Hub : Genes

MRPS22

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.072	0.029	0.0043	0.067	0.004	0.052	0.04	0.047	1.3e-08	0.08500	5.6e-07	1.1e-05	2.0e-06
2	TCGA	Stomach Adenocarcinoma	0.089	0.045	0.0026	0.054	0.042	0.044	NA	0.050	9.2e-05	0.00052	4.0e-04	NA	1.7e-04
3	TCGA	Thyroid Carcinoma	0.035	0.020	0.0069	-0.002	0.011	0.007	NA	0.000	5.8e-01	0.02400	6.7e-02	NA	3.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.2	0.3	-0.6	0.5	0.1
Bipolar Disorder or Schizophrenia	0.2	0.5	1.3	-0.0	-0.2	1.2
Depressed Affect (Nagel 2018)	0.1	0.3	0.4	0.5	-0.6	0.5
Depression (Nagel 2018)	1.8	2.6	6.2	-0.6	1.1	2.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.2	0.3	0.6	1.1
Neuroticism (Nagel 2018)	0.5	1.3	2.1	-1.0	0.8	1.5
Schizophrenia (2018)	0.4	0.9	2.1	0.4	-0.7	1.4
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.2	0.0	0.0
Worry (Nagel 2018)	0.2	0.4	0.5	-0.7	0.5	0.7
Alzheimer’s Disease (in mother)	1.0	1.2	3.5	0.2	-0.4	-1.9
Alzheimer’s Disease (in father)	1.6	1.7	3.5	1.2	-0.6	-1.9
Alzheimer’s Disease (including proxy)	1.3	1.9	3.7	1.0	-0.9	-1.9
Crohns Disease (2017)	0.4	1.0	1.6	1.1	-1.3	0.2
Irritable Bowel Disease (IBD)	0.5	1.3	2.0	1.3	-1.4	-0.5
Ulcerative Colitis (UC)	0.5	0.9	1.4	1.1	-1.2	-0.3
Major Depression (MDD)	0.6	0.7	1.6	0.5	-0.4	1.3
Reaction Time	0.2	0.3	0.4	-0.5	0.6	0.6
Verbal and Numeric Reasoning (VNR)	0.7	1.7	2.9	-0.6	1.4	1.7
Breast Cancer	2.7	6.5	9.0	-2.9	3.0	-1.5
Ovarian Cancer	1.6	2.1	2.5	-1.6	1.5	1.2
Prostate Cancer	0.1	0.1	0.3	0.1	0.5	-0.2
Age at First Birth	0.2	0.3	0.8	-0.1	-0.5	-0.9
Bipolar Disorder (2011)	0.6	0.6	1.1	-0.4	0.8	1.0
Body Mass Index (BMI) (2010)	0.9	1.3	2.1	-1.3	1.4	0.2
Coronary Artery Disease (CAD)	0.6	0.7	1.3	0.9	0.0	1.2
Crohns Disease (2012)	0.6	0.9	2.6	1.6	0.0	0.5
Mean Putamen Volume	0.5	0.6	1.5	-0.5	1.2	-0.3
Fasting Glucose	0.5	0.6	1.2	-0.8	1.1	-0.3
HbA1C	0.0	0.0	0.1	-0.2	-0.2	-0.1
HDL Cholesterol	2.3	3.8	4.5	1.8	-2.1	-1.9
LDL Cholesterol	0.2	0.4	1.0	0.2	0.2	-1.0
Lupus	0.7	1.1	1.7	-1.3	0.8	0.9
Neuroticism (2016)	1.0	1.4	2.0	1.4	-1.4	-0.5
Primary Biliary Cirrhosis	0.1	0.1	0.1	0.4	0.0	0.3
Rheumatoid Arthritis	0.2	0.2	0.5	0.7	0.0	-0.3
Schizophrenia (2014)	0.3	0.7	1.5	0.6	-1.2	0.4
Triglycerides	0.7	1.1	2.4	-0.9	1.6	0.1
Type 2 Diabetes (T2D) (2012)	3.9	4.5	5.9	-2.3	2.4	1.4
Ulcerative Colitis	0.6	0.9	2.7	1.6	0.0	-0.4
Blood Eosinophil Count	0.1	0.5	0.8	0.6	-0.6	-0.9
Blood Platelet Count	0.0	0.1	0.2	-0.1	0.2	0.5
Blood Red Count	0.1	1.3	3.7	0.3	0.1	1.9
Blood White Count	0.2	1.7	2.0	-1.3	1.4	1.1
Heel T-Score	0.6	4.7	8.9	-1.6	1.6	3.0
BMI	0.1	0.6	1.6	-0.2	0.2	1.3
Height	0.0	0.1	0.3	-0.6	-0.0	-0.2
Waist Hip Ratio (WHR)	0.5	2.4	4.7	2.2	-1.5	0.6
Systolic Blood Pressure	0.2	0.9	1.1	-1.0	1.0	-0.7
Smoking Status	0.6	1.4	2.7	0.9	-0.7	1.6
