Best TWAS P=1.73e-20 · Best GWAS P=1.94e-22 conditioned to 0.0032
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ECE2 | 0.24 | 0.20 | bslmm | 542 | 0.19 | 1.6e-22 | 7.4 | 7.3 | 4.1e-13 | -0.37 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SENP2 | 0.21 | 0.18 | enet | 33 | 0.19 | 4.2e-22 | -5.1 | 5.5 | 4.6e-08 | 0.02 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Artery Tibial | PSMD2 | 0.13 | 0.09 | lasso | 5 | 0.08 | 1.3e-06 | -5.7 | 6.0 | 2.2e-09 | -0.42 | 0.88 | 0.02 | FALSE |
| 4 | GTEx | Brain Putamen basal ganglia | ECE2 | 0.38 | 0.03 | enet | 22 | 0.11 | 1.4e-03 | 7.4 | 6.3 | 2.2e-10 | -0.28 | 0.08 | 0.16 | FALSE |
| 5 | GTEx | Pituitary | ECE2 | 0.52 | 0.30 | lasso | 7 | 0.23 | 1.5e-06 | 7.4 | 6.1 | 1.2e-09 | -0.31 | 0.39 | 0.23 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | ABCF3 | 0.13 | 0.08 | lasso | 4 | 0.11 | 1.6e-09 | 5.6 | 7.0 | 3.5e-12 | -0.36 | 0.98 | 0.01 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | PSMD2 | 0.13 | 0.14 | lasso | 4 | 0.15 | 1.4e-12 | -5.7 | 5.9 | 3.7e-09 | -0.39 | 1.00 | 0.00 | FALSE |
| 8 | YFS | Blood | PSMD2 | 0.26 | 0.22 | lasso | 5 | 0.24 | 2.4e-77 | -5.7 | 5.5 | 4.4e-08 | -0.39 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PSMD2 | 0.03 | 0.03 | blup | 50 | 0.03 | 4.8e-06 | -5.7 | 5.4 | 7.8e-08 | -0.48 | 0.66 | 0.27 | FALSE |
| 10 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | VWA5B2 | 0.15 | 0.00 | blup | 52 | 0.01 | 1.4e-01 | 4.3 | 5.4 | 5.3e-08 | -0.16 | 0.01 | 0.04 | FALSE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | ABCF3 | 0.07 | 0.00 | blup | 51 | 0.01 | 4.4e-02 | 5.6 | 5.5 | 3.4e-08 | -0.26 | 0.01 | 0.87 | TRUE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ETV5 | 0.03 | 0.01 | blup | 55 | 0.02 | 1.3e-03 | -5.8 | -5.7 | 1.1e-08 | -0.04 | 0.01 | 0.85 | TRUE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ECE2 | 0.04 | 0.02 | blup | 61 | 0.03 | 3.5e-04 | 7.4 | 6.7 | 2.1e-11 | -0.24 | 0.54 | 0.02 | FALSE |
| 14 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABCF3 | 0.08 | 0.03 | blup | 51 | 0.06 | 6.1e-04 | 2.7 | 5.4 | 5.7e-08 | -0.25 | 0.02 | 0.68 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | PSMD2 | 0.09 | 0.02 | blup | 50 | 0.05 | 1.2e-06 | -9.0 | 9.3 | 1.7e-20 | -0.73 | 0.03 | 0.84 | TRUE |
| 16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PSMD2 | 0.05 | 0.00 | enet | 10 | 0.01 | 3.6e-02 | 7.4 | 5.8 | 4.9e-09 | -0.49 | 0.01 | 0.10 | FALSE |
| 17 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | VWA5B2 | 0.10 | 0.04 | blup | 51 | 0.04 | 1.8e-02 | 5.6 | -7.9 | 2.1e-15 | 0.43 | 0.03 | 0.33 | FALSE |