Hub : Genes

CYP11A1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Sigmoid	0.1580	0.0860	0.0090	0.018	NA	0.003	NA	0.038	0.0740	NA	0.2500	NA	0.0170
2	GTEx	Lung	0.0970	0.0452	0.0020	0.006	NA	0.021	NA	0.006	0.1100	NA	0.0095	NA	0.1100
3	GTEx	Nerve Tibial	0.0606	0.0320	0.0079	-0.002	NA	-0.004	NA	-0.003	0.5000	NA	0.8900	NA	0.5900
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0900	0.0450	0.0026	0.002	0.022	0.018	NA	0.001	0.2500	0.019	0.0320	NA	0.2700
5	TCGA	Thyroid Carcinoma	0.0460	0.0320	0.0071	0.023	0.015	0.015	NA	0.025	0.0023	0.011	0.0110	NA	0.0015

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.6	2.5	7.6	0.1	-1.8	-1.3	-2.8	0.2
Bipolar Disorder or Schizophrenia	1.0	2.4	6.1	0.8	-2.3	0.2	-2.5	-0.2
Depressed Affect (Nagel 2018)	1.0	2.1	6.6	-1.0	-0.4	-0.7	-2.6	-1.5
Depression (Nagel 2018)	1.4	2.1	4.3	-2.0	0.8	-0.5	-2.1	-1.2
Intelligence (Savage-Jansen 2018)	0.9	2.8	9.9	1.3	3.2	0.0	0.1	-1.5
Neuroticism (Nagel 2018)	0.5	1.1	4.0	-0.7	-0.2	0.4	-2.0	-0.9
Schizophrenia (2018)	0.6	1.1	2.2	0.9	-1.5	1.2	-1.0	-0.5
Schizophrenia vs Biploar Disorder	0.5	0.6	1.7	-0.9	-0.2	1.3	-0.0	-0.7
Worry (Nagel 2018)	0.7	1.5	5.3	-1.1	-0.6	0.6	-2.3	0.6
Alzheimer’s Disease (in mother)	0.6	0.7	1.7	0.7	0.9	0.4	1.3	-0.7
Alzheimer’s Disease (in father)	1.3	1.5	3.8	-1.4	0.7	-1.0	0.0	-2.0
Alzheimer’s Disease (including proxy)	1.1	1.6	2.8	-0.1	1.7	-0.2	1.6	-1.6
Crohns Disease (2017)	0.5	1.1	3.9	-0.5	-0.1	-1.0	-0.5	-2.0
Irritable Bowel Disease (IBD)	0.9	2.1	6.0	-0.9	0.9	-1.7	-0.5	-2.4
Ulcerative Colitis (UC)	1.1	2.0	3.8	-1.5	1.1	-1.5	-0.4	-1.9
Major Depression (MDD)	0.4	0.5	1.1	-1.0	0.9	-0.6	-0.2	0.5
Reaction Time	0.3	0.6	1.3	1.1	-1.0	0.6	0.5	0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.2	1.0	1.4	0.1	-1.5	-0.6
Breast Cancer	2.1	4.9	11.4	0.7	-3.4	0.9	-0.8	3.4
Ovarian Cancer	0.2	0.2	0.5	0.4	0.2	-0.6	-0.1	0.7
Prostate Cancer	1.6	2.3	4.9	-0.4	1.4	-2.2	1.1	-1.8
Age at First Birth	1.1	1.6	4.1	2.0	-1.4	-1.2	0.8	-0.2
Bipolar Disorder (2011)	1.1	1.1	3.1	-1.3	-0.1	-0.5	-0.7	-1.8
Body Mass Index (BMI) (2010)	0.4	0.5	2.1	-0.5	1.5	-0.4	0.2	0.1
Coronary Artery Disease (CAD)	0.1	0.1	0.4	0.0	-0.1	-0.4	0.4	-0.6
Crohns Disease (2012)	0.7	1.1	2.1	-0.9	0.4	-1.1	-1.1	-1.5
Mean Putamen Volume	1.3	1.5	3.3	1.8	-1.2	1.3	0.8	-0.5
Fasting Glucose	1.3	1.5	2.6	1.6	-1.3	0.6	1.6	0.6
HbA1C	1.4	1.5	4.2	0.4	0.3	1.4	1.1	2.1
HDL Cholesterol	0.3	0.5	2.2	-0.6	-0.0	0.0	-0.1	-1.5
LDL Cholesterol	0.9	1.4	2.4	-1.5	1.6	-0.5	-0.2	-1.5
Lupus	2.2	3.3	7.7	1.0	-2.8	0.3	-2.3	-1.6
Neuroticism (2016)	0.9	1.3	3.3	-0.4	0.8	0.1	-1.8	-1.6
Primary Biliary Cirrhosis	0.2	0.3	0.9	1.0	0.0	0.5	-0.1	0.6
Rheumatoid Arthritis	1.3	1.8	5.2	-0.7	-0.0	-1.0	-1.6	-2.3
Schizophrenia (2014)	0.9	1.9	3.6	-1.5	-1.8	-0.2	-1.9	-0.8
Triglycerides	0.7	1.1	2.8	-0.1	-1.7	-0.3	0.2	1.5
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.8	-0.5	1.0	-1.7	-0.9	-1.3
