Hub : Genes

CYP11A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Sigmoid 0.1580 0.0860 0.0090 0.018 NA 0.003 NA 0.038 0.0740 NA 0.2500 NA 0.0170
2 GTEx Lung 0.0970 0.0452 0.0020 0.006 NA 0.021 NA 0.006 0.1100 NA 0.0095 NA 0.1100
3 GTEx Nerve Tibial 0.0606 0.0320 0.0079 -0.002 NA -0.004 NA -0.003 0.5000 NA 0.8900 NA 0.5900
4 TCGA Kidney Renal Papillary Cell Carcinoma 0.0900 0.0450 0.0026 0.002 0.022 0.018 NA 0.001 0.2500 0.019 0.0320 NA 0.2700
5 TCGA Thyroid Carcinoma 0.0460 0.0320 0.0071 0.023 0.015 0.015 NA 0.025 0.0023 0.011 0.0110 NA 0.0015

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.6 2.5 7.6 0.1 -1.8 -1.3 -2.8 0.2
Bipolar Disorder or Schizophrenia 1.0 2.4 6.1 0.8 -2.3 0.2 -2.5 -0.2
Depressed Affect (Nagel 2018) 1.0 2.1 6.6 -1.0 -0.4 -0.7 -2.6 -1.5
Depression (Nagel 2018) 1.4 2.1 4.3 -2.0 0.8 -0.5 -2.1 -1.2
Intelligence (Savage-Jansen 2018) 0.9 2.8 9.9 1.3 3.2 0.0 0.1 -1.5
Neuroticism (Nagel 2018) 0.5 1.1 4.0 -0.7 -0.2 0.4 -2.0 -0.9
Schizophrenia (2018) 0.6 1.1 2.2 0.9 -1.5 1.2 -1.0 -0.5
Schizophrenia vs Biploar Disorder 0.5 0.6 1.7 -0.9 -0.2 1.3 -0.0 -0.7
Worry (Nagel 2018) 0.7 1.5 5.3 -1.1 -0.6 0.6 -2.3 0.6
Alzheimer’s Disease (in mother) 0.6 0.7 1.7 0.7 0.9 0.4 1.3 -0.7
Alzheimer’s Disease (in father) 1.3 1.5 3.8 -1.4 0.7 -1.0 0.0 -2.0
Alzheimer’s Disease (including proxy) 1.1 1.6 2.8 -0.1 1.7 -0.2 1.6 -1.6
Crohns Disease (2017) 0.5 1.1 3.9 -0.5 -0.1 -1.0 -0.5 -2.0
Irritable Bowel Disease (IBD) 0.9 2.1 6.0 -0.9 0.9 -1.7 -0.5 -2.4
Ulcerative Colitis (UC) 1.1 2.0 3.8 -1.5 1.1 -1.5 -0.4 -1.9
Major Depression (MDD) 0.4 0.5 1.1 -1.0 0.9 -0.6 -0.2 0.5
Reaction Time 0.3 0.6 1.3 1.1 -1.0 0.6 0.5 0.1
Verbal and Numeric Reasoning (VNR) 0.5 1.1 2.2 1.0 1.4 0.1 -1.5 -0.6
Breast Cancer 2.1 4.9 11.4 0.7 -3.4 0.9 -0.8 3.4
Ovarian Cancer 0.2 0.2 0.5 0.4 0.2 -0.6 -0.1 0.7
Prostate Cancer 1.6 2.3 4.9 -0.4 1.4 -2.2 1.1 -1.8
Age at First Birth 1.1 1.6 4.1 2.0 -1.4 -1.2 0.8 -0.2
Bipolar Disorder (2011) 1.1 1.1 3.1 -1.3 -0.1 -0.5 -0.7 -1.8
Body Mass Index (BMI) (2010) 0.4 0.5 2.1 -0.5 1.5 -0.4 0.2 0.1
Coronary Artery Disease (CAD) 0.1 0.1 0.4 0.0 -0.1 -0.4 0.4 -0.6
Crohns Disease (2012) 0.7 1.1 2.1 -0.9 0.4 -1.1 -1.1 -1.5
Mean Putamen Volume 1.3 1.5 3.3 1.8 -1.2 1.3 0.8 -0.5
Fasting Glucose 1.3 1.5 2.6 1.6 -1.3 0.6 1.6 0.6
HbA1C 1.4 1.5 4.2 0.4 0.3 1.4 1.1 2.1
HDL Cholesterol 0.3 0.5 2.2 -0.6 -0.0 0.0 -0.1 -1.5
LDL Cholesterol 0.9 1.4 2.4 -1.5 1.6 -0.5 -0.2 -1.5
Lupus 2.2 3.3 7.7 1.0 -2.8 0.3 -2.3 -1.6
Neuroticism (2016) 0.9 1.3 3.3 -0.4 0.8 0.1 -1.8 -1.6
Primary Biliary Cirrhosis 0.2 0.3 0.9 1.0 0.0 0.5 -0.1 0.6
Rheumatoid Arthritis 1.3 1.8 5.2 -0.7 -0.0 -1.0 -1.6 -2.3
Schizophrenia (2014) 0.9 1.9 3.6 -1.5 -1.8 -0.2 -1.9 -0.8
Triglycerides 0.7 1.1 2.8 -0.1 -1.7 -0.3 0.2 1.5
Type 2 Diabetes (T2D) (2012) 1.1 1.3 2.8 -0.5 1.0 -1.7 -0.9 -1.3
