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chr15:73,524,629-76,650,702

Best TWAS P=7.05e-13 · Best GWAS P=2.37e-13 conditioned to 2.8e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MAN2C1	0.13	0.17	lasso	5	0.18	2.5e-21	5.3	5.9	3.9e-09	0.02	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	NEIL1	0.05	0.03	lasso	5	0.02	1.6e-02	5.3	5.3	1.3e-07	0.04	0.03	0.97	FALSE
3	GTEx	Adipose Subcutaneous	SNUPN	0.09	0.08	lasso	4	0.07	4.2e-06	-4.5	5.3	1.1e-07	0.03	0.54	0.43	FALSE
4	GTEx	Adipose Visceral Omentum	MAN2C1	0.46	0.52	lasso	5	0.52	1.8e-31	5.3	5.3	9.2e-08	0.03	0.02	0.98	FALSE
5	GTEx	Adipose Visceral Omentum	SNUPN	0.14	0.12	enet	7	0.11	2.0e-06	-4.5	5.7	1.4e-08	0.04	0.50	0.45	FALSE
6	GTEx	Adipose Visceral Omentum	CTD-2323K18.1	0.14	0.13	lasso	5	0.10	4.1e-06	-4.5	5.3	1.2e-07	0.03	0.63	0.35	FALSE
7	GTEx	Adrenal Gland	MAN2C1	0.20	0.24	lasso	6	0.21	4.3e-08	5.6	5.3	8.9e-08	0.04	0.02	0.98	FALSE
8	GTEx	Adrenal Gland	SNUPN	0.17	0.05	enet	17	0.11	1.3e-04	-3.5	7.2	7.1e-13	0.08	0.04	0.39	TRUE
9	GTEx	Artery Aorta	MAN2C1	0.48	0.60	lasso	5	0.59	7.1e-40	5.5	5.5	4.0e-08	0.04	0.02	0.98	FALSE
10	GTEx	Artery Coronary	MAN2C1	0.54	0.39	lasso	7	0.35	1.7e-12	5.5	5.3	1.0e-07	0.04	0.02	0.98	FALSE
11	GTEx	Artery Coronary	SNUPN	0.19	0.00	enet	8	0.02	6.2e-02	-4.5	5.6	1.9e-08	0.05	0.04	0.10	FALSE
12	GTEx	Artery Coronary	CTD-2323K18.1	0.21	0.13	lasso	5	0.13	4.9e-05	-4.5	5.4	8.7e-08	0.03	0.13	0.18	FALSE
13	GTEx	Artery Tibial	MAN2C1	0.33	0.45	lasso	4	0.44	9.2e-38	5.5	5.4	5.1e-08	0.03	0.02	0.98	FALSE
14	GTEx	Brain Caudate basal ganglia	MAN2C1	0.23	0.24	enet	20	0.22	7.9e-07	5.5	5.4	8.2e-08	0.05	0.02	0.98	FALSE
15	GTEx	Brain Cerebellar Hemisphere	MAN2C1	0.23	0.15	lasso	5	0.15	1.2e-04	3.9	5.2	2.3e-07	0.07	0.03	0.85	FALSE
16	GTEx	Brain Frontal Cortex BA9	MAN2C1	0.27	0.25	lasso	3	0.21	2.8e-06	5.5	5.5	3.8e-08	0.04	0.02	0.97	FALSE
17	GTEx	Brain Hippocampus	MAN2C1	0.21	0.26	lasso	3	0.26	9.4e-07	5.3	5.4	6.9e-08	0.03	0.02	0.96	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	MAN2C1	0.14	0.17	lasso	3	0.12	3.3e-04	5.1	5.2	2.1e-07	0.03	0.03	0.95	FALSE
19	GTEx	Breast Mammary Tissue	MAN2C1	0.42	0.54	lasso	5	0.52	4.6e-31	5.5	5.5	4.3e-08	0.04	0.02	0.98	FALSE
20	GTEx	Breast Mammary Tissue (Male)	MAN2C1	0.37	0.38	lasso	3	0.34	9.7e-09	5.4	5.1	2.8e-07	0.03	0.02	0.97	FALSE
21	GTEx	Breast Mammary Tissue (Male)	CTD-2323K18.1	0.36	0.24	lasso	5	0.19	3.4e-05	-4.8	5.3	1.5e-07	0.01	0.11	0.40	FALSE
22	GTEx	Breast Mammary Tissue (Female)	MAN2C1	0.39	0.41	lasso	6	0.45	7.6e-15	5.4	5.3	9.5e-08	0.03	0.03	0.97	FALSE
23	GTEx	Breast Mammary Tissue (Female)	SNUPN	0.11	0.12	lasso	5	0.10	7.7e-04	-4.5	5.1	2.8e-07	0.04	0.06	0.24	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	CTD-2323K18.1	0.39	0.13	enet	28	0.26	3.3e-09	-4.3	5.2	1.8e-07	0.04	0.28	0.51	FALSE
25	GTEx	Cells Transformed fibroblasts	MAN2C1	0.38	0.50	lasso	4	0.49	6.2e-42	5.5	5.4	5.8e-08	0.03	0.02	0.98	FALSE