Ulcerative Colitis	1.9	2.7	5.3	-1.5	1.5	-0.7	-1.8	-2.3
Blood Eosinophil Count	0.2	1.2	4.9	2.2	0.2	-0.3	0.8	0.2
Blood Platelet Count	0.4	4.5	8.7	-1.8	3.0	-1.4	1.7	-2.3
Blood Red Count	1.4	13.5	32.1	2.4	-5.7	1.5	-3.2	4.1
Blood White Count	0.2	1.6	4.9	-1.2	0.0	-0.6	-2.2	-1.0
Heel T-Score	0.4	3.1	11.0	1.8	-0.2	3.3	0.8	1.1
BMI	0.5	3.0	12.0	-0.6	3.5	-0.9	-1.2	0.7
Height	1.7	32.9	73.3	-3.2	-5.8	-8.6	-0.3	6.8
Waist Hip Ratio (WHR)	1.6	7.2	20.9	-2.6	4.6	0.1	-2.5	-1.5
Systolic Blood Pressure	2.6	12.8	44.0	0.8	-6.6	-0.3	-3.2	3.0
Smoking Status	0.3	0.6	1.9	-0.1	-1.0	0.3	1.4	0.1
Allergy or Eczema	0.4	1.1	3.8	-0.1	2.0	-0.8	0.9	0.3
Cardiovascular Disease	5.5	18.3	51.0	2.4	-7.1	-0.7	-3.7	4.5
Hypothyroidism (self reported)	0.1	0.2	0.7	0.5	0.8	-0.2	-0.3	0.4
Respiratory disease	0.7	1.5	3.8	-0.1	0.7	-1.9	1.8	-0.6
Type 2 Diabetes (T2D) (2018)	1.2	2.2	4.3	-0.4	-0.5	-1.5	-2.0	2.1
Lung FEV1/FVC ratio	0.1	0.5	1.2	0.7	-0.6	0.7	-1.1	0.2
Lung FVC	0.4	2.0	5.7	-0.0	-0.4	-0.7	1.9	-2.4
Neuroticism	0.7	1.7	5.5	-0.6	-1.1	0.4	-2.3	-1.0
Chronotype (morning person)	0.0	0.1	0.2	0.1	0.2	0.3	-0.5	0.2
Hair Pigment	0.1	1.9	6.0	0.1	2.4	-1.6	0.9	-0.3
Tanning	0.2	3.0	6.4	-2.1	1.8	-2.5	0.6	-0.7
Hand grip strength (left)	1.4	3.7	8.9	-3.0	-0.1	-3.0	0.8	0.5
Number of treatments/medications taken	0.4	0.6	2.4	-0.4	-0.3	-0.5	-1.6	-0.6
Average weekly spirits intake	0.6	0.7	1.4	-1.1	-0.1	-0.5	-0.7	-1.2
Sensitivity / hurt feelings	0.3	0.6	1.0	-0.8	-0.8	1.0	-0.5	-0.5
Frequency of depressed mood in last 2 weeks	2.1	2.9	4.3	-1.9	-0.2	-1.6	-1.9	-2.1
Hearing difficulty/problems: Yes	0.9	1.3	4.6	-1.2	0.5	-2.2	0.3	0.2
Relative age of first facial hair	0.8	1.7	6.5	2.5	0.9	-0.3	0.7	0.8
Other serious medical condition/disability diagnosed by doctor	1.7	2.3	5.7	-2.4	2.3	-0.3	-0.2	-0.1
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.1	1.1	-0.4	0.5	1.2	1.7
Ever had hysterectomy (womb removed)	0.5	0.5	1.3	0.1	-1.1	-0.2	-1.0	0.4
Systolic blood pressure, automated reading	1.6	4.5	15.3	-1.0	-3.9	-0.4	-2.0	1.5
Eye problems/disorders: Diabetes related eye disease	2.4	2.7	10.0	-0.4	-0.8	-1.5	-0.5	3.2
Angina	0.2	0.3	0.6	-0.5	-0.7	0.2	-0.2	0.8
Medication for hormone replacement therapy	0.9	1.0	2.6	0.3	1.6	-1.1	0.8	-0.6
Vitamin and mineral supplements	1.0	1.3	2.5	1.0	-1.5	1.6	0.9	-0.3
Supplements: Zinc	0.3	0.3	1.3	-0.3	-0.1	-0.1	-1.2	0.1
Medication: Co-codamol	1.0	1.1	2.3	-1.2	1.5	0.4	-0.0	-1.4
Medication: Metformin	0.9	1.3	3.4	0.3	-1.8	-0.4	-1.4	0.8
Diabetes (father)	0.6	0.8	1.5	0.8	-0.3	0.8	-1.0	1.2
Diabetes (mother)	1.0	1.3	3.3	-1.8	0.2	-1.2	-1.2	-0.5
Severe depression (siblings)	0.0	0.0	0.1	0.3	0.1	-0.3	0.2	0.1
Pack years adult smoking proportion	0.4	0.6	1.8	-1.3	0.2	0.9	0.4	-0.3
Impedance of leg (right)	0.6	2.8	11.3	1.3	-3.4	0.6	-0.3	0.6
Leg fat-free mass (left)	1.1	5.7	18.0	-2.6	1.3	-4.2	0.1	1.3
