Hub : Genes

RBP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1350 0.0390 1.5e-06 0.077 0.029 0.076 0.082 0.087 1.1e-09 1.6e-04 1.7e-09 3e-10 9.7e-11
2 GTEx Artery Tibial 0.1432 0.0531 2.8e-03 -0.002 NA 0.009 NA 0.012 5.1e-01 NA 5.7e-02 NA 3.7e-02
3 GTEx Brain Putamen basal ganglia 0.2840 0.1020 8.9e-03 0.008 NA 0.012 NA 0.002 2.1e-01 NA 1.6e-01 NA 2.8e-01
4 GTEx Heart Atrial Appendage 0.1960 0.0650 3.2e-04 0.058 NA 0.049 NA 0.076 1.4e-03 NA 2.9e-03 NA 2.7e-04
5 GTEx Muscle Skeletal 0.2754 0.0721 1.6e-04 0.120 NA 0.071 NA 0.088 8.3e-12 NA 1.7e-07 NA 5.4e-09
6 GTEx Nerve Tibial 0.1899 0.0673 9.9e-04 0.031 NA 0.008 NA 0.038 2.9e-03 NA 8.4e-02 NA 1.1e-03
7 GTEx Pancreas 0.1710 0.0590 1.2e-03 0.029 NA 0.027 NA 0.032 2.2e-02 NA 2.5e-02 NA 1.7e-02
8 TCGA Breast Invasive Carcinoma 0.1371 0.0405 0.0e+00 0.114 0.124 0.133 NA 0.130 1.6e-22 2.1e-24 3.6e-26 NA 1.5e-25
9 TCGA Ovarian Serous Cystadenocarcinoma 0.0440 0.0250 9.1e-03 0.020 0.018 0.048 NA 0.035 1.6e-02 2.1e-02 3.6e-04 NA 1.9e-03
10 TCGA Prostate Adenocarcinoma 0.0678 0.0339 1.8e-03 0.038 0.034 0.039 NA 0.048 6.7e-05 1.7e-04 6.1e-05 NA 8.3e-06
11 TCGA Testicular Germ Cell Tumors 0.1750 0.0680 7.7e-05 0.051 0.154 0.144 NA 0.141 7.0e-03 4.2e-06 8.6e-06 NA 1.1e-05
12 TCGA Thyroid Carcinoma 0.0890 0.0410 4.9e-04 0.030 0.028 0.026 NA 0.022 5.4e-04 8.7e-04 1.3e-03 NA 3.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 0.6 1.0 4.0 -0.1 -1.0 0.3 0.1 0.4 1.6 0.1 -1.2 0.1 -2.0 -0.7 1.6
Bipolar Disorder or Schizophrenia 0.2 0.6 2.6 0.1 0.2 -0.2 1.3 -0.1 -0.3 -1.5 0.0 0.5 -0.2 1.6 -0.3
Depressed Affect (Nagel 2018) 0.5 1.1 3.3 0.7 0.2 -0.2 1.4 1.4 1.3 -1.4 0.6 1.8 -0.5 0.8 -0.1
Depression (Nagel 2018) 0.9 1.4 4.1 0.4 0.2 0.4 1.8 0.6 -0.6 -1.7 1.0 1.5 0.6 2.0 -1.2
Intelligence (Savage-Jansen 2018) 0.5 1.6 5.4 -0.5 1.1 2.2 1.1 -1.6 0.3 -1.0 0.6 -0.2 2.3 1.0 -0.9
Neuroticism (Nagel 2018) 0.2 0.6 1.9 -0.4 -0.9 -0.2 1.4 0.4 0.7 -0.7 -0.8 0.6 -0.8 0.6 -1.0
Schizophrenia (2018) 1.0 2.0 6.9 0.2 1.1 -0.4 1.6 -0.5 -1.7 -1.9 1.0 0.6 1.4 2.6 -1.7
Schizophrenia vs Biploar Disorder 0.8 1.1 6.1 -1.0 1.2 -0.3 -0.1 -2.5 -0.6 -0.2 0.0 -1.5 0.7 0.7 -0.9
Worry (Nagel 2018) 0.2 0.4 1.6 -0.8 -1.2 -0.0 0.4 -0.6 0.3 -0.2 -1.3 -0.0 -0.6 -0.4 -0.6
Alzheimer’s Disease (in mother) 2.2 2.6 10.4 0.5 0.5 -1.0 -3.2 0.8 -0.7 2.7 -0.5 -0.9 -1.1 -2.0 2.1
Alzheimer’s Disease (in father) 1.1 1.2 3.2 -0.5 -0.9 -0.4 -1.0 -0.8 -0.9 0.6 -1.4 -0.6 -1.5 -1.8 1.6
Alzheimer’s Disease (including proxy) 2.2 3.2 9.7 -0.3 -0.7 -0.8 -3.1 -0.2 -1.2 2.3 -1.5 -1.4 -1.8 -2.5 2.5
Crohns Disease (2017) 0.5 1.0 3.7 -1.3 -0.5 -1.9 0.6 -1.1 -1.3 -0.7 0.0 -0.8 1.1 0.6 -0.9
Irritable Bowel Disease (IBD) 0.3 0.8 3.5 -1.2 -1.4 -0.8 0.3 -1.0 -1.9 -0.5 -0.6 -0.5 0.5 0.1 -0.5
Ulcerative Colitis (UC) 0.2 0.4 2.0 -0.5 -1.2 0.5 0.2 -0.4 -1.4 -0.4 -0.5 -0.0 0.5 -0.1 -0.1
Major Depression (MDD) 0.6 0.7 1.4 0.8 0.7 -0.4 0.7 1.1 1.1 -1.2 0.9 1.2 0.3 0.1 0.9
Reaction Time 0.2 0.4 2.7 -0.0 0.1 1.6 0.2 -0.1 0.9 0.4 0.4 0.0 -0.1 -0.1 -0.8
Verbal and Numeric Reasoning (VNR) 0.7 1.8 6.6 -0.4 1.1 0.6 1.4 -1.6 0.1 -1.0 1.1 -0.3 2.6 1.8 -1.7
Breast Cancer 0.7 1.7 6.9 -1.0 -0.8 -0.4 -1.6 -1.1 -0.3 2.6 -1.6 -1.9 -0.1 -0.6 -1.1
Ovarian Cancer 0.8 1.1 2.6 1.6 1.6 -0.2 0.4 1.4 0.9 0.7 1.5 0.4 0.8 1.1 -0.8
Prostate Cancer 0.2 0.3 0.9 -0.5 0.9 -0.2 0.6 -0.7 0.7 -0.6 -0.5 0.1 0.7 0.4 -0.6
Age at First Birth 1.0 1.4 3.3 -1.0 -1.2 1.7 -1.1 -1.4 -0.4 0.5 -1.5 -0.9 -1.8 -0.9 1.1
Bipolar Disorder (2011) 0.5 0.5 2.3 -0.1 -0.6 -0.2 0.8 0.3 -1.5 -0.7 -0.3 0.7 -1.0 0.3 0.3
Body Mass Index (BMI) (2010) 0.4 0.6 1.7 1.0 0.3 -0.7 -1.1 1.1 0.0 1.3 0.7 0.3 -0.2 0.5 -0.0
Coronary Artery Disease (CAD) 0.5 0.6 1.7 -0.0 -1.3 -0.6 -0.1 0.3 -0.9 -1.1 -0.3 0.7 -1.0 -0.4 1.0
Crohns Disease (2012) 0.6 0.9 3.5 -1.3 -1.0 -1.9 0.5 -0.6 -1.1 -1.3 -0.4 -0.3 0.7 0.5 -0.2
Mean Putamen Volume 0.4 0.4 1.5 -0.1 -0.4 -0.4 -0.8 -0.4 0.5 1.2 -0.7 -0.8 -1.0 -0.2 0.5
Fasting Glucose 0.6 0.7 2.7 1.1 -0.1 -0.7 -0.1 1.3 1.6 0.3 0.8 1.1 -0.1 -0.0 0.3
HbA1C 0.3 0.3 0.9 0.6 -0.0 -0.4 0.4 0.9 0.6 -0.4 0.3 0.9 0.5 0.5 -0.6
HDL Cholesterol 0.5 0.8 3.6 -0.9 0.7 -0.1 0.5 -1.9 0.2 -0.5 0.2 -1.0 1.5 -0.7 -0.2
LDL Cholesterol 0.9 1.5 3.0 -1.7 -1.3 -1.2 -1.3 -0.8 -0.6 1.3 -1.7 -1.7 -0.9 -0.7 0.4
Lupus 0.9 1.3 4.3 -0.4 1.2 -0.5 1.3 -0.4 0.8 -0.8 0.1 -0.2 1.9 1.7 -2.1
