Best TWAS P=2.72e-24 · Best GWAS P=1.8e-19 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | RP11-250B2.6 | 0.16 | 0.05 | lasso | 6 | 0.06 | 7.8e-04 | 7.3 | -8.0 | 1.7e-15 | -0.57 | 0.22 | 0.45 | FALSE |
| 2 | GTEx | Artery Aorta | BCKDHB | 0.14 | 0.14 | lasso | 1 | 0.13 | 9.8e-08 | 5.9 | 5.9 | 3.5e-09 | 0.15 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Aorta | ELOVL4 | 0.11 | 0.13 | lasso | 2 | 0.11 | 1.7e-06 | 5.4 | 5.4 | 6.4e-08 | 0.45 | 0.94 | 0.00 | FALSE |
| 4 | GTEx | Artery Tibial | BCKDHB | 0.16 | 0.16 | lasso | 11 | 0.15 | 4.9e-12 | 6.1 | 5.8 | 8.8e-09 | 0.15 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Brain Cerebellum | RP11-250B2.5 | 0.43 | 0.11 | lasso | 5 | 0.14 | 4.7e-05 | -8.2 | -8.3 | 1.5e-16 | -0.76 | 0.08 | 0.82 | FALSE |
| 6 | GTEx | Cells EBV-transformed lymphocytes | RP11-250B2.6 | 0.21 | 0.03 | enet | 37 | 0.13 | 4.7e-05 | 6.1 | -7.2 | 8.2e-13 | -0.23 | 0.14 | 0.08 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | BCKDHB | 0.16 | 0.02 | enet | 42 | 0.04 | 3.7e-04 | 5.4 | 9.0 | 2.2e-19 | 0.49 | 0.25 | 0.64 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | RP11-250B2.6 | 0.11 | 0.01 | lasso | 7 | 0.00 | 1.4e-01 | -8.0 | -5.9 | 4.1e-09 | -0.51 | 0.35 | 0.10 | TRUE |
| 9 | GTEx | Colon Transverse | RP11-250B2.5 | 0.13 | 0.02 | enet | 3 | 0.01 | 6.3e-02 | -3.0 | -5.8 | 5.2e-09 | -0.61 | 0.06 | 0.48 | TRUE |
| 10 | GTEx | Esophagus Mucosa | RP11-250B2.6 | 0.20 | 0.16 | lasso | 7 | 0.23 | 3.3e-15 | -8.0 | -8.1 | 7.7e-16 | -0.65 | 0.93 | 0.07 | FALSE |
| 11 | GTEx | Esophagus Muscularis | BCKDHB | 0.18 | 0.07 | enet | 25 | 0.06 | 2.4e-04 | 6.0 | 5.8 | 8.2e-09 | 0.15 | 0.94 | 0.01 | FALSE |
| 12 | GTEx | Heart Atrial Appendage | RP11-250B2.6 | 0.20 | 0.00 | enet | 17 | 0.03 | 2.6e-02 | -4.7 | -10.2 | 2.7e-24 | -0.41 | 0.05 | 0.48 | TRUE |
| 13 | GTEx | Heart Left Ventricle | RP11-250B2.6 | 0.09 | 0.00 | enet | 6 | 0.02 | 2.0e-02 | 8.0 | -7.6 | 3.5e-14 | -0.82 | 0.05 | 0.69 | FALSE |
| 14 | GTEx | Lung | BCKDHB | 0.09 | 0.06 | enet | 10 | 0.05 | 1.8e-04 | 6.0 | 6.0 | 1.9e-09 | 0.15 | 0.89 | 0.02 | FALSE |
| 15 | GTEx | Lung | RP11-250B2.6 | 0.09 | 0.05 | enet | 16 | 0.07 | 5.3e-06 | 5.5 | -7.9 | 3.4e-15 | -0.36 | 0.83 | 0.02 | TRUE |
| 16 | GTEx | Muscle Skeletal | RP11-250B2.6 | 0.07 | 0.04 | lasso | 5 | 0.04 | 4.2e-05 | 8.7 | -8.9 | 4.5e-19 | -0.94 | 0.02 | 0.98 | FALSE |
| 17 | GTEx | Nerve Tibial | BCKDHB | 0.18 | 0.11 | lasso | 9 | 0.10 | 2.4e-07 | 6.1 | 6.1 | 1.0e-09 | 0.15 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Testis | RP11-250B2.5 | 0.13 | 0.17 | lasso | 3 | 0.14 | 7.0e-07 | -8.1 | -7.8 | 4.5e-15 | -0.88 | 0.04 | 0.96 | FALSE |
| 19 | GTEx | Thyroid | BCKDHB | 0.17 | 0.06 | lasso | 8 | 0.10 | 3.4e-08 | 5.5 | 7.3 | 2.2e-13 | 0.46 | 0.98 | 0.02 | TRUE |
| 20 | GTEx | Thyroid | RP11-250B2.6 | 0.11 | 0.10 | lasso | 2 | 0.07 | 3.2e-06 | 5.4 | -5.4 | 6.1e-08 | -0.13 | 1.00 | 0.00 | FALSE |
| 21 | METSIM | Adipose | BCKDHB | 0.05 | 0.03 | blup | 558 | 0.05 | 1.1e-07 | -8.1 | 5.5 | 4.3e-08 | 0.55 | 0.88 | 0.12 | TRUE |
| 22 | METSIM | Adipose | RP11-250B2.6 | 0.04 | 0.04 | lasso | 12 | 0.02 | 1.7e-04 | 7.7 | -6.9 | 6.4e-12 | -0.60 | 0.68 | 0.10 | FALSE |
| 23 | ROSMAP | Brain Pre-frontal Cortex | BCKDHB | 0.18 | 0.13 | lasso | 6 | 0.14 | 2.9e-17 | 6.1 | 5.2 | 2.0e-07 | 0.18 | 1.00 | 0.00 | TRUE |
| 24 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BCKDHB | 0.12 | 0.06 | lasso | 4 | 0.06 | 4.2e-07 | 6.8 | -6.3 | 3.4e-10 | -0.75 | 0.53 | 0.46 | FALSE |
| 25 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | BCKDHB | 0.19 | 0.02 | blup | 137 | 0.06 | 2.6e-03 | 6.0 | 5.1 | 2.9e-07 | 0.02 | 0.03 | 0.05 | TRUE |