Best TWAS P=9.49e-09 · Best GWAS P=2.8e-09 conditioned to 0.115
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | MSH6 | 0.09 | 0.04 | lasso | 2 | 0.03 | 4.1e-03 | 5.8 | 5.7 | 9.5e-09 | 0.95 | 0 | 0.99 | TRUE |
| 2 | GTEx | Lung | MSH6 | 0.16 | 0.02 | lasso | 4 | 0.04 | 2.4e-04 | 5.8 | 5.2 | 2.1e-07 | 0.82 | 0 | 0.99 | FALSE |
| 3 | GTEx | Testis | MSH6 | 0.26 | 0.19 | lasso | 2 | 0.19 | 1.0e-08 | 5.8 | 5.7 | 1.3e-08 | 0.97 | 0 | 1.00 | FALSE |
| 4 | GTEx | Thyroid | MSH6 | 0.15 | 0.17 | enet | 12 | 0.16 | 3.5e-12 | 5.8 | 5.2 | 1.8e-07 | 0.90 | 0 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MSH6 | 0.03 | 0.01 | blup | 26 | 0.01 | 1.5e-02 | 5.9 | 5.3 | 1.1e-07 | 0.83 | 0 | 0.98 | FALSE |