Neuroticism (2016) 0.5 0.8 4.8 -0.2 -1.0 -0.1 0.5 0.9 2.2 -0.9 -0.3 1.0 -0.4 -0.2 0.2
Primary Biliary Cirrhosis 1.5 2.1 5.4 -0.5 -2.1 -1.8 -1.1 0.2 0.7 0.4 -1.5 -0.1 -2.3 -2.1 1.9
Rheumatoid Arthritis 0.9 1.2 6.2 -1.2 -1.0 -2.5 -0.3 -1.2 -1.3 0.1 -0.7 -1.1 0.6 -0.2 -0.7
Schizophrenia (2014) 0.5 1.1 2.8 -0.8 0.8 -0.6 0.7 -1.6 -1.2 -1.7 0.4 -0.2 0.6 1.6 -1.2
Triglycerides 1.8 2.9 6.9 -2.2 -2.5 -1.0 -1.2 -1.1 0.9 2.0 -2.6 -2.2 -1.9 -0.5 0.1
Type 2 Diabetes (T2D) (2012) 1.4 1.6 3.5 -0.3 0.7 -1.7 1.0 -1.4 -1.9 0.4 1.1 -1.0 0.8 1.8 -1.9
Ulcerative Colitis 0.6 0.8 3.6 -1.0 -1.9 -0.1 -0.3 -0.8 -0.0 -0.3 -1.1 -0.2 -0.6 -1.3 0.9
Blood Eosinophil Count 0.0 0.1 0.4 -0.7 -0.2 0.6 0.2 -0.3 -0.0 -0.3 0.2 -0.2 -0.1 0.4 -0.4
Blood Platelet Count 0.1 1.2 3.1 0.8 -0.7 0.9 -1.2 1.7 1.1 1.0 0.0 0.6 -1.5 -0.1 1.8
Blood Red Count 0.2 2.0 4.6 -1.8 0.0 0.3 1.9 -1.9 -1.3 -1.5 -0.0 -1.1 1.0 1.4 -2.1
Blood White Count 0.2 1.1 3.8 1.4 -0.7 0.7 0.9 1.9 0.6 -0.4 1.0 1.6 -0.4 1.2 0.2
Heel T-Score 0.2 1.4 4.4 0.9 1.8 1.6 0.4 0.4 0.3 -0.7 1.5 0.3 1.2 2.1 -1.3
BMI 0.8 4.4 8.8 2.2 1.9 1.9 3.0 2.3 1.1 -2.2 2.6 2.9 1.1 1.9 -0.4
Height 0.2 3.2 6.9 -1.8 -2.6 1.5 2.1 -2.3 -2.6 -1.8 -1.0 -0.4 0.9 1.1 -1.6
Waist Hip Ratio (WHR) 0.4 1.8 6.4 1.0 1.4 -1.0 0.7 1.1 -2.5 -1.7 1.5 1.5 1.2 0.7 -0.2
Systolic Blood Pressure 0.3 1.6 5.0 1.2 0.8 -0.7 -2.2 2.0 0.9 1.7 1.1 0.6 -0.2 -1.2 0.7
Smoking Status 1.2 2.9 9.6 0.3 1.1 0.9 2.5 0.7 0.2 -3.1 1.8 2.1 1.4 2.4 -1.1
Allergy or Eczema 0.5 1.2 5.7 0.6 1.2 0.1 0.8 0.6 0.4 -0.3 0.8 0.2 2.4 1.9 -1.3
Cardiovascular Disease 0.3 0.8 3.9 1.0 -0.2 -0.5 -0.5 2.0 -1.3 -0.0 0.8 1.3 -0.7 -0.2 0.4
Hypothyroidism (self reported) 0.6 1.5 5.2 0.9 1.7 1.0 0.8 0.1 0.4 -0.9 1.5 0.5 2.3 1.6 -1.1
Respiratory disease 1.2 2.8 7.8 1.9 2.0 -0.4 2.8 1.6 0.4 -1.5 2.0 2.0 1.0 2.0 -0.5
Type 2 Diabetes (T2D) (2018) 1.1 2.0 6.9 1.1 0.8 -0.4 1.5 1.2 -1.1 -2.6 1.8 2.1 1.3 0.7 -0.2
Lung FEV1/FVC ratio 0.7 3.4 8.2 1.7 2.7 1.2 1.7 0.8 -1.2 -1.1 2.1 1.0 2.9 2.1 -2.0
Lung FVC 0.2 0.8 2.0 -1.0 0.7 0.9 -0.8 -1.4 -0.4 1.1 -1.1 -1.4 0.7 -0.4 -0.6
Neuroticism 0.3 0.7 2.2 -0.2 0.1 -0.4 1.5 0.5 1.2 -1.4 -0.2 1.1 -0.7 0.6 -0.7
Chronotype (morning person) 1.3 2.9 9.4 -0.4 -1.8 -1.0 -2.1 0.3 0.0 1.4 -1.3 -0.5 -3.1 -2.3 2.8
Hair Pigment 0.1 2.6 6.3 2.0 2.4 -0.7 1.6 1.7 -0.9 -0.8 2.5 1.8 1.0 1.9 -0.5
Tanning 0.1 1.2 5.3 1.1 -0.3 2.0 0.4 1.3 2.3 -0.0 0.4 1.0 0.8 0.2 -0.2
Hand grip strength (left) 0.3 0.8 4.6 -0.5 -0.8 -0.8 -0.1 -0.5 -2.2 -0.9 -0.7 0.1 -0.3 -0.1 1.1
Number of treatments/medications taken 0.3 0.6 2.7 0.9 0.7 -0.1 0.2 1.6 0.6 0.1 0.8 0.9 0.4 0.7 0.2
Average weekly spirits intake 0.1 0.1 0.4 -0.2 -0.0 -0.4 -0.4 -0.6 0.5 0.2 -0.4 -0.4 -0.3 -0.3 0.4
Sensitivity / hurt feelings 0.6 1.0 3.3 -1.2 -1.8 0.7 1.0 -0.0 1.2 -0.7 -1.3 0.2 -1.0 0.4 -0.7
Frequency of depressed mood in last 2 weeks 1.4 2.0 4.3 1.6 0.2 0.1 1.4 2.1 1.1 -1.1 1.8 2.1 0.7 1.9 -1.2
Hearing difficulty/problems: Yes 3.8 5.7 11.3 2.4 2.3 2.4 2.9 2.2 1.4 -3.2 3.2 3.4 1.8 1.4 -0.1
Relative age of first facial hair 0.7 1.5 6.2 1.3 0.4 -0.3 0.7 1.7 2.5 -1.2 0.6 1.5 -0.2 -0.6 1.5
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 4.9 0.4 0.0 0.8 -0.1 0.3 2.2 0.1 -0.6 0.2 0.3 -0.4 0.5
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.5 -0.1 -0.2 -0.3 0.4 -0.1 -0.2 -0.7 -0.0 0.1 0.1 0.1 0.5
Ever had hysterectomy (womb removed) 0.8 0.9 3.4 0.7 0.0 -0.1 -0.7 1.1 0.6 -0.7 -0.4 1.3 -1.1 -0.9 1.8
Systolic blood pressure, automated reading 0.3 1.0 3.5 0.5 0.6 -0.3 -1.9 1.6 -0.2 1.2 0.5 0.3 -0.6 -1.2 1.0
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.1 -0.0 0.4 -1.1 1.4 -0.5 -1.3 -0.4 1.3 -0.2 1.0 0.5 -1.3
Angina 1.0 1.3 3.8 1.2 0.8 1.1 -0.3 1.9 1.6 -0.7 0.2 1.7 -0.4 0.0 1.5
Medication for hormone replacement therapy 1.0 1.1 2.0 -1.2 -1.4 -1.0 -0.5 -1.3 -0.6 0.9 -1.2 -1.1 -0.7 -1.4 0.8
Vitamin and mineral supplements 0.3 0.4 1.7 0.5 0.5 0.3 -1.3 -0.3 0.4 0.8 0.3 -0.6 -0.2 -0.5 0.7
Supplements: Zinc 1.1 1.2 3.8 -0.9 0.6 1.6 1.9 -0.9 0.4 -0.4 -0.2 -0.7 0.6 1.1 -1.8
Medication: Co-codamol 2.1 2.4 8.6 2.6 1.1 0.2 0.0 2.9 1.4 0.4 1.7 2.0 -0.6 1.6 0.9
Medication: Metformin 0.4 0.6 1.9 0.2 0.2 -1.2 0.3 0.2 -1.4 -1.4 0.8 1.0 0.1 0.6 0.1
Diabetes (father) 1.2 1.5 5.2 0.2 0.4 -2.0 1.0 -0.8 -2.3 -1.7 1.7 0.7 0.7 0.5 0.1
