Best TWAS P=6.42e-15 · Best GWAS P=8.14e-12 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DTX2P1-UPK3BP1-PMS2P11 | 0.18 | 0.09 | enet | 21 | 0.12 | 6.1e-15 | 6.1 | 7.8 | 6.4e-15 | 0.82 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | RP11-467H10.2 | 0.12 | 0.00 | lasso | 6 | 0.01 | 2.1e-02 | 3.2 | 6.1 | 1.2e-09 | 0.05 | 0.13 | 0.04 | FALSE |
| 3 | GTEx | Artery Aorta | GSAP | 0.19 | 0.07 | lasso | 2 | 0.04 | 2.8e-03 | 5.6 | -5.9 | 3.1e-09 | -0.03 | 0.25 | 0.10 | TRUE |
| 4 | GTEx | Brain Cerebellum | GSAP | 0.38 | 0.30 | lasso | 4 | 0.31 | 6.4e-10 | 5.4 | -5.6 | 1.7e-08 | -0.01 | 0.74 | 0.21 | FALSE |
| 5 | GTEx | Brain Frontal Cortex BA9 | GSAP | 0.38 | 0.22 | lasso | 6 | 0.21 | 3.0e-06 | 5.6 | -6.5 | 9.8e-11 | -0.13 | 0.14 | 0.23 | TRUE |
| 6 | GTEx | Heart Left Ventricle | GSAP | 0.21 | 0.02 | lasso | 5 | 0.03 | 9.3e-03 | 4.8 | -5.7 | 1.6e-08 | -0.01 | 0.12 | 0.05 | TRUE |
| 7 | GTEx | Muscle Skeletal | GSAP | 0.20 | 0.12 | lasso | 2 | 0.12 | 1.8e-11 | 5.6 | -5.7 | 1.4e-08 | -0.04 | 0.75 | 0.25 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | DTX2P1 | 0.16 | 0.03 | enet | 22 | 0.05 | 4.8e-05 | 6.8 | 5.4 | 8.0e-08 | 0.70 | 0.00 | 0.99 | FALSE |
| 9 | GTEx | Thyroid | GSAP | 0.19 | 0.08 | lasso | 3 | 0.07 | 3.3e-06 | 5.6 | -5.7 | 9.6e-09 | -0.02 | 0.66 | 0.26 | FALSE |
| 10 | GTEx | Thyroid | AC007000.12 | 0.13 | 0.08 | enet | 24 | 0.07 | 2.6e-06 | -4.6 | -5.6 | 1.7e-08 | -0.18 | 0.66 | 0.02 | TRUE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | GSAP | 0.36 | 0.27 | lasso | 7 | 0.28 | 1.5e-35 | 5.6 | -5.5 | 4.8e-08 | -0.02 | 0.74 | 0.26 | TRUE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PION | 0.08 | 0.05 | lasso | 3 | 0.05 | 8.5e-07 | 5.6 | -5.7 | 1.5e-08 | -0.06 | 0.00 | 1.00 | TRUE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PION | 0.13 | 0.07 | enet | 9 | 0.08 | 3.4e-09 | 5.6 | -5.5 | 5.1e-08 | -0.03 | 0.00 | 1.00 | FALSE |