Best TWAS P=1.81e-08 · Best GWAS P=2.27e-08 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FADS1 | 0.14 | 0.16 | lasso | 2 | 0.16 | 7.2e-19 | -5.4 | 5.4 | 5.6e-08 | -0.96 | 0.02 | 0.98 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | FEN1 | 0.07 | 0.06 | lasso | 4 | 0.06 | 1.1e-07 | -5.4 | -5.4 | 8.2e-08 | 0.96 | 0.02 | 0.98 | FALSE |
3 | GTEx | Artery Tibial | TMEM258 | 0.08 | 0.05 | lasso | 5 | 0.02 | 1.1e-02 | -5.6 | -5.6 | 1.8e-08 | 0.97 | 0.01 | 0.98 | TRUE |
4 | GTEx | Pancreas | FADS1 | 0.17 | 0.13 | lasso | 6 | 0.12 | 1.2e-05 | -5.0 | 5.2 | 2.6e-07 | -0.91 | 0.03 | 0.97 | FALSE |
5 | NTR | Blood | C11orf10 | 0.06 | 0.08 | bslmm | 399 | 0.08 | 1.3e-24 | -4.9 | -5.3 | 1.5e-07 | 0.91 | 0.07 | 0.93 | FALSE |
6 | ROSMAP | Brain Pre-frontal Cortex | FADS1 | 0.08 | 0.08 | enet | 10 | 0.09 | 1.5e-11 | -5.5 | 5.4 | 6.8e-08 | -0.95 | 0.02 | 0.98 | FALSE |
7 | The Cancer Genome Atlas | Thyroid Carcinoma | C11orf10 | 0.02 | 0.02 | blup | 44 | 0.02 | 1.8e-03 | -5.4 | -5.5 | 3.7e-08 | 0.95 | 0.02 | 0.74 | FALSE |