Diabetes (mother) 2.2 2.8 5.3 1.5 2.0 0.6 2.1 0.8 -0.6 -1.7 2.0 1.5 2.3 2.3 -1.4
Severe depression (siblings) 0.7 0.8 2.1 -1.1 -0.7 0.8 1.3 -0.5 -1.4 -1.4 -0.2 0.2 0.2 0.8 -0.5
Pack years adult smoking proportion 0.5 0.7 2.6 0.6 0.6 -1.3 -0.3 1.6 -0.7 0.0 0.9 0.7 -0.8 0.8 0.9
Impedance of leg (right) 1.5 7.2 12.9 -3.1 -2.0 -3.1 -3.1 -2.8 -2.2 2.2 -3.2 -3.6 -2.2 -2.7 1.1
Leg fat-free mass (left) 0.8 4.1 11.3 1.2 0.3 2.0 3.4 0.5 -1.0 -2.4 2.2 2.1 2.5 2.4 -2.0
Trunk fat percentage 0.1 0.5 1.8 0.4 0.6 0.5 1.1 0.2 -1.3 -0.2 1.0 0.2 0.1 0.7 -0.7
Hand grip strength (right) 0.3 0.8 1.9 -0.8 -1.2 0.1 -0.7 -1.0 -1.4 -0.1 -1.4 -0.7 -0.4 -0.6 0.9
Townsend deprivation index at recruitment 0.5 0.7 4.5 0.6 0.2 0.1 0.2 1.3 2.1 -0.4 0.0 1.0 0.1 -0.3 0.5
Current tobacco smoking 0.2 0.3 2.6 -0.1 0.4 0.3 0.1 -0.2 1.6 -0.2 0.2 0.1 -0.1 0.7 0.0
Average weekly fortified wine intake 1.0 1.2 3.1 -1.0 -0.3 -1.2 -0.7 -1.8 -1.5 1.0 -0.6 -1.7 0.3 0.4 -1.1
Maternal smoking around birth 0.2 0.3 2.9 -0.0 -0.3 0.5 0.3 0.2 1.7 0.3 -0.0 -0.1 0.3 0.0 0.2
Fed-up feelings 0.2 0.4 0.9 0.0 -0.9 -0.9 0.9 0.6 0.1 -0.7 -0.5 0.8 -0.8 0.6 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.8 5.5 0.0 -0.3 1.0 2.4 0.0 -0.9 -2.3 0.4 1.2 0.2 2.3 -1.4
Relative age voice broke 0.4 0.7 3.0 0.3 -0.0 -1.2 0.3 0.6 0.8 -1.0 -0.0 0.7 -0.7 -0.7 1.7
Taking other prescription medications 0.1 0.2 1.1 -0.2 -0.3 -1.1 0.5 0.3 -0.3 -0.3 -0.2 0.2 -0.2 -0.0 0.5
Age when periods started (menarche) 0.1 0.3 0.9 0.4 -0.0 0.6 0.9 0.1 -0.0 -0.8 0.7 0.4 0.5 0.7 0.3
Bilateral oophorectomy (both ovaries removed) 1.2 1.3 4.8 0.8 0.2 0.6 2.0 0.1 -0.5 -1.2 0.9 0.9 1.0 2.2 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 7.3 -0.8 0.6 -0.1 -0.1 -1.1 -2.7 0.8 0.1 -1.2 0.7 1.0 -1.5
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 4.8 0.9 2.0 0.1 0.6 0.3 0.7 0.0 1.8 0.2 2.2 1.2 -1.7
Qualifications: CSEs or equivalent 0.8 1.0 5.1 -0.1 0.3 0.6 0.6 -0.7 -0.4 1.0 1.2 -0.9 1.5 0.6 -2.3
Serious illness, injury or assault to yourself 1.3 1.5 3.9 1.8 1.2 1.1 1.3 1.5 1.5 -0.9 1.1 2.0 -0.2 0.2 0.4
High blood pressure 0.5 1.4 6.6 1.6 0.2 0.2 -0.5 2.6 -1.2 -0.3 0.8 1.8 -1.0 0.3 0.9
Hayfever, allergic rhinitis or eczema 0.7 1.6 6.5 0.9 1.2 -0.5 1.3 0.6 0.2 -1.2 1.2 0.8 2.5 1.6 -1.2
Multivitamins +/- minerals 0.3 0.4 1.6 -1.1 -0.7 -0.2 1.2 -0.4 -0.2 -0.9 -0.6 0.2 -0.5 -0.1 -0.3
Stomach or abdominal pain in last month 0.6 0.8 1.9 -1.4 -0.1 -1.3 -0.1 -1.4 0.3 -0.2 -1.3 -1.0 -0.6 0.2 -0.5
Supplements: Glucosamine 1.0 1.3 3.1 -1.2 -0.8 -1.6 -1.2 -0.4 0.2 0.7 -1.7 -0.6 -1.2 -1.8 1.0
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.8 -0.7 -0.4 -0.5 0.6 -0.8 0.8 -1.4 -0.8 -0.0 0.2 0.3 0.3
Medication: Atenolol 0.4 0.5 1.0 1.0 -0.1 -0.9 -0.7 1.0 0.1 0.4 0.3 0.8 -0.8 -0.4 0.7
Medication: Levothyroxine sodium 0.4 0.7 4.0 0.6 1.2 0.5 0.2 0.4 0.7 -0.7 0.7 0.2 2.0 0.0 -0.4
Sitting height 0.5 3.6 14.2 -0.8 -2.3 1.3 3.8 -1.0 -1.5 -3.4 0.1 1.2 1.0 1.5 -1.5
Chronic bronchitis/emphysema (father) 0.6 0.7 1.9 0.6 0.1 0.5 -1.0 1.0 1.3 0.6 -0.4 0.4 -1.2 -0.6 1.4
High blood pressure (mother) 1.3 1.8 5.2 0.3 0.5 0.8 1.3 -0.4 -0.6 -1.9 1.2 0.8 2.1 2.3 -1.7
Body mass index (BMI) 0.5 2.3 5.7 2.4 1.5 1.2 1.1 2.4 -0.2 -0.5 2.3 2.1 0.3 1.3 0.0
Impedance of leg (left) 1.3 6.1 10.4 -2.6 -1.5 -3.0 -3.0 -2.5 -1.7 2.0 -2.9 -3.2 -2.4 -2.5 1.3
Leg predicted mass (left) 0.8 4.5 12.0 1.3 0.4 2.2 3.5 0.6 -1.0 -2.5 2.3 2.2 2.5 2.5 -2.1
Trunk fat mass 0.2 1.0 2.9 0.6 0.5 0.8 1.7 0.3 -1.5 -0.8 1.4 0.7 0.6 1.1 -1.0
Waist circumference 0.8 3.0 7.0 2.2 1.1 0.9 1.8 2.2 -0.8 -1.8 2.7 2.6 1.0 1.6 -0.4
Number of incorrect matches in round 0.4 0.6 2.2 -0.6 -0.9 -0.7 -0.2 0.3 -0.6 1.1 -1.2 -0.4 -1.5 -0.5 0.4
Past tobacco smoking 1.4 2.5 8.0 0.9 -0.4 -0.6 -2.0 0.6 0.9 2.8 -1.3 -0.8 -2.5 -1.9 2.0
Alcohol usually taken with meals 0.3 0.4 1.8 -0.3 1.3 -0.9 -0.3 -0.5 0.3 0.7 0.0 -0.7 0.8 -0.2 -0.6
Nervous feelings 0.4 0.8 4.3 -0.6 -2.1 0.3 0.1 -0.1 -0.1 -0.5 -1.7 0.4 -1.2 -0.4 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.6 0.2 0.3 -1.3 0.5 0.2 0.6 -0.7 0.7 0.6 0.5 0.7 -0.7
Hearing difficulty/problems with background noise 2.7 4.3 9.6 2.4 2.2 1.0 2.0 2.1 2.2 -2.3 3.1 2.7 0.8 1.9 -0.2
Hair/balding pattern: Pattern 2 2.7 3.4 10.7 -2.0 0.7 -3.2 -1.1 -1.6 -3.3 1.9 -1.0 -2.3 0.0 -0.1 -1.4
