TWAS hub - COMMD4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0630	0.0260	0.00012	0.041	0.029	0.038	0.033	0.044	7.7e-06	0.00017	1.7e-05	6.7e-05	3.7e-06
2	GTEx	Skin Sun Exposed Lower leg	0.0940	0.0360	0.00025	0.070	NA	0.059	NA	0.070	1.9e-06	NA	1.1e-05	NA	2.0e-06
3	TCGA	Breast Invasive Carcinoma	0.0232	0.0139	0.00083	0.005	0.008	0.011	NA	0.005	2.8e-02	0.00580	1.6e-03	NA	2.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Allopurinol	7.8	10.3	13.4	-3.3	-3.7	-2.6
Medication: Paracetamol	7.8	12.0	13.8	3.5	3.7	3.2
Type 2 Diabetes (T2D) (2018)	7.2	13.4	19.2	2.8	4.4	3.6
Birth weight of first child	6.3	11.5	16.1	3.8	4.0	2.0
Medication: Metformin	6.2	8.7	11.6	2.7	3.4	2.7
Breast Cancer	6.1	14.6	19.2	-2.9	-4.0	-4.4
Guilty feelings	5.8	8.7	10.6	-2.9	-3.3	-2.6
Frequency of tiredness / lethargy in last 2 weeks	5.5	8.9	10.8	2.5	3.3	3.1
Osteoarthritis (self-reported)	5.5	7.2	8.1	2.7	2.8	2.4
Diabetes (self-reported)	5.4	8.3	11.7	2.4	3.4	2.7
Medication: Paracetamol	5.4	8.9	10.0	2.8	3.2	3.0
Severe depression (siblings)	5.0	5.6	7.1	-2.0	-2.7	-2.4
Impedance of leg (left)	4.9	24.0	24.9	5.0	4.8	4.9
High blood pressure (mother)	4.6	6.5	7.0	-2.7	-2.4	-2.6
Diabetes diagnosed by doctor	4.6	7.6	10.8	2.4	3.3	2.5
Coronary Artery Disease (CAD)	4.4	5.3	6.6	-2.6	-2.0	-2.3
Handedness (chirality/laterality): Left-handed	4.4	5.3	5.7	2.3	2.4	2.2
Blood Platelet Count	4.2	48.3	60.0	5.3	7.7	7.5
Mouth/teeth dental problems: Dentures	4.2	7.1	9.9	3.1	2.9	1.6
Ever highly irritable/argumentative for 2 days	4.2	5.0	6.4	1.7	2.5	2.4
Back pain experienced in last month	4.2	6.1	7.1	2.6	2.7	2.1
Impedance of leg (right)	4.1	19.9	20.2	4.5	4.4	4.4
Age at First Birth	3.9	5.6	6.0	-2.4	-2.3	-2.4
Diabetes (father)	3.7	4.5	6.4	2.1	2.5	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.7	4.3	5.1	2.1	2.3	1.9
Pain experienced in last month	3.7	6.2	7.2	-2.5	-2.7	-2.3
Impedance of whole body	3.7	18.7	18.9	4.3	4.3	4.3
Trunk fat-free mass	3.6	20.9	28.6	-3.3	-4.8	-5.3
Gout (self-reported)	3.6	4.9	6.2	-2.5	-2.4	-1.7
Family relationship satisfaction	3.6	4.4	4.9	1.9	2.2	2.2
Lung FVC	3.5	17.8	21.4	-3.4	-4.6	-4.5
Lung cancer (father)	3.5	4.1	4.7	-2.2	-2.1	-1.7
Trunk predicted mass	3.5	20.0	27.8	-3.2	-4.7	-5.3
Leg fat percentage (right)	3.5	12.7	15.9	3.1	4.0	3.6
Medication: Ibuprofen	3.5	4.2	4.3	2.0	2.0	2.1
Qualifications: NVQ or HND or HNC or equivalent	3.5	4.3	5.3	-2.3	-2.2	-1.6
Mother’s age at death	3.5	4.4	7.0	-1.1	-2.2	-2.6
Stomach or abdominal pain in last month	3.4	4.2	5.1	2.2	2.3	1.6
Falls in the last year	3.4	4.6	8.0	2.8	2.1	1.1
Migraine (self-reported)	3.4	4.3	4.8	-2.1	-2.2	-1.9
Leg fat percentage (left)	3.4	12.4	15.1	3.1	3.9	3.5
Sitting height	3.3	23.4	29.6	-3.5	-5.4	-5.3
Pain type(s) experienced in last month: Hip pain	3.3	4.2	5.6	2.4	2.0	1.7
