Best TWAS P=1.9e-68 · Best GWAS P=7.79e-63 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FAM184B | 0.14 | 0.25 | enet | 21 | 0.24 | 2.0e-28 | -4.79 | 5.2 | 2.0e-07 | -0.14 | 1.00 | 0.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | MED28 | 0.07 | 0.09 | enet | 9 | 0.11 | 7.1e-13 | -5.43 | 5.5 | 3.0e-08 | -0.18 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | DCAF16 | 0.21 | 0.15 | lasso | 3 | 0.17 | 5.1e-14 | 10.15 | 9.9 | 4.6e-23 | -0.24 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | DCAF16 | 0.19 | 0.06 | enet | 10 | 0.11 | 3.9e-06 | 10.15 | 11.4 | 7.3e-30 | -0.35 | 0.26 | 0.51 | FALSE |
| 5 | GTEx | Artery Aorta | DCAF16 | 0.10 | 0.01 | enet | 6 | 0.02 | 4.7e-02 | -15.64 | 17.5 | 1.9e-68 | -0.81 | 0.04 | 0.81 | TRUE |
| 6 | GTEx | Artery Tibial | DCAF16 | 0.16 | 0.16 | lasso | 5 | 0.13 | 1.5e-10 | 11.47 | 12.9 | 4.3e-38 | -0.36 | 1.00 | 0.00 | TRUE |
| 7 | GTEx | Breast Mammary Tissue | DCAF16 | 0.12 | 0.08 | lasso | 4 | 0.10 | 6.4e-06 | 10.14 | 13.5 | 1.9e-41 | -0.52 | 0.17 | 0.59 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Male) | DCAF16 | 0.24 | 0.03 | enet | 18 | -0.01 | 4.4e-01 | -14.88 | 14.9 | 3.5e-50 | -0.76 | 0.05 | 0.54 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | DCAF16 | 0.16 | 0.13 | lasso | 2 | 0.06 | 7.8e-03 | 10.15 | 10.3 | 5.6e-25 | -0.27 | 0.06 | 0.08 | FALSE |
| 10 | GTEx | Colon Transverse | MED28 | 0.13 | 0.05 | lasso | 3 | 0.02 | 5.8e-02 | -4.59 | 5.2 | 1.9e-07 | -0.11 | 0.20 | 0.04 | FALSE |
| 11 | GTEx | Esophagus Mucosa | DCAF16 | 0.10 | 0.02 | lasso | 4 | 0.02 | 8.3e-03 | 10.14 | 10.9 | 1.6e-27 | -0.37 | 0.13 | 0.42 | FALSE |
| 12 | GTEx | Esophagus Muscularis | DCAF16 | 0.16 | 0.14 | lasso | 3 | 0.14 | 9.3e-09 | 10.15 | 9.9 | 2.8e-23 | -0.27 | 0.99 | 0.00 | FALSE |
| 13 | GTEx | Nerve Tibial | DCAF16 | 0.16 | 0.14 | lasso | 3 | 0.14 | 2.8e-10 | 10.15 | 11.7 | 2.3e-31 | -0.37 | 0.99 | 0.01 | FALSE |
| 14 | GTEx | Pituitary | DCAF16 | 0.27 | 0.20 | enet | 15 | 0.19 | 1.3e-05 | 10.15 | 10.2 | 1.9e-24 | -0.38 | 0.07 | 0.37 | FALSE |
| 15 | GTEx | Skin Not Sun Exposed Suprapubic | DCAF16 | 0.16 | 0.08 | lasso | 5 | 0.12 | 4.4e-07 | 11.15 | 12.3 | 1.1e-34 | -0.35 | 0.64 | 0.03 | TRUE |
| 16 | GTEx | Skin Sun Exposed Lower leg | DCAF16 | 0.14 | 0.12 | enet | 14 | 0.12 | 5.4e-10 | 10.14 | 11.4 | 3.2e-30 | -0.28 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Spleen | DCAF16 | 0.35 | 0.02 | lasso | 5 | 0.11 | 8.5e-04 | 10.15 | 15.6 | 4.8e-55 | -0.66 | 0.06 | 0.50 | FALSE |
| 18 | GTEx | Stomach | DCAF16 | 0.21 | 0.04 | lasso | 6 | 0.02 | 5.6e-02 | 11.25 | 12.3 | 9.8e-35 | -0.26 | 0.19 | 0.04 | FALSE |
| 19 | GTEx | Thyroid | DCAF16 | 0.11 | 0.02 | lasso | 5 | 0.03 | 2.3e-03 | 10.15 | 14.8 | 1.2e-49 | -0.54 | 0.16 | 0.71 | FALSE |
