[Hub]/) : Traits : Age when periods started (menarche) : ← →

chr6:41,005,502-42,598,371

Best TWAS P=2.95e-10 · Best GWAS P=1.56e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	PRICKLE4	0.10	0.09	lasso	8	0.08	9.2e-07	3.9	-6.1	1.2e-09	0.29	0.33	0.67	TRUE
2	GTEx	Adipose Subcutaneous	MED20	0.08	0.07	enet	9	0.05	4.7e-05	5.8	5.7	1.0e-08	0.92	0.06	0.94	FALSE
3	GTEx	Artery Tibial	MED20	0.14	0.11	lasso	2	0.09	9.7e-08	5.8	5.8	7.4e-09	0.93	0.09	0.91	FALSE
4	GTEx	Esophagus Mucosa	MED20	0.09	0.07	enet	10	0.02	2.7e-02	-5.4	5.6	2.7e-08	0.89	0.19	0.79	TRUE
5	GTEx	Heart Atrial Appendage	MED20	0.14	0.12	enet	11	0.09	5.9e-05	5.8	5.6	2.5e-08	0.91	0.02	0.98	FALSE
6	GTEx	Heart Left Ventricle	PRICKLE4	0.11	0.05	lasso	4	0.03	9.8e-03	6.4	-6.2	4.1e-10	-0.99	0.01	0.96	FALSE
7	GTEx	Heart Left Ventricle	MED20	0.22	0.19	enet	8	0.12	5.8e-07	5.7	5.6	2.0e-08	0.91	0.10	0.90	FALSE
8	GTEx	Lung	BYSL	0.08	0.03	lasso	4	0.02	4.9e-03	4.4	-5.4	6.8e-08	-0.87	0.05	0.92	FALSE
9	GTEx	Lung	PRICKLE4	0.12	0.05	lasso	3	0.06	2.2e-05	6.4	-6.1	9.4e-10	-0.92	0.01	0.99	FALSE
10	GTEx	Muscle Skeletal	PRICKLE4	0.07	0.05	lasso	2	0.05	2.1e-05	-3.7	-5.2	2.2e-07	-0.74	0.05	0.94	TRUE
11	GTEx	Muscle Skeletal	MED20	0.16	0.15	lasso	4	0.16	6.7e-16	6.4	6.3	3.0e-10	1.00	0.00	1.00	TRUE
12	GTEx	Nerve Tibial	MED20	0.13	0.11	enet	8	0.10	1.5e-07	5.8	5.6	2.2e-08	0.90	0.12	0.88	FALSE
13	GTEx	Thyroid	MED20	0.05	0.05	lasso	2	0.02	8.1e-03	5.7	5.6	2.4e-08	0.91	0.07	0.91	FALSE
14	METSIM	Adipose	MED20	0.13	0.11	enet	27	0.11	2.3e-16	5.6	5.2	2.4e-07	0.86	0.04	0.96	TRUE
15	ROSMAP	Brain Pre-frontal Cortex	PGC	0.13	0.06	blup	520	0.06	3.2e-08	3.5	-5.5	4.8e-08	-0.56	0.82	0.18	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	MED20	0.10	0.10	enet	21	0.09	6.0e-12	5.7	6.0	1.8e-09	0.93	0.02	0.98	FALSE
17	YFS	Blood	BYSL	0.07	0.06	lasso	7	0.09	2.8e-28	5.8	-5.8	7.7e-09	-0.85	0.07	0.93	TRUE
18	YFS	Blood	MED20	0.04	0.03	lasso	5	0.03	3.6e-11	6.4	5.5	3.5e-08	0.95	0.00	1.00	TRUE
19	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PRICKLE4	0.04	0.05	blup	43	0.06	2.2e-07	-3.9	-5.5	4.7e-08	-0.63	0.16	0.84	TRUE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	MED20	0.04	0.06	enet	6	0.05	2.6e-06	6.4	6.1	1.4e-09	0.98	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRICKLE4	0.03	0.00	blup	43	0.01	5.5e-02	5.8	-6.0	1.7e-09	-0.83	0.00	0.76	TRUE
22	The Cancer Genome Atlas	Thyroid Carcinoma	BYSL	0.05	0.06	enet	7	0.06	4.3e-06	5.7	-5.4	7.6e-08	-0.88	0.01	0.98	FALSE