Peak expiratory flow (PEF)	3.2	7.5	10.6	-1.9	-3.3	-2.9
Eye problems/disorders: None of the above	3.1	3.6	6.7	-2.6	-1.5	-1.3
Whole body water mass	3.0	17.0	24.0	-3.0	-4.3	-4.9
Number of treatments/medications taken	2.9	5.3	6.7	1.7	2.5	2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.9	3.9	4.6	1.8	2.1	1.9
Medication: Ibuprofen (e.g. Nurofen)	2.9	3.7	3.8	1.9	1.9	1.9
Knee pain experienced in last month	2.9	4.4	7.0	1.9	2.6	1.6
Whole body fat-free mass	2.9	16.6	23.4	-3.0	-4.2	-4.8
Diabetes (mother)	2.8	3.6	6.9	0.8	1.8	2.6
Supplements: Glucosamine	2.8	3.7	7.0	2.6	1.7	1.0
Neck or shoulder pain in last month	2.8	4.0	5.1	2.2	2.2	1.4
Fed-up feelings	2.7	4.8	6.7	2.1	2.6	1.8
Current tobacco smoking	2.6	4.2	8.0	-2.8	-1.7	-1.3
Impedance of arm (left)	2.6	11.9	13.0	3.4	3.6	3.4
Ovarian Cancer	2.5	3.3	5.4	-2.3	-1.9	-1.0
Arm fat-free mass (right)	2.5	12.9	18.6	-2.5	-3.7	-4.3
Arm predicted mass (right)	2.5	12.8	18.7	-2.5	-3.7	-4.3
Chronotype (morning person)	2.4	5.6	6.3	2.5	2.4	2.2
Impedance of arm (right)	2.4	11.3	12.0	3.3	3.5	3.3
Smoking status: Current	2.4	3.9	7.0	-2.6	-1.6	-1.4
Alcohol drinker status: Previous	2.4	2.7	2.9	1.6	1.6	1.7
Trunk fat percentage	2.3	9.3	12.2	2.9	3.5	2.7
Body fat percentage	2.3	9.2	12.2	2.7	3.5	2.9
Miserableness	2.3	4.0	5.9	2.4	2.2	1.0
Financial situation satisfaction	2.3	2.8	5.2	2.3	1.8	0.2
Arm fat-free mass (left)	2.3	11.5	16.4	-2.4	-3.5	-4.1
Arm predicted mass (left)	2.3	11.5	17.6	-2.2	-3.5	-4.2
Qualifications: None of the above	2.2	4.7	5.7	1.7	2.4	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.1	9.6	-1.5	-3.1	-3.1
Medication: Amlodipine	2.2	3.0	4.3	-2.1	-1.8	-1.3
Illnesses of siblings: Diabetes	2.2	2.7	5.5	-2.3	-1.5	-0.5
Mood swings	2.2	4.0	5.1	1.4	2.2	2.2
Friendships satisfaction	2.2	2.8	3.9	1.5	1.5	2.0
Medication: Gliclazide	2.2	2.5	4.0	1.0	2.0	1.5
Leg predicted mass (right)	2.2	11.7	16.5	-2.6	-3.5	-4.1
LDL Cholesterol	2.1	3.3	4.6	2.2	1.7	1.6
Leg fat-free mass (right)	2.1	11.2	15.5	-2.5	-3.4	-3.9
Long-standing illness, disability or infirmity	2.1	3.2	5.1	1.7	2.3	1.3
Basal metabolic rate	2.1	11.4	17.0	-2.4	-3.4	-4.1
Diastolic blood pressure, automated reading	2.1	6.4	10.5	-3.2	-2.7	-1.2
Medication: Co-codamol	2.0	2.3	3.5	1.9	1.4	1.2
Leg fat-free mass (left)	2.0	10.5	15.3	-2.4	-3.2	-3.9
Leg predicted mass (left)	2.0	10.7	15.7	-2.4	-3.2	-4.0
Tense / ‘highly strung’	2.0	3.3	5.8	1.6	2.4	1.2
Forced vital capacity (FVC), Best measure	2.0	7.3	10.5	-1.5	-3.2	-3.0
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	3.8	1.3	2.0	1.8
Forced vital capacity (FVC)	1.9	7.3	10.4	-1.2	-3.2	-3.2
Forced expiratory volume in 1-second (FEV1)	1.9	6.3	9.4	-1.2	-2.8	-3.1
Happiness	1.9	2.3	5.8	0.6	0.9	2.4
Commuting to job workplace: Walk	1.9	2.1	3.3	-0.7	-1.6	-1.8