Allergy or Eczema	0.0	0.0	0.1	-0.1	-0.3	0.2
Cardiovascular Disease	0.1	0.4	0.7	0.6	-0.8	-0.4
Hypothyroidism (self reported)	0.5	1.1	1.6	1.3	-1.2	0.4
Respiratory disease	0.6	1.3	2.1	-1.1	0.7	1.5
Type 2 Diabetes (T2D) (2018)	2.7	5.0	7.9	2.7	-2.8	-0.3
Lung FEV1/FVC ratio	0.6	3.0	5.9	-1.0	1.4	2.4
Lung FVC	0.1	0.7	2.0	-0.2	-0.1	-1.4
Neuroticism	0.0	0.1	0.1	0.3	-0.4	0.3
Chronotype (morning person)	0.1	0.3	0.8	0.0	-0.4	-0.9
Hair Pigment	0.0	0.9	2.5	-0.1	0.4	1.6
Tanning	0.1	0.8	1.3	-1.1	1.0	0.4
Hand grip strength (left)	0.5	1.2	1.8	1.4	-1.1	-0.7
Number of treatments/medications taken	0.2	0.3	0.6	0.4	-0.3	0.8
Average weekly spirits intake	1.7	2.2	3.0	1.7	-1.3	-1.4
Sensitivity / hurt feelings	0.2	0.3	0.9	0.1	-0.2	0.9
Frequency of depressed mood in last 2 weeks	3.1	4.4	6.0	-1.8	1.9	2.4
Hearing difficulty/problems: Yes	0.7	1.1	2.3	0.9	-0.6	1.5
Relative age of first facial hair	0.3	0.5	0.8	0.2	-0.9	0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.0	1.0	-1.0	-0.3
Ever used hormone-replacement therapy (HRT)	1.4	1.7	2.7	1.5	-1.7	-0.5
Ever had hysterectomy (womb removed)	3.4	3.9	6.9	2.6	-2.1	-0.5
Systolic blood pressure, automated reading	0.2	0.5	1.0	-0.2	0.6	-1.0
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	0.1	0.0	0.1
Angina	1.3	1.7	2.8	1.7	-1.5	0.0
Medication for hormone replacement therapy	0.9	1.0	2.9	0.3	-0.1	-1.7
Vitamin and mineral supplements	0.2	0.3	0.9	0.2	-0.1	1.0
Supplements: Zinc	1.7	1.8	4.1	-2.0	1.1	-0.1
Medication: Co-codamol	3.2	3.7	7.3	-1.2	1.6	2.7
Medication: Metformin	2.6	3.7	5.9	2.4	-2.2	-0.6
Diabetes (father)	1.1	1.4	2.5	1.6	-1.3	0.4
Diabetes (mother)	1.7	2.1	4.8	-0.9	0.8	2.2
Severe depression (siblings)	0.9	1.0	2.7	0.1	-0.3	1.7
Pack years adult smoking proportion	0.2	0.3	0.5	0.7	0.2	0.6
Impedance of leg (right)	0.2	1.0	2.3	0.6	-0.4	-1.5
Leg fat-free mass (left)	0.1	0.4	0.6	-0.6	0.8	0.4
Trunk fat percentage	0.1	0.4	0.9	-0.5	0.9	0.4
Hand grip strength (right)	0.2	0.6	1.1	0.6	-0.7	-1.0
Townsend deprivation index at recruitment	0.2	0.2	0.4	0.6	-0.5	0.3
Current tobacco smoking	0.2	0.4	1.1	-0.3	1.0	0.2
Average weekly fortified wine intake	0.2	0.2	0.4	-0.1	0.4	-0.6
Maternal smoking around birth	0.2	0.2	0.3	-0.6	0.5	0.2
Fed-up feelings	0.0	0.0	0.0	-0.2	0.2	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	5.3	-0.2	0.5	2.3
Relative age voice broke	1.0	1.6	2.5	1.4	-1.6	0.4
Taking other prescription medications	1.2	1.9	3.5	1.9	-1.4	0.2
Age when periods started (menarche)	0.0	0.1	0.1	0.2	-0.3	0.1
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	3.0	-0.9	1.5	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.8	-0.1	0.9	0.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.1	-1.1	0.5	0.7
Qualifications: CSEs or equivalent	2.9	3.8	5.9	-2.3	2.4	0.5
