Best TWAS P=1.63e-07 · Best GWAS P=1.84e-09 conditioned to 0.00482
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | COG6 | 0.15 | 0.11 | lasso | 4 | 0.12 | 8.1e-10 | 4.7 | -5.1 | 2.8e-07 | -0.70 | 0.72 | 0.28 | FALSE |
| 2 | GTEx | Lung | COG6 | 0.10 | 0.04 | enet | 13 | 0.06 | 2.5e-05 | 4.5 | -5.2 | 1.7e-07 | -0.63 | 0.68 | 0.24 | TRUE |
| 3 | GTEx | Muscle Skeletal | COG6 | 0.41 | 0.40 | enet | 25 | 0.45 | 8.6e-49 | 4.5 | -5.1 | 2.6e-07 | -0.70 | 0.90 | 0.09 | FALSE |
| 4 | GTEx | Testis | COG6 | 0.43 | 0.37 | enet | 37 | 0.37 | 2.2e-17 | -4.2 | -5.2 | 1.6e-07 | -0.52 | 0.97 | 0.03 | TRUE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | COG6 | 0.13 | 0.15 | lasso | 14 | 0.19 | 1.1e-20 | 4.5 | -5.2 | 1.7e-07 | -0.66 | 0.86 | 0.14 | FALSE |