Best TWAS P=1.02e-11 · Best GWAS P=4.83e-11 conditioned to 0.347
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | REXO1 | 0.07 | 0.01 | bslmm | 391 | 0.01 | 1.7e-02 | -3.5 | 6.7 | 2.0e-11 | 0.51 | 0.04 | 0.85 | TRUE |
| 2 | GTEx | Esophagus Muscularis | KLF16 | 0.17 | 0.07 | enet | 9 | 0.09 | 3.7e-06 | -6.1 | -5.7 | 1.6e-08 | -0.49 | 0.06 | 0.92 | FALSE |
| 3 | GTEx | Esophagus Muscularis | CTB-31O20.6 | 0.16 | 0.07 | lasso | 5 | 0.05 | 7.8e-04 | -6.1 | -6.0 | 1.5e-09 | -0.49 | 0.05 | 0.92 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | ATP8B3 | 0.24 | 0.12 | lasso | 3 | 0.10 | 2.3e-05 | -6.0 | -6.0 | 2.1e-09 | -0.59 | 0.04 | 0.74 | FALSE |
| 5 | GTEx | Stomach | MUM1 | 0.19 | 0.04 | lasso | 2 | 0.07 | 4.3e-04 | -1.7 | -5.5 | 4.4e-08 | -0.32 | 0.14 | 0.59 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | KLF16 | 0.12 | 0.08 | bslmm | 372 | 0.08 | 1.0e-10 | -6.6 | -6.8 | 1.0e-11 | -0.85 | 0.00 | 1.00 | TRUE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ATP8B3 | 0.06 | 0.00 | blup | 49 | 0.03 | 2.7e-04 | -3.5 | -5.7 | 1.1e-08 | -0.55 | 0.05 | 0.41 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ATP8B3 | 0.04 | 0.01 | blup | 49 | 0.02 | 2.2e-03 | -6.6 | -6.2 | 4.6e-10 | -0.85 | 0.00 | 0.73 | FALSE |