Best TWAS P=1.1e-10 · Best GWAS P=7.98e-11 conditioned to 0.1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | C12orf23 | 0.07 | 0.02 | lasso | 4 | 0.02 | 5.5e-03 | -6.0 | 5.2 | 2.3e-07 | -0.57 | 0.07 | 0.77 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RP11-412D9.4 | 0.22 | 0.13 | lasso | 5 | 0.13 | 5.1e-11 | -5.9 | 6.1 | 9.1e-10 | -0.77 | 0.04 | 0.96 | FALSE |
| 3 | GTEx | Artery Tibial | C12orf23 | 0.15 | 0.10 | enet | 21 | 0.15 | 8.1e-12 | 5.9 | 5.2 | 2.5e-07 | -0.56 | 0.18 | 0.82 | FALSE |
| 4 | GTEx | Artery Tibial | RP11-412D9.4 | 0.06 | 0.05 | lasso | 3 | 0.06 | 2.9e-05 | -6.0 | 6.2 | 6.3e-10 | -0.72 | 0.06 | 0.92 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | RP11-412D9.4 | 0.23 | 0.26 | lasso | 4 | 0.26 | 9.7e-14 | -6.0 | 5.9 | 3.4e-09 | -0.74 | 0.03 | 0.97 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | RP11-412D9.4 | 0.20 | 0.14 | lasso | 4 | 0.13 | 9.0e-05 | -6.0 | 5.5 | 3.2e-08 | -0.72 | 0.05 | 0.82 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | RP11-412D9.4 | 0.12 | 0.10 | lasso | 4 | 0.09 | 2.1e-07 | -5.9 | 6.5 | 1.1e-10 | -0.89 | 0.02 | 0.98 | TRUE |
| 8 | GTEx | Colon Sigmoid | RP11-412D9.4 | 0.17 | 0.06 | lasso | 3 | 0.07 | 1.4e-03 | 5.4 | 5.5 | 3.7e-08 | -0.62 | 0.14 | 0.33 | FALSE |
| 9 | GTEx | Lung | C12orf23 | 0.04 | 0.03 | lasso | 2 | 0.02 | 9.9e-03 | -5.0 | 5.2 | 1.9e-07 | -0.62 | 0.12 | 0.62 | FALSE |
| 10 | GTEx | Nerve Tibial | C12orf23 | 0.09 | 0.12 | enet | 10 | 0.12 | 1.1e-08 | -6.0 | 6.3 | 4.0e-10 | -0.76 | 0.04 | 0.96 | FALSE |
| 11 | GTEx | Nerve Tibial | RP11-412D9.4 | 0.18 | 0.18 | enet | 11 | 0.20 | 5.6e-14 | -5.9 | 6.2 | 7.7e-10 | -0.77 | 0.04 | 0.96 | FALSE |
| 12 | GTEx | Pancreas | RP11-412D9.4 | 0.09 | 0.06 | enet | 12 | 0.06 | 1.2e-03 | -6.0 | 5.6 | 1.7e-08 | -0.61 | 0.09 | 0.75 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | C12orf23 | 0.06 | 0.04 | lasso | 3 | 0.03 | 8.0e-04 | -6.0 | 6.2 | 5.1e-10 | -0.72 | 0.04 | 0.94 | FALSE |
| 14 | GTEx | Testis | RP11-412D9.4 | 0.25 | 0.24 | lasso | 5 | 0.20 | 3.7e-09 | -6.0 | 6.1 | 1.3e-09 | -0.71 | 0.03 | 0.97 | FALSE |
| 15 | GTEx | Thyroid | RP11-412D9.4 | 0.10 | 0.10 | enet | 7 | 0.12 | 9.3e-10 | 5.9 | 6.3 | 3.0e-10 | -0.74 | 0.06 | 0.94 | FALSE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C12orf23 | 0.03 | 0.05 | enet | 7 | 0.05 | 2.2e-10 | 5.4 | 5.5 | 4.0e-08 | -0.62 | 0.38 | 0.62 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MTERFD3 | 0.02 | 0.01 | lasso | 4 | 0.01 | 1.3e-03 | -5.9 | 6.3 | 2.7e-10 | -0.87 | 0.01 | 0.94 | FALSE |
| 18 | The Cancer Genome Atlas | Colon Adenocarcinoma | MTERFD3 | 0.08 | 0.06 | lasso | 6 | 0.05 | 7.1e-04 | -5.9 | 5.9 | 3.5e-09 | -0.80 | 0.01 | 0.83 | FALSE |
| 19 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C12orf23 | 0.06 | 0.05 | enet | 8 | 0.05 | 5.0e-03 | -6.0 | 6.1 | 1.3e-09 | -0.85 | 0.01 | 0.67 | FALSE |