Serious illness, injury or assault to yourself	0.2	0.3	0.5	-0.7	0.4	0.4
High blood pressure	0.2	0.6	1.7	0.5	-0.2	1.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.2	0.0	-0.5	0.5
Multivitamins +/- minerals	0.3	0.4	0.8	0.3	-0.5	-0.9
Stomach or abdominal pain in last month	0.0	0.0	0.1	0.1	-0.0	0.2
Supplements: Glucosamine	2.4	3.2	4.4	1.6	-1.6	-2.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.2	1.1	-0.8	0.5
Medication: Atenolol	0.6	0.8	1.4	-0.6	1.2	0.9
Medication: Levothyroxine sodium	0.9	1.5	2.5	1.4	-1.6	-0.3
Sitting height	0.0	0.2	0.4	-0.3	-0.3	0.6
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	0.3	-0.3	0.1
High blood pressure (mother)	0.8	1.1	3.0	0.3	-0.3	1.7
Body mass index (BMI)	0.2	0.7	1.0	-0.4	1.0	1.0
Impedance of leg (left)	0.3	1.2	2.8	0.7	-0.6	-1.7
Leg predicted mass (left)	0.1	0.5	0.7	-0.7	0.8	0.5
Trunk fat mass	0.1	0.5	1.0	-0.6	1.0	0.5
Waist circumference	0.1	0.3	0.8	0.4	0.0	0.9
Number of incorrect matches in round	0.2	0.3	0.5	-0.7	0.7	-0.1
Past tobacco smoking	1.6	3.0	4.6	-1.9	2.1	-0.8
Alcohol usually taken with meals	0.3	0.5	0.9	-0.3	-0.7	-1.0
Nervous feelings	0.0	0.0	0.0	-0.1	0.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.4	0.7	-0.6	0.5
Hearing difficulty/problems with background noise	1.3	2.1	6.0	0.4	-0.3	2.4
Hair/balding pattern: Pattern 2	0.3	0.4	0.6	0.8	0.7	-0.2
Had menopause	1.5	1.9	3.2	1.5	-1.8	-0.4
Had other major operations	0.4	0.5	0.7	-0.8	0.8	0.5
Forced vital capacity (FVC)	0.2	0.8	1.7	-1.3	0.8	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.2	0.4	0.3	-0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	1.5	-1.2	1.2	0.5
Qualifications: None of the above	0.6	1.2	1.9	1.3	-1.4	0.5
Financial difficulties in last 2 years	2.2	3.0	4.9	-2.0	2.2	0.1
Mouth/teeth dental problems	0.2	0.4	0.7	-0.8	0.6	-0.1
Heart attack	2.5	3.1	4.8	2.2	-2.0	-0.8
Allergy	0.0	0.1	0.2	0.5	-0.0	-0.3
Pain all over the body in last month	0.2	0.2	0.4	0.3	0.1	-0.7
Diabetes (self-reported)	1.4	2.1	3.4	1.8	-1.7	0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.1	0.3	0.0	-1.1
Medication: Ramipril	0.1	0.1	0.1	0.4	-0.2	-0.1
Medication: Simvastatin	1.6	2.3	3.7	1.9	-1.7	0.4
Fluid intelligence score	0.9	1.9	3.7	-0.9	1.9	1.1
Illnesses of siblings	0.6	0.8	1.7	-0.8	1.3	0.3
Neuroticism score	0.1	0.1	0.2	-0.4	0.3	0.4
Weight	0.1	0.4	0.6	-0.4	0.8	0.7
Impedance of arm (right)	0.0	0.2	0.3	0.4	-0.5	-0.5
Arm fat percentage (right)	0.1	0.2	0.4	-0.1	0.6	0.5
Trunk fat-free mass	0.0	0.1	0.2	0.2	0.1	-0.4
Hip circumference	0.1	0.2	0.4	-0.4	0.7	0.3
Time employed in main current job	0.4	0.4	0.7	0.9	-0.3	0.6
Alcohol intake versus 10 years previously	0.2	0.3	0.8	-0.1	0.0	0.9
Father’s age at death	0.3	0.4	0.6	0.7	-0.6	-0.5
