Best TWAS P=6.85e-16 · Best GWAS P=6.06e-17 conditioned to 0.266
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | COL14A1 | 0.07 | 0.02 | enet | 21 | 0.04 | 2.1e-05 | -1.8 | 5.3 | 1.5e-07 | -0.01 | 0.01 | 0.99 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | NOV | 0.06 | 0.02 | enet | 8 | 0.05 | 1.5e-06 | -4.3 | -6.0 | 2.6e-09 | 0.71 | 0.14 | 0.85 | FALSE |
| 3 | GTEx | Adrenal Gland | DEPTOR | 0.16 | -0.01 | enet | 24 | 0.00 | 3.7e-01 | -3.5 | 5.7 | 9.8e-09 | -0.08 | 0.10 | 0.06 | TRUE |
| 4 | GTEx | Artery Aorta | NOV | 0.12 | 0.05 | enet | 18 | 0.04 | 3.7e-03 | -6.2 | -7.5 | 5.5e-14 | 0.79 | 0.03 | 0.84 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | NOV | 0.10 | 0.04 | enet | 30 | 0.03 | 3.7e-03 | -7.9 | -5.6 | 2.0e-08 | 0.56 | 0.08 | 0.85 | FALSE |
| 6 | GTEx | Colon Sigmoid | NOV | 0.15 | 0.16 | lasso | 4 | 0.15 | 6.6e-06 | -8.0 | -7.9 | 2.6e-15 | 0.91 | 0.03 | 0.96 | FALSE |
| 7 | GTEx | Esophagus Muscularis | NOV | 0.11 | 0.03 | enet | 19 | 0.05 | 3.9e-04 | -8.0 | -5.2 | 2.0e-07 | 0.71 | 0.04 | 0.92 | FALSE |
| 8 | GTEx | Lung | NOV | 0.06 | 0.02 | enet | 23 | 0.03 | 2.5e-03 | -4.1 | -7.0 | 2.8e-12 | 0.66 | 0.20 | 0.46 | FALSE |
| 9 | GTEx | Nerve Tibial | TAF2 | 0.14 | 0.04 | enet | 10 | 0.07 | 1.5e-05 | 4.8 | -6.2 | 5.6e-10 | 0.19 | 0.89 | 0.04 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | NOV | 0.11 | 0.03 | lasso | 7 | 0.04 | 1.4e-04 | -7.7 | -7.0 | 3.0e-12 | 0.95 | 0.01 | 0.99 | FALSE |
| 11 | NTR | Blood | NOV | 0.02 | 0.01 | bslmm | 481 | 0.01 | 1.7e-04 | -8.0 | -7.0 | 2.0e-12 | 0.78 | 0.02 | 0.98 | FALSE |
| 12 | YFS | Blood | ENPP2 | 0.03 | 0.02 | enet | 8 | 0.03 | 7.6e-09 | -4.6 | -5.7 | 9.4e-09 | 0.10 | 1.00 | 0.00 | TRUE |
| 13 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NOV | 0.03 | 0.00 | blup | 42 | 0.01 | 5.3e-02 | -7.7 | -7.9 | 2.7e-15 | 0.97 | 0.02 | 0.78 | FALSE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | NOV | 0.31 | 0.10 | blup | 42 | 0.10 | 1.2e-06 | -8.4 | -6.9 | 6.9e-12 | 0.83 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NOV | 0.11 | 0.02 | enet | 15 | 0.05 | 2.9e-03 | -8.4 | -8.1 | 6.8e-16 | 0.84 | 0.01 | 0.64 | TRUE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NOV | 0.04 | 0.05 | blup | 42 | 0.05 | 8.7e-06 | -8.0 | -6.9 | 4.6e-12 | 0.82 | 0.04 | 0.95 | FALSE |