Best TWAS P=1.93e-21 · Best GWAS P=4.06e-25 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | POC5 | 0.17 | 0.16 | lasso | 5 | 0.15 | 5.2e-18 | -9.6 | 9.5 | 1.9e-21 | -0.90 | 0.26 | 0.74 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | POC5 | 0.08 | 0.07 | lasso | 7 | 0.07 | 3.2e-06 | -8.1 | -8.1 | 4.5e-16 | 0.56 | 0.96 | 0.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | POC5 | 0.13 | 0.08 | lasso | 9 | 0.08 | 6.1e-05 | -7.8 | -7.9 | 2.3e-15 | 0.60 | 0.82 | 0.07 | FALSE |
| 4 | GTEx | Adrenal Gland | GCNT4 | 0.13 | 0.02 | lasso | 8 | 0.01 | 1.3e-01 | -6.5 | -7.1 | 1.7e-12 | 0.49 | 0.20 | 0.48 | FALSE |
| 5 | GTEx | Artery Tibial | GCNT4 | 0.08 | 0.07 | lasso | 2 | 0.04 | 3.9e-04 | -6.5 | 6.5 | 8.6e-11 | -0.44 | 0.54 | 0.26 | FALSE |
| 6 | GTEx | Brain Cerebellar Hemisphere | POLK | 0.27 | 0.20 | lasso | 6 | 0.16 | 8.3e-05 | -6.2 | -8.0 | 1.1e-15 | 0.64 | 0.35 | 0.14 | FALSE |
| 7 | GTEx | Brain Cerebellar Hemisphere | POC5 | 0.31 | 0.15 | enet | 18 | 0.30 | 1.6e-08 | -8.1 | -8.8 | 1.0e-18 | 0.61 | 0.61 | 0.23 | FALSE |
| 8 | GTEx | Brain Hypothalamus | CTC-366B18.4 | 0.26 | 0.12 | lasso | 8 | 0.07 | 9.0e-03 | -8.1 | 8.2 | 2.3e-16 | -0.56 | 0.10 | 0.09 | FALSE |
| 9 | GTEx | Cells EBV-transformed lymphocytes | POC5 | 0.47 | 0.36 | lasso | 4 | 0.39 | 1.3e-13 | -8.1 | -8.1 | 8.2e-16 | 0.57 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | POLK | 0.06 | 0.04 | lasso | 3 | 0.04 | 1.0e-03 | -8.0 | 8.2 | 1.6e-16 | -0.61 | 0.25 | 0.46 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | POC5 | 0.15 | 0.17 | lasso | 6 | 0.16 | 3.4e-12 | -7.8 | -7.8 | 5.4e-15 | 0.57 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Colon Transverse | POC5 | 0.23 | 0.16 | lasso | 4 | 0.18 | 6.0e-09 | -7.7 | -6.5 | 6.7e-11 | 0.39 | 0.96 | 0.00 | FALSE |
| 13 | GTEx | Esophagus Mucosa | COL4A3BP | 0.09 | 0.06 | lasso | 5 | 0.05 | 4.2e-04 | -3.6 | 5.4 | 7.1e-08 | -0.51 | 0.80 | 0.04 | FALSE |
| 14 | GTEx | Esophagus Mucosa | POC5 | 0.18 | 0.16 | lasso | 1 | 0.15 | 4.8e-10 | -7.8 | -7.8 | 5.4e-15 | 0.57 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Lung | POC5 | 0.18 | 0.09 | enet | 46 | 0.09 | 2.5e-07 | -8.1 | -5.5 | 4.2e-08 | 0.24 | 0.98 | 0.00 | TRUE |
| 16 | GTEx | Nerve Tibial | POC5 | 0.16 | 0.12 | lasso | 5 | 0.10 | 7.6e-08 | -7.7 | -7.8 | 6.7e-15 | 0.57 | 0.99 | 0.00 | FALSE |
| 17 | GTEx | Pancreas | POC5 | 0.32 | 0.23 | lasso | 3 | 0.21 | 3.5e-09 | -7.8 | -7.9 | 3.7e-15 | 0.57 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Spleen | POLK | 0.18 | -0.01 | lasso | 16 | 0.03 | 5.1e-02 | -3.9 | -8.5 | 2.0e-17 | 0.59 | 0.17 | 0.20 | TRUE |