Trunk fat percentage	0.3	1.4	2.7	-0.9	1.5	-1.0	-1.6	-0.1
Hand grip strength (right)	1.2	3.2	6.9	-2.5	0.6	-2.6	1.1	1.2
Townsend deprivation index at recruitment	0.4	0.6	2.2	-1.5	-0.7	0.2	-0.2	-0.3
Current tobacco smoking	0.9	1.4	6.2	-0.2	-2.5	0.2	0.9	0.1
Average weekly fortified wine intake	0.9	1.0	2.2	1.0	-0.6	-1.5	1.2	0.2
Maternal smoking around birth	1.2	1.8	6.2	-0.7	2.5	-0.6	1.1	-0.7
Fed-up feelings	1.4	2.5	5.3	-1.7	-0.7	0.0	-2.3	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	7.0	-2.6	0.3	-0.7	-1.4	-2.1
Relative age voice broke	1.0	1.5	5.2	2.3	0.1	0.7	-0.3	1.2
Taking other prescription medications	0.0	0.1	0.3	-0.1	-0.5	0.2	-0.2	-0.1
Age when periods started (menarche)	1.1	2.6	4.6	-1.8	-0.9	-1.5	-1.5	-2.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.5	-0.3	-0.9	-0.2	1.6	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	4.6	0.5	-0.9	0.8	1.5	2.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	0.3	-0.8	-0.3	-0.2	0.8
Qualifications: CSEs or equivalent	1.0	1.3	3.7	-0.2	1.9	1.5	0.1	-0.5
Serious illness, injury or assault to yourself	1.0	1.2	1.7	-1.2	1.3	0.9	0.8	-1.3
High blood pressure	5.0	13.9	46.8	2.4	-6.8	-1.0	-1.9	3.5
Hayfever, allergic rhinitis or eczema	0.5	1.1	4.0	-0.3	2.0	-1.1	0.1	-0.4
Multivitamins +/- minerals	2.2	2.8	4.2	-1.7	2.0	-1.5	-1.2	-1.9
Stomach or abdominal pain in last month	0.9	1.1	3.5	-1.9	1.3	0.2	-0.4	-0.4
Supplements: Glucosamine	2.2	2.9	8.9	1.0	3.0	0.3	1.2	-1.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	3.3	0.1	1.0	0.2	-0.4	-1.8
Medication: Atenolol	2.1	2.6	6.0	0.3	-2.5	-0.2	-1.2	2.3
Medication: Levothyroxine sodium	0.5	0.8	1.6	-1.1	1.3	0.5	-0.9	-0.3
Sitting height	2.7	19.3	70.1	-3.5	-2.2	-8.4	1.3	2.8
Chronic bronchitis/emphysema (father)	1.9	2.2	3.1	-1.7	1.7	-1.4	-0.6	-1.8
High blood pressure (mother)	0.7	1.0	2.7	0.5	-1.6	-0.4	-1.4	-0.5
Body mass index (BMI)	1.2	5.1	16.9	-2.0	4.1	-1.0	-1.0	-1.5
Impedance of leg (left)	0.4	2.0	7.8	1.1	-2.8	0.8	-0.5	0.6
Leg predicted mass (left)	1.0	5.5	17.7	-2.6	1.3	-4.2	0.1	1.3
Trunk fat mass	0.6	2.7	6.4	-1.6	1.7	-2.5	-1.2	0.3
Waist circumference	2.2	8.0	21.7	-2.9	4.7	-2.4	-1.8	-0.9
Number of incorrect matches in round	0.1	0.1	0.2	-0.4	-0.4	-0.1	-0.2	0.4
Past tobacco smoking	0.2	0.3	0.7	0.5	-0.8	0.1	0.0	0.7
Alcohol usually taken with meals	0.1	0.2	0.9	0.9	0.2	0.4	-0.3	0.0
Nervous feelings	0.3	0.6	1.6	-0.2	-1.3	-0.1	-1.0	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.5	0.2	-0.5	-0.3	0.8	-1.2
Hearing difficulty/problems with background noise	1.6	2.6	7.5	-0.0	2.7	-1.6	1.7	-0.3
Hair/balding pattern: Pattern 2	0.7	0.9	2.2	0.9	1.5	1.0	0.7	0.2
Had menopause	2.6	3.2	6.0	2.4	-0.2	1.3	1.6	2.4
Had other major operations	4.3	5.3	13.9	-1.4	2.0	0.8	-2.4	-3.7
Forced vital capacity (FVC)	1.5	5.7	20.8	-2.0	-0.9	-4.6	1.7	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.9	1.3	-0.3	0.4	0.8	1.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.6	-1.9	0.8	-0.6	0.0	0.1
