[Hub]/) : Traits : Age when periods started (menarche) : ← →

chr11:46,543,524-48,485,877

Best TWAS P=3.08e-12 · Best GWAS P=1.65e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FAM180B	0.07	0.08	lasso	3	0.08	9.1e-10	-5.8	-5.5	4.5e-08	0.95	0.04	0.96	FALSE
2	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	-6.0	5.9	3.5e-09	-0.98	0.01	0.99	FALSE
3	GTEx	Artery Aorta	C1QTNF4	0.09	0.10	lasso	1	0.08	3.2e-05	-5.8	5.8	5.2e-09	-1.00	0.01	0.98	FALSE
4	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	-5.7	-5.5	3.2e-08	0.79	0.03	0.93	FALSE
5	GTEx	Cells Transformed fibroblasts	MADD	0.19	0.00	enet	17	0.09	3.3e-07	2.5	-6.0	1.8e-09	0.30	0.49	0.12	FALSE
6	GTEx	Cells Transformed fibroblasts	NDUFS3	0.08	0.01	lasso	2	0.01	3.3e-02	-6.0	5.1	2.9e-07	-0.98	0.01	0.93	TRUE
7	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	-6.0	5.9	3.3e-09	-0.96	0.02	0.93	FALSE
8	GTEx	Esophagus Mucosa	MADD	0.27	0.04	enet	18	0.12	4.1e-08	4.1	-6.7	2.6e-11	0.40	0.22	0.22	FALSE
9	GTEx	Esophagus Mucosa	C1QTNF4	0.10	0.11	lasso	1	0.10	5.0e-07	-5.8	5.8	5.2e-09	-1.00	0.01	0.99	FALSE
10	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	-5.3	-5.4	5.5e-08	0.78	0.06	0.88	FALSE
11	GTEx	Esophagus Muscularis	MADD	0.13	0.07	enet	8	0.11	2.0e-07	4.1	-5.2	2.5e-07	0.17	0.27	0.64	FALSE
12	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	-5.8	5.4	7.9e-08	-0.95	0.03	0.97	FALSE
13	GTEx	Heart Left Ventricle	MADD	0.14	0.01	enet	17	0.05	7.0e-04	3.8	-5.4	6.8e-08	0.70	0.05	0.89	FALSE
14	GTEx	Heart Left Ventricle	C1QTNF4	0.10	0.11	lasso	1	0.09	1.1e-05	-5.8	5.8	5.2e-09	-1.00	0.01	0.97	FALSE
15	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	-5.8	6.8	1.3e-11	-0.84	0.03	0.95	FALSE
16	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	-4.8	5.3	9.4e-08	-0.91	0.09	0.91	FALSE
17	GTEx	Muscle Skeletal	MTCH2	0.05	0.03	enet	15	0.04	1.5e-04	-5.3	-5.8	8.7e-09	0.84	0.07	0.92	FALSE
18	GTEx	Muscle Skeletal	C1QTNF4	0.09	0.14	lasso	3	0.13	9.9e-13	-5.8	6.0	2.3e-09	-0.98	0.01	0.99	FALSE
19	GTEx	Nerve Tibial	NR1H3	0.10	0.00	enet	24	0.08	4.7e-06	2.2	5.9	4.1e-09	-0.52	0.02	0.71	TRUE
20	GTEx	Nerve Tibial	C1QTNF4	0.20	0.23	enet	12	0.23	1.7e-16	-5.8	5.8	6.2e-09	-0.96	0.01	0.99	FALSE
21	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	4.7	-6.3	3.8e-10	0.60	0.06	0.91	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	C1QTNF4	0.32	0.18	enet	33	0.20	5.2e-11	-5.8	6.0	2.3e-09	-0.90	0.01	0.99	TRUE
23	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	-5.8	5.6	2.4e-08	-0.95	0.01	0.99	FALSE
24	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	-5.7	5.5	4.4e-08	-0.89	0.04	0.96	FALSE
25	GTEx	Thyroid	MADD	0.11	0.00	enet	13	0.01	6.1e-02	-1.3	-5.2	2.3e-07	0.25	0.06	0.06	FALSE
26	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	-5.7	5.6	1.8e-08	-0.86	0.04	0.93	FALSE
27	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	-5.3	5.4	7.7e-08	-0.86	0.17	0.83	FALSE