| 20 | NTR | Blood | MED28 | 0.09 | 0.18 | lasso | 2 | 0.18 | 3.7e-54 | -5.08 | 5.2 | 1.8e-07 | -0.16 | 1.00 | 0.00 | FALSE |
| 21 | ROSMAP | Brain Pre-frontal Cortex | FAM184B | 0.17 | 0.14 | enet | 31 | 0.18 | 5.1e-23 | -5.43 | -7.7 | 9.9e-15 | 0.26 | 1.00 | 0.00 | FALSE |
| 22 | ROSMAP | Brain Pre-frontal Cortex | MED28 | 0.02 | 0.01 | bslmm | 411 | 0.00 | 1.9e-01 | -5.24 | 7.5 | 9.6e-14 | -0.30 | 0.22 | 0.03 | FALSE |
| 23 | ROSMAP | Brain Pre-frontal Cortex | DCAF16 | 0.04 | 0.02 | bslmm | 379 | 0.01 | 3.9e-02 | -14.94 | 14.1 | 6.3e-45 | -0.83 | 0.03 | 0.89 | TRUE |
| 24 | YFS | Blood | DCAF16 | 0.02 | 0.02 | lasso | 1 | 0.01 | 1.1e-04 | 11.47 | 11.5 | 1.8e-30 | -0.25 | 0.84 | 0.04 | FALSE |
| 25 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NCAPG | 0.03 | 0.04 | enet | 5 | 0.04 | 8.1e-09 | -0.77 | -6.1 | 1.1e-09 | 0.55 | 0.95 | 0.05 | TRUE |
| 26 | The Cancer Genome Atlas | Colon Adenocarcinoma | NCAPG | 0.08 | 0.04 | blup | 34 | 0.09 | 1.1e-05 | -15.01 | -13.3 | 3.4e-40 | 0.84 | 0.02 | 0.97 | FALSE |
| 27 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FAM184B | 0.02 | 0.03 | lasso | 2 | 0.02 | 2.6e-03 | -5.46 | -5.5 | 3.2e-08 | 0.16 | 0.24 | 0.03 | FALSE |
| 28 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NCAPG | 0.14 | 0.07 | lasso | 3 | 0.07 | 5.2e-08 | -14.94 | -14.6 | 4.0e-48 | 0.84 | 0.81 | 0.18 | FALSE |
| 29 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DCAF16 | 0.09 | 0.02 | lasso | 3 | 0.04 | 5.2e-05 | 11.47 | 16.3 | 7.7e-60 | -0.64 | 0.07 | 0.83 | FALSE |
| 30 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NCAPG | 0.02 | 0.03 | lasso | 1 | 0.02 | 9.0e-04 | -15.01 | -15.0 | 6.8e-51 | 0.88 | 0.03 | 0.56 | FALSE |
| 31 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | MED28 | 0.08 | 0.05 | blup | 34 | 0.05 | 2.9e-03 | -5.22 | 5.4 | 6.1e-08 | -0.17 | 0.02 | 0.76 | FALSE |
| 32 | The Cancer Genome Atlas | Lung Adenocarcinoma | NCAPG | 0.06 | 0.02 | blup | 34 | 0.04 | 1.0e-05 | -15.01 | -9.7 | 2.4e-22 | 0.68 | 0.05 | 0.62 | TRUE |
| 33 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DCAF16 | 0.04 | 0.04 | blup | 31 | 0.04 | 2.2e-05 | 10.15 | 14.6 | 1.6e-48 | -0.58 | 0.27 | 0.23 | FALSE |
| 34 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NCAPG | 0.02 | 0.02 | blup | 34 | 0.02 | 3.4e-03 | -13.68 | -12.6 | 1.9e-36 | 0.76 | 0.01 | 0.83 | FALSE |
| 35 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LAP3 | 0.07 | 0.03 | blup | 36 | 0.06 | 5.3e-05 | -3.57 | -5.5 | 4.1e-08 | 0.15 | 0.02 | 0.97 | FALSE |
| 36 | The Cancer Genome Atlas | Thyroid Carcinoma | DCAF16 | 0.07 | 0.04 | blup | 31 | 0.07 | 4.9e-07 | 11.25 | 15.7 | 1.9e-55 | -0.65 | 0.14 | 0.79 | FALSE |