Qualifications: None of the above	0.5	1.1	3.8	0.4	-0.9	2.0	-0.5	0.6
Financial difficulties in last 2 years	1.4	1.8	4.4	-1.3	2.1	-0.3	-0.0	-1.7
Mouth/teeth dental problems	1.4	2.2	7.6	0.9	-2.8	-0.4	0.1	1.5
Heart attack	0.6	0.8	3.5	-0.5	-1.9	0.3	0.3	0.1
Allergy	0.7	1.6	3.8	0.6	-1.6	1.9	-0.4	1.1
Pain all over the body in last month	0.2	0.3	0.9	0.3	-0.1	0.9	0.4	0.4
Diabetes (self-reported)	0.7	1.1	3.0	0.2	-0.7	-1.0	-1.7	0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.1	1.0	1.1	0.2	-0.3	-0.9
Medication: Ramipril	2.2	2.9	6.2	1.1	-1.9	-1.6	-0.9	2.5
Medication: Simvastatin	1.6	2.3	6.6	0.4	-1.7	0.1	-2.6	1.4
Fluid intelligence score	0.3	0.7	1.5	0.7	1.2	0.6	-1.0	0.4
Illnesses of siblings	0.7	1.0	2.0	-0.3	1.2	-1.4	0.5	-1.1
Neuroticism score	1.1	2.2	4.8	-1.7	-1.3	-0.2	-2.2	-1.3
Weight	1.2	6.1	17.6	-2.6	2.4	-4.2	-0.4	0.7
Impedance of arm (right)	2.1	9.9	26.5	3.6	-5.2	2.1	-0.2	2.3
Arm fat percentage (right)	0.4	1.7	3.9	-0.4	2.0	0.0	-1.9	-0.8
Trunk fat-free mass	1.5	8.4	27.8	-3.2	1.0	-5.3	0.6	1.7
Hip circumference	0.9	3.7	12.2	-1.7	1.5	-3.5	-0.6	1.0
Time employed in main current job	0.7	0.8	2.9	-0.2	0.7	-0.1	1.7	0.8
Alcohol intake versus 10 years previously	0.5	0.8	1.7	-1.0	0.6	0.8	-0.4	-1.3
Father’s age at death	1.4	1.8	5.2	0.6	1.3	-2.3	1.2	0.6
Worrier / anxious feelings	1.1	2.0	4.1	-0.6	-1.7	1.2	-2.0	-1.2
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.2	10.2	-3.2	2.8	-1.1	0.5	-1.1
Falls in the last year	0.8	1.1	3.3	-1.8	1.2	-0.9	-0.2	0.3
Hair/balding pattern: Pattern 3	2.1	3.1	6.9	-0.5	-2.4	-1.7	-2.6	0.2
Number of live births	1.1	1.5	3.4	-1.1	-1.1	1.1	-0.8	1.9
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	13.4	-1.6	-0.2	-3.7	1.6	-0.2
Pulse rate	0.8	1.4	2.2	-1.2	0.4	-1.2	-1.3	-1.5
Happiness	0.3	0.3	0.6	-0.4	-0.6	0.8	-0.3	0.7
Noisy workplace	0.8	1.0	2.1	-1.5	0.3	-0.9	-0.0	-1.4
Qualifications: A levels/AS levels or equivalent	0.9	2.1	6.6	-1.0	2.6	1.0	0.5	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	2.4	1.6	1.3	0.3	-0.1	1.6
Mouth/teeth dental problems: Dentures	0.5	0.9	1.9	0.1	0.9	1.1	-1.4	-0.5
Asthma	0.6	1.2	3.7	-0.7	-0.2	-1.9	0.7	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.5	2.0	5.5	0.1	2.3	-0.2	-0.4	-2.0
Medication: Cholesterol lowering	1.9	3.0	7.8	0.8	-2.8	0.5	-2.4	0.9
Depression (self-reported)	0.9	1.0	2.1	-0.8	1.0	-0.2	-1.5	-1.1
Medication: Lansoprazole	0.3	0.3	0.6	0.6	-0.6	0.8	0.3	-0.1
Prospective memory result	0.6	0.7	2.2	-0.5	-1.5	0.2	-0.9	0.4
Lung cancer (father)	1.2	1.4	2.7	-1.6	-1.2	1.0	-1.1	0.8
Illnesses of mother	0.1	0.1	0.5	-0.2	0.2	-0.7	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	8.6	-0.7	-0.5	-2.9	1.9	0.3
Pulse wave Arterial Stiffness index	1.8	2.1	6.6	-2.6	-1.6	-1.0	-0.2	-0.4
Impedance of arm (left)	2.1	9.5	24.1	3.4	-4.9	2.4	-0.2	2.6
