Best TWAS P=2.04e-13 · Best GWAS P=4.42e-13 conditioned to 0.0243
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PLEKHA1 | 0.14 | 0.06 | lasso | 2 | 0.03 | 2.4e-03 | 6.6 | -6.7 | 1.8e-11 | 0.76 | 0.14 | 0.81 | FALSE |
| 2 | GTEx | Muscle Skeletal | PLEKHA1 | 0.10 | 0.04 | lasso | 3 | 0.04 | 8.2e-05 | -7.2 | -5.7 | 1.3e-08 | 0.86 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Nerve Tibial | PLEKHA1 | 0.22 | 0.23 | enet | 17 | 0.19 | 1.1e-13 | 6.6 | -5.9 | 3.4e-09 | 0.64 | 0.20 | 0.80 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | PLEKHA1 | 0.16 | 0.02 | lasso | 5 | 0.01 | 4.0e-02 | -6.3 | -6.7 | 2.6e-11 | 0.81 | 0.02 | 0.96 | FALSE |
| 5 | METSIM | Adipose | PLEKHA1 | 0.05 | 0.03 | lasso | 4 | 0.04 | 3.6e-07 | 6.6 | -7.3 | 2.0e-13 | 0.80 | 0.08 | 0.92 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PLEKHA1 | 0.06 | 0.05 | lasso | 4 | 0.05 | 1.3e-06 | -7.1 | -7.1 | 1.5e-12 | 0.99 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PLEKHA1 | 0.04 | 0.05 | lasso | 2 | 0.04 | 4.3e-05 | 6.6 | -6.6 | 3.8e-11 | 0.77 | 0.10 | 0.87 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ARMS2 | 0.23 | 0.20 | lasso | 2 | 0.21 | 7.0e-09 | -5.6 | -5.8 | 6.7e-09 | 0.65 | 0.88 | 0.07 | FALSE |
| 9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PLEKHA1 | 0.08 | 0.06 | blup | 103 | 0.02 | 4.0e-02 | 6.6 | -5.7 | 1.5e-08 | 0.83 | 0.02 | 0.80 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARMS2 | 0.06 | 0.04 | blup | 71 | 0.05 | 4.9e-06 | -7.1 | -6.8 | 1.5e-11 | 0.81 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | PLEKHA1 | 0.08 | 0.10 | lasso | 1 | 0.09 | 3.5e-09 | 6.6 | -6.6 | 5.2e-11 | 0.77 | 0.24 | 0.76 | FALSE |