Ever smoked	1.9	3.3	4.5	-1.3	-1.9	-2.1
Commuting to job workplace: Cycle	1.9	2.3	5.4	-0.3	-1.2	-2.3
Schizophrenia vs Biploar Disorder	1.8	2.4	2.9	-1.7	-1.4	-1.5
Waist Hip Ratio (WHR)	1.8	8.0	14.3	2.6	3.8	1.6
Hand grip strength (left)	1.8	4.8	6.6	-1.7	-2.6	-2.3
Medication: Seretide 50 evohaler	1.8	2.1	2.1	1.5	1.5	1.4
Illnesses of father: Heart disease	1.8	2.5	4.4	-1.0	-1.5	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.8	2.0	2.9	-1.2	-1.2	-1.7
Lung FEV1/FVC ratio	1.7	8.4	9.9	-3.1	-2.4	-3.1
Alcohol intake frequency.	1.7	3.9	8.6	0.9	1.5	2.9
Wears glasses or contact lenses	1.7	1.9	3.3	1.8	1.5	0.5
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	3.6	1.6	1.9	0.3
Taking other prescription medications	1.6	2.5	4.3	1.5	2.1	1.1
Alcohol usually taken with meals	1.6	2.6	3.2	1.8	1.5	1.6
Financial difficulties in last 2 years	1.6	2.1	4.5	2.1	1.2	0.6
Breastfed as a baby	1.6	2.0	2.5	-1.3	-1.6	-1.3
Depressed Affect (Nagel 2018)	1.5	3.1	5.0	1.4	2.2	1.5
Hand grip strength (right)	1.5	4.0	6.2	-0.8	-2.3	-2.5
Had other major operations	1.5	1.9	2.5	1.1	1.6	1.4
Pain all over the body in last month	1.5	1.6	2.4	-1.6	-1.5	-0.1
Allergy or Eczema	1.4	3.8	4.2	2.1	2.0	1.8
Number of live births	1.4	2.0	2.1	-1.4	-1.4	-1.4
Noisy workplace	1.4	1.7	2.9	-1.2	-0.9	-1.7
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	4.7	-0.8	-1.7	-2.2
Overall health rating	1.4	3.0	5.7	1.1	2.4	1.5
Unable to work because of sickness or disability	1.4	1.8	3.0	1.3	1.7	0.8
Myopia	1.4	2.0	4.2	-2.0	-1.2	-0.5
Mean Putamen Volume	1.3	1.5	2.2	-1.5	-1.1	-1.1
Frequency of depressed mood in last 2 weeks	1.3	1.8	2.9	0.7	1.4	1.7
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	1.9	1.4	1.4	1.2
Medication: Ramipril	1.3	1.6	3.1	-1.8	-1.3	0.0
Ever had bowel cancer screening	1.3	1.5	3.0	1.1	1.7	0.6
Medication: Bendroflumethiazide	1.3	1.9	2.8	-1.1	-1.7	-1.3
Alcohol drinker status: Never	1.3	1.5	2.1	0.7	1.4	1.5
Fasting Glucose	1.2	1.4	2.5	-1.6	-0.8	-1.0
Rheumatoid Arthritis	1.2	1.6	1.6	1.2	1.3	1.3
Waist circumference	1.2	4.6	7.5	2.3	2.7	1.0
Allergy	1.2	2.8	3.5	-1.7	-1.9	-1.4
Pulse rate	1.2	2.1	2.9	-1.2	-1.4	-1.7
Number of full sisters	1.2	1.4	2.6	-1.0	-0.8	-1.6
Irritability	1.2	2.0	2.5	1.6	1.5	1.1
Triglycerides	1.1	1.8	2.3	-0.9	-1.5	-1.5
Past tobacco smoking	1.1	2.1	2.9	0.8	1.6	1.7
Mouth/teeth dental problems	1.1	1.7	3.0	-1.7	-1.4	0.1
Prospective memory result	1.1	1.3	2.0	-1.4	-1.4	-0.2
Shortness of breath walking on level ground	1.1	1.3	1.7	1.3	1.3	0.7
Depression (Nagel 2018)	1.0	1.5	2.3	0.7	1.4	1.5
Chronic bronchitis/emphysema (mother)	1.0	1.1	1.7	-1.0	-0.9	-1.3
Medication for pain relief, constipation, heartburn	1.0	1.8	2.8	-0.8	-1.3	-1.7
Leg pain on walking	1.0	1.2	1.9	1.4	1.1	0.8
Arm fat percentage (left)	1.0	4.2	6.3	1.5	2.5	2.0