Arm fat mass (right)	0.7	2.9	6.8	-1.5	2.6	-1.9	-1.3	-0.1
Trunk predicted mass	1.5	8.4	27.3	-3.1	1.1	-5.2	0.7	1.8
Standing height	1.9	18.8	51.9	-1.7	-3.6	-7.2	1.2	5.0
Length of working week for main job	1.5	1.7	5.0	-1.0	2.2	-1.0	-0.8	-0.9
Exposure to tobacco smoke at home	0.5	0.5	1.2	1.1	0.9	-0.5	0.6	0.1
Breastfed as a baby	0.8	1.0	2.7	1.1	-0.3	-1.6	0.5	-1.0
Tense / ‘highly strung’	1.0	1.7	4.0	-1.8	-0.7	-0.7	-2.0	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.4	-1.6	0.4	-1.2	-0.9	-0.8
Hair/balding pattern: Pattern 4	0.3	0.6	2.6	-1.6	-0.7	-0.1	0.4	-0.0
Birth weight of first child	0.5	1.0	2.7	-1.0	0.8	-1.6	0.3	-0.7
Peak expiratory flow (PEF)	1.0	2.2	9.7	0.7	-3.1	-0.5	0.2	0.7
Pulse wave reflection index	0.3	0.4	1.4	-1.2	-0.5	-0.1	0.5	-0.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.0	-1.4	0.8	0.1	-0.2	0.6
Loud music exposure frequency	0.3	0.4	1.1	-0.3	0.5	-1.1	0.1	-0.6
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	4.2	-1.4	2.0	0.8	0.5	-1.5
Mouth/teeth dental problems: Bleeding gums	2.2	2.9	5.5	-0.8	2.4	-1.7	1.6	-1.7
Blood clot in the leg (DVT)	0.7	0.8	1.6	-1.0	0.8	-1.3	0.9	0.2
Medication: Paracetamol	3.0	5.0	11.4	-1.0	2.7	-1.4	-1.8	-3.4
Headache pain in last month	0.6	1.1	1.9	-1.3	-0.9	-0.8	-1.4	0.7
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	8.9	-0.5	3.0	0.7	1.9	-1.7
Glaucoma (self-reported)	0.3	0.4	1.5	-1.2	0.4	0.1	0.0	-0.5
Gout (self-reported)	0.8	1.1	1.9	1.4	-1.2	-1.4	-0.3	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	-0.3	0.6	0.8	-0.4	-0.3
Medication: Amlodipine	2.4	3.4	8.0	1.8	-2.8	-0.2	-0.8	2.3
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.4	-0.3	-0.7	-0.9	1.6	-0.1
Birth weight	0.4	0.9	1.4	-0.8	-1.2	-1.2	-0.8	-0.7
Chronic bronchitis/emphysema (mother)	3.0	3.5	8.0	0.1	2.8	1.0	2.8	-0.7
High blood pressure (siblings)	0.7	1.0	2.7	0.3	-1.7	1.0	-0.5	1.0
Forced vital capacity (FVC), Best measure	1.1	3.9	12.0	-1.0	-1.2	-3.5	2.2	0.3
Body fat percentage	0.5	1.8	3.9	-0.8	2.0	-0.7	-1.9	-0.6
Leg fat percentage (right)	0.9	3.2	8.3	-1.5	2.9	-0.9	-1.5	-1.5
Arm fat-free mass (right)	1.8	9.4	27.1	-3.7	2.2	-5.2	0.2	1.2
Exposure to tobacco smoke outside home	1.7	2.2	4.2	-2.1	1.5	-0.7	-1.8	-1.0
Comparative body size at age 10	0.1	0.3	0.8	-0.3	0.8	0.9	-0.1	-0.2
Number of full brothers	1.3	1.7	5.7	-0.6	0.9	0.9	-0.9	-2.4
Worry too long after embarrassment	0.2	0.4	0.7	-0.3	0.5	0.8	0.6	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.0	-0.3	1.3	-0.2	-0.4	-1.7
Wheeze or whistling in the chest in last year	2.0	3.5	9.7	-1.4	3.1	-0.6	-0.7	-2.2
Number of children fathered	0.3	0.4	0.9	-0.3	0.8	-0.4	0.3	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	2.0	0.8	-0.0	-1.4	0.6	0.4
Age at first live birth	1.4	2.5	6.5	1.0	-2.5	0.4	1.2	1.8
Pulse wave peak to peak time	1.3	1.6	5.2	2.3	1.3	0.8	0.2	0.6