Ulcerative Colitis 1.9 2.7 5.3 -1.5 1.5 -0.7 -1.8 -2.3
Blood Eosinophil Count 0.2 1.2 4.9 2.2 0.2 -0.3 0.8 0.2
Blood Platelet Count 0.4 4.5 8.7 -1.8 3.0 -1.4 1.7 -2.3
Blood Red Count 1.4 13.5 32.1 2.4 -5.7 1.5 -3.2 4.1
Blood White Count 0.2 1.6 4.9 -1.2 0.0 -0.6 -2.2 -1.0
Heel T-Score 0.4 3.1 11.0 1.8 -0.2 3.3 0.8 1.1
BMI 0.5 3.0 12.0 -0.6 3.5 -0.9 -1.2 0.7
Height 1.7 32.9 73.3 -3.2 -5.8 -8.6 -0.3 6.8
Waist Hip Ratio (WHR) 1.6 7.2 20.9 -2.6 4.6 0.1 -2.5 -1.5
Systolic Blood Pressure 2.6 12.8 44.0 0.8 -6.6 -0.3 -3.2 3.0
Smoking Status 0.3 0.6 1.9 -0.1 -1.0 0.3 1.4 0.1
Allergy or Eczema 0.4 1.1 3.8 -0.1 2.0 -0.8 0.9 0.3
Cardiovascular Disease 5.5 18.3 51.0 2.4 -7.1 -0.7 -3.7 4.5
Hypothyroidism (self reported) 0.1 0.2 0.7 0.5 0.8 -0.2 -0.3 0.4
Respiratory disease 0.7 1.5 3.8 -0.1 0.7 -1.9 1.8 -0.6
Type 2 Diabetes (T2D) (2018) 1.2 2.2 4.3 -0.4 -0.5 -1.5 -2.0 2.1
Lung FEV1/FVC ratio 0.1 0.5 1.2 0.7 -0.6 0.7 -1.1 0.2
Lung FVC 0.4 2.0 5.7 -0.0 -0.4 -0.7 1.9 -2.4
Neuroticism 0.7 1.7 5.5 -0.6 -1.1 0.4 -2.3 -1.0
Chronotype (morning person) 0.0 0.1 0.2 0.1 0.2 0.3 -0.5 0.2
Hair Pigment 0.1 1.9 6.0 0.1 2.4 -1.6 0.9 -0.3
Tanning 0.2 3.0 6.4 -2.1 1.8 -2.5 0.6 -0.7
Hand grip strength (left) 1.4 3.7 8.9 -3.0 -0.1 -3.0 0.8 0.5
Number of treatments/medications taken 0.4 0.6 2.4 -0.4 -0.3 -0.5 -1.6 -0.6
Average weekly spirits intake 0.6 0.7 1.4 -1.1 -0.1 -0.5 -0.7 -1.2
Sensitivity / hurt feelings 0.3 0.6 1.0 -0.8 -0.8 1.0 -0.5 -0.5
Frequency of depressed mood in last 2 weeks 2.1 2.9 4.3 -1.9 -0.2 -1.6 -1.9 -2.1
Hearing difficulty/problems: Yes 0.9 1.3 4.6 -1.2 0.5 -2.2 0.3 0.2
Relative age of first facial hair 0.8 1.7 6.5 2.5 0.9 -0.3 0.7 0.8
Other serious medical condition/disability diagnosed by doctor 1.7 2.3 5.7 -2.4 2.3 -0.3 -0.2 -0.1
Ever used hormone-replacement therapy (HRT) 1.0 1.2 3.1 1.1 -0.4 0.5 1.2 1.7
Ever had hysterectomy (womb removed) 0.5 0.5 1.3 0.1 -1.1 -0.2 -1.0 0.4
Systolic blood pressure, automated reading 1.6 4.5 15.3 -1.0 -3.9 -0.4 -2.0 1.5
Eye problems/disorders: Diabetes related eye disease 2.4 2.7 10.0 -0.4 -0.8 -1.5 -0.5 3.2
Angina 0.2 0.3 0.6 -0.5 -0.7 0.2 -0.2 0.8
Medication for hormone replacement therapy 0.9 1.0 2.6 0.3 1.6 -1.1 0.8 -0.6
Vitamin and mineral supplements 1.0 1.3 2.5 1.0 -1.5 1.6 0.9 -0.3
Supplements: Zinc 0.3 0.3 1.3 -0.3 -0.1 -0.1 -1.2 0.1
Medication: Co-codamol 1.0 1.1 2.3 -1.2 1.5 0.4 -0.0 -1.4
Medication: Metformin 0.9 1.3 3.4 0.3 -1.8 -0.4 -1.4 0.8
Diabetes (father) 0.6 0.8 1.5 0.8 -0.3 0.8 -1.0 1.2
Diabetes (mother) 1.0 1.3 3.3 -1.8 0.2 -1.2 -1.2 -0.5
Severe depression (siblings) 0.0 0.0 0.1 0.3 0.1 -0.3 0.2 0.1
Pack years adult smoking proportion 0.4 0.6 1.8 -1.3 0.2 0.9 0.4 -0.3
Impedance of leg (right) 0.6 2.8 11.3 1.3 -3.4 0.6 -0.3 0.6
Leg fat-free mass (left) 1.1 5.7 18.0 -2.6 1.3 -4.2 0.1 1.3
Trunk fat percentage 0.3 1.4 2.7 -0.9 1.5 -1.0 -1.6 -0.1
