Best TWAS P=6.78e-22 · Best GWAS P=2.38e-86 conditioned to 7.53e-61
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | RP11-219D15.3 | 0.27 | 0.24 | lasso | 6 | 0.26 | 1.1e-09 | -5.9 | -5.1 | 2.9e-07 | -0.20 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | RBP1 | 0.28 | 0.01 | enet | 47 | 0.01 | 1.6e-01 | 2.5 | -6.0 | 1.6e-09 | -0.16 | 0.06 | 0.12 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | RP11-219D15.3 | 0.18 | 0.02 | enet | 21 | 0.04 | 2.1e-02 | -5.4 | -5.6 | 2.7e-08 | -0.21 | 0.20 | 0.04 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | RP11-219D15.3 | 0.28 | 0.16 | lasso | 3 | 0.14 | 3.6e-05 | -5.4 | -5.4 | 6.4e-08 | -0.22 | 0.72 | 0.02 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | RP11-219D15.3 | 0.24 | 0.15 | enet | 24 | 0.13 | 9.8e-10 | -5.4 | -5.2 | 1.6e-07 | -0.21 | 1.00 | 0.00 | TRUE |
| 6 | GTEx | Esophagus Mucosa | RP11-219D15.3 | 0.12 | 0.09 | lasso | 3 | 0.07 | 2.9e-05 | -5.4 | -5.3 | 1.1e-07 | -0.20 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Lung | RP11-219D15.3 | 0.16 | 0.06 | lasso | 8 | 0.10 | 2.1e-08 | -5.9 | -5.2 | 1.6e-07 | -0.19 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Nerve Tibial | RBP1 | 0.19 | 0.03 | lasso | 10 | 0.04 | 1.1e-03 | -1.6 | -5.2 | 1.8e-07 | -0.11 | 0.18 | 0.04 | TRUE |
| 9 | GTEx | Pancreas | RBP1 | 0.17 | 0.03 | lasso | 8 | 0.03 | 1.7e-02 | -5.8 | 6.1 | 1.3e-09 | 0.19 | 0.26 | 0.04 | FALSE |
| 10 | GTEx | Pancreas | COPB2 | 0.19 | 0.09 | enet | 26 | 0.11 | 1.8e-05 | -5.5 | 5.9 | 4.8e-09 | 0.18 | 0.84 | 0.01 | FALSE |
| 11 | GTEx | Stomach | RP11-219D15.3 | 0.22 | 0.17 | lasso | 4 | 0.19 | 1.5e-09 | -5.2 | -9.6 | 6.8e-22 | -0.25 | 0.98 | 0.00 | TRUE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | MRPS22 | 0.04 | 0.00 | blup | 59 | 0.01 | 2.4e-02 | -2.3 | -5.3 | 1.2e-07 | -0.21 | 0.02 | 0.04 | FALSE |