26	GTEx	Cells Transformed fibroblasts	IMP3	0.05	0.06	lasso	2	0.05	1.3e-04	5.1	-5.2	1.6e-07	-0.05	0.04	0.92	FALSE
27	GTEx	Colon Sigmoid	MAN2C1	0.36	0.46	lasso	3	0.45	1.9e-17	5.3	5.3	9.3e-08	0.03	0.02	0.98	FALSE
28	GTEx	Colon Transverse	MAN2C1	0.42	0.55	lasso	6	0.54	8.1e-30	5.6	5.5	4.1e-08	0.04	0.02	0.98	FALSE
29	GTEx	Colon Transverse	SNUPN	0.15	0.12	lasso	3	0.08	7.7e-05	5.5	5.6	2.6e-08	0.04	0.02	0.97	FALSE
30	GTEx	Colon Transverse	CTD-2323K18.1	0.13	0.04	lasso	11	0.05	1.8e-03	5.5	6.2	4.7e-10	0.04	0.03	0.92	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	MAN2C1	0.37	0.49	lasso	2	0.49	7.3e-20	5.3	5.3	8.9e-08	0.03	0.03	0.97	FALSE
32	GTEx	Esophagus Mucosa	MAN2C1	0.27	0.38	lasso	2	0.39	9.9e-28	5.5	5.4	5.5e-08	0.03	0.02	0.98	FALSE
33	GTEx	Esophagus Muscularis	MAN2C1	0.55	0.60	lasso	3	0.62	3.6e-47	5.5	5.5	4.4e-08	0.03	0.02	0.98	FALSE
34	GTEx	Heart Atrial Appendage	MAN2C1	0.30	0.28	lasso	5	0.29	1.8e-13	5.3	5.4	7.8e-08	0.03	0.02	0.98	FALSE
35	GTEx	Heart Left Ventricle	MAN2C1	0.18	0.19	lasso	4	0.16	4.8e-09	5.5	5.5	4.8e-08	0.03	0.02	0.98	FALSE
36	GTEx	Lung	MAN2C1	0.33	0.51	lasso	3	0.50	2.1e-43	5.3	5.4	8.2e-08	0.03	0.03	0.97	FALSE
37	GTEx	Lung	SNUPN	0.14	0.06	lasso	2	0.07	2.7e-06	5.5	6.2	7.3e-10	0.04	0.03	0.97	FALSE
38	GTEx	Muscle Skeletal	MAN2C1	0.05	0.01	enet	6	0.03	5.6e-04	5.5	6.1	9.4e-10	0.04	0.02	0.96	FALSE
39	GTEx	Nerve Tibial	MAN2C1	0.37	0.52	enet	20	0.53	5.6e-44	5.5	5.4	6.2e-08	0.03	0.02	0.98	FALSE
40	GTEx	Nerve Tibial	CYP11A1	0.06	0.00	lasso	2	0.00	5.9e-01	-5.2	-5.2	1.7e-07	-0.03	0.65	0.02	TRUE
41	GTEx	Nerve Tibial	CTD-2323K18.1	0.19	0.11	lasso	7	0.10	1.6e-07	-4.5	5.4	7.9e-08	0.04	0.65	0.34	FALSE
42	GTEx	Pancreas	MAN2C1	0.39	0.41	lasso	1	0.39	1.0e-17	5.5	5.5	3.8e-08	0.04	0.02	0.98	FALSE
43	GTEx	Pituitary	MAN2C1	0.31	0.37	lasso	5	0.34	2.1e-09	5.3	5.4	6.7e-08	0.03	0.02	0.98	FALSE
44	GTEx	Prostate	MAN2C1	0.26	0.30	lasso	3	0.33	4.6e-09	5.3	5.4	7.2e-08	0.03	0.03	0.97	FALSE
45	GTEx	Prostate	CTD-2323K18.1	0.34	0.18	enet	22	0.17	4.3e-05	-4.5	5.3	1.4e-07	0.01	0.29	0.20	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	MAN2C1	0.39	0.44	lasso	4	0.44	1.2e-26	5.3	5.4	5.2e-08	0.03	0.02	0.98	FALSE
47	GTEx	Skin Sun Exposed Lower leg	MAN2C1	0.30	0.36	enet	17	0.38	1.6e-32	5.4	5.3	1.1e-07	0.05	0.02	0.97	FALSE
48	GTEx	Spleen	MAN2C1	0.70	0.62	lasso	5	0.57	1.2e-17	5.5	5.2	1.5e-07	0.03	0.02	0.98	FALSE
49	GTEx	Stomach	MAN2C1	0.36	0.45	lasso	3	0.46	2.0e-24	5.3	5.4	5.6e-08	0.03	0.02	0.98	FALSE
50	GTEx	Thyroid	NEIL1	0.06	0.06	lasso	2	0.07	9.0e-06	5.4	5.4	6.8e-08	0.03	0.03	0.96	FALSE
51	GTEx	Thyroid	MAN2C1	0.44	0.53	lasso	6	0.55	3.1e-49	5.3	5.3	1.3e-07	0.03	0.02	0.97	FALSE
52	GTEx	Thyroid	SNUPN	0.15	0.10	lasso	7	0.16	6.2e-12	-4.8	6.2	4.4e-10	0.03	0.08	0.92	FALSE
53	GTEx	Thyroid	RP11-817O13.6	0.05	0.05	lasso	1	0.03	1.3e-03	5.4	5.4	5.4e-08	0.03	0.03	0.92	FALSE