Hand grip strength (right) 1.2 3.2 6.9 -2.5 0.6 -2.6 1.1 1.2
Townsend deprivation index at recruitment 0.4 0.6 2.2 -1.5 -0.7 0.2 -0.2 -0.3
Current tobacco smoking 0.9 1.4 6.2 -0.2 -2.5 0.2 0.9 0.1
Average weekly fortified wine intake 0.9 1.0 2.2 1.0 -0.6 -1.5 1.2 0.2
Maternal smoking around birth 1.2 1.8 6.2 -0.7 2.5 -0.6 1.1 -0.7
Fed-up feelings 1.4 2.5 5.3 -1.7 -0.7 0.0 -2.3 -2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 2.1 2.8 7.0 -2.6 0.3 -0.7 -1.4 -2.1
Relative age voice broke 1.0 1.5 5.2 2.3 0.1 0.7 -0.3 1.2
Taking other prescription medications 0.0 0.1 0.3 -0.1 -0.5 0.2 -0.2 -0.1
Age when periods started (menarche) 1.1 2.6 4.6 -1.8 -0.9 -1.5 -1.5 -2.2
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 2.5 -0.3 -0.9 -0.2 1.6 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 4.6 0.5 -0.9 0.8 1.5 2.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.7 0.3 -0.8 -0.3 -0.2 0.8
Qualifications: CSEs or equivalent 1.0 1.3 3.7 -0.2 1.9 1.5 0.1 -0.5
Serious illness, injury or assault to yourself 1.0 1.2 1.7 -1.2 1.3 0.9 0.8 -1.3
High blood pressure 5.0 13.9 46.8 2.4 -6.8 -1.0 -1.9 3.5
Hayfever, allergic rhinitis or eczema 0.5 1.1 4.0 -0.3 2.0 -1.1 0.1 -0.4
Multivitamins +/- minerals 2.2 2.8 4.2 -1.7 2.0 -1.5 -1.2 -1.9
Stomach or abdominal pain in last month 0.9 1.1 3.5 -1.9 1.3 0.2 -0.4 -0.4
Supplements: Glucosamine 2.2 2.9 8.9 1.0 3.0 0.3 1.2 -1.7
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 3.3 0.1 1.0 0.2 -0.4 -1.8
Medication: Atenolol 2.1 2.6 6.0 0.3 -2.5 -0.2 -1.2 2.3
Medication: Levothyroxine sodium 0.5 0.8 1.6 -1.1 1.3 0.5 -0.9 -0.3
Sitting height 2.7 19.3 70.1 -3.5 -2.2 -8.4 1.3 2.8
Chronic bronchitis/emphysema (father) 1.9 2.2 3.1 -1.7 1.7 -1.4 -0.6 -1.8
High blood pressure (mother) 0.7 1.0 2.7 0.5 -1.6 -0.4 -1.4 -0.5
Body mass index (BMI) 1.2 5.1 16.9 -2.0 4.1 -1.0 -1.0 -1.5
Impedance of leg (left) 0.4 2.0 7.8 1.1 -2.8 0.8 -0.5 0.6
Leg predicted mass (left) 1.0 5.5 17.7 -2.6 1.3 -4.2 0.1 1.3
Trunk fat mass 0.6 2.7 6.4 -1.6 1.7 -2.5 -1.2 0.3
Waist circumference 2.2 8.0 21.7 -2.9 4.7 -2.4 -1.8 -0.9
Number of incorrect matches in round 0.1 0.1 0.2 -0.4 -0.4 -0.1 -0.2 0.4
Past tobacco smoking 0.2 0.3 0.7 0.5 -0.8 0.1 0.0 0.7
Alcohol usually taken with meals 0.1 0.2 0.9 0.9 0.2 0.4 -0.3 0.0
Nervous feelings 0.3 0.6 1.6 -0.2 -1.3 -0.1 -1.0 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.5 0.2 -0.5 -0.3 0.8 -1.2
Hearing difficulty/problems with background noise 1.6 2.6 7.5 -0.0 2.7 -1.6 1.7 -0.3
Hair/balding pattern: Pattern 2 0.7 0.9 2.2 0.9 1.5 1.0 0.7 0.2
Had menopause 2.6 3.2 6.0 2.4 -0.2 1.3 1.6 2.4
Had other major operations 4.3 5.3 13.9 -1.4 2.0 0.8 -2.4 -3.7
Forced vital capacity (FVC) 1.5 5.7 20.8 -2.0 -0.9 -4.6 1.7 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.9 1.3 -0.3 0.4 0.8 1.7