Worrier / anxious feelings	0.7	1.3	1.6	-1.2	1.3	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.5	-0.3	0.2	1.2
Falls in the last year	1.3	1.8	2.7	-1.6	1.6	0.3
Hair/balding pattern: Pattern 3	4.7	7.0	14.4	-3.8	0.1	2.5
Number of live births	1.8	2.6	3.1	1.5	-1.5	-1.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.4	-1.2	0.8	-0.0
Pulse rate	0.0	0.0	0.1	-0.3	0.1	-0.2
Happiness	0.5	0.6	1.5	0.3	-0.3	1.2
Noisy workplace	1.9	2.4	2.4	1.5	-1.6	1.5
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.5	0.0	0.1	-2.1
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	1.9	1.4	-1.3	-0.8
Mouth/teeth dental problems: Dentures	2.6	4.4	7.6	2.8	-2.4	-0.2
Asthma	0.7	1.4	3.3	-0.8	0.5	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.3	1.1	-1.1	0.4
Medication: Cholesterol lowering	0.4	0.6	1.0	0.9	-0.2	-1.0
Depression (self-reported)	1.9	2.2	4.0	2.0	-1.7	0.1
Medication: Lansoprazole	1.4	1.6	1.9	-1.1	1.3	1.4
Prospective memory result	0.5	0.7	1.6	-0.4	-0.5	1.2
Lung cancer (father)	0.2	0.3	0.8	-0.1	-0.0	0.9
Illnesses of mother	0.4	0.4	0.6	-0.7	0.8	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.8	-0.7	0.2	-0.9
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	0.5	-0.3	-0.5
Impedance of arm (left)	0.0	0.2	0.3	0.1	-0.4	-0.5
Arm fat mass (right)	0.1	0.4	0.8	-0.3	0.9	0.6
Trunk predicted mass	0.0	0.1	0.1	0.1	0.2	-0.4
Standing height	0.0	0.1	0.2	0.1	-0.2	-0.5
Length of working week for main job	0.1	0.2	0.5	0.0	-0.1	-0.7
Exposure to tobacco smoke at home	0.6	0.7	1.3	0.9	-1.1	-0.0
Breastfed as a baby	0.1	0.2	0.4	0.4	-0.1	-0.6
Tense / ‘highly strung’	0.1	0.1	0.3	-0.5	0.1	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.1	-0.2	0.0
Hair/balding pattern: Pattern 4	6.3	15.3	28.1	4.1	1.1	-5.3
Birth weight of first child	0.9	1.6	2.5	1.6	-1.1	-1.1
Peak expiratory flow (PEF)	0.3	0.6	1.6	-1.3	0.4	-0.1
Pulse wave reflection index	0.3	0.4	0.8	-0.4	0.4	0.9
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.2	0.8	-1.1	-0.6
Loud music exposure frequency	1.6	1.7	4.6	0.3	-0.7	2.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.4	0.4	-0.2	-1.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	0.9	0.7	-0.9	-0.8
Blood clot in the leg (DVT)	2.6	3.4	8.0	0.8	-1.3	-2.8
Medication: Paracetamol	1.0	1.6	2.0	-1.4	1.2	1.2
Headache pain in last month	0.5	0.9	1.6	-0.9	0.6	-1.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.0	-0.6	0.2	1.0
Glaucoma (self-reported)	3.1	3.6	5.6	2.0	-2.4	-1.2
Gout (self-reported)	0.7	0.9	1.5	-1.0	1.2	0.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	1.9	1.4	-1.2	0.6
Medication: Amlodipine	0.3	0.4	0.9	0.3	-0.5	-1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.5	-0.3	0.1	1.2
Birth weight	0.1	0.3	0.6	0.5	-0.2	0.8
