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chr19:35,448,803-36,956,110

Best TWAS P=4.94e-13 · Best GWAS P=1e-11 conditioned to 0.0543

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	U2AF1L4	0.09	0.06	lasso	4	0.06	4.6e-08	6.3	-6.5	1.1e-10	-0.91	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	COX6B1	0.11	0.09	lasso	3	0.07	1.3e-06	5.6	-5.5	4.0e-08	-0.37	0.31	0.68	FALSE
3	GTEx	Adipose Subcutaneous	C19orf55	0.14	0.08	enet	13	0.10	2.7e-08	6.5	-6.7	2.9e-11	-0.87	0.01	0.99	FALSE
4	GTEx	Adipose Visceral Omentum	C19orf55	0.16	0.05	lasso	4	0.08	5.9e-05	5.3	-5.4	6.9e-08	-0.34	0.20	0.45	FALSE
5	GTEx	Artery Tibial	COX6B1	0.13	0.08	enet	6	0.06	9.7e-06	6.0	-6.1	1.2e-09	-0.35	0.21	0.79	FALSE
6	GTEx	Artery Tibial	C19orf55	0.11	0.03	lasso	5	0.00	1.2e-01	5.3	-5.3	1.5e-07	-0.43	0.13	0.39	FALSE
7	GTEx	Brain Cerebellar Hemisphere	U2AF1L4	0.24	0.07	lasso	6	0.05	1.6e-02	5.3	6.2	6.5e-10	0.53	0.05	0.56	FALSE
8	GTEx	Brain Cerebellum	COX6B1	0.33	0.27	enet	22	0.19	3.5e-06	6.1	-5.6	2.1e-08	-0.41	0.17	0.81	FALSE
9	GTEx	Brain Cerebellum	U2AF1L4	0.36	0.03	lasso	11	0.07	5.0e-03	5.8	5.4	6.2e-08	0.48	0.07	0.63	FALSE
10	GTEx	Brain Cerebellum	C19orf55	0.26	0.04	lasso	11	0.00	2.7e-01	5.3	-5.5	4.1e-08	-0.55	0.04	0.63	FALSE
11	GTEx	Brain Cortex	COX6B1	0.39	0.00	enet	28	0.18	1.0e-05	4.2	-5.8	6.9e-09	-0.39	0.04	0.75	FALSE
12	GTEx	Breast Mammary Tissue	C19orf55	0.19	0.10	lasso	6	0.08	6.9e-05	6.4	-6.2	6.2e-10	-0.95	0.01	0.97	FALSE
13	GTEx	Breast Mammary Tissue (Female)	C19orf55	0.14	0.08	lasso	5	0.04	2.1e-02	6.4	-6.6	3.3e-11	-0.96	0.02	0.79	FALSE
14	GTEx	Colon Transverse	C19orf55	0.26	0.13	lasso	8	0.13	1.2e-06	-5.5	-5.7	1.5e-08	-0.35	0.36	0.62	FALSE
15	GTEx	Esophagus Muscularis	COX6B1	0.10	0.12	enet	7	0.11	5.7e-07	5.6	-6.1	8.6e-10	-0.39	0.17	0.83	FALSE
16	GTEx	Esophagus Muscularis	C19orf55	0.16	0.07	lasso	4	0.10	2.0e-06	-4.8	-5.4	7.4e-08	-0.49	0.13	0.80	FALSE
17	GTEx	Lung	C19orf55	0.11	0.03	enet	21	0.01	2.4e-02	-5.5	-5.6	2.3e-08	-0.46	0.27	0.60	FALSE
18	GTEx	Muscle Skeletal	COX6B1	0.24	0.20	lasso	6	0.23	4.4e-22	5.6	-5.8	5.9e-09	-0.34	0.48	0.52	FALSE
19	GTEx	Nerve Tibial	COX6B1	0.23	0.12	enet	13	0.13	2.6e-09	-5.5	-5.5	4.0e-08	-0.33	0.22	0.78	FALSE
20	GTEx	Nerve Tibial	U2AF1L4	0.28	0.11	lasso	5	0.12	4.8e-09	4.0	6.2	6.7e-10	0.43	0.91	0.08	FALSE
21	GTEx	Pancreas	C19orf55	0.20	0.01	lasso	4	0.01	1.0e-01	5.3	-6.1	9.7e-10	-0.64	0.03	0.78	FALSE
22	GTEx	Pituitary	C19orf55	0.27	0.10	lasso	7	0.13	4.5e-04	-5.8	-6.1	1.0e-09	-0.42	0.10	0.62	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	C19orf55	0.33	0.09	lasso	10	0.19	1.0e-10	6.5	-6.6	4.0e-11	-0.81	0.01	0.99	FALSE
24	GTEx	Skin Sun Exposed Lower leg	COX6B1	0.11	0.07	enet	12	0.02	9.9e-03	6.1	-5.8	8.0e-09	-0.35	0.15	0.84	FALSE
25	GTEx	Skin Sun Exposed Lower leg	C19orf55	0.13	0.04	lasso	4	0.07	1.4e-06	3.9	-5.9	3.0e-09	-0.74	0.02	0.98	FALSE
26	GTEx	Stomach	AC002398.13	0.14	0.09	enet	7	0.12	1.5e-06	-5.5	-5.5	4.0e-08	-0.45	0.37	0.56	FALSE
