | 0.02 | 0.89 | TRUE |
| 6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | AP3B1 | 0.16 | 0.06 | enet | 18 | 0.09 | 2.2e-05 | 6.68 | -7.0 | 2.3e-12 | 0.52 | 0.04 | 0.53 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | AP3B1 | 0.08 | 0.01 | enet | 20 | 0.02 | 9.7e-04 | -8.68 | -6.4 | 1.8e-10 | 0.60 | 0.02 | 0.81 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | AP3B1 | 0.05 | 0.03 | lasso | 3 | 0.04 | 4.4e-05 | 6.68 | -6.5 | 1.1e-10 | 0.38 | 0.42 | 0.27 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AP3B1 | 0.05 | 0.02 | blup | 126 | 0.03 | 5.0e-04 | 6.67 | -8.7 | 4.5e-18 | 0.81 | 0.02 | 0.91 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | AP3B1 | 0.11 | 0.06 | lasso | 2 | 0.05 | 1.3e-05 | 5.97 | -5.5 | 3.0e-08 | 0.20 | 0.59 | 0.05 | FALSE |