Health satisfaction	0.5	0.7	1.3	-0.6	1.1	-0.5	-0.8	-0.9
Shortness of breath walking on level ground	2.1	2.4	4.3	2.1	-0.1	-0.4	1.9	2.0
Qualifications: College or University degree	0.2	0.7	2.5	-0.0	-0.4	-0.6	1.6	0.7
Eye problems/disorders: None of the above	1.7	1.9	4.7	1.9	-0.2	2.2	-0.6	-0.8
Mouth/teeth dental problems: Loose teeth	2.9	3.5	7.2	-2.7	2.4	-0.2	1.2	-1.7
Emphysema/chronic bronchitis	1.2	1.3	3.5	0.2	1.9	-0.9	0.7	-1.4
Medication for pain relief, constipation, heartburn	0.7	1.2	3.0	0.0	-1.2	0.9	0.8	1.7
Neck or shoulder pain in last month	1.0	1.4	3.7	-1.9	1.6	-0.0	0.5	-0.3
Medication: Blood pressure	2.3	4.0	10.5	0.7	-3.2	-1.6	-1.1	2.3
Angina (self-reported)	0.3	0.4	0.8	-0.5	-0.8	0.4	-0.1	0.9
Migraine (self-reported)	0.8	1.0	2.3	-0.6	-0.9	1.0	-1.5	0.7
Medication: Ibuprofen	1.2	1.5	4.5	-0.4	2.1	-0.6	-0.1	-1.5
Medication: Allopurinol	1.4	1.9	5.1	1.8	-2.2	-0.5	0.8	0.4
Medication: Omeprazole	0.6	0.7	1.5	0.9	-0.8	-0.5	-0.4	1.2
Medication: Seretide 50 evohaler	1.2	1.4	2.8	-1.2	0.0	-0.0	-1.6	-1.7
Mean time to correctly identify matches	0.4	0.8	1.7	1.3	-1.3	0.8	-0.1	0.2
Heart disease (mother)	2.2	2.7	6.3	-1.8	-2.5	-0.1	-1.4	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.7	0.9	0.2	1.6	0.7	0.3
Whole body fat mass	0.6	2.5	4.7	-1.4	2.1	-2.2	-1.3	0.0
Leg fat mass (right)	1.1	4.2	8.1	-2.2	2.8	-2.4	-1.4	-1.0
Arm predicted mass (right)	1.7	8.6	24.5	-3.4	2.2	-5.0	0.2	1.4
Pulse rate, automated reading	2.0	6.3	15.2	-2.6	2.3	-1.4	-1.7	-3.9
Alcohol intake frequency.	1.9	4.4	10.4	0.6	-3.2	1.5	-2.1	2.2
Comparative height size at age 10	1.4	7.7	20.6	-0.7	-3.0	-4.5	0.5	2.9
Number of full sisters	0.9	1.1	2.8	-0.9	1.7	-0.2	-0.6	-1.2
Suffer from ‘nerves’	0.8	1.3	2.9	-0.3	0.9	1.7	-0.9	1.3
Overall health rating	1.6	3.4	8.6	-2.9	0.3	-1.1	-1.4	-2.3
Chest pain or discomfort	0.3	0.5	1.6	-0.2	1.3	0.3	0.6	0.5
Had major operations	1.8	2.1	6.5	-2.6	1.4	-1.1	0.7	-0.6
Age at last live birth	2.2	3.2	14.3	-0.5	-3.8	0.2	0.2	1.1
Family relationship satisfaction	0.5	0.6	2.0	-1.0	0.0	0.4	-1.4	0.0
Leg pain on walking	2.1	2.6	4.9	-1.9	2.2	-1.8	1.2	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	4.2	-1.1	1.0	-0.9	-0.5	-2.0
Commuting to job workplace: Car/motor vehicle	2.1	2.4	4.8	-1.7	-0.0	-0.3	-2.2	-2.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.8	0.4	-0.0	0.6	0.7	1.7
Medication: Aspirin	2.1	2.8	8.5	1.2	-1.5	-0.4	1.3	2.9
Supplements: Vitamin C	1.2	1.4	4.5	0.1	1.0	-2.1	0.4	1.3
Knee pain experienced in last month	3.2	5.0	9.4	-1.8	3.1	-2.2	0.9	-2.6
Hypertension (Self-reported)	5.2	14.5	46.4	2.9	-6.8	-1.2	-1.8	3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	3.3	0.6	0.2	-0.2	1.8	-0.3
Illnesses of father: Heart disease	0.5	0.7	1.3	-0.5	-1.2	-0.4	-1.1	-0.9
Illnesses of siblings: Diabetes	1.1	1.4	3.9	1.5	-0.4	0.5	-2.0	-0.7