| 19 | GTEx | Spleen | POC5 | 0.42 | 0.37 | lasso | 4 | 0.34 | 1.3e-09 | -8.1 | -8.3 | 1.4e-16 | 0.57 | 0.95 | 0.03 | FALSE |
| 20 | GTEx | Spleen | CTC-366B18.2 | 0.16 | 0.11 | lasso | 3 | 0.14 | 2.2e-04 | -8.1 | -9.4 | 8.4e-21 | 0.72 | 0.18 | 0.34 | TRUE |
| 21 | GTEx | Stomach | POC5 | 0.10 | 0.06 | enet | 12 | 0.08 | 8.3e-05 | -8.0 | -6.9 | 5.3e-12 | 0.43 | 0.56 | 0.02 | FALSE |
| 22 | GTEx | Testis | POC5 | 0.27 | 0.13 | lasso | 8 | 0.09 | 8.1e-05 | -8.2 | 6.8 | 8.3e-12 | -0.65 | 0.60 | 0.19 | FALSE |
| 23 | GTEx | Testis | GCNT4 | 0.42 | 0.35 | enet | 62 | 0.37 | 3.8e-17 | -5.1 | -6.6 | 3.4e-11 | 0.50 | 1.00 | 0.00 | FALSE |
| 24 | GTEx | Thyroid | POC5 | 0.26 | 0.23 | enet | 15 | 0.23 | 1.8e-17 | -7.7 | -7.1 | 1.3e-12 | 0.49 | 1.00 | 0.00 | TRUE |
| 25 | GTEx | Thyroid | CTC-366B18.2 | 0.06 | 0.03 | lasso | 9 | 0.02 | 6.2e-03 | -7.2 | -7.8 | 4.5e-15 | 0.62 | 0.31 | 0.13 | FALSE |
| 26 | METSIM | Adipose | POC5 | 0.11 | 0.09 | enet | 29 | 0.10 | 7.5e-15 | -7.7 | -7.2 | 4.5e-13 | 0.48 | 1.00 | 0.00 | FALSE |
| 27 | METSIM | Adipose | POLK | 0.05 | 0.01 | enet | 16 | 0.03 | 4.3e-05 | -7.3 | -6.6 | 3.0e-11 | 0.58 | 0.97 | 0.02 | FALSE |
| 28 | ROSMAP | Brain Pre-frontal Cortex | POLK | 0.03 | 0.01 | lasso | 7 | 0.02 | 3.9e-03 | -7.8 | -8.5 | 1.3e-17 | 0.81 | 0.27 | 0.63 | FALSE |
| 29 | ROSMAP | Brain Pre-frontal Cortex | POC5 | 0.05 | 0.00 | blup | 384 | 0.02 | 8.6e-04 | -7.7 | -8.3 | 1.2e-16 | 0.57 | 0.30 | 0.13 | FALSE |
| 30 | ROSMAP | Brain Pre-frontal Cortex | ANKDD1B | 0.07 | 0.00 | bslmm | 382 | 0.03 | 7.0e-05 | -4.1 | 7.2 | 5.5e-13 | -0.63 | 0.08 | 0.54 | FALSE |
| 31 | The Cancer Genome Atlas | Colon Adenocarcinoma | GCNT4 | 0.10 | 0.06 | enet | 6 | 0.05 | 8.7e-04 | -5.5 | 6.7 | 1.5e-11 | -0.41 | 0.02 | 0.85 | FALSE |
| 32 | The Cancer Genome Atlas | Brain Lower Grade Glioma | POC5 | 0.04 | 0.00 | enet | 7 | 0.03 | 2.1e-04 | -9.6 | 6.8 | 1.0e-11 | -0.77 | 0.02 | 0.57 | FALSE |
| 33 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | HMGCR | 0.04 | 0.02 | enet | 4 | 0.03 | 6.0e-03 | -5.4 | -6.2 | 5.5e-10 | 0.57 | 0.03 | 0.49 | TRUE |
| 34 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POLK | 0.03 | 0.01 | blup | 53 | 0.01 | 1.6e-02 | -5.5 | 7.1 | 1.2e-12 | -0.57 | 0.12 | 0.78 | FALSE |
| 35 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | POC5 | 0.24 | 0.13 | blup | 70 | 0.14 | 1.2e-04 | -7.6 | -7.9 | 3.8e-15 | 0.73 | 0.05 | 0.80 | FALSE |