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.8	-1.1	1.7	0.7
High blood pressure (siblings)	0.5	0.8	2.1	0.2	-0.4	-1.4
Forced vital capacity (FVC), Best measure	0.2	0.7	1.8	-0.6	-0.0	-1.4
Body fat percentage	0.1	0.3	0.6	-0.3	0.8	0.4
Leg fat percentage (right)	0.1	0.2	0.4	-0.1	0.7	0.5
Arm fat-free mass (right)	0.0	0.1	0.3	-0.3	0.5	-0.1
Exposure to tobacco smoke outside home	0.4	0.5	0.6	-0.7	0.7	0.7
Comparative body size at age 10	0.3	0.8	1.0	-0.7	0.9	1.0
Number of full brothers	0.2	0.3	0.4	0.5	-0.7	0.2
Worry too long after embarrassment	2.1	3.5	4.7	-2.2	2.1	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.1	1.1	-1.0	-0.5
Wheeze or whistling in the chest in last year	0.7	1.2	2.1	-1.2	1.4	0.2
Number of children fathered	0.4	0.4	1.0	0.4	-0.3	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.4	-0.1	0.5
Age at first live birth	0.1	0.2	0.5	0.0	0.3	-0.7
Pulse wave peak to peak time	0.1	0.2	0.3	-0.4	0.2	0.5
Health satisfaction	0.7	0.9	1.8	-0.9	0.1	1.3
Shortness of breath walking on level ground	1.9	2.2	3.7	-1.2	1.3	1.9
Qualifications: College or University degree	1.0	3.3	5.5	2.0	-2.4	-0.6
Eye problems/disorders: None of the above	0.4	0.4	0.8	-0.9	0.7	-0.0
Mouth/teeth dental problems: Loose teeth	2.0	2.4	4.6	-1.6	2.1	0.2
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.1	0.2	0.6
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	0.6	-0.3	-0.1
Neck or shoulder pain in last month	0.2	0.2	0.4	-0.6	0.4	-0.4
Medication: Blood pressure	0.2	0.4	0.7	-0.6	0.9	0.1
Angina (self-reported)	1.0	1.3	2.2	1.5	-1.2	0.2
Migraine (self-reported)	0.3	0.4	0.8	0.4	-0.9	-0.3
Medication: Ibuprofen	1.2	1.5	2.2	1.5	-1.5	0.3
Medication: Allopurinol	0.3	0.3	0.6	-0.5	0.7	-0.5
Medication: Omeprazole	0.7	0.8	1.8	0.8	-1.3	-0.1
Medication: Seretide 50 evohaler	1.3	1.5	1.9	1.0	-1.2	1.4
Mean time to correctly identify matches	0.0	0.1	0.1	0.3	-0.3	-0.2
Heart disease (mother)	3.4	4.1	6.1	2.5	-2.4	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.5	0.3	-0.5	0.7
Whole body fat mass	0.1	0.3	0.7	-0.4	0.8	0.4
Leg fat mass (right)	0.1	0.5	0.9	-0.5	0.9	0.5
Arm predicted mass (right)	0.1	0.3	0.6	-0.5	0.8	-0.3
Pulse rate, automated reading	0.3	1.1	1.4	0.9	-1.0	-1.2
Alcohol intake frequency.	1.0	2.4	6.1	-0.3	1.0	2.5
Comparative height size at age 10	0.0	0.1	0.2	0.2	-0.3	0.5
Number of full sisters	1.1	1.4	2.1	-1.2	1.4	0.7
Suffer from ‘nerves’	0.1	0.2	0.5	-0.4	0.2	0.7
Overall health rating	0.2	0.5	1.6	0.2	0.0	-1.2
Chest pain or discomfort	1.2	1.8	5.3	-0.2	0.2	-2.3
Had major operations	0.2	0.3	0.4	-0.6	0.5	-0.4
Age at last live birth	0.9	1.3	2.5	1.1	-1.6	0.2
Family relationship satisfaction	0.9	1.1	3.2	-0.2	-0.2	1.8
Leg pain on walking	0.5	0.7	1.9	-0.3	-0.1	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	0.0	0.0	0.8
