Best TWAS P=1.37e-10 · Best GWAS P=1.16e-09 conditioned to 0.0164
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | USP45 | 0.26 | 0.12 | enet | 36 | 0.22 | 6.6e-26 | 3.2 | -5.6 | 2.5e-08 | -0.42 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Hypothalamus | RP1-199J3.5 | 0.41 | -0.01 | lasso | 9 | 0.00 | 4.3e-01 | -4.8 | -5.4 | 5.4e-08 | -0.08 | 0.09 | 0.08 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | RP1-199J3.5 | 0.30 | 0.04 | enet | 29 | 0.14 | 8.0e-05 | 4.5 | -5.1 | 2.9e-07 | -0.06 | 0.73 | 0.07 | FALSE |
| 4 | GTEx | Pancreas | RP1-199J3.5 | 0.26 | 0.13 | lasso | 17 | 0.14 | 2.1e-06 | 4.4 | -6.4 | 1.4e-10 | -0.08 | 0.86 | 0.11 | TRUE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CCNC | 0.04 | 0.01 | blup | 46 | 0.01 | 1.5e-02 | 4.1 | 5.5 | 4.0e-08 | 0.70 | 0.00 | 0.76 | TRUE |