Best TWAS P=6.16e-10 · Best GWAS P=3.2e-09 conditioned to 0.0441
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | WDR19 | 0.05 | 0.01 | lasso | 5 | 0.00 | 1.3e-01 | -5.3 | 5.5 | 2.9e-08 | 0.89 | 0.05 | 0.91 | FALSE |
2 | GTEx | Adrenal Gland | RP11-360F5.3 | 0.09 | 0.01 | enet | 12 | 0.02 | 6.2e-02 | 5.9 | 5.7 | 1.2e-08 | 0.88 | 0.03 | 0.91 | FALSE |
3 | GTEx | Stomach | UGDH-AS1 | 0.08 | 0.01 | lasso | 7 | 0.02 | 3.8e-02 | -5.3 | 5.4 | 8.1e-08 | 0.80 | 0.05 | 0.72 | FALSE |
4 | GTEx | Testis | WDR19 | 0.28 | 0.29 | lasso | 5 | 0.27 | 1.6e-12 | -5.3 | 5.8 | 7.3e-09 | 0.87 | 0.10 | 0.90 | FALSE |
5 | METSIM | Adipose | UGDH | 0.12 | 0.06 | blup | 366 | 0.07 | 2.6e-10 | -3.1 | 5.8 | 6.5e-09 | 0.45 | 1.00 | 0.00 | TRUE |
6 | METSIM | Adipose | WDR19 | 0.04 | 0.01 | enet | 20 | 0.02 | 7.7e-04 | -5.5 | 6.2 | 6.2e-10 | 0.51 | 0.06 | 0.91 | TRUE |
7 | ROSMAP | Brain Pre-frontal Cortex | WDR19 | 0.02 | 0.02 | enet | 9 | 0.02 | 2.8e-03 | 5.9 | 6.1 | 1.2e-09 | 0.99 | 0.02 | 0.94 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | WDR19 | 0.03 | 0.04 | blup | 61 | 0.02 | 3.6e-03 | -5.4 | 5.5 | 4.6e-08 | 0.89 | 0.04 | 0.96 | FALSE |
9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | WDR19 | 0.08 | 0.00 | blup | 61 | 0.03 | 1.9e-02 | -5.5 | 5.6 | 2.7e-08 | 0.86 | 0.03 | 0.52 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | WDR19 | 0.04 | 0.01 | blup | 61 | 0.02 | 2.4e-03 | 5.9 | 5.5 | 4.4e-08 | 0.90 | 0.02 | 0.96 | FALSE |
11 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | WDR19 | 0.09 | 0.01 | blup | 61 | 0.03 | 4.1e-02 | -5.3 | 5.4 | 6.0e-08 | 0.88 | 0.02 | 0.41 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | WDR19 | 0.02 | 0.00 | blup | 61 | 0.01 | 2.8e-02 | -3.6 | 5.4 | 8.0e-08 | 0.84 | 0.04 | 0.64 | FALSE |