Best TWAS P=2.2e-09 · Best GWAS P=5.1e-11 conditioned to 3.66e-07
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PHLPP2 | 0.04 | 0.01 | bslmm | 456 | 0.02 | 4.7e-04 | -4.8 | -5.8 | 8.0e-09 | 0.57 | 0.09 | 0.90 | FALSE |
2 | GTEx | Adrenal Gland | AP1G1 | 0.22 | 0.06 | enet | 25 | 0.14 | 8.0e-06 | -6.1 | -5.8 | 5.1e-09 | 0.58 | 0.05 | 0.94 | FALSE |
3 | GTEx | Artery Aorta | AP1G1 | 0.10 | 0.09 | lasso | 2 | 0.07 | 1.3e-04 | -5.1 | -5.1 | 2.8e-07 | 0.66 | 0.11 | 0.80 | FALSE |
4 | GTEx | Skin Sun Exposed Lower leg | AP1G1 | 0.06 | 0.00 | enet | 15 | 0.01 | 5.7e-02 | -5.4 | -5.2 | 1.6e-07 | 0.54 | 0.10 | 0.78 | FALSE |
5 | GTEx | Testis | PHLPP2 | 0.29 | 0.38 | enet | 20 | 0.37 | 3.0e-17 | -6.2 | 5.9 | 2.8e-09 | -0.64 | 0.04 | 0.96 | FALSE |
6 | METSIM | Adipose | PHLPP2 | 0.07 | 0.03 | lasso | 5 | 0.06 | 1.7e-09 | 4.2 | 5.6 | 1.9e-08 | -0.46 | 1.00 | 0.00 | FALSE |
7 | YFS | Blood | ATXN1L | 0.02 | 0.02 | blup | 413 | 0.02 | 6.5e-07 | 3.9 | 5.6 | 2.8e-08 | -0.45 | 0.96 | 0.03 | FALSE |
8 | YFS | Blood | PHLPP2 | 0.04 | 0.03 | bslmm | 459 | 0.05 | 5.5e-16 | -6.0 | 6.0 | 2.6e-09 | -0.52 | 0.07 | 0.93 | FALSE |
9 | The Cancer Genome Atlas | Esophageal Carcinoma | PHLPP2 | 0.18 | 0.03 | blup | 67 | 0.07 | 2.9e-03 | -6.2 | -5.3 | 8.7e-08 | 0.56 | 0.02 | 0.74 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AP1G1 | 0.03 | 0.03 | lasso | 4 | 0.02 | 2.1e-03 | -4.0 | -5.4 | 7.7e-08 | 0.62 | 0.02 | 0.86 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AP1G1 | 0.11 | 0.02 | enet | 27 | 0.04 | 1.2e-04 | 4.2 | -6.0 | 2.2e-09 | 0.28 | 0.08 | 0.24 | TRUE |
12 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PHLPP2 | 0.11 | 0.03 | lasso | 6 | 0.01 | 1.2e-01 | 4.1 | 5.7 | 1.6e-08 | -0.43 | 0.03 | 0.46 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | MARVELD3 | 0.08 | 0.01 | blup | 44 | 0.06 | 7.1e-07 | -6.1 | 5.8 | 7.7e-09 | -0.49 | 0.02 | 0.96 | FALSE |