Had menopause 0.4 0.5 1.6 0.6 0.7 0.4 -0.1 0.4 1.0 -0.9 0.4 0.7 -0.5 -0.6 1.2
Had other major operations 1.0 1.2 4.8 1.4 -0.1 2.2 -0.8 1.3 1.7 0.8 0.7 0.7 -0.4 -0.1 0.7
Forced vital capacity (FVC) 0.4 1.6 5.9 -0.7 0.4 1.3 1.2 -2.1 -0.6 -0.5 0.0 -0.7 2.4 0.7 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 6.5 -1.3 -0.3 0.3 -1.0 -1.3 -2.6 1.3 -1.3 -1.7 -0.6 -0.3 -0.4
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.4 -0.4 -0.3 -0.3 -0.4 -0.5 0.1 0.4 -0.6 -0.6 0.0 0.3 -0.3
Qualifications: None of the above 0.3 0.7 2.8 0.2 0.1 0.4 0.8 0.6 0.8 -1.7 1.2 1.1 -0.3 0.9 0.1
Financial difficulties in last 2 years 1.1 1.5 3.7 1.9 1.3 0.4 -1.4 1.6 0.6 1.9 1.3 0.7 -0.7 0.1 0.9
Mouth/teeth dental problems 0.2 0.3 1.5 -0.1 0.6 -0.6 -0.3 -0.3 -1.2 0.5 0.0 -0.5 -0.3 -0.3 0.4
Heart attack 0.8 1.0 2.5 1.1 -0.2 -0.8 0.1 1.4 0.0 -1.1 -0.0 1.6 -0.8 -1.1 1.6
Allergy 0.5 1.1 2.2 -1.5 -1.1 0.7 -0.9 -1.3 -0.7 0.9 -1.1 -1.3 -1.1 -0.9 0.1
Pain all over the body in last month 0.4 0.4 1.5 -0.8 -1.2 0.7 -0.2 -0.4 -0.7 0.5 -0.4 -0.5 -0.1 -0.9 -0.2
Diabetes (self-reported) 0.3 0.5 1.6 0.5 0.2 -0.5 0.8 0.7 0.0 -1.3 0.9 1.1 0.6 0.5 -0.2
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.4 -0.2 0.6 -0.7 -0.4 0.1 0.4 1.2 -1.0 -0.7 -0.2 -0.6 0.2
Medication: Ramipril 0.9 1.2 3.6 1.8 0.5 0.9 -0.1 1.9 0.6 -0.1 0.6 1.6 -0.7 -0.7 1.5
Medication: Simvastatin 1.7 2.4 6.3 2.2 0.7 1.3 0.9 2.4 1.2 -1.2 1.6 2.5 1.2 1.2 0.8
Fluid intelligence score 1.2 2.5 11.0 -0.4 1.6 -0.1 1.2 -1.9 -0.6 -0.7 1.8 -0.5 3.3 1.5 -2.3
Illnesses of siblings 1.1 1.5 6.7 -1.0 -2.6 -1.2 -0.8 -0.3 0.3 0.9 -1.8 -0.7 -1.7 -0.8 0.1
Neuroticism score 0.4 0.8 3.5 -0.2 -1.3 -0.7 0.6 0.8 1.9 -0.5 -0.7 0.8 -1.4 0.0 -0.2
Weight 0.6 3.0 7.4 1.4 0.5 1.6 2.7 1.1 -1.5 -2.0 2.1 2.1 1.3 2.0 -1.2
Impedance of arm (right) 0.6 2.8 7.9 -2.3 -1.5 -1.9 -1.1 -2.5 -0.3 1.1 -2.0 -2.8 -0.7 -1.2 -0.4
Arm fat percentage (right) 0.2 0.7 2.2 1.3 0.8 0.2 0.6 1.4 -0.8 0.1 1.5 0.9 0.0 0.4 -0.0
Trunk fat-free mass 0.5 3.1 7.2 0.5 -0.5 1.5 2.7 0.0 -1.7 -2.6 1.5 1.9 2.1 1.9 -1.7
Hip circumference 0.4 1.5 4.1 0.9 -0.3 1.7 2.0 0.7 0.3 -1.6 1.5 1.7 0.4 1.4 -0.6
Time employed in main current job 1.7 2.0 6.2 -1.6 -2.0 -2.1 -0.6 -1.0 -1.1 0.5 -2.5 -1.3 -1.5 -0.4 0.2
Alcohol intake versus 10 years previously 1.7 2.5 6.1 0.8 1.9 1.6 2.5 0.6 1.3 -1.8 1.8 1.4 1.3 2.0 -1.1
Father’s age at death 0.8 1.0 4.8 -0.8 -0.8 -0.5 -1.4 -1.2 -2.2 0.5 -0.4 -1.1 0.1 -0.9 0.4
Worrier / anxious feelings 0.1 0.2 1.9 0.1 -0.4 -0.3 0.0 0.1 1.4 0.4 -0.2 0.2 -0.2 -0.6 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 3.7 1.4 0.8 0.5 0.9 1.9 1.6 -0.5 1.3 1.6 0.2 1.9 -0.5
Falls in the last year 1.0 1.3 4.2 0.9 -1.1 -1.2 -1.6 1.0 -0.5 2.1 -0.1 -0.3 -1.2 -1.3 1.0
Hair/balding pattern: Pattern 3 12.3 18.4 50.1 2.4 1.4 7.1 4.8 1.3 6.7 -5.3 3.9 4.2 3.5 4.0 -1.8
Number of live births 0.7 1.0 5.0 -0.7 0.1 0.8 -0.9 -0.3 -2.2 0.3 -1.1 -0.6 -0.9 -1.1 1.2
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 10.4 0.4 1.5 1.4 1.7 -1.3 -0.9 -0.9 1.0 0.1 3.2 1.4 -2.2
Pulse rate 0.8 1.3 3.1 -1.0 -0.3 -1.8 -0.0 -0.8 -1.6 0.7 -0.4 -1.1 1.0 1.4 -1.8
Happiness 1.6 1.9 4.8 1.6 0.8 -0.6 1.1 1.1 0.4 -2.2 2.1 2.1 0.4 1.5 0.5
Noisy workplace 1.1 1.3 4.6 0.8 -0.4 1.2 0.2 2.1 -0.5 -1.1 0.6 1.6 -1.4 0.1 1.6
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.2 -0.8 0.4 0.0 -0.3 -1.1 -0.5 1.1 -0.9 -0.9 -0.8 -0.8 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.6 -0.0 -0.9 -1.2 -0.7 0.0 -0.2 -0.6 -0.6 0.5 -0.9 -0.7 1.2
Mouth/teeth dental problems: Dentures 0.5 0.8 2.4 0.8 0.5 0.3 -0.5 1.3 1.2 -1.2 0.9 1.6 0.1 0.3 0.7
Asthma 0.7 1.5 2.8 1.6 1.0 -0.7 1.6 1.7 1.1 -1.0 1.4 1.6 -0.6 1.0 0.4
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 3.9 0.7 -0.1 -0.7 1.0 0.4 0.4 -1.0 1.1 0.8 1.1 2.0 -0.6
Medication: Cholesterol lowering 0.3 0.5 1.2 0.7 0.8 1.0 0.1 1.1 -0.3 0.5 1.0 0.6 0.5 0.3 -0.0
Depression (self-reported) 1.4 1.7 4.2 1.0 -1.7 -1.6 -1.1 1.6 -0.0 -0.5 -0.3 1.6 -1.3 -0.9 2.0
Medication: Lansoprazole 0.7 0.8 3.1 0.8 -0.4 0.9 -0.3 1.2 1.8 1.0 0.4 0.4 -1.1 0.0 0.8
Prospective memory result 0.7 0.8 2.3 0.5 -0.6 -1.2 -0.3 1.3 1.1 -0.2 -0.7 0.7 -1.5 -0.2 1.0
Lung cancer (father) 1.1 1.3 3.2 0.3 0.3 1.0 1.7 0.3 0.5 -1.7 1.8 1.1 1.0 1.5 -0.8