Smoking status: Previous	0.3	0.5	1.2	-0.4	1.1	-0.1	0.1	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	5.7	0.6	-1.3	-2.3	1.5	2.4
Whole body fat-free mass	1.4	7.8	24.1	-3.2	1.5	-4.9	0.5	1.5
Leg fat-free mass (right)	1.0	5.6	16.4	-2.7	1.5	-4.0	0.3	1.3
Arm fat percentage (left)	0.5	1.9	4.7	-0.6	2.2	0.1	-1.9	-0.8
Average weekly red wine intake	1.5	2.3	8.2	-1.4	2.9	0.7	0.6	-0.6
Handedness (chirality/laterality): Left-handed	1.2	1.4	3.5	-0.9	1.1	-1.9	0.5	-1.1
Mood swings	1.8	3.3	5.2	-1.9	-2.3	-0.7	-2.2	-1.6
Loneliness, isolation	1.1	1.5	4.2	-1.4	0.8	-0.9	-2.0	-0.3
Long-standing illness, disability or infirmity	1.4	2.2	6.1	-2.5	1.8	-0.1	-0.5	-1.2
Ever had bowel cancer screening	0.7	0.8	2.0	0.4	0.3	-1.4	-0.1	1.3
Diabetes diagnosed by doctor	1.1	1.9	3.3	-0.2	-1.4	-1.0	-1.7	1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.6	-1.3	0.7	-0.6	-0.2	-1.1
Friendships satisfaction	1.1	1.4	5.5	0.5	-0.6	1.0	-2.4	0.2
Qualifications: nursing, teaching	0.9	1.4	4.1	-0.4	1.0	-2.0	1.2	0.4
Commuting to job workplace: Walk	1.9	2.0	4.5	2.0	0.1	0.5	1.3	2.1
Eye problems/disorders: Cataract	0.3	0.3	0.8	-0.0	-0.3	-0.9	0.4	0.8
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	5.0	0.5	0.3	2.2	0.0	1.5
Medication for cholesterol	1.0	1.5	3.8	-2.0	1.4	-0.3	1.1	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.6	-0.7	1.2	-1.0	-1.3	-0.5
Back pain experienced in last month	0.4	0.5	1.4	-1.2	1.0	-0.4	-0.2	0.1
Mineral and other dietary supplements	0.4	0.5	2.6	-0.2	-1.6	0.2	-0.2	0.2
Breast cancer (self-reported)	0.0	0.0	0.1	-0.0	0.2	-0.2	0.2	0.2
Asthma (self-reported)	0.7	1.3	4.1	-0.8	-0.0	-2.0	0.4	-1.2
Osteoporosis (self-reported)	0.3	0.4	0.9	0.9	-0.7	0.7	0.1	-0.1
Osteoarthritis (self-reported)	2.7	3.5	9.2	-1.8	3.0	1.1	-0.1	-2.0
Medication: Aspirin	1.8	2.4	7.0	1.1	-1.6	-0.8	0.8	2.6
Medication: Gliclazide	1.4	1.6	3.8	-0.4	-1.4	-2.0	-0.9	1.2
Illnesses of father: None of the above (group 1)	2.9	3.6	10.2	0.6	-1.7	1.5	1.5	3.2
Smoking status: Current	0.6	1.0	4.0	0.0	-2.0	0.7	0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.1	0.2	1.2	-0.8	0.2	-1.5
Whole body water mass	1.3	7.7	23.8	-3.1	1.4	-4.9	0.5	1.7
Leg predicted mass (right)	1.1	5.6	16.4	-2.8	1.5	-4.0	0.2	1.3
Arm fat mass (left)	0.7	2.9	7.2	-1.5	2.7	-1.5	-1.6	-0.4
Number of self-reported non-cancer illnesses	0.9	1.5	3.8	-0.2	-2.0	0.8	-1.6	0.7
Average weekly champagne plus white wine intake	1.1	1.6	3.2	0.0	1.4	-1.4	-0.9	-1.8
Miserableness	1.5	2.6	7.2	-1.5	0.6	-1.6	-0.8	-2.7
Guilty feelings	0.3	0.5	1.2	-1.1	0.0	-0.2	-0.9	-0.4
Wears glasses or contact lenses	1.5	1.7	3.9	0.2	1.8	-2.0	-1.1	0.3
Ever taken oral contraceptive pill	4.0	4.5	10.8	-3.3	2.3	-0.6	-0.5	-2.4
Hearing aid user	0.8	0.9	2.2	-0.4	0.6	-1.5	0.8	1.2
Mother’s age at death	1.3	1.7	3.3	1.2	-1.2	-1.8	0.1	1.4
Financial situation satisfaction	1.1	1.4	2.8	0.9	1.7	-0.3	0.9	-1.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	4.0	-0.3	-0.0	-0.0	-2.0	0.0