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.2	0.1	0.4
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.1	1.8	-1.5	-0.3
Medication: Aspirin	1.2	1.5	3.5	0.9	-0.6	-1.9
Supplements: Vitamin C	1.0	1.1	2.0	-1.4	1.0	0.6
Knee pain experienced in last month	0.1	0.1	0.2	-0.1	-0.4	-0.5
Hypertension (Self-reported)	0.2	0.6	1.6	-0.1	0.4	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	0.5	-1.0	0.5
Illnesses of father: Heart disease	0.9	1.3	3.3	0.5	-0.6	-1.8
Illnesses of siblings: Diabetes	0.5	0.6	0.8	0.9	-0.8	-0.6
Smoking status: Previous	1.9	2.8	4.2	1.6	-2.1	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	4.9	-2.1	2.2	0.1
Whole body fat-free mass	0.0	0.1	0.3	-0.3	0.5	-0.1
Leg fat-free mass (right)	0.1	0.4	0.5	-0.6	0.7	0.4
Arm fat percentage (left)	0.1	0.3	0.4	-0.3	0.6	0.6
Average weekly red wine intake	0.7	1.1	1.5	0.5	-1.2	-1.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.0	1.0	-0.8	-0.2
Mood swings	0.3	0.5	0.8	-0.8	0.9	-0.1
Loneliness, isolation	0.1	0.1	0.2	0.0	-0.2	-0.5
Long-standing illness, disability or infirmity	0.7	1.0	1.6	1.3	-1.0	0.6
Ever had bowel cancer screening	0.1	0.1	0.2	0.1	-0.5	0.0
Diabetes diagnosed by doctor	1.8	3.0	4.6	2.1	-2.0	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	2.5	-1.6	1.3	-0.9
Friendships satisfaction	0.0	0.0	0.0	-0.1	-0.0	0.2
Qualifications: nursing, teaching	0.9	1.5	4.1	-0.0	0.6	-2.0
Commuting to job workplace: Walk	0.5	0.5	0.7	0.8	-0.8	0.3
Eye problems/disorders: Cataract	0.2	0.3	0.7	-0.2	0.3	0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.8	-0.5	0.4	0.9
Medication for cholesterol	0.1	0.2	0.2	-0.4	0.5	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.0	-1.0	0.8	1.0
Back pain experienced in last month	0.6	0.9	1.3	-0.9	0.7	1.2
Mineral and other dietary supplements	0.1	0.1	0.4	0.0	0.1	0.6
Breast cancer (self-reported)	4.3	5.1	6.6	2.2	-2.6	-2.0
Asthma (self-reported)	1.1	2.1	4.8	-1.0	0.7	2.2
Osteoporosis (self-reported)	0.3	0.3	0.6	-0.6	0.8	-0.3
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.1	0.0	0.5
Medication: Aspirin	1.5	1.9	4.0	1.1	-0.8	-2.0
Medication: Gliclazide	0.2	0.2	0.5	0.7	-0.3	-0.1
Illnesses of father: None of the above (group 1)	1.2	1.4	1.9	-1.3	0.8	1.4
Smoking status: Current	0.2	0.3	0.7	-0.1	0.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.4	-0.0	-0.5	-1.6
Whole body water mass	0.0	0.2	0.4	-0.4	0.7	0.1
Leg predicted mass (right)	0.1	0.4	0.6	-0.7	0.8	0.3
Arm fat mass (left)	0.1	0.3	0.6	-0.3	0.8	0.5
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.0	0.3	0.7
Average weekly champagne plus white wine intake	0.0	0.0	0.1	-0.3	-0.1	-0.0
Miserableness	0.1	0.2	0.3	0.2	-0.4	-0.6
Guilty feelings	0.6	1.0	1.2	-1.1	0.8	1.0