Cholesterol lowering medication	1.0	1.5	3.2	1.0	1.8	0.6
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.0	-0.4	-0.6	-1.7
Heart disease (siblings)	1.0	1.3	2.0	0.8	1.0	1.4
Blood White Count	0.9	6.4	10.8	1.0	2.7	3.3
Smoking Status	0.9	2.0	2.7	-1.7	-1.6	-0.9
Hypothyroidism (self reported)	0.9	2.0	3.5	-0.5	-1.5	-1.9
Age when periods started (menarche)	0.9	2.1	3.5	-0.7	-1.5	-1.9
Hayfever, allergic rhinitis or eczema	0.9	2.0	2.4	1.2	1.6	1.5
Heart attack	0.9	1.2	1.5	-1.2	-1.1	-0.9
Arm fat percentage (right)	0.9	3.6	5.6	1.4	2.4	1.8
Standing height	0.9	8.8	14.2	-0.8	-3.4	-3.8
High blood pressure (siblings)	0.9	1.4	2.1	-1.5	-1.3	-0.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.9	0.5	0.9	1.4
Average weekly beer plus cider intake	0.9	1.3	3.0	-1.7	-0.8	-0.3
Height	0.8	16.3	31.0	-0.3	-4.2	-5.6
Neuroticism	0.8	1.9	3.3	0.8	1.8	1.3
Townsend deprivation index at recruitment	0.8	1.1	1.8	-1.4	-1.1	-0.3
Multivitamins +/- minerals	0.8	1.0	2.2	1.5	0.8	0.5
Nervous feelings	0.8	1.6	3.1	0.7	1.8	1.0
Glaucoma (self-reported)	0.8	0.9	1.3	1.1	1.0	0.7
Worry too long after embarrassment	0.8	1.3	2.1	-1.4	-1.1	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.3	-0.4	-0.6	-1.8
Mineral and other dietary supplements	0.8	1.1	2.8	-1.7	-0.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	2.5	-1.1	-1.6	-1.3
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.3	-1.2	-1.0	-0.8
Major Depression (MDD)	0.7	0.9	1.5	-1.2	-0.8	-0.8
Reaction Time	0.7	1.4	3.0	-0.8	-0.8	-1.7
Neuroticism (2016)	0.7	1.0	1.6	0.9	1.3	0.8
Systolic blood pressure, automated reading	0.7	2.0	2.5	1.0	1.5	1.6
Qualifications: CSEs or equivalent	0.7	1.0	1.5	-1.2	-1.1	-0.4
Medication: Levothyroxine sodium	0.7	1.2	1.6	-0.7	-1.3	-1.2
Number of incorrect matches in round	0.7	1.1	2.2	0.7	0.8	1.5
Comparative body size at age 10	0.7	2.0	4.0	2.0	1.4	-0.1
Medication: Omeprazole	0.7	0.8	2.3	0.2	-0.2	-1.5
Mean time to correctly identify matches	0.7	1.2	3.6	-0.3	-0.2	-1.9
Vascular/heart problems diagnosed by doctor	0.7	2.0	4.1	2.0	1.4	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.5	1.2	0.7	0.7
Leg fat mass (left)	0.7	2.6	3.5	1.6	1.9	1.3
Worry (Nagel 2018)	0.6	1.3	2.7	0.8	1.6	0.9
Alzheimer’s Disease (including proxy)	0.6	0.9	2.3	1.5	0.6	0.2
Schizophrenia (2014)	0.6	1.4	2.2	-1.5	-1.0	-1.1
Heel T-Score	0.6	4.5	8.1	2.8	2.0	1.1
Average weekly spirits intake	0.6	0.8	1.5	1.2	0.8	-0.4
Trunk fat mass	0.6	2.7	3.6	1.8	1.9	1.2
Had menopause	0.6	0.7	1.8	-0.2	-0.6	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.0	1.4	1.0	1.1
Neuroticism score	0.6	1.3	1.9	0.7	1.4	1.2
Worrier / anxious feelings	0.6	1.1	1.7	0.4	1.2	1.3
Leg fat mass (right)	0.6	2.4	3.4	1.5	1.8	1.3
Suffer from ‘nerves’	0.6	0.9	1.7	0.1	1.0	1.3
Hypertension (Self-reported)	0.6	1.6	2.9	-1.7	-1.3	-0.3
