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chr4:16,922,182-18,507,692

Best TWAS P=1.9e-68 · Best GWAS P=7.79e-63 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Artery Aorta	DCAF16	0.10	0.01	enet	6	0.02	4.7e-02	-15.64	17.5	1.9e-68	-0.81	0.04	0.81	TRUE
23	ROSMAP	Brain Pre-frontal Cortex	DCAF16	0.04	0.02	bslmm	379	0.01	3.9e-02	-14.94	14.1	6.3e-45	-0.83	0.03	0.89	TRUE
6	GTEx	Artery Tibial	DCAF16	0.16	0.16	lasso	5	0.13	1.5e-10	11.47	12.9	4.3e-38	-0.36	1.00	0.00	TRUE
15	GTEx	Skin Not Sun Exposed Suprapubic	DCAF16	0.16	0.08	lasso	5	0.12	4.4e-07	11.15	12.3	1.1e-34	-0.35	0.64	0.03	TRUE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	NCAPG	0.06	0.02	blup	34	0.04	1.0e-05	-15.01	-9.7	2.4e-22	0.68	0.05	0.62	TRUE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	NCAPG	0.03	0.04	enet	5	0.04	8.1e-09	-0.77	-6.1	1.1e-09	0.55	0.95	0.05	TRUE
1	CommonMind	Brain Pre-frontal Cortex	FAM184B	0.14	0.25	enet	21	0.24	2.0e-28	-4.79	5.2	2.0e-07	-0.14	1.00	0.00	TRUE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	DCAF16	0.09	0.02	lasso	3	0.04	5.2e-05	11.47	16.3	7.7e-60	-0.64	0.07	0.83	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	DCAF16	0.07	0.04	blup	31	0.07	4.9e-07	11.25	15.7	1.9e-55	-0.65	0.14	0.79	FALSE
17	GTEx	Spleen	DCAF16	0.35	0.02	lasso	5	0.11	8.5e-04	10.15	15.6	4.8e-55	-0.66	0.06	0.50	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	NCAPG	0.02	0.03	lasso	1	0.02	9.0e-04	-15.01	-15.0	6.8e-51	0.88	0.03	0.56	FALSE
8	GTEx	Breast Mammary Tissue (Male)	DCAF16	0.24	0.03	enet	18	-0.01	4.4e-01	-14.88	14.9	3.5e-50	-0.76	0.05	0.54	FALSE
19	GTEx	Thyroid	DCAF16	0.11	0.02	lasso	5	0.03	2.3e-03	10.15	14.8	1.2e-49	-0.54	0.16	0.71	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	DCAF16	0.04	0.04	blup	31	0.04	2.2e-05	10.15	14.6	1.6e-48	-0.58	0.27	0.23	FALSE
28	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NCAPG	0.14	0.07	lasso	3	0.07	5.2e-08	-14.94	-14.6	4.0e-48	0.84	0.81	0.18	FALSE
7	GTEx	Breast Mammary Tissue	DCAF16	0.12	0.08	lasso	4	0.10	6.4e-06	10.14	13.5	1.9e-41	-0.52	0.17	0.59	FALSE
26	The Cancer Genome Atlas	Colon Adenocarcinoma	NCAPG	0.08	0.04	blup	34	0.09	1.1e-05	-15.01	-13.3	3.4e-40	0.84	0.02	0.97	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	NCAPG	0.02	0.02	blup	34	0.02	3.4e-03	-13.68	-12.6	1.9e-36	0.76	0.01	0.83	FALSE
18	GTEx	Stomach	DCAF16	0.21	0.04	lasso	6	0.02	5.6e-02	11.25	12.3	9.8e-35	-0.26	0.19	0.04	FALSE
13	GTEx	Nerve Tibial	DCAF16	0.16	0.14	lasso	3	0.14	2.8e-10	10.15	11.7	2.3e-31	-0.37	0.99	0.01	FALSE
24	YFS	Blood	DCAF16	0.02	0.02	lasso	1	0.01	1.1e-04	11.47	11.5	1.8e-30	-0.25	0.84	0.04	FALSE
16	GTEx	Skin Sun Exposed Lower leg	DCAF16	0.14	0.12	enet	14	0.12	5.4e-10	10.14	11.4	3.2e-30	-0.28	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	DCAF16	0.19	0.06	enet	10	0.11	3.9e-06	10.15	11.4	7.3e-30	-0.35	0.26	0.51	FALSE
11	GTEx	Esophagus Mucosa	DCAF16	0.10	0.02	lasso	4	0.02	8.3e-03	10.14	10.9	1.6e-27	-0.37	0.13	0.42	FALSE
9	GTEx	Breast Mammary Tissue (Female)	DCAF16	0.16	0.13	lasso	2	0.06	7.8e-03	10.15	10.3	5.6e-25	-0.27	0.06	0.08	FALSE
14	GTEx	Pituitary	DCAF16	0.27	0.20	enet	15	0.19	1.3e-05	10.15	10.2	1.9e-24	-0.38	0.07	0.37	FALSE
12	GTEx	Esophagus Muscularis	DCAF16	0.16	0.14	lasso	3	0.14	9.3e-09	10.15	9.9	2.8e-23	-0.27	0.99	0.00	FALSE
3	GTEx	Adipose Subcutaneous	DCAF16	0.21	0.15	lasso	3	0.17	5.1e-14	10.15	9.9	4.6e-23	-0.24	1.00	0.00	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	FAM184B	0.17	0.14	enet	31	0.18	5.1e-23	-5.43	-7.7	9.9e-15	0.26	1.00	0.00	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	MED28	0.02	0.01	bslmm	411	0.00	1.9e-01	-5.24	7.5	9.6e-14	-0.30	0.22	0.03	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MED28	0.07	0.09	enet	9	0.11	7.1e-13	-5.43	5.5	3.0e-08	-0.18	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FAM184B	0.02	0.03	lasso	2	0.02	2.6e-03	-5.46	-5.5	3.2e-08	0.16	0.24	0.03	FALSE
35	The Cancer Genome Atlas	Stomach Adenocarcinoma	LAP3	0.07	0.03	blup	36	0.06	5.3e-05	-3.57	-5.5	4.1e-08	0.15	0.02	0.97	FALSE
31	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MED28	0.08	0.05	blup	34	0.05	2.9e-03	-5.22	5.4	6.1e-08	-0.17	0.02	0.76	FALSE
20	NTR	Blood	MED28	0.09	0.18	lasso	2	0.18	3.7e-54	-5.08	5.2	1.8e-07	-0.16	1.00	0.00	FALSE
10	GTEx	Colon Transverse	MED28	0.13	0.05	lasso	3	0.02	5.8e-02	-4.59	5.2	1.9e-07	-0.11	0.20	0.04	FALSE