Best TWAS P=1.92e-16 · Best GWAS P=8.64e-24 conditioned to 0.153
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ATXN2 | 0.02 | 0.03 | enet | 8 | 0.02 | 4.8e-04 | 5.0 | -5.3 | 1.3e-07 | 0.56 | 0.27 | 0.63 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | HECTD4 | 0.06 | 0.00 | enet | 15 | 0.02 | 1.0e-02 | 3.9 | -6.6 | 3.3e-11 | 0.65 | 0.06 | 0.84 | FALSE |
| 3 | GTEx | Adrenal Gland | PPTC7 | 0.13 | -0.01 | lasso | 6 | 0.00 | 3.4e-01 | 4.4 | 5.6 | 1.9e-08 | -0.26 | 0.04 | 0.13 | FALSE |
| 4 | GTEx | Artery Tibial | HECTD4 | 0.05 | 0.02 | lasso | 3 | 0.01 | 3.1e-02 | -8.6 | -8.2 | 1.9e-16 | 0.78 | 0.01 | 0.92 | TRUE |
| 5 | GTEx | Breast Mammary Tissue (Female) | VPS29 | 0.10 | -0.01 | lasso | 2 | 0.02 | 1.0e-01 | -4.7 | 5.8 | 6.9e-09 | -0.34 | 0.03 | 0.14 | TRUE |
| 6 | GTEx | Colon Transverse | FAM109A | 0.21 | 0.00 | lasso | 4 | 0.01 | 1.3e-01 | 5.6 | -6.5 | 8.7e-11 | 0.41 | 0.06 | 0.06 | FALSE |
| 7 | GTEx | Nerve Tibial | HECTD4 | 0.05 | 0.01 | enet | 6 | 0.01 | 3.6e-02 | 5.8 | -6.0 | 1.9e-09 | 0.41 | 0.23 | 0.45 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | MAPKAPK5-AS1 | 0.04 | 0.00 | enet | 30 | 0.00 | 7.0e-01 | 3.8 | 5.2 | 2.1e-07 | -0.53 | 0.21 | 0.17 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | ALDH2 | 0.10 | 0.09 | enet | 13 | 0.13 | 6.7e-11 | 3.6 | -6.5 | 8.0e-11 | 0.62 | 0.98 | 0.02 | FALSE |
| 10 | GTEx | Thyroid | BRAP | 0.07 | 0.02 | lasso | 7 | 0.03 | 1.1e-03 | 3.9 | 5.8 | 7.1e-09 | -0.54 | 0.38 | 0.39 | FALSE |
| 11 | GTEx | Thyroid | VPS29 | 0.07 | 0.01 | lasso | 5 | 0.01 | 8.9e-02 | 4.6 | 5.3 | 1.4e-07 | -0.11 | 0.09 | 0.20 | FALSE |
| 12 | NTR | Blood | ALDH2 | 0.06 | 0.01 | blup | 222 | 0.02 | 4.3e-08 | 3.6 | 5.8 | 5.0e-09 | -0.43 | 0.99 | 0.00 | FALSE |
| 13 | NTR | Blood | GPN3 | 0.03 | 0.01 | blup | 236 | 0.02 | 2.7e-06 | 4.2 | -5.2 | 2.3e-07 | 0.12 | 0.59 | 0.37 | FALSE |
| 14 | YFS | Blood | SH2B3 | 0.05 | 0.01 | enet | 22 | 0.02 | 3.3e-07 | 3.9 | -6.6 | 4.5e-11 | 0.64 | 0.66 | 0.34 | FALSE |
| 15 | YFS | Blood | TRAFD1 | 0.04 | 0.02 | lasso | 2 | 0.01 | 2.9e-05 | -4.0 | -5.2 | 1.8e-07 | 0.55 | 0.09 | 0.85 | FALSE |
| 16 | The Cancer Genome Atlas | Colon Adenocarcinoma | ALDH2 | 0.07 | 0.03 | lasso | 4 | 0.06 | 3.9e-04 | 3.2 | -5.4 | 7.9e-08 | 0.44 | 0.02 | 0.90 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ACAD10 | 0.02 | 0.02 | lasso | 3 | 0.01 | 7.0e-03 | 5.9 | 5.9 | 2.8e-09 | -0.50 | 0.01 | 0.91 | FALSE |
| 18 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ERP29 | 0.11 | 0.03 | blup | 25 | 0.05 | 5.0e-03 | 3.8 | 5.7 | 1.1e-08 | -0.60 | 0.01 | 0.75 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CUX2 | 0.08 | 0.01 | blup | 95 | 0.02 | 1.3e-03 | 4.8 | 6.6 | 4.9e-11 | -0.15 | 0.09 | 0.47 | TRUE |