Medication: Aspirin	0.6	0.8	1.4	0.4	0.8	1.2
Alzheimer’s Disease (in mother)	0.5	0.5	1.2	1.1	0.2	-0.6
HDL Cholesterol	0.5	0.9	1.0	0.8	1.0	0.9
Respiratory disease	0.5	1.1	1.5	1.2	1.2	0.6
Serious illness, injury or assault to yourself	0.5	0.6	1.5	-0.2	-0.4	-1.2
High blood pressure	0.5	1.5	3.0	-1.7	-1.2	-0.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.6	-1.3	-0.5	-0.2
Father’s age at death	0.5	0.7	1.7	1.3	0.5	-0.3
Medication: Ventolin 100micrograms inhaler	0.5	0.6	0.8	-0.6	-0.8	-0.9
Birth weight	0.5	1.2	3.3	-0.0	-0.5	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.0	-0.8	-1.0	-0.6
Qualifications: College or University degree	0.5	1.5	2.1	-1.0	-1.4	-1.1
Heart disease (mother)	0.5	0.5	1.0	0.3	0.7	1.0
Whole body fat mass	0.5	2.2	3.1	1.5	1.8	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.5	0.0	-0.4	-1.2
Average weekly red wine intake	0.5	0.7	1.9	-0.3	-0.5	-1.4
Eye problems/disorders: Glaucoma	0.5	0.5	1.0	1.0	0.6	0.4
Fractured/broken bones in last 5 years	0.5	0.7	1.3	0.2	-0.8	-1.2
Lupus	0.4	0.7	1.3	-1.2	-0.7	0.4
Supplements: Zinc	0.4	0.4	0.7	0.7	-0.0	-0.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	-0.1	0.8	0.9
Medication: Atenolol	0.4	0.6	1.6	-1.3	-0.3	-0.0
Medication: Simvastatin	0.4	0.6	1.4	0.5	1.2	0.4
Fluid intelligence score	0.4	0.9	1.6	1.3	1.0	0.5
Illnesses of siblings	0.4	0.5	0.8	0.9	-0.0	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.7	-0.4	0.8	0.9
Depression (self-reported)	0.4	0.5	0.8	0.7	0.9	-0.3
Length of working week for main job	0.4	0.5	0.7	0.3	0.8	0.8
Blood clot in the leg (DVT)	0.4	0.5	0.9	0.9	0.5	0.6
Wheeze or whistling in the chest in last year	0.4	0.7	1.1	1.0	1.0	0.4
Emphysema/chronic bronchitis	0.4	0.4	0.7	0.7	0.4	-0.8
Supplements: Vitamin C	0.4	0.4	0.9	-0.4	-0.9	-0.5
Number of self-reported non-cancer illnesses	0.4	0.6	0.8	0.6	0.8	0.9
Ever taken oral contraceptive pill	0.4	0.5	0.7	-0.9	-0.6	-0.6
Hearing aid user	0.4	0.5	0.8	0.9	-0.3	-0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.9	1.0	0.1	-0.8
Bipolar Disorder (2018)	0.3	0.5	0.6	-0.6	-0.7	-0.8
Alzheimer’s Disease (in father)	0.3	0.3	0.5	0.7	0.6	0.1
Crohns Disease (2012)	0.3	0.4	0.6	-0.5	-0.7	-0.7
Cardiovascular Disease	0.3	1.0	2.1	-1.5	-0.9	0.4
Hearing difficulty/problems: Yes	0.3	0.4	0.8	0.9	0.4	-0.5
Relative age of first facial hair	0.3	0.6	1.7	0.1	-0.1	-1.3
Ever had hysterectomy (womb removed)	0.3	0.4	1.1	-1.0	-0.2	0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.5	0.4	0.4	0.7
Vitamin and mineral supplements	0.3	0.4	1.1	-1.0	-0.3	0.1
Pack years adult smoking proportion	0.3	0.4	1.0	-1.0	-0.5	0.2
Maternal smoking around birth	0.3	0.4	1.1	-1.0	-0.5	0.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	-0.1	-0.5	-0.8
Hearing difficulty/problems with background noise	0.3	0.5	1.2	1.1	0.7	-0.0