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 3.6 -1.9 0.8 -0.6 0.0 0.1
Qualifications: None of the above 0.5 1.1 3.8 0.4 -0.9 2.0 -0.5 0.6
Financial difficulties in last 2 years 1.4 1.8 4.4 -1.3 2.1 -0.3 -0.0 -1.7
Mouth/teeth dental problems 1.4 2.2 7.6 0.9 -2.8 -0.4 0.1 1.5
Heart attack 0.6 0.8 3.5 -0.5 -1.9 0.3 0.3 0.1
Allergy 0.7 1.6 3.8 0.6 -1.6 1.9 -0.4 1.1
Pain all over the body in last month 0.2 0.3 0.9 0.3 -0.1 0.9 0.4 0.4
Diabetes (self-reported) 0.7 1.1 3.0 0.2 -0.7 -1.0 -1.7 0.9
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.1 1.0 1.1 0.2 -0.3 -0.9
Medication: Ramipril 2.2 2.9 6.2 1.1 -1.9 -1.6 -0.9 2.5
Medication: Simvastatin 1.6 2.3 6.6 0.4 -1.7 0.1 -2.6 1.4
Fluid intelligence score 0.3 0.7 1.5 0.7 1.2 0.6 -1.0 0.4
Illnesses of siblings 0.7 1.0 2.0 -0.3 1.2 -1.4 0.5 -1.1
Neuroticism score 1.1 2.2 4.8 -1.7 -1.3 -0.2 -2.2 -1.3
Weight 1.2 6.1 17.6 -2.6 2.4 -4.2 -0.4 0.7
Impedance of arm (right) 2.1 9.9 26.5 3.6 -5.2 2.1 -0.2 2.3
Arm fat percentage (right) 0.4 1.7 3.9 -0.4 2.0 0.0 -1.9 -0.8
Trunk fat-free mass 1.5 8.4 27.8 -3.2 1.0 -5.3 0.6 1.7
Hip circumference 0.9 3.7 12.2 -1.7 1.5 -3.5 -0.6 1.0
Time employed in main current job 0.7 0.8 2.9 -0.2 0.7 -0.1 1.7 0.8
Alcohol intake versus 10 years previously 0.5 0.8 1.7 -1.0 0.6 0.8 -0.4 -1.3
Father’s age at death 1.4 1.8 5.2 0.6 1.3 -2.3 1.2 0.6
Worrier / anxious feelings 1.1 2.0 4.1 -0.6 -1.7 1.2 -2.0 -1.2
Frequency of tiredness / lethargy in last 2 weeks 2.6 4.2 10.2 -3.2 2.8 -1.1 0.5 -1.1
Falls in the last year 0.8 1.1 3.3 -1.8 1.2 -0.9 -0.2 0.3
Hair/balding pattern: Pattern 3 2.1 3.1 6.9 -0.5 -2.4 -1.7 -2.6 0.2
Number of live births 1.1 1.5 3.4 -1.1 -1.1 1.1 -0.8 1.9
Forced expiratory volume in 1-second (FEV1) 1.1 3.7 13.4 -1.6 -0.2 -3.7 1.6 -0.2
Pulse rate 0.8 1.4 2.2 -1.2 0.4 -1.2 -1.3 -1.5
Happiness 0.3 0.3 0.6 -0.4 -0.6 0.8 -0.3 0.7
Noisy workplace 0.8 1.0 2.1 -1.5 0.3 -0.9 -0.0 -1.4
Qualifications: A levels/AS levels or equivalent 0.9 2.1 6.6 -1.0 2.6 1.0 0.5 -1.2
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.3 2.4 1.6 1.3 0.3 -0.1 1.6
Mouth/teeth dental problems: Dentures 0.5 0.9 1.9 0.1 0.9 1.1 -1.4 -0.5
Asthma 0.6 1.2 3.7 -0.7 -0.2 -1.9 0.7 -1.1
Medication: Ibuprofen (e.g. Nurofen) 1.5 2.0 5.5 0.1 2.3 -0.2 -0.4 -2.0
Medication: Cholesterol lowering 1.9 3.0 7.8 0.8 -2.8 0.5 -2.4 0.9
Depression (self-reported) 0.9 1.0 2.1 -0.8 1.0 -0.2 -1.5 -1.1
Medication: Lansoprazole 0.3 0.3 0.6 0.6 -0.6 0.8 0.3 -0.1
Prospective memory result 0.6 0.7 2.2 -0.5 -1.5 0.2 -0.9 0.4
Lung cancer (father) 1.2 1.4 2.7 -1.6 -1.2 1.0 -1.1 0.8
Illnesses of mother 0.1 0.1 0.5 -0.2 0.2 -0.7 -0.1 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.6 8.6 -0.7 -0.5 -2.9 1.9 0.3
Pulse wave Arterial Stiffness index 1.8 2.1 6.6 -2.6 -1.6 -1.0 -0.2 -0.4
Impedance of arm (left) 2.1 9.5 24.1 3.4 -4.9 2.4 -0.2 2.6