Illnesses of mother 0.3 0.3 1.3 -0.3 -0.9 -0.3 -0.6 -0.0 0.6 0.8 -0.1 -0.5 -0.2 -1.1 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 6.3 0.2 0.5 0.9 1.3 -1.2 -1.3 -0.7 0.3 0.0 2.5 1.0 -1.6
Pulse wave Arterial Stiffness index 0.9 1.0 3.1 -0.0 -0.1 -1.2 -1.2 0.9 1.8 1.3 -0.8 -0.4 -1.1 -1.1 0.7
Impedance of arm (left) 0.6 2.8 8.0 -2.4 -1.5 -1.5 -0.6 -2.6 -0.7 1.1 -2.0 -2.8 -0.6 -1.1 -0.7
Arm fat mass (right) 0.4 1.6 3.8 1.5 0.8 0.7 1.7 1.3 -1.0 -0.9 1.9 1.5 0.6 1.3 -0.7
Trunk predicted mass 0.5 2.9 6.6 0.5 -0.6 1.4 2.6 0.0 -1.8 -2.5 1.4 1.8 2.1 1.9 -1.7
Standing height 0.6 5.5 13.0 -1.9 -2.0 0.8 3.6 -2.8 -3.1 -3.3 -0.2 0.1 2.0 2.0 -2.9
Length of working week for main job 0.2 0.2 0.6 -0.5 0.0 -0.7 -0.3 -0.6 0.2 0.5 -0.3 -0.8 0.1 0.5 -0.4
Exposure to tobacco smoke at home 0.6 0.7 2.8 0.6 -1.2 0.2 -1.4 0.8 0.3 0.1 -0.2 0.5 -0.4 -0.9 1.7
Breastfed as a baby 0.4 0.4 1.6 -0.3 1.1 0.0 -0.8 -0.2 -1.2 0.8 0.2 -0.6 0.2 -0.4 0.7
Tense / ‘highly strung’ 0.4 0.6 2.8 -0.8 -1.7 -0.2 0.1 -0.3 0.1 -0.2 -1.5 -0.2 -1.1 -0.7 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 2.1 0.1 -0.4 -0.5 -1.1 0.6 1.1 0.7 -0.9 0.1 -1.3 -1.3 1.5
Hair/balding pattern: Pattern 4 7.7 18.7 36.8 -2.8 -2.1 -6.0 -4.7 -1.8 -5.2 6.1 -5.1 -4.7 -3.7 -4.6 1.8
Birth weight of first child 0.6 1.0 7.5 -0.9 -1.3 -0.7 -0.7 -0.2 -2.7 -0.3 -0.9 -0.0 -0.4 -0.6 0.1
Peak expiratory flow (PEF) 1.5 3.5 10.6 0.5 1.9 1.8 2.7 -1.1 -0.3 -1.9 1.5 0.6 3.3 1.9 -2.5
Pulse wave reflection index 0.6 0.8 1.9 1.3 0.7 -0.4 -0.1 1.2 1.4 -0.1 0.5 1.1 -0.4 -1.1 0.8
Ever highly irritable/argumentative for 2 days 0.9 1.1 3.7 -0.6 -1.3 -1.4 -1.1 -0.3 0.2 -0.2 -1.1 -0.0 -1.4 -0.7 1.9
Loud music exposure frequency 1.7 1.9 4.0 1.1 1.9 0.8 1.5 -0.0 1.3 -2.0 1.8 1.1 1.2 1.7 -0.4
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 3.7 -1.5 0.8 -1.5 -0.5 -1.9 -1.6 0.8 -1.1 -1.6 0.2 -0.2 -0.6
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 3.3 -1.4 -0.2 -0.3 0.7 -1.8 -0.1 -0.5 -0.0 -1.4 1.5 0.0 -1.4
Blood clot in the leg (DVT) 1.6 2.1 7.7 -0.1 -1.2 -0.4 -2.5 -0.5 0.5 1.3 -1.3 -0.7 -1.1 -2.8 2.0
Medication: Paracetamol 0.8 1.3 7.2 1.7 0.1 -0.0 -0.1 2.7 1.0 0.5 0.3 1.6 -0.8 0.6 0.8
Headache pain in last month 2.5 4.4 8.8 -1.8 -1.8 -1.8 -2.2 -0.6 1.0 2.6 -2.9 -1.9 -3.0 -2.5 1.7
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 2.4 -0.2 0.1 -0.8 0.8 -1.0 -0.3 -1.5 0.0 0.1 0.9 0.9 -0.9
Glaucoma (self-reported) 1.5 1.8 5.5 1.0 0.5 -1.6 -0.9 1.9 -1.1 -0.1 0.2 1.1 -2.0 -1.1 2.3
Gout (self-reported) 1.1 1.4 5.1 0.2 1.0 -1.2 0.8 -0.6 -0.9 0.4 1.6 -0.3 2.0 1.0 -2.3
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 7.3 0.3 1.1 1.0 1.2 -0.3 -0.1 -1.4 1.5 0.3 2.7 1.5 -1.7
Medication: Amlodipine 0.1 0.1 0.3 0.1 -0.1 -0.4 0.5 0.2 -0.5 -0.2 0.6 0.2 0.2 -0.4 -0.3
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.7 0.7 -0.3 -0.8 0.3 1.3 0.1 -0.2 0.6 0.8 -1.3 0.0 0.8
Birth weight 0.3 0.6 2.5 0.5 -0.1 -0.4 1.1 0.0 -0.5 -1.6 0.3 1.2 0.6 0.8 -0.1
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.4 0.8 1.2 -0.5 0.0 0.7 0.8 0.3 0.4 0.4 -0.3 0.3 -0.0
High blood pressure (siblings) 1.1 1.7 8.8 0.5 3.0 1.9 -0.4 -0.3 -0.8 0.2 1.5 -0.2 1.8 0.2 -0.9
Forced vital capacity (FVC), Best measure 0.3 0.9 3.3 -0.7 -0.6 0.8 0.9 -1.7 -0.7 -0.4 -0.4 -0.5 1.8 0.5 -1.2
Body fat percentage 0.1 0.4 1.6 0.7 0.7 0.4 0.7 0.7 -1.3 0.0 1.0 0.4 -0.2 0.4 -0.1
Leg fat percentage (right) 0.1 0.4 2.8 0.4 0.4 -0.3 -0.2 0.8 -1.7 0.5 0.7 0.2 -0.7 -0.1 0.4
Arm fat-free mass (right) 0.7 3.8 8.9 0.8 0.5 1.8 3.0 0.1 -1.8 -2.6 1.9 1.9 2.4 2.4 -2.0
Exposure to tobacco smoke outside home 0.1 0.2 0.6 0.4 -0.5 0.0 -0.5 0.2 -0.6 0.8 -0.3 -0.4 0.1 -0.6 0.4
Comparative body size at age 10 1.0 2.8 5.6 1.6 1.1 2.0 2.1 1.5 1.1 -1.2 2.4 1.7 1.1 2.2 -1.5
Number of full brothers 0.9 1.2 3.5 1.4 1.0 1.8 0.2 1.0 1.9 -0.3 0.9 1.2 0.6 0.8 0.4
Worry too long after embarrassment 0.3 0.6 2.2 -0.3 -0.5 -0.3 1.0 -0.2 1.5 0.5 -0.6 -0.4 -1.0 0.4 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 2.0 0.2 -0.5 0.1 -1.1 1.1 0.3 0.4 -0.7 0.3 -0.8 -0.6 1.4
Wheeze or whistling in the chest in last year 0.1 0.1 0.4 -0.3 0.4 -0.2 0.3 -0.1 -0.1 0.6 -0.4 -0.5 -0.4 -0.2 -0.6
Number of children fathered 2.3 2.6 9.1 -1.1 -2.4 -0.4 -1.1 -0.4 -1.4 1.0 -1.8 -0.8 -3.0 -1.7 1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 1.2 0.3 0.7 -1.1 0.4 -0.2 0.7 -0.3 0.5 0.2 0.4 0.4 -0.1