Hair/balding pattern: Pattern 3	0.3	0.4	0.8	-0.9	-0.3	-0.5
Illnesses of mother	0.3	0.4	0.7	0.8	0.5	0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.5	0.7	0.5	0.6
Headache pain in last month	0.3	0.4	0.9	-1.0	-0.6	0.2
Number of children fathered	0.3	0.4	1.0	0.1	0.3	1.0
Chest pain or discomfort	0.3	0.5	0.9	1.0	0.7	-0.1
Age at last live birth	0.3	0.5	0.7	-0.6	-0.6	-0.8
Medication: Aspirin	0.3	0.4	1.0	0.1	0.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	0.9	0.2	-0.9	-1.0
Loneliness, isolation	0.3	0.4	0.8	-0.5	0.4	0.9
Eye problems/disorders: Cataract	0.3	0.4	1.0	1.0	0.2	-0.1
Breast cancer (self-reported)	0.3	0.4	0.7	0.2	0.6	0.8
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.8	0.6	0.9	-0.2
High cholesterol (Self-reported)	0.3	0.6	1.0	0.8	1.0	0.2
Medication: Lisinopril	0.3	0.4	1.1	-1.1	-0.4	-0.2
Risk taking	0.3	0.4	0.7	-0.8	-0.6	-0.4
Basal cell carcinoma (self-reported)	0.3	0.3	0.8	-0.5	-0.9	0.0
Bipolar Disorder or Schizophrenia	0.2	0.5	0.8	-0.9	-0.5	-0.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	0.9	1.0	0.8	0.4
Neuroticism (Nagel 2018)	0.2	0.4	1.0	0.1	1.0	0.4
Crohns Disease (2017)	0.2	0.4	0.7	-0.9	-0.7	-0.3
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	-1.1	-0.4	-0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.0	-0.3	-0.4	-1.0
Prostate Cancer	0.2	0.3	0.4	0.6	0.6	0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.2	0.7	0.4
Blood Red Count	0.2	1.7	4.3	-0.8	0.6	2.1
Systolic Blood Pressure	0.2	0.8	2.4	0.3	0.1	1.6
Angina	0.2	0.2	0.5	0.2	0.7	0.3
Medication for hormone replacement therapy	0.2	0.2	0.5	0.7	0.1	0.2
Relative age voice broke	0.2	0.4	0.7	-0.8	-0.5	-0.4
Weight	0.2	0.8	1.9	-0.2	-0.6	-1.4
Hip circumference	0.2	0.8	1.4	1.2	0.9	0.3
Asthma	0.2	0.3	0.5	0.6	0.7	0.0
Arm fat mass (right)	0.2	0.8	1.5	0.9	1.2	0.4
Hair/balding pattern: Pattern 4	0.2	0.5	0.8	-0.9	-0.6	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.7	0.9	0.4	-0.6
Medication: Blood pressure	0.2	0.4	0.6	-0.8	-0.1	0.7
Had major operations	0.2	0.2	0.3	0.3	0.6	0.5
Smoking status: Previous	0.2	0.3	0.5	0.7	-0.4	-0.4
Qualifications: nursing, teaching	0.2	0.3	0.6	-0.3	-0.3	-0.8
Medication for cholesterol	0.2	0.3	0.9	0.0	-0.3	-1.0
Asthma (self-reported)	0.2	0.3	0.5	0.7	0.7	0.0
Arm fat mass (left)	0.2	0.9	1.7	0.8	1.3	0.6
Medication: Blood pressure	0.2	0.3	0.5	-0.6	-0.7	-0.0
Medication: Atorvastatin	0.2	0.2	0.4	0.3	0.3	-0.6
Number of operations (self-reported)	0.2	0.2	0.4	0.7	0.4	0.3
Ever depressed for a whole week	0.2	0.2	0.7	-0.8	-0.0	0.1
Supplements: Calcium	0.2	0.2	0.3	-0.5	0.1	0.6
Schizophrenia (2018)	0.1	0.2	0.5	-0.7	-0.1	-0.1
Ulcerative Colitis (UC)	0.1	0.2	0.5	-0.7	0.2	0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.0	-0.5	-0.3