Arm fat mass (right) 0.7 2.9 6.8 -1.5 2.6 -1.9 -1.3 -0.1
Trunk predicted mass 1.5 8.4 27.3 -3.1 1.1 -5.2 0.7 1.8
Standing height 1.9 18.8 51.9 -1.7 -3.6 -7.2 1.2 5.0
Length of working week for main job 1.5 1.7 5.0 -1.0 2.2 -1.0 -0.8 -0.9
Exposure to tobacco smoke at home 0.5 0.5 1.2 1.1 0.9 -0.5 0.6 0.1
Breastfed as a baby 0.8 1.0 2.7 1.1 -0.3 -1.6 0.5 -1.0
Tense / ‘highly strung’ 1.0 1.7 4.0 -1.8 -0.7 -0.7 -2.0 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 2.4 -1.6 0.4 -1.2 -0.9 -0.8
Hair/balding pattern: Pattern 4 0.3 0.6 2.6 -1.6 -0.7 -0.1 0.4 -0.0
Birth weight of first child 0.5 1.0 2.7 -1.0 0.8 -1.6 0.3 -0.7
Peak expiratory flow (PEF) 1.0 2.2 9.7 0.7 -3.1 -0.5 0.2 0.7
Pulse wave reflection index 0.3 0.4 1.4 -1.2 -0.5 -0.1 0.5 -0.2
Ever highly irritable/argumentative for 2 days 0.5 0.6 2.0 -1.4 0.8 0.1 -0.2 0.6
Loud music exposure frequency 0.3 0.4 1.1 -0.3 0.5 -1.1 0.1 -0.6
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 4.2 -1.4 2.0 0.8 0.5 -1.5
Mouth/teeth dental problems: Bleeding gums 2.2 2.9 5.5 -0.8 2.4 -1.7 1.6 -1.7
Blood clot in the leg (DVT) 0.7 0.8 1.6 -1.0 0.8 -1.3 0.9 0.2
Medication: Paracetamol 3.0 5.0 11.4 -1.0 2.7 -1.4 -1.8 -3.4
Headache pain in last month 0.6 1.1 1.9 -1.3 -0.9 -0.8 -1.4 0.7
Medication for cholesterol, blood pressure or diabetes 1.9 3.2 8.9 -0.5 3.0 0.7 1.9 -1.7
Glaucoma (self-reported) 0.3 0.4 1.5 -1.2 0.4 0.1 0.0 -0.5
Gout (self-reported) 0.8 1.1 1.9 1.4 -1.2 -1.4 -0.3 -0.5
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.6 -0.3 0.6 0.8 -0.4 -0.3
Medication: Amlodipine 2.4 3.4 8.0 1.8 -2.8 -0.2 -0.8 2.3
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.4 -0.3 -0.7 -0.9 1.6 -0.1
Birth weight 0.4 0.9 1.4 -0.8 -1.2 -1.2 -0.8 -0.7
Chronic bronchitis/emphysema (mother) 3.0 3.5 8.0 0.1 2.8 1.0 2.8 -0.7
High blood pressure (siblings) 0.7 1.0 2.7 0.3 -1.7 1.0 -0.5 1.0
Forced vital capacity (FVC), Best measure 1.1 3.9 12.0 -1.0 -1.2 -3.5 2.2 0.3
Body fat percentage 0.5 1.8 3.9 -0.8 2.0 -0.7 -1.9 -0.6
Leg fat percentage (right) 0.9 3.2 8.3 -1.5 2.9 -0.9 -1.5 -1.5
Arm fat-free mass (right) 1.8 9.4 27.1 -3.7 2.2 -5.2 0.2 1.2
Exposure to tobacco smoke outside home 1.7 2.2 4.2 -2.1 1.5 -0.7 -1.8 -1.0
Comparative body size at age 10 0.1 0.3 0.8 -0.3 0.8 0.9 -0.1 -0.2
Number of full brothers 1.3 1.7 5.7 -0.6 0.9 0.9 -0.9 -2.4
Worry too long after embarrassment 0.2 0.4 0.7 -0.3 0.5 0.8 0.6 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 3.0 -0.3 1.3 -0.2 -0.4 -1.7
Wheeze or whistling in the chest in last year 2.0 3.5 9.7 -1.4 3.1 -0.6 -0.7 -2.2
Number of children fathered 0.3 0.4 0.9 -0.3 0.8 -0.4 0.3 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.6 2.0 0.8 -0.0 -1.4 0.6 0.4
Age at first live birth 1.4 2.5 6.5 1.0 -2.5 0.4 1.2 1.8
Pulse wave peak to peak time 1.3 1.6 5.2 2.3 1.3 0.8 0.2 0.6
