Best TWAS P=1.25e-12 · Best GWAS P=9.61e-11 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | MED20 | 0.15 | 0.11 | blup | 471 | 0.13 | 3.1e-15 | -5.4 | 5.5 | 3.7e-08 | 0.84 | 0.02 | 0.98 | FALSE |
2 | GTEx | Adipose Subcutaneous | PRICKLE4 | 0.10 | 0.09 | lasso | 8 | 0.08 | 9.2e-07 | 3.8 | -6.0 | 2.6e-09 | 0.35 | 0.48 | 0.51 | TRUE |
3 | GTEx | Adipose Subcutaneous | MED20 | 0.08 | 0.07 | enet | 9 | 0.05 | 4.7e-05 | 6.2 | 5.9 | 3.0e-09 | 0.97 | 0.02 | 0.98 | FALSE |
4 | GTEx | Artery Tibial | MED20 | 0.14 | 0.11 | lasso | 2 | 0.09 | 9.7e-08 | 6.1 | 6.1 | 1.2e-09 | 0.98 | 0.01 | 0.99 | FALSE |
5 | GTEx | Esophagus Gastroesophageal Junction | MED20 | 0.19 | 0.03 | enet | 11 | 0.07 | 2.0e-03 | 5.7 | 5.8 | 8.8e-09 | 0.76 | 0.03 | 0.87 | TRUE |
6 | GTEx | Esophagus Mucosa | MED20 | 0.09 | 0.07 | enet | 10 | 0.02 | 2.7e-02 | -5.4 | 5.5 | 3.3e-08 | 0.96 | 0.03 | 0.96 | TRUE |
7 | GTEx | Heart Atrial Appendage | MED20 | 0.14 | 0.12 | enet | 11 | 0.09 | 5.9e-05 | 6.5 | 6.8 | 1.3e-11 | 0.95 | 0.01 | 0.99 | TRUE |
8 | GTEx | Heart Left Ventricle | PRICKLE4 | 0.11 | 0.05 | lasso | 4 | 0.03 | 9.8e-03 | 5.8 | -6.2 | 4.4e-10 | -0.96 | 0.02 | 0.93 | FALSE |
9 | GTEx | Heart Left Ventricle | MED20 | 0.22 | 0.19 | enet | 8 | 0.12 | 5.8e-07 | 6.1 | 6.3 | 3.6e-10 | 0.98 | 0.01 | 0.99 | FALSE |
10 | GTEx | Lung | PRICKLE4 | 0.12 | 0.05 | lasso | 3 | 0.06 | 2.2e-05 | 5.8 | -5.6 | 2.0e-08 | -0.86 | 0.04 | 0.93 | TRUE |
11 | GTEx | Muscle Skeletal | MED20 | 0.16 | 0.15 | lasso | 4 | 0.16 | 6.7e-16 | 5.8 | 6.0 | 2.2e-09 | 0.92 | 0.07 | 0.93 | FALSE |
12 | GTEx | Nerve Tibial | MED20 | 0.13 | 0.11 | enet | 8 | 0.10 | 1.5e-07 | 6.5 | 6.2 | 6.2e-10 | 0.98 | 0.01 | 0.99 | FALSE |
13 | GTEx | Thyroid | MED20 | 0.05 | 0.05 | lasso | 2 | 0.02 | 8.1e-03 | 6.0 | 6.2 | 7.3e-10 | 0.97 | 0.02 | 0.98 | FALSE |
14 | METSIM | Adipose | MED20 | 0.13 | 0.11 | enet | 27 | 0.11 | 2.3e-16 | 6.3 | 5.5 | 3.2e-08 | 0.90 | 0.01 | 0.99 | TRUE |
15 | ROSMAP | Brain Pre-frontal Cortex | MED20 | 0.10 | 0.10 | enet | 21 | 0.09 | 6.0e-12 | 6.0 | 5.3 | 1.4e-07 | 0.93 | 0.01 | 0.99 | FALSE |
16 | YFS | Blood | BYSL | 0.07 | 0.06 | lasso | 7 | 0.09 | 2.8e-28 | 6.1 | -5.6 | 2.1e-08 | -0.85 | 0.01 | 0.99 | FALSE |
17 | YFS | Blood | MED20 | 0.04 | 0.03 | lasso | 5 | 0.03 | 3.6e-11 | 5.8 | 5.5 | 3.7e-08 | 0.85 | 0.05 | 0.95 | FALSE |
18 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PRICKLE4 | 0.04 | 0.05 | blup | 43 | 0.06 | 2.2e-07 | -3.8 | -6.4 | 1.3e-10 | -0.72 | 0.16 | 0.84 | TRUE |
19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MED20 | 0.04 | 0.06 | enet | 6 | 0.05 | 2.6e-06 | 5.8 | 5.7 | 1.5e-08 | 0.90 | 0.01 | 0.99 | TRUE |
20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PRICKLE4 | 0.03 | 0.00 | blup | 43 | 0.01 | 5.5e-02 | 6.5 | -7.1 | 1.2e-12 | -0.84 | 0.00 | 0.77 | TRUE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | BYSL | 0.05 | 0.06 | enet | 7 | 0.06 | 4.3e-06 | 6.0 | -6.0 | 2.1e-09 | -0.91 | 0.00 | 1.00 | FALSE |