Wears glasses or contact lenses	0.5	0.6	1.3	0.7	-0.2	-1.2
Ever taken oral contraceptive pill	1.1	1.2	1.6	-0.8	1.2	1.3
Hearing aid user	0.1	0.1	0.1	-0.3	-0.3	0.2
Mother’s age at death	0.5	0.6	1.2	-0.7	0.3	-1.1
Financial situation satisfaction	1.8	2.2	3.1	-1.8	1.1	1.5
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.0	1.1	-1.0	1.4
Commuting to job workplace: Public transport	1.0	1.2	2.4	-1.6	1.1	0.2
Eye problems/disorders: Glaucoma	2.1	2.5	3.9	1.5	-2.0	-1.2
Medication: Blood pressure	0.3	0.6	1.0	0.4	-0.8	1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	-0.5	0.5	0.9
Supplements: Fish oil (including cod liver oil)	0.8	1.1	1.8	-1.2	1.3	0.4
High cholesterol (Self-reported)	0.1	0.2	0.4	0.5	-0.6	-0.1
Medication: Bendroflumethiazide	0.7	1.0	1.6	-1.3	0.8	0.9
Medication: Paracetamol	0.3	0.5	1.1	-0.6	0.1	1.0
Medication: Lisinopril	0.1	0.1	0.3	-0.1	-0.1	0.6
Medication: Atorvastatin	0.9	1.1	1.3	1.1	-0.9	-1.1
Illnesses of father: High blood pressure	1.0	1.3	3.7	-0.0	0.3	-1.9
Alcohol drinker status: Never	2.6	3.1	3.3	1.7	-1.8	1.8
Ever smoked	1.2	2.1	3.3	1.7	-1.8	0.5
Basal metabolic rate	0.0	0.2	0.4	-0.4	0.6	0.0
Leg fat percentage (left)	0.0	0.1	0.3	-0.0	0.5	0.4
Arm fat-free mass (left)	0.0	0.1	0.2	0.0	0.4	-0.3
Number of operations (self-reported)	0.8	1.2	2.5	-0.5	0.9	1.6
Average weekly beer plus cider intake	1.2	1.7	4.9	-0.3	0.1	2.2
Irritability	0.2	0.4	1.0	-1.0	0.5	-0.1
Risk taking	2.9	4.2	6.2	1.9	-1.7	-2.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.3	-0.1	0.4
Fractured/broken bones in last 5 years	0.8	1.1	3.0	0.2	-0.3	-1.7
Age started oral contraceptive pill	0.5	0.6	1.0	0.9	-1.0	-0.1
Diastolic blood pressure, automated reading	0.1	0.2	0.6	0.3	-0.2	-0.7
Ever depressed for a whole week	0.3	0.3	0.7	-0.8	0.4	-0.2
Unable to work because of sickness or disability	1.1	1.4	2.1	1.5	-1.3	-0.5
Commuting to job workplace: Cycle	2.3	2.8	6.6	0.8	-1.1	-2.6
Myopia	0.4	0.6	1.0	-0.9	0.3	1.0
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.8	-0.7	0.5	-0.9
Cholesterol lowering medication	0.8	1.2	1.4	1.2	-1.2	0.8
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.6	1.0	-1.3	-0.6
Pain experienced in last month	0.7	1.1	2.0	1.4	-0.9	-0.6
Supplements: Calcium	1.6	1.8	4.5	-0.7	0.5	-2.1
Basal cell carcinoma (self-reported)	0.3	0.4	0.9	-0.3	0.3	1.0
Heart attack/myocardial infarction (self-reported)	2.1	2.8	4.5	2.1	-1.9	-0.5
Deep venous thrombosis (DVT) (self-reported)	2.8	3.6	8.8	0.8	-1.2	-3.0
Heart disease (siblings)	0.9	1.1	1.6	1.2	-1.3	0.3
Alcohol drinker status: Previous	0.2	0.3	0.4	-0.3	0.5	0.7
Pack years of smoking	0.3	0.4	1.0	1.0	-0.1	0.4
Impedance of whole body	0.1	0.6	1.0	0.6	-0.6	-1.0
Leg fat mass (left)	0.1	0.2	0.4	-0.2	0.7	0.5
Arm predicted mass (left)	0.0	0.2	0.3	0.1	0.4	-0.5