Age at first live birth 0.7 1.3 2.9 -1.3 -0.9 0.4 -0.5 -1.4 -1.7 0.8 -1.6 -1.1 -1.5 -0.7 0.5
Pulse wave peak to peak time 1.3 1.5 4.6 -0.3 -0.2 1.2 1.6 -1.3 -2.2 -1.6 0.7 0.3 1.4 1.2 -1.0
Health satisfaction 0.5 0.6 1.5 -0.2 0.5 -1.2 0.9 -0.9 0.3 -0.8 0.9 -0.4 1.0 0.8 -1.2
Shortness of breath walking on level ground 3.0 3.6 8.3 1.3 0.9 2.2 2.9 0.5 0.7 -2.2 2.5 1.9 2.2 2.0 -2.0
Qualifications: College or University degree 0.2 0.6 1.9 -0.0 -1.2 -0.3 -0.1 -0.5 1.4 -1.2 -0.6 0.4 0.7 -0.8 0.9
Eye problems/disorders: None of the above 1.5 1.7 5.0 -2.0 -0.7 -1.2 -0.5 -2.2 -1.2 1.0 -1.2 -2.2 -0.3 -0.6 -0.4
Mouth/teeth dental problems: Loose teeth 1.5 1.8 6.3 -0.1 0.4 2.4 2.5 -1.0 0.1 -0.5 0.7 0.1 0.9 1.6 -1.9
Emphysema/chronic bronchitis 2.7 3.0 5.4 0.7 1.8 1.7 2.3 -0.1 0.2 -2.2 2.1 1.2 2.2 2.3 -1.7
Medication for pain relief, constipation, heartburn 0.3 0.5 3.5 -0.7 -0.1 0.4 0.3 -0.9 -1.9 -0.6 0.1 -0.4 0.0 -0.5 -0.0
Neck or shoulder pain in last month 0.4 0.6 2.9 0.6 -0.1 -1.0 -0.1 0.7 1.7 0.4 -0.5 0.3 -0.7 -0.8 0.5
Medication: Blood pressure 0.9 1.5 4.5 1.6 0.8 0.3 -1.5 2.1 0.6 1.9 0.9 0.5 -0.8 -1.1 1.2
Angina (self-reported) 1.4 1.9 6.0 1.7 0.8 1.1 -0.4 2.5 1.8 -0.6 0.5 2.1 -0.5 -0.0 1.7
Migraine (self-reported) 0.2 0.2 1.4 0.4 0.7 -0.1 -0.3 0.2 -0.2 -0.1 0.2 0.2 0.2 1.2 -0.2
Medication: Ibuprofen 1.0 1.2 3.8 0.7 0.3 -0.7 1.1 0.7 0.6 -1.3 1.3 1.0 1.5 1.9 -0.7
Medication: Allopurinol 0.4 0.6 1.8 -0.3 0.5 -1.3 -0.5 -0.8 0.0 1.1 0.4 -1.0 0.5 -0.7 -0.7
Medication: Omeprazole 0.4 0.4 1.6 -1.0 -0.3 0.4 -0.3 -1.3 0.3 -0.2 -1.2 -0.6 -0.2 -0.7 0.1
Medication: Seretide 50 evohaler 0.9 1.0 3.3 0.4 -0.7 0.3 1.4 0.9 -0.8 -1.8 0.6 1.4 -0.3 1.3 -0.5
Mean time to correctly identify matches 0.5 1.0 4.7 -1.2 -0.6 2.2 -0.3 -1.2 0.4 0.6 -0.9 -1.0 -0.8 -0.9 -0.5
Heart disease (mother) 0.1 0.2 0.8 -0.4 0.5 -0.9 -0.3 -0.1 -0.1 -0.2 -0.4 -0.2 -0.1 -0.1 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.5 -0.2 0.6 -0.9 1.1 -1.1 0.2 -0.8 0.4 -0.5 1.2 0.7 -1.2
Whole body fat mass 0.2 0.9 2.4 0.9 0.6 0.5 1.4 0.6 -1.6 -0.6 1.5 0.9 0.4 1.0 -0.6
Leg fat mass (right) 0.2 0.9 3.1 1.0 0.5 0.4 1.1 1.1 -1.8 -0.5 1.4 1.1 -0.1 0.7 -0.1
Arm predicted mass (right) 0.6 2.9 6.1 0.9 0.5 1.7 2.5 0.3 -1.8 -2.1 1.8 1.8 2.2 1.9 -1.6
Pulse rate, automated reading 0.9 3.0 5.6 -1.6 -2.0 -2.4 -2.1 -0.5 -1.5 1.8 -2.3 -1.8 -1.3 -1.8 0.7
Alcohol intake frequency. 0.9 2.1 4.8 1.9 0.4 1.7 1.3 2.2 0.7 -0.9 1.6 2.1 -0.2 1.9 -0.2
Comparative height size at age 10 0.7 3.9 10.0 -1.6 -0.6 0.7 3.2 -1.9 -3.0 -3.0 0.2 0.2 1.7 1.8 -2.4
Number of full sisters 0.9 1.0 5.0 0.7 0.5 2.2 1.3 0.6 0.7 -0.3 0.9 0.7 0.3 1.4 -0.7
Suffer from ‘nerves’ 0.2 0.3 2.9 -0.0 0.1 -0.1 0.2 -0.2 1.7 -0.0 -0.4 -0.0 -0.4 -0.2 0.1
Overall health rating 0.3 0.6 1.9 -1.1 -1.4 -0.0 0.1 -0.8 -0.7 0.5 -1.0 -0.7 -0.6 -0.5 -1.0
Chest pain or discomfort 0.4 0.6 1.8 0.2 0.2 -0.1 -1.3 -0.3 1.0 1.3 -0.7 -0.6 -0.3 -1.2 0.2
Had major operations 0.8 0.9 6.3 0.9 -0.5 2.5 -1.2 0.7 0.2 0.8 -0.1 0.4 -0.5 -0.6 0.6
Age at last live birth 0.4 0.6 2.5 -0.2 0.4 1.6 0.4 -0.2 -1.2 -1.4 0.2 0.6 -0.1 0.4 0.4
Family relationship satisfaction 2.2 2.7 5.7 1.8 1.5 0.1 2.4 1.0 0.1 -2.4 2.4 2.1 1.2 1.8 -0.3
Leg pain on walking 0.3 0.4 1.6 0.4 -0.5 0.1 1.1 0.4 1.3 -0.9 0.3 0.5 0.1 0.3 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.6 1.0 0.8 0.5 0.5 1.3 -0.4 -0.6 1.1 1.1 -0.1 0.4 0.8
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.7 -0.4 0.0 -0.5 -0.1 -0.6 0.0 0.9 0.2 -1.2 1.3 -0.5 -0.0
Illness, injury, bereavement, stress in last 2 years 2.3 2.8 7.6 -2.8 -2.1 -1.2 -0.4 -2.3 -1.5 -0.0 -2.6 -2.2 -0.3 -0.8 -0.3
Medication: Aspirin 0.2 0.2 0.9 -0.3 0.4 -0.4 -0.6 -0.4 -0.5 0.4 -0.4 -0.6 0.0 -1.0 -0.0
Supplements: Vitamin C 1.0 1.2 3.0 0.8 0.6 1.1 1.7 1.0 1.1 -0.8 0.5 0.7 0.8 1.7 -1.3
Knee pain experienced in last month 0.6 0.9 3.7 0.1 -0.9 0.6 1.5 0.4 1.9 -0.7 -0.1 0.7 -1.1 1.2 -0.2
Hypertension (Self-reported) 0.5 1.5 7.1 1.6 -0.1 -0.0 -0.6 2.7 -1.4 0.0 0.7 1.8 -1.3 0.1 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.6 -0.3 -0.2 -0.5 -0.5 -0.2 0.9 -0.2 -0.2 -0.1 -0.2 -0.7 1.3
Illnesses of father: Heart disease 1.2 1.6 4.9 -1.1 -0.6 -2.2 -1.3 -0.9 0.2 1.4 -1.9 -1.5 -1.0 -1.1 0.5