Health satisfaction 0.5 0.7 1.3 -0.6 1.1 -0.5 -0.8 -0.9
Shortness of breath walking on level ground 2.1 2.4 4.3 2.1 -0.1 -0.4 1.9 2.0
Qualifications: College or University degree 0.2 0.7 2.5 -0.0 -0.4 -0.6 1.6 0.7
Eye problems/disorders: None of the above 1.7 1.9 4.7 1.9 -0.2 2.2 -0.6 -0.8
Mouth/teeth dental problems: Loose teeth 2.9 3.5 7.2 -2.7 2.4 -0.2 1.2 -1.7
Emphysema/chronic bronchitis 1.2 1.3 3.5 0.2 1.9 -0.9 0.7 -1.4
Medication for pain relief, constipation, heartburn 0.7 1.2 3.0 0.0 -1.2 0.9 0.8 1.7
Neck or shoulder pain in last month 1.0 1.4 3.7 -1.9 1.6 -0.0 0.5 -0.3
Medication: Blood pressure 2.3 4.0 10.5 0.7 -3.2 -1.6 -1.1 2.3
Angina (self-reported) 0.3 0.4 0.8 -0.5 -0.8 0.4 -0.1 0.9
Migraine (self-reported) 0.8 1.0 2.3 -0.6 -0.9 1.0 -1.5 0.7
Medication: Ibuprofen 1.2 1.5 4.5 -0.4 2.1 -0.6 -0.1 -1.5
Medication: Allopurinol 1.4 1.9 5.1 1.8 -2.2 -0.5 0.8 0.4
Medication: Omeprazole 0.6 0.7 1.5 0.9 -0.8 -0.5 -0.4 1.2
Medication: Seretide 50 evohaler 1.2 1.4 2.8 -1.2 0.0 -0.0 -1.6 -1.7
Mean time to correctly identify matches 0.4 0.8 1.7 1.3 -1.3 0.8 -0.1 0.2
Heart disease (mother) 2.2 2.7 6.3 -1.8 -2.5 -0.1 -1.4 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 2.7 0.9 0.2 1.6 0.7 0.3
Whole body fat mass 0.6 2.5 4.7 -1.4 2.1 -2.2 -1.3 0.0
Leg fat mass (right) 1.1 4.2 8.1 -2.2 2.8 -2.4 -1.4 -1.0
Arm predicted mass (right) 1.7 8.6 24.5 -3.4 2.2 -5.0 0.2 1.4
Pulse rate, automated reading 2.0 6.3 15.2 -2.6 2.3 -1.4 -1.7 -3.9
Alcohol intake frequency. 1.9 4.4 10.4 0.6 -3.2 1.5 -2.1 2.2
Comparative height size at age 10 1.4 7.7 20.6 -0.7 -3.0 -4.5 0.5 2.9
Number of full sisters 0.9 1.1 2.8 -0.9 1.7 -0.2 -0.6 -1.2
Suffer from ‘nerves’ 0.8 1.3 2.9 -0.3 0.9 1.7 -0.9 1.3
Overall health rating 1.6 3.4 8.6 -2.9 0.3 -1.1 -1.4 -2.3
Chest pain or discomfort 0.3 0.5 1.6 -0.2 1.3 0.3 0.6 0.5
Had major operations 1.8 2.1 6.5 -2.6 1.4 -1.1 0.7 -0.6
Age at last live birth 2.2 3.2 14.3 -0.5 -3.8 0.2 0.2 1.1
Family relationship satisfaction 0.5 0.6 2.0 -1.0 0.0 0.4 -1.4 0.0
Leg pain on walking 2.1 2.6 4.9 -1.9 2.2 -1.8 1.2 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 4.2 -1.1 1.0 -0.9 -0.5 -2.0
Commuting to job workplace: Car/motor vehicle 2.1 2.4 4.8 -1.7 -0.0 -0.3 -2.2 -2.0
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.8 0.4 -0.0 0.6 0.7 1.7
Medication: Aspirin 2.1 2.8 8.5 1.2 -1.5 -0.4 1.3 2.9
Supplements: Vitamin C 1.2 1.4 4.5 0.1 1.0 -2.1 0.4 1.3
Knee pain experienced in last month 3.2 5.0 9.4 -1.8 3.1 -2.2 0.9 -2.6
Hypertension (Self-reported) 5.2 14.5 46.4 2.9 -6.8 -1.2 -1.8 3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 3.3 0.6 0.2 -0.2 1.8 -0.3
Illnesses of father: Heart disease 0.5 0.7 1.3 -0.5 -1.2 -0.4 -1.1 -0.9
Illnesses of siblings: Diabetes 1.1 1.4 3.9 1.5 -0.4 0.5 -2.0 -0.7
Smoking status: Previous 0.3 0.5 1.2 -0.4 1.1 -0.1 0.1 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 1.5 3.1 5.7 0.6 -1.3 -2.3 1.5 2.4