Commuting to job workplace: Public transport	0.8	0.9	2.0	1.3	1.4	-0.2	0.4	0.9
Eye problems/disorders: Glaucoma	0.7	0.9	3.2	-1.8	0.9	-0.5	-0.0	-0.2
Medication: Blood pressure	3.2	6.1	14.6	2.8	-3.8	0.0	-1.6	2.4
Pain type(s) experienced in last month: Hip pain	0.9	1.2	3.3	-1.1	1.8	-0.6	0.8	-0.6
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.2	-0.8	0.0	-1.5	-0.7	0.4
High cholesterol (Self-reported)	2.4	4.2	7.0	1.1	-2.6	1.6	-2.4	2.1
Medication: Bendroflumethiazide	1.3	2.0	6.7	0.8	-2.6	-0.8	-0.3	1.4
Medication: Paracetamol	2.9	4.5	10.4	-1.3	3.2	-1.1	-1.1	-2.8
Medication: Lisinopril	1.2	1.5	3.7	-0.3	-1.4	1.9	-0.8	1.2
Medication: Atorvastatin	1.7	2.1	5.1	1.7	-2.3	0.8	-1.0	0.9
Illnesses of father: High blood pressure	0.6	0.8	2.4	0.2	0.6	-0.4	-0.9	-1.6
Alcohol drinker status: Never	0.4	0.5	0.8	0.7	-0.4	0.9	0.7	0.7
Ever smoked	0.1	0.2	0.5	-0.4	0.1	0.1	-0.6	-0.7
Basal metabolic rate	1.3	7.5	22.7	-3.1	1.7	-4.8	0.2	1.4
Leg fat percentage (left)	1.0	3.8	11.0	-1.7	3.3	-0.8	-1.5	-1.5
Arm fat-free mass (left)	1.6	8.2	23.0	-3.2	2.5	-4.8	0.4	1.2
Number of operations (self-reported)	2.1	3.1	8.1	-1.2	2.8	0.5	0.9	-2.2
Average weekly beer plus cider intake	0.3	0.4	1.2	-0.7	-1.1	0.0	0.6	0.3
Irritability	0.6	0.9	2.5	-1.6	-0.4	-0.8	-0.7	-0.9
Risk taking	2.2	3.2	5.4	-1.6	2.1	-2.3	1.8	0.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.4	-0.6	0.8	1.2	-0.1	0.3
Fractured/broken bones in last 5 years	1.1	1.4	3.7	1.9	0.6	0.8	1.5	-0.5
Age started oral contraceptive pill	2.0	2.5	11.2	3.3	-0.8	-0.0	0.5	0.7
Diastolic blood pressure, automated reading	3.2	9.8	26.3	-1.7	-5.1	-3.0	-2.8	1.7
Ever depressed for a whole week	1.0	1.2	2.8	-1.4	1.7	0.8	-0.2	0.7
Unable to work because of sickness or disability	0.5	0.7	1.5	-0.2	-1.0	-1.2	-0.5	-0.6
Commuting to job workplace: Cycle	4.3	5.2	15.8	2.4	0.3	-0.2	4.0	2.0
Myopia	0.5	0.7	2.8	0.4	0.5	-1.7	0.4	0.6
Vascular/heart problems diagnosed by doctor	5.0	13.7	46.8	-2.1	6.8	0.9	1.6	-3.7
Cholesterol lowering medication	0.8	1.1	2.9	1.1	-0.6	0.5	-1.7	0.9
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.5	1.2	-0.3	-0.7	0.7	1.2
Pain experienced in last month	1.7	2.9	8.5	2.9	-1.9	0.7	-0.6	1.2
Supplements: Calcium	0.2	0.3	0.4	0.5	0.5	0.6	-0.4	0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.8	-0.9	0.3	-0.2	0.0	-0.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	4.0	-0.4	-2.0	0.6	0.2	0.0
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.5	-0.9	0.7	-1.2	1.2	0.4
Heart disease (siblings)	0.2	0.3	0.8	-0.2	-0.2	0.9	-0.5	-0.6
Alcohol drinker status: Previous	0.5	0.5	1.3	-0.4	-0.7	0.2	-1.1	0.9
Pack years of smoking	0.4	0.6	1.6	-1.3	0.2	1.0	-0.2	-0.5
Impedance of whole body	1.3	6.5	18.7	2.7	-4.3	1.7	-0.3	1.9
Leg fat mass (left)	1.1	4.3	10.1	-2.1	3.2	-2.3	-1.1	-0.7
Arm predicted mass (left)	1.4	7.2	20.2	-3.0	2.2	-4.5	0.5	1.3