Illnesses of siblings: Diabetes 0.9 1.1 2.9 0.7 1.3 -0.5 1.6 0.7 1.2 -0.9 1.7 1.1 1.0 0.8 -0.6
Smoking status: Previous 1.7 2.6 7.1 -0.3 0.9 -0.2 2.0 -0.1 -1.5 -2.7 1.5 1.0 2.3 2.2 -1.9
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 6.7 -1.1 -0.8 -0.6 2.0 -1.6 -1.0 -0.5 -0.4 -0.7 1.1 1.2 -2.6
Whole body fat-free mass 0.6 3.7 8.8 1.0 0.0 1.9 3.0 0.4 -1.4 -2.5 1.9 2.2 2.4 2.2 -1.9
Leg fat-free mass (right) 0.9 5.0 13.0 1.5 0.7 2.3 3.6 0.7 -0.7 -2.7 2.4 2.4 2.7 2.7 -2.2
Arm fat percentage (left) 0.2 0.9 2.9 1.4 1.1 0.4 0.9 1.3 -0.9 -0.1 1.7 0.9 0.3 0.7 -0.3
Average weekly red wine intake 1.0 1.4 3.8 -1.8 -1.1 0.3 -0.9 -1.7 -0.6 0.5 -2.0 -1.2 -0.2 -1.7 0.0
Handedness (chirality/laterality): Left-handed 0.2 0.2 1.1 -0.1 0.3 -0.4 0.1 -0.3 0.7 -0.4 0.2 0.1 -1.1 0.0 0.5
Mood swings 0.6 1.0 4.6 0.3 -0.8 -0.1 -0.3 1.6 2.1 0.7 -0.5 0.6 -1.4 -0.8 0.8
Loneliness, isolation 1.1 1.5 3.9 1.8 1.0 0.6 0.4 1.4 1.4 -0.9 2.0 1.7 0.6 0.8 -0.3
Long-standing illness, disability or infirmity 0.6 0.9 2.8 1.0 -0.0 1.5 -0.7 0.9 1.7 -0.1 0.1 0.9 -0.8 -0.4 1.4
Ever had bowel cancer screening 0.7 0.9 3.1 -1.2 -1.8 0.7 0.9 -0.9 -0.9 -0.8 -1.3 -0.4 -0.4 -0.1 -0.3
Diabetes diagnosed by doctor 0.9 1.5 4.1 1.0 0.4 -0.9 1.2 1.1 -0.9 -2.0 1.6 1.8 0.9 1.0 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.8 -0.7 -0.2 0.8 -0.2 -0.6 -1.2 0.9 -1.0 -1.2 0.8 0.1 -1.3
Friendships satisfaction 2.4 3.0 9.3 3.0 2.0 -0.3 0.2 2.5 0.9 -0.7 2.5 2.4 0.6 1.1 1.0
Qualifications: nursing, teaching 0.6 1.0 3.9 -0.3 0.3 -0.1 -0.9 -0.6 0.3 2.0 -1.4 -1.4 0.2 -1.6 0.0
Commuting to job workplace: Walk 0.4 0.5 1.7 0.1 0.3 0.8 0.3 0.4 0.0 -1.2 -0.6 0.9 -1.3 -0.2 0.7
Eye problems/disorders: Cataract 2.1 2.4 4.9 1.3 1.4 2.2 1.9 0.9 0.6 -1.3 1.7 1.3 2.0 1.7 -1.6
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.8 -0.4 -0.4 0.4 0.9 -0.6 0.8 -0.3 -0.4 -0.2 0.9 1.1 -1.3
Medication for cholesterol 0.3 0.4 1.4 0.1 1.1 0.5 -0.8 -0.3 1.2 0.7 0.3 -0.6 0.3 -0.2 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 2.8 -0.4 0.7 -0.4 0.3 -0.1 1.7 0.4 -0.2 -0.7 0.7 1.2 -1.3
Back pain experienced in last month 0.1 0.2 0.6 -0.5 -0.4 -0.2 0.7 -0.6 -0.3 -0.8 -0.1 -0.0 -0.6 0.2 -0.4
Mineral and other dietary supplements 0.2 0.2 0.7 0.5 0.4 -0.2 -0.4 -0.3 -0.1 -0.3 0.9 0.2 0.4 -0.6 0.7
Breast cancer (self-reported) 0.9 1.0 4.2 -1.0 -0.6 -0.5 -0.4 -0.5 0.1 -1.0 -1.3 -0.0 -1.1 -2.1 1.5
Asthma (self-reported) 1.0 1.9 4.7 2.1 1.4 -0.5 1.3 2.2 1.4 -0.8 1.6 1.8 -0.5 1.0 0.5
Osteoporosis (self-reported) 0.2 0.3 1.6 -0.2 -0.3 0.1 0.3 0.3 0.7 0.8 -0.3 -0.3 -1.3 -0.0 0.0
Osteoarthritis (self-reported) 0.7 0.9 2.1 0.7 -0.5 0.4 1.1 1.2 1.0 -0.8 0.8 1.5 -0.6 1.4 -0.6
Medication: Aspirin 0.5 0.7 1.5 -0.9 0.0 -0.8 -1.2 -0.9 -0.3 0.7 -0.9 -1.2 -0.0 -1.2 0.1
Medication: Gliclazide 0.5 0.6 1.4 0.3 0.1 1.1 1.0 0.4 -0.5 -1.2 0.4 1.0 1.2 -0.2 -0.4
Illnesses of father: None of the above (group 1) 0.8 0.9 3.4 -0.1 0.1 1.2 1.8 0.3 1.1 -1.0 0.5 0.6 0.7 1.3 -1.1
Smoking status: Current 0.2 0.3 2.7 -0.3 -0.1 0.3 0.3 -0.4 1.6 -0.3 0.0 0.1 -0.0 0.6 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 3.8 0.2 2.0 -0.6 0.1 -0.8 -1.3 0.5 0.2 -0.7 1.0 -0.1 -0.7
Whole body water mass 0.7 4.1 10.1 1.1 -0.1 1.9 3.2 0.5 -1.4 -2.7 2.0 2.3 2.4 2.4 -2.0
Leg predicted mass (right) 0.9 5.0 12.5 1.6 0.7 2.2 3.5 0.7 -0.7 -2.6 2.5 2.4 2.7 2.8 -2.2
Arm fat mass (left) 0.4 1.5 3.4 1.3 0.8 0.6 1.8 1.1 -1.4 -0.9 1.9 1.4 0.7 1.4 -0.9
Number of self-reported non-cancer illnesses 0.5 0.8 2.9 1.2 -0.3 -0.0 -0.4 1.7 -0.3 0.4 0.2 1.2 -1.1 0.3 1.5
Average weekly champagne plus white wine intake 0.4 0.6 1.9 1.1 0.6 -1.1 -0.3 0.6 0.9 -0.2 1.4 0.8 -0.2 0.3 0.6
Miserableness 0.9 1.6 4.7 -0.4 -1.3 -2.2 -0.7 0.7 1.4 0.5 -1.3 0.2 -2.1 -1.3 1.3
Guilty feelings 0.9 1.3 4.1 1.4 0.4 -0.1 0.5 1.8 2.0 -0.1 1.6 1.3 0.1 1.0 -0.6
Wears glasses or contact lenses 0.9 1.0 2.5 -1.3 -0.4 1.6 -0.7 -1.2 -0.6 0.8 -1.3 -1.3 -0.2 -1.1 -0.3
Ever taken oral contraceptive pill 0.4 0.5 2.5 0.3 0.6 -1.6 -0.4 0.2 -1.0 1.0 0.2 -0.4 -0.4 0.6 0.3
Hearing aid user 0.9 1.1 3.2 1.2 0.2 1.8 0.2 1.7 1.0 -0.6 0.5 1.4 0.6 0.9 0.1
Mother’s age at death 0.9 1.1 3.3 -0.8 1.2 -1.8 -1.2 -1.1 -0.6 1.1 -0.8 -1.3 -0.6 -1.0 0.2
Financial situation satisfaction 1.6 1.9 7.6 1.5 1.2 1.2 1.1 0.5 -0.6 -0.9 2.8 1.1 1.8 1.6 -1.0