28	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	-5.3	5.3	8.9e-08	-0.88	0.06	0.94	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	-5.3	-5.5	4.3e-08	0.91	0.17	0.82	TRUE
30	ROSMAP	Brain Pre-frontal Cortex	MADD	0.33	0.16	enet	23	0.23	1.9e-29	4.1	-5.3	8.6e-08	0.08	0.98	0.02	TRUE
31	YFS	Blood	DDB2	0.02	0.00	bslmm	306	0.01	1.9e-04	4.0	-5.5	4.5e-08	0.20	0.25	0.04	FALSE
32	YFS	Blood	FNBP4	0.02	0.01	bslmm	301	0.01	8.9e-05	5.0	-5.5	4.6e-08	0.78	0.05	0.93	FALSE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	-5.3	5.6	1.9e-08	-0.93	0.01	0.98	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	MADD	0.11	0.03	enet	14	0.06	1.4e-11	4.1	-6.5	5.9e-11	0.56	0.02	0.88	FALSE
35	The Cancer Genome Atlas	Colon Adenocarcinoma	C1QTNF4	0.12	0.12	lasso	1	0.12	1.6e-07	-5.8	5.8	5.2e-09	-1.00	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Esophageal Carcinoma	C1QTNF4	0.39	0.33	blup	15	0.35	6.1e-12	-5.8	5.4	5.4e-08	-0.98	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	-5.3	5.3	1.1e-07	-0.88	0.04	0.96	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUP160	0.08	0.03	blup	42	0.04	6.7e-05	-5.7	-6.3	3.1e-10	0.71	0.01	0.97	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	-5.3	5.7	1.4e-08	-0.95	0.04	0.96	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MADD	0.20	0.07	enet	9	0.08	2.4e-09	4.1	-6.4	1.2e-10	0.32	0.03	0.85	FALSE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	-5.3	5.3	9.1e-08	-0.88	0.04	0.96	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	MADD	0.08	0.01	lasso	5	0.05	3.1e-06	-4.4	-6.8	1.2e-11	0.62	0.01	0.67	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	-5.3	-5.3	1.1e-07	0.87	0.04	0.96	FALSE
44	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	-5.3	5.3	1.1e-07	-0.87	0.04	0.96	FALSE
45	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMC3	0.09	0.07	blup	39	0.06	8.7e-04	-4.6	-5.5	4.2e-08	0.85	0.23	0.60	FALSE
46	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	-5.8	6.6	3.3e-11	-0.97	0.01	0.93	TRUE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MADD	0.16	0.05	blup	64	0.08	2.2e-09	-1.5	-5.5	4.7e-08	0.10	0.22	0.02	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	MADD	0.15	0.04	enet	10	0.06	4.5e-07	4.1	-5.4	6.2e-08	0.30	0.02	0.54	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	-5.3	-5.9	2.9e-09	0.83	0.01	0.90	FALSE
50	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	-5.3	5.6	2.1e-08	-0.92	0.01	0.83	FALSE
51	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MADD	0.21	0.04	blup	64	0.07	1.3e-03	3.9	-5.9	3.2e-09	0.28	0.01	0.12	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	C1QTNF4	0.04	0.01	blup	15	0.03	7.9e-04	-5.8	7.0	3.1e-12	-0.89	0.00	0.87	TRUE
53	The Cancer Genome Atlas	Thyroid Carcinoma	MADD	0.07	0.00	enet	11	0.03	6.7e-04	3.1	-5.5	3.1e-08	0.36	0.01	0.13	FALSE