54	GTEx	Thyroid	LOXL1-AS1	0.15	0.03	enet	40	0.03	2.6e-03	-2.5	6.3	2.7e-10	0.34	0.08	0.48	TRUE
55	GTEx	Uterus	MAN2C1	0.52	0.56	lasso	2	0.61	1.4e-15	5.3	5.4	7.7e-08	0.03	0.02	0.98	FALSE
56	GTEx	Vagina	MAN2C1	0.31	0.30	enet	6	0.27	5.6e-07	5.6	5.4	8.5e-08	0.03	0.02	0.98	FALSE
57	GTEx	Whole Blood	MAN2C1	0.28	0.29	lasso	5	0.29	3.2e-27	5.3	5.2	1.8e-07	0.02	0.02	0.98	FALSE
58	METSIM	Adipose	IMP3	0.04	0.01	blup	226	0.03	5.0e-05	-4.4	-5.7	1.1e-08	-0.07	0.39	0.16	FALSE
59	METSIM	Adipose	MAN2C1	0.22	0.41	lasso	6	0.41	1.1e-66	5.3	5.2	1.7e-07	0.04	0.03	0.97	FALSE
60	METSIM	Adipose	SNX33	0.10	0.05	lasso	7	0.05	6.1e-08	-4.1	-5.3	1.4e-07	-0.01	0.90	0.08	FALSE
61	NTR	Blood	MAN2C1	0.02	0.03	lasso	2	0.03	1.5e-10	5.3	5.3	8.9e-08	0.02	0.03	0.97	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	COMMD4	0.02	0.00	enet	4	0.01	1.6e-03	-4.5	-5.3	1.4e-07	0.01	0.01	0.40	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNUPN	0.04	0.02	lasso	3	0.03	3.3e-06	-4.5	6.0	1.9e-09	0.03	0.02	0.96	FALSE
64	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MAN2C1	0.12	0.11	blup	14	0.12	1.4e-06	5.1	5.5	3.3e-08	0.02	0.00	1.00	FALSE
65	The Cancer Genome Atlas	Colon Adenocarcinoma	SNUPN	0.11	0.10	lasso	4	0.11	6.9e-07	5.6	5.3	1.4e-07	0.03	0.00	1.00	FALSE
66	The Cancer Genome Atlas	Esophageal Carcinoma	SNUPN	0.18	0.11	lasso	5	0.07	2.6e-03	5.6	5.7	1.0e-08	0.03	0.00	0.93	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNUPN	0.05	0.03	blup	38	0.05	4.0e-06	5.4	5.7	9.6e-09	0.03	0.01	0.99	FALSE
68	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MAN2C1	0.11	0.05	lasso	5	0.09	1.2e-05	-4.5	5.8	7.9e-09	0.02	0.00	0.91	FALSE
69	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAN2C1	0.08	0.06	blup	14	0.09	2.0e-10	5.1	5.7	9.2e-09	0.02	0.00	1.00	FALSE
70	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SNUPN	0.14	0.10	lasso	4	0.08	1.1e-04	5.5	5.5	3.6e-08	0.03	0.00	0.99	FALSE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	SNUPN	0.03	0.03	enet	8	0.02	9.9e-04	5.4	6.4	1.7e-10	0.04	0.01	0.98	FALSE
72	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MAN2C1	0.08	0.02	blup	14	0.04	1.3e-02	5.1	5.5	2.9e-08	0.03	0.00	0.68	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	MAN2C1	0.07	0.04	blup	15	0.05	6.6e-06	-4.5	5.3	1.1e-07	0.04	0.05	0.76	FALSE
74	The Cancer Genome Atlas	Prostate Adenocarcinoma	NEIL1	0.05	0.05	lasso	3	0.05	9.0e-06	5.2	5.2	1.5e-07	0.02	0.00	0.99	FALSE
75	The Cancer Genome Atlas	Prostate Adenocarcinoma	SNUPN	0.13	0.09	blup	38	0.12	6.0e-13	-4.5	6.3	3.2e-10	0.05	0.22	0.77	FALSE
76	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GOLGA6C	0.14	0.06	lasso	2	0.13	2.6e-05	-4.4	-5.1	2.9e-07	-0.06	0.00	0.23	FALSE
77	The Cancer Genome Atlas	Thyroid Carcinoma	MAN2C1	0.09	0.05	blup	13	0.06	3.1e-06	-4.5	5.2	1.6e-07	0.04	0.05	0.81	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	SNUPN	0.19	0.12	enet	11	0.20	1.1e-19	-4.5	5.9	4.5e-09	0.04	0.05	0.95	FALSE