Ulcerative Colitis	0.1	0.2	0.4	-0.6	-0.4	-0.3
Blood Eosinophil Count	0.1	0.8	1.9	-0.3	0.6	1.4
Tanning	0.1	0.8	0.9	0.9	0.8	1.0
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.1	-0.4	-0.5
Average weekly fortified wine intake	0.1	0.2	0.5	0.1	-0.7	0.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	-0.4	-0.3	-0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	-0.3	-0.3	-0.4
Body mass index (BMI)	0.1	0.6	1.4	0.4	1.2	0.5
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.1	0.4	0.4
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.4	0.4	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.1	0.6	0.4
Pulse wave reflection index	0.1	0.1	0.2	-0.3	-0.3	0.4
Loud music exposure frequency	0.1	0.1	0.2	-0.4	0.3	-0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.4	0.4	-0.1
Exposure to tobacco smoke outside home	0.1	0.1	0.2	-0.0	0.4	0.4
Number of full brothers	0.1	0.1	0.2	-0.2	-0.2	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.4	-0.7	-0.2	-0.2
Pulse wave peak to peak time	0.1	0.1	0.2	0.0	-0.1	-0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	0.6	0.3	-0.3
Angina (self-reported)	0.1	0.1	0.4	0.1	0.6	0.0
Comparative height size at age 10	0.1	0.6	1.1	0.1	-1.0	-0.8
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	-0.6	-0.3	0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.3	-0.1	0.4
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.1	-0.5	-0.4
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.4	-0.1	0.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.1	-0.4	-0.4
Age started oral contraceptive pill	0.1	0.1	0.1	0.1	0.4	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.0	0.1	-0.1	0.3	0.1
Primary Biliary Cirrhosis	0.0	0.0	0.0	-0.1	0.0	0.1
BMI	0.0	0.3	0.5	0.5	0.7	-0.2
Hair Pigment	0.0	1.3	3.0	-1.7	-1.0	0.3
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.3	-0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	0.5	0.1	0.2
Hair/balding pattern: Pattern 2	0.0	0.1	0.1	0.3	-0.1	-0.3
Time employed in main current job	0.0	0.0	0.0	-0.1	-0.1	-0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.0	0.1	-0.2	-0.1
Medication: Cholesterol lowering	0.0	0.0	0.0	-0.2	-0.1	0.2
Medication: Lansoprazole	0.0	0.1	0.1	-0.3	0.3	0.0
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	-0.2	-0.2	0.1
Age at first live birth	0.0	0.1	0.2	0.2	-0.2	-0.4
Health satisfaction	0.0	0.0	0.0	-0.1	-0.0	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.0	-0.0	0.2
Pulse rate, automated reading	0.0	0.2	0.3	0.4	0.2	-0.6
Osteoporosis (self-reported)	0.0	0.0	0.1	0.1	0.1	0.3
Average weekly champagne plus white wine intake	0.0	0.1	0.1	-0.2	-0.3	0.3
Pack years of smoking	0.0	0.1	0.1	-0.4	-0.0	0.2

Hub : Genes

COMMD4

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Trait associations