Best TWAS P=1.39e-13 · Best GWAS P=2.41e-13 conditioned to 1.26e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellum | KIAA0895L | 0.47 | 0.06 | enet | 39 | 0.13 | 1.5e-04 | -0.81 | -5.6 | 2.3e-08 | -0.04 | 0.39 | 0.04 | FALSE |
2 | GTEx | Brain Cerebellum | PSMB10 | 0.11 | 0.03 | lasso | 4 | 0.05 | 1.6e-02 | -0.97 | 5.5 | 3.1e-08 | 0.28 | 0.09 | 0.06 | FALSE |
3 | GTEx | Lung | NFATC3 | 0.04 | 0.01 | lasso | 4 | 0.01 | 4.1e-02 | 5.92 | -6.2 | 4.0e-10 | -0.32 | 0.28 | 0.13 | FALSE |
4 | GTEx | Spleen | NFATC3 | 0.29 | 0.30 | lasso | 2 | 0.25 | 3.3e-07 | 5.40 | -5.3 | 1.3e-07 | -0.31 | 0.38 | 0.19 | FALSE |
5 | GTEx | Thyroid | PLA2G15 | 0.06 | 0.04 | enet | 5 | 0.04 | 5.7e-04 | 6.42 | 6.4 | 1.3e-10 | 0.38 | 0.37 | 0.52 | TRUE |
6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KCTD19 | 0.02 | 0.02 | blup | 29 | 0.03 | 3.5e-06 | -5.04 | -6.0 | 1.7e-09 | -0.03 | 0.01 | 0.98 | FALSE |
7 | The Cancer Genome Atlas | Colon Adenocarcinoma | NFATC3 | 0.22 | 0.05 | lasso | 3 | 0.06 | 3.6e-04 | 3.38 | -5.8 | 5.1e-09 | -0.35 | 0.00 | 0.98 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AGRP | 0.06 | 0.00 | enet | 9 | 0.02 | 5.3e-03 | -2.35 | -5.3 | 9.6e-08 | -0.09 | 0.00 | 0.33 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NFATC3 | 0.11 | 0.04 | enet | 4 | 0.04 | 2.8e-05 | 6.70 | -6.4 | 1.5e-10 | -0.36 | 0.00 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NFATC3 | 0.23 | 0.05 | lasso | 2 | 0.06 | 8.5e-08 | 6.70 | -5.8 | 7.7e-09 | -0.31 | 0.00 | 1.00 | FALSE |
11 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | AGRP | 0.11 | 0.01 | enet | 6 | 0.07 | 2.5e-05 | 6.29 | -7.4 | 1.4e-13 | -0.12 | 0.00 | 0.78 | TRUE |
12 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NFATC3 | 0.26 | 0.09 | enet | 4 | 0.13 | 9.8e-06 | 6.70 | -5.2 | 1.7e-07 | -0.29 | 0.01 | 0.96 | FALSE |
13 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | NFATC3 | 0.46 | 0.16 | lasso | 4 | 0.20 | 1.7e-07 | -3.32 | -5.5 | 4.9e-08 | -0.33 | 0.01 | 0.98 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | C16orf48 | 0.04 | 0.02 | blup | 17 | 0.04 | 8.5e-05 | -2.47 | 6.1 | 8.4e-10 | 0.37 | 0.01 | 0.49 | FALSE |