Tinnitus: Yes, now most or all of the time 0.6 0.7 4.5 -0.1 -0.8 -0.4 1.4 -0.1 -0.1 -2.1 0.3 0.8 -0.3 -0.1 0.3
Commuting to job workplace: Public transport 0.6 0.7 2.4 -1.3 -0.1 0.6 0.9 -1.4 -0.3 -0.3 -0.1 -0.8 0.2 0.7 -1.5
Eye problems/disorders: Glaucoma 1.3 1.5 4.8 0.6 -0.4 -1.1 -1.6 1.8 -0.5 0.4 -0.4 0.7 -1.8 -1.2 2.2
Medication: Blood pressure 0.3 0.6 1.5 0.3 -1.1 0.6 0.3 0.8 -1.2 -1.1 -0.4 1.1 -0.8 0.2 0.3
Pain type(s) experienced in last month: Hip pain 1.6 2.0 5.9 2.0 0.9 1.6 0.6 2.4 0.9 -0.7 1.4 2.4 -0.6 0.8 0.8
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.8 -0.7 -0.5 -0.3 0.0 0.3 0.3 0.9 -0.9 -0.5 -0.8 0.2 -0.5
High cholesterol (Self-reported) 1.0 1.9 5.2 0.4 1.7 -0.6 1.5 0.1 -1.8 -0.7 1.8 0.5 2.3 1.4 -1.6
Medication: Bendroflumethiazide 1.7 2.6 7.9 -0.1 -2.5 -1.1 -1.3 1.2 -0.3 1.1 -1.7 0.2 -2.8 -2.0 2.1
Medication: Paracetamol 1.2 1.8 6.7 1.7 0.4 0.5 1.1 2.6 1.3 -1.1 0.9 2.3 0.2 1.4 0.1
Medication: Lisinopril 0.4 0.5 1.4 -1.1 0.2 -0.8 -0.3 -1.0 0.0 0.1 0.0 -1.2 0.7 0.8 -0.6
Medication: Atorvastatin 0.9 1.1 4.6 -0.3 0.6 -1.5 -1.7 -0.1 -2.1 1.1 0.3 -1.2 0.1 -1.0 0.0
Illnesses of father: High blood pressure 1.1 1.3 4.0 -1.1 0.1 -0.8 -1.5 -1.6 -0.8 1.8 -0.4 -2.0 -0.2 -1.2 -0.4
Alcohol drinker status: Never 1.2 1.5 4.0 2.0 0.4 -0.0 -0.2 2.0 1.0 -1.0 1.3 1.9 -0.8 0.4 1.3
Ever smoked 1.6 2.8 8.2 -0.4 1.3 1.3 1.7 -0.5 -0.4 -2.7 1.6 1.1 2.9 2.0 -1.9
Basal metabolic rate 0.6 3.5 8.8 1.0 0.0 1.7 3.0 0.4 -1.5 -2.4 2.0 2.1 2.2 2.1 -1.8
Leg fat percentage (left) 0.1 0.5 1.7 0.7 0.7 -0.3 -0.1 1.0 -1.3 0.3 0.8 0.5 -0.8 0.1 0.4
Arm fat-free mass (left) 0.5 2.7 6.8 0.6 -0.1 1.4 2.6 0.2 -1.8 -2.4 1.5 1.8 1.8 1.9 -1.5
Number of operations (self-reported) 1.6 2.3 6.5 2.3 -0.2 2.5 -0.8 2.6 1.3 0.0 0.5 2.1 -0.9 -0.1 1.5
Average weekly beer plus cider intake 0.3 0.4 2.2 -0.4 -1.5 -0.4 1.0 -0.0 -0.3 -0.6 -0.9 -0.1 -0.1 0.0 -0.0
Irritability 1.1 1.9 8.6 -1.8 -2.9 -1.1 -0.3 -0.2 -0.4 0.4 -2.4 -0.7 -1.7 -0.9 -0.1
Risk taking 1.7 2.5 10.2 0.9 -0.9 -1.0 -2.2 1.1 0.5 0.8 -0.0 0.6 -1.6 -2.7 3.2
Ever had prostate specific antigen (PSA) test 0.9 1.0 3.9 -1.2 -1.1 0.4 0.7 -1.3 -2.0 0.1 -1.2 -0.9 -0.8 -0.0 -0.5
Fractured/broken bones in last 5 years 1.4 1.9 4.0 -0.9 -0.4 -0.3 -1.6 -0.6 -0.9 1.7 -1.6 -1.4 -2.0 -1.7 1.7
Age started oral contraceptive pill 1.2 1.6 5.9 -1.0 1.3 0.9 1.3 -1.7 -2.4 -1.2 -0.1 -0.8 0.6 1.1 -0.9
Diastolic blood pressure, automated reading 0.3 1.0 3.2 0.1 0.1 -0.4 -1.3 1.4 -0.5 0.3 -0.3 0.6 -1.1 -1.8 1.6
Ever depressed for a whole week 1.8 2.2 4.6 -0.7 -2.0 -1.1 -2.1 -0.5 0.1 1.4 -2.0 -1.2 -2.0 -1.6 1.6
Unable to work because of sickness or disability 0.6 0.8 3.2 -0.0 -0.7 -1.8 -1.7 0.3 -0.0 -0.2 -0.2 0.1 -0.5 -0.9 1.1
Commuting to job workplace: Cycle 0.6 0.7 4.3 -0.4 -1.1 0.4 -0.1 -0.3 0.0 0.4 -1.3 -0.1 -0.6 -2.1 0.6
Myopia 1.4 2.1 7.0 1.3 2.6 -0.4 1.4 -0.2 0.9 -1.2 2.2 1.0 2.0 1.2 -1.0
Vascular/heart problems diagnosed by doctor 0.6 1.7 7.7 -1.6 0.1 -0.6 0.5 -2.8 1.0 0.3 -0.6 -2.0 1.3 -0.1 -1.2
Cholesterol lowering medication 1.1 1.6 3.5 1.3 1.4 -0.0 1.1 1.3 -0.7 -1.3 1.5 1.4 1.4 1.9 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.3 -0.3 -0.5 0.1 -1.1 -0.3 1.1 0.6 -1.1 -0.5 -0.7 -0.6 0.8
Pain experienced in last month 0.4 0.6 3.4 -0.0 0.9 0.1 -0.5 -0.4 -1.2 -0.0 0.8 -0.4 1.9 0.3 -0.7
Supplements: Calcium 2.4 2.7 5.8 -2.2 -0.8 -2.2 -0.6 -1.9 -1.6 1.4 -2.4 -2.3 -1.0 -0.9 -0.8
Basal cell carcinoma (self-reported) 0.5 0.5 2.1 0.2 -0.3 -0.8 -0.7 -0.2 -1.2 -0.2 -0.2 0.4 -1.1 -0.5 1.5
Heart attack/myocardial infarction (self-reported) 0.7 1.0 2.7 1.1 -0.3 -0.8 0.2 1.3 0.0 -1.3 0.0 1.6 -0.5 -1.0 1.4
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 8.0 -0.2 -1.4 -0.5 -2.6 -0.5 0.7 1.4 -1.4 -0.7 -1.2 -2.8 2.0
Heart disease (siblings) 0.6 0.7 2.5 1.2 1.3 0.3 0.0 0.7 0.7 -0.5 0.6 0.6 1.6 0.8 -0.0
Alcohol drinker status: Previous 0.4 0.5 1.4 1.1 1.0 0.1 -0.2 0.5 -0.4 0.4 1.2 0.3 0.7 1.0 -0.5
Pack years of smoking 0.4 0.6 2.5 0.5 0.4 -0.7 -0.3 1.6 -0.6 0.2 0.8 0.6 -0.8 0.5 1.0
Impedance of whole body 0.9 4.4 11.2 -2.8 -1.4 -2.2 -1.7 -3.0 -1.3 1.5 -2.5 -3.3 -1.2 -1.6 0.0
Leg fat mass (left) 0.3 1.1 2.3 1.3 0.7 0.5 1.1 1.4 -1.5 -0.7 1.4 1.4 -0.2 0.7 0.1
Arm predicted mass (left) 0.5 2.4 5.7 0.7 -0.1 1.2 2.4 0.3 -1.8 -2.2 1.4 1.9 1.6 1.7 -1.3