27	GTEx	Thyroid	C19orf55	0.19	0.06	enet	26	0.10	2.0e-08	5.3	-6.0	2.0e-09	-0.60	0.51	0.49	FALSE
28	NTR	Blood	COX6B1	0.04	0.02	lasso	6	0.02	6.4e-08	5.6	-6.0	2.6e-09	-0.37	0.29	0.71	FALSE
29	YFS	Blood	COX6B1	0.11	0.11	bslmm	429	0.11	9.3e-34	-5.5	-5.3	1.4e-07	-0.40	0.73	0.27	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	RBM42	0.03	0.00	enet	10	0.01	6.8e-03	5.3	5.5	4.0e-08	0.32	0.01	0.33	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZBTB32	0.07	0.10	lasso	6	0.10	7.6e-19	6.0	5.7	1.4e-08	0.31	0.16	0.84	FALSE
32	The Cancer Genome Atlas	Glioblastoma Multiforme	ZBTB32	0.12	0.07	enet	7	0.05	1.2e-02	-5.8	6.2	7.2e-10	0.41	0.04	0.22	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	U2AF1L4	0.08	0.06	enet	5	0.07	4.0e-08	6.5	-5.8	7.2e-09	-0.95	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UPK1A	0.03	0.00	blup	41	0.01	4.3e-02	4.6	7.2	4.9e-13	0.77	0.01	0.62	TRUE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZBTB32	0.14	0.10	lasso	4	0.09	1.9e-10	6.0	6.1	1.3e-09	0.38	0.15	0.85	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	COX6B1	0.20	0.06	lasso	2	0.06	2.9e-04	-5.5	-5.5	4.9e-08	-0.26	0.40	0.13	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ZBTB32	0.17	0.23	enet	5	0.21	3.2e-12	-5.8	6.1	9.9e-10	0.38	0.17	0.83	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	COX6B1	0.08	0.07	enet	3	0.06	4.0e-07	-5.5	-5.6	2.1e-08	-0.34	0.72	0.27	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	UPK1A	0.08	0.10	enet	5	0.10	1.9e-11	-5.5	5.6	2.3e-08	0.31	0.76	0.24	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	U2AF1L4	0.09	0.03	lasso	4	0.02	1.3e-03	6.3	-5.5	3.5e-08	-0.93	0.01	0.98	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	ZBTB32	0.05	0.06	lasso	4	0.05	1.0e-06	-5.8	6.0	2.1e-09	0.39	0.19	0.81	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	U2AF1L4	0.05	0.04	blup	46	0.04	2.6e-05	6.4	-5.3	1.4e-07	-0.82	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ZBTB32	0.17	0.19	enet	10	0.19	1.0e-12	-5.8	5.7	1.6e-08	0.30	0.18	0.82	FALSE
44	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ZBTB32	0.14	0.07	enet	7	0.07	1.1e-03	6.1	5.9	4.1e-09	0.40	0.14	0.59	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZBTB32	0.12	0.20	enet	7	0.17	9.2e-18	6.0	6.0	2.5e-09	0.36	0.20	0.80	FALSE
46	The Cancer Genome Atlas	Soft Tissue Sarcoma	U2AF1L4	0.10	0.03	blup	46	0.05	5.5e-04	6.3	-5.5	4.9e-08	-0.73	0.01	0.89	FALSE
47	The Cancer Genome Atlas	Soft Tissue Sarcoma	ZBTB32	0.06	0.03	lasso	3	0.04	2.5e-03	5.9	5.9	4.7e-09	0.36	0.06	0.30	FALSE
48	The Cancer Genome Atlas	Skin Cutaneous Melanoma	UPK1A	0.30	0.12	lasso	3	0.12	4.1e-04	5.8	5.9	3.1e-09	0.63	0.03	0.31	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	ARHGAP33	0.06	0.03	enet	10	0.05	1.1e-05	6.4	-5.8	7.2e-09	-0.86	0.01	0.99	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	ZBTB32	0.15	0.20	enet	13	0.21	1.0e-19	5.9	5.3	1.4e-07	0.31	0.23	0.77	FALSE