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chr21:39,849,553-41,498,432

Best TWAS P=2.66e-15 · Best GWAS P=1.11e-13 conditioned to 0.0186

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	BRWD1	0.12	0.15	lasso	8	0.15	1.1e-17	5.9	-6.3	2.2e-10	0.56	0.95	0.05	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PSMG1	0.19	0.24	enet	30	0.26	2.0e-31	-6.0	-6.4	2.0e-10	0.84	0.93	0.07	FALSE
3	CommonMind	Brain Pre-frontal Cortex	WRB	0.04	0.00	bslmm	698	0.01	7.7e-03	4.8	5.6	2.5e-08	-0.56	0.14	0.18	FALSE
4	GTEx	Adipose Subcutaneous	PSMG1	0.19	0.12	enet	26	0.13	4.1e-11	6.0	-6.6	3.8e-11	0.72	0.93	0.07	FALSE
5	GTEx	Adipose Subcutaneous	BRWD1-IT2	0.11	0.08	lasso	3	0.06	7.0e-06	-6.0	6.1	9.8e-10	-0.87	0.13	0.86	FALSE
6	GTEx	Adipose Visceral Omentum	BRWD1-IT2	0.13	0.01	lasso	3	0.02	2.4e-02	6.1	6.1	9.9e-10	-0.59	0.49	0.35	FALSE
7	GTEx	Artery Aorta	PSMG1	0.13	0.08	lasso	2	0.04	3.6e-03	5.4	-5.4	6.6e-08	0.70	0.33	0.08	FALSE
8	GTEx	Artery Coronary	PSMG1	0.24	0.07	lasso	5	0.04	1.4e-02	5.4	-5.6	2.5e-08	0.69	0.08	0.72	FALSE
9	GTEx	Artery Tibial	PSMG1	0.26	0.25	enet	37	0.31	7.8e-25	-6.0	-6.1	7.8e-10	0.82	0.94	0.06	FALSE
10	GTEx	Artery Tibial	BRWD1-IT2	0.15	0.13	lasso	3	0.12	9.0e-10	5.8	6.0	1.5e-09	-0.87	0.03	0.97	FALSE
11	GTEx	Brain Cerebellum	PSMG1	0.28	0.13	lasso	8	0.09	1.2e-03	-6.1	-5.9	3.2e-09	0.85	0.07	0.80	FALSE
12	GTEx	Brain Hypothalamus	PSMG1	0.46	0.20	lasso	5	0.16	1.5e-04	-6.0	-6.4	1.9e-10	0.81	0.07	0.90	FALSE
13	GTEx	Breast Mammary Tissue	PSMG1	0.28	0.26	lasso	4	0.23	5.2e-12	6.0	-6.2	5.2e-10	0.64	0.91	0.09	FALSE
14	GTEx	Breast Mammary Tissue (Female)	PSMG1	0.14	0.09	lasso	11	0.07	3.3e-03	6