Whole body fat-free mass 1.4 7.8 24.1 -3.2 1.5 -4.9 0.5 1.5
Leg fat-free mass (right) 1.0 5.6 16.4 -2.7 1.5 -4.0 0.3 1.3
Arm fat percentage (left) 0.5 1.9 4.7 -0.6 2.2 0.1 -1.9 -0.8
Average weekly red wine intake 1.5 2.3 8.2 -1.4 2.9 0.7 0.6 -0.6
Handedness (chirality/laterality): Left-handed 1.2 1.4 3.5 -0.9 1.1 -1.9 0.5 -1.1
Mood swings 1.8 3.3 5.2 -1.9 -2.3 -0.7 -2.2 -1.6
Loneliness, isolation 1.1 1.5 4.2 -1.4 0.8 -0.9 -2.0 -0.3
Long-standing illness, disability or infirmity 1.4 2.2 6.1 -2.5 1.8 -0.1 -0.5 -1.2
Ever had bowel cancer screening 0.7 0.8 2.0 0.4 0.3 -1.4 -0.1 1.3
Diabetes diagnosed by doctor 1.1 1.9 3.3 -0.2 -1.4 -1.0 -1.7 1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.6 -1.3 0.7 -0.6 -0.2 -1.1
Friendships satisfaction 1.1 1.4 5.5 0.5 -0.6 1.0 -2.4 0.2
Qualifications: nursing, teaching 0.9 1.4 4.1 -0.4 1.0 -2.0 1.2 0.4
Commuting to job workplace: Walk 1.9 2.0 4.5 2.0 0.1 0.5 1.3 2.1
Eye problems/disorders: Cataract 0.3 0.3 0.8 -0.0 -0.3 -0.9 0.4 0.8
Mouth/teeth dental problems: Mouth ulcers 1.0 1.5 5.0 0.5 0.3 2.2 0.0 1.5
Medication for cholesterol 1.0 1.5 3.8 -2.0 1.4 -0.3 1.1 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 1.6 -0.7 1.2 -1.0 -1.3 -0.5
Back pain experienced in last month 0.4 0.5 1.4 -1.2 1.0 -0.4 -0.2 0.1
Mineral and other dietary supplements 0.4 0.5 2.6 -0.2 -1.6 0.2 -0.2 0.2
Breast cancer (self-reported) 0.0 0.0 0.1 -0.0 0.2 -0.2 0.2 0.2
Asthma (self-reported) 0.7 1.3 4.1 -0.8 -0.0 -2.0 0.4 -1.2
Osteoporosis (self-reported) 0.3 0.4 0.9 0.9 -0.7 0.7 0.1 -0.1
Osteoarthritis (self-reported) 2.7 3.5 9.2 -1.8 3.0 1.1 -0.1 -2.0
Medication: Aspirin 1.8 2.4 7.0 1.1 -1.6 -0.8 0.8 2.6
Medication: Gliclazide 1.4 1.6 3.8 -0.4 -1.4 -2.0 -0.9 1.2
Illnesses of father: None of the above (group 1) 2.9 3.6 10.2 0.6 -1.7 1.5 1.5 3.2
Smoking status: Current 0.6 1.0 4.0 0.0 -2.0 0.7 0.6 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.1 0.2 1.2 -0.8 0.2 -1.5
Whole body water mass 1.3 7.7 23.8 -3.1 1.4 -4.9 0.5 1.7
Leg predicted mass (right) 1.1 5.6 16.4 -2.8 1.5 -4.0 0.2 1.3
Arm fat mass (left) 0.7 2.9 7.2 -1.5 2.7 -1.5 -1.6 -0.4
Number of self-reported non-cancer illnesses 0.9 1.5 3.8 -0.2 -2.0 0.8 -1.6 0.7
Average weekly champagne plus white wine intake 1.1 1.6 3.2 0.0 1.4 -1.4 -0.9 -1.8
Miserableness 1.5 2.6 7.2 -1.5 0.6 -1.6 -0.8 -2.7
Guilty feelings 0.3 0.5 1.2 -1.1 0.0 -0.2 -0.9 -0.4
Wears glasses or contact lenses 1.5 1.7 3.9 0.2 1.8 -2.0 -1.1 0.3
Ever taken oral contraceptive pill 4.0 4.5 10.8 -3.3 2.3 -0.6 -0.5 -2.4
Hearing aid user 0.8 0.9 2.2 -0.4 0.6 -1.5 0.8 1.2
Mother’s age at death 1.3 1.7 3.3 1.2 -1.2 -1.8 0.1 1.4
Financial situation satisfaction 1.1 1.4 2.8 0.9 1.7 -0.3 0.9 -1.6
Tinnitus: Yes, now most or all of the time 0.7 0.8 4.0 -0.3 -0.0 -0.0 -2.0 0.0
Commuting to job workplace: Public transport 0.8 0.9 2.0 1.3 1.4 -0.2 0.4 0.9
Eye problems/disorders: Glaucoma 0.7 0.9 3.2 -1.8 0.9 -0.5 -0.0 -0.2
Medication: Blood pressure 3.2 6.1 14.6 2.8 -3.8 0.0 -1.6 2.4
Pain type(s) experienced in last month: Hip pain 0.9 1.2 3.3 -1.1 1.8 -0.6 0.8 -0.6
Supplements: Fish oil (including cod liver oil) 0.5 0.7 2.2 -0.8 0.0 -1.5 -0.7 0.4
High cholesterol (Self-reported) 2.4 4.2 7.0 1.1 -2.6 1.6 -2.4 2.1
Medication: Bendroflumethiazide 1.3 2.0 6.7 0.8 -2.6 -0.8 -0.3 1.4
Medication: Paracetamol 2.9 4.5 10.4 -1.3 3.2 -1.1 -1.1 -2.8
Medication: Lisinopril 1.2 1.5 3.7 -0.3 -1.4 1.9 -0.8 1.2
Medication: Atorvastatin 1.7 2.1 5.1 1.7 -2.3 0.8 -1.0 0.9
Illnesses of father: High blood pressure 0.6 0.8 2.4 0.2 0.6 -0.4 -0.9 -1.6
Alcohol drinker status: Never 0.4 0.5 0.8 0.7 -0.4 0.9 0.7 0.7
Ever smoked 0.1 0.2 0.5 -0.4 0.1 0.1 -0.6 -0.7
Basal metabolic rate 1.3 7.5 22.7 -3.1 1.7 -4.8 0.2 1.4
Leg fat percentage (left) 1.0 3.8 11.0 -1.7 3.3 -0.8 -1.5 -1.5
Arm fat-free mass (left) 1.6 8.2 23.0 -3.2 2.5 -4.8 0.4 1.2
Number of operations (self-reported) 2.1 3.1 8.1 -1.2 2.8 0.5 0.9 -2.2
Average weekly beer plus cider intake 0.3 0.4 1.2 -0.7 -1.1 0.0 0.6 0.3
Irritability 0.6 0.9 2.5 -1.6 -0.4 -0.8 -0.7 -0.9
Risk taking 2.2 3.2 5.4 -1.6 2.1 -2.3 1.8 0.7
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.4 -0.6 0.8 1.2 -0.1 0.3
Fractured/broken bones in last 5 years 1.1 1.4 3.7 1.9 0.6 0.8 1.5 -0.5
Age started oral contraceptive pill 2.0 2.5 11.2 3.3 -0.8 -0.0 0.5 0.7
Diastolic blood pressure, automated reading 3.2 9.8 26.3 -1.7 -5.1 -3.0 -2.8 1.7
Ever depressed for a whole week 1.0 1.2 2.8 -1.4 1.7 0.8 -0.2 0.7
Unable to work because of sickness or disability 0.5 0.7 1.5 -0.2 -1.0 -1.2 -0.5 -0.6
Commuting to job workplace: Cycle 4.3 5.2 15.8 2.4 0.3 -0.2 4.0 2.0
Myopia 0.5 0.7 2.8 0.4 0.5 -1.7 0.4 0.6
Vascular/heart problems diagnosed by doctor 5.0 13.7 46.8 -2.1 6.8 0.9 1.6 -3.7
Cholesterol lowering medication 0.8 1.1 2.9 1.1 -0.6 0.5 -1.7 0.9
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.5 1.2 -0.3 -0.7 0.7 1.2
Pain experienced in last month 1.7 2.9 8.5 2.9 -1.9 0.7 -0.6 1.2
Supplements: Calcium 0.2 0.3 0.4 0.5 0.5 0.6 -0.4 0.6
Basal cell carcinoma (self-reported) 0.2 0.2 0.8 -0.9 0.3 -0.2 0.0 -0.3
Heart attack/myocardial infarction (self-reported) 0.7 0.9 4.0 -0.4 -2.0 0.6 0.2 0.0
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 1.5 -0.9 0.7 -1.2 1.2 0.4
Heart disease (siblings) 0.2 0.3 0.8 -0.2 -0.2 0.9 -0.5 -0.6
Alcohol drinker status: Previous 0.5 0.5 1.3 -0.4 -0.7 0.2 -1.1 0.9
Pack years of smoking 0.4 0.6 1.6 -1.3 0.2 1.0 -0.2 -0.5
Impedance of whole body 1.3 6.5 18.7 2.7 -4.3 1.7 -0.3 1.9
Leg fat mass (left) 1.1 4.3 10.1 -2.1 3.2 -2.3 -1.1 -0.7
Arm predicted mass (left) 1.4 7.2 20.2 -3.0 2.2 -4.5 0.5 1.3