TWAS
hub
About
Usage
Models
Genes
Traits
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Traits
:
Trunk predicted mass
:
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chr10:119,742,699-121,632,800
Best TWAS P=2.11e-12 · Best GWAS P=3.33e-11 conditioned to 0.243
120M
120.5M
121M
121.5M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Pheochromocytoma and Paraganglioma
C10orf46
0.23
0.04
lasso
4
0.04
8.6e-03
-6.4
7.0
2.1e-12
0.66
0.01
0.63
TRUE
2
GTEx
Esophagus Gastroesophageal Junction
FAM45A
0.24
0.13
enet
51
0.09
2.7e-04
4.7
6.0
1.8e-09
0.19
0.14
0.08
TRUE
3
ROSMAP
Brain Pre-frontal Cortex
CACUL1
0.12
0.08
lasso
4
0.06
1.2e-08
-6.4
6.4
1.7e-10
0.57
0.01
0.99
FALSE
1
GTEx
Breast Mammary Tissue (Female)
PRDX3
0.34
0.11
enet
31
0.12
1.9e-04
4.0
5.1
3.0e-07
0.21
0.11
0.05
FALSE