Best TWAS P=9.57e-10 · Best GWAS P=1.49e-08 conditioned to 0.0167
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADCY3 | 0.16 | 0.12 | lasso | 10 | 0.14 | 3.2e-17 | -5.4 | 6.1 | 9.6e-10 | -0.62 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Nerve Tibial | ADCY3 | 0.09 | 0.05 | enet | 6 | 0.03 | 2.2e-03 | -3.3 | 5.3 | 1.3e-07 | -0.46 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Nerve Tibial | RP11-443B20.1 | 0.07 | 0.03 | enet | 6 | 0.02 | 1.1e-02 | -3.3 | 5.3 | 1.0e-07 | -0.58 | 0.05 | 0.94 | FALSE |
| 4 | GTEx | Whole Blood | ADCY3 | 0.23 | 0.24 | enet | 24 | 0.27 | 5.5e-25 | -5.1 | -5.6 | 2.6e-08 | 0.48 | 0.05 | 0.94 | FALSE |
| 5 | GTEx | Whole Blood | RP11-443B20.1 | 0.21 | 0.17 | enet | 32 | 0.20 | 1.8e-18 | -4.5 | -5.4 | 5.1e-08 | 0.49 | 0.08 | 0.91 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | ADCY3 | 0.17 | 0.26 | enet | 32 | 0.26 | 6.8e-33 | -5.1 | 5.3 | 8.9e-08 | -0.41 | 0.05 | 0.95 | FALSE |