Best TWAS P=6.64e-24 · Best GWAS P=4.7e-45 conditioned to 1.03e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MKLN1-AS2 | 0.12 | 0.10 | lasso | 3 | 0.10 | 3.4e-08 | -7.4 | -7.1 | 9.6e-13 | -0.55 | 0.98 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | MKLN1-AS2 | 0.14 | 0.07 | enet | 10 | 0.05 | 1.2e-03 | -7.4 | -7.2 | 7.6e-13 | -0.58 | 0.63 | 0.06 | TRUE |
| 3 | GTEx | Artery Coronary | MKLN1-AS2 | 0.39 | 0.01 | enet | 9 | -0.01 | 6.5e-01 | -11.0 | -9.2 | 5.4e-20 | -0.52 | 0.03 | 0.68 | TRUE |
| 4 | GTEx | Artery Tibial | MKLN1-AS2 | 0.14 | 0.05 | enet | 22 | 0.04 | 2.4e-04 | -5.0 | -7.8 | 9.2e-15 | -0.65 | 0.08 | 0.90 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | MKLN1-AS2 | 0.15 | 0.00 | lasso | 4 | 0.01 | 1.1e-01 | -7.4 | -5.9 | 2.9e-09 | -0.51 | 0.14 | 0.03 | FALSE |
| 6 | GTEx | Esophagus Gastroesophageal Junction | MKLN1-AS2 | 0.20 | 0.05 | lasso | 6 | 0.02 | 7.8e-02 | -7.4 | -9.4 | 5.9e-21 | -0.69 | 0.05 | 0.79 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | MKLN1-AS2 | 0.15 | 0.06 | lasso | 3 | 0.08 | 2.2e-04 | -5.0 | -6.1 | 8.0e-10 | -0.52 | 0.45 | 0.06 | FALSE |
| 8 | GTEx | Lung | MKLN1-AS2 | 0.15 | 0.02 | lasso | 5 | 0.03 | 3.0e-03 | -7.4 | -7.1 | 9.8e-13 | -0.54 | 0.26 | 0.04 | TRUE |
| 9 | GTEx | Nerve Tibial | MKLN1-AS2 | 0.20 | 0.16 | lasso | 7 | 0.16 | 1.3e-11 | -7.4 | -10.1 | 6.6e-24 | -0.74 | 0.63 | 0.37 | TRUE |
| 10 | GTEx | Thyroid | MKLN1 | 0.13 | 0.01 | lasso | 4 | 0.02 | 1.7e-02 | -9.4 | -6.5 | 5.7e-11 | -0.43 | 0.15 | 0.06 | FALSE |
| 11 | GTEx | Thyroid | MKLN1-AS2 | 0.28 | 0.22 | lasso | 6 | 0.25 | 8.6e-19 | -7.4 | -9.2 | 5.6e-20 | -0.67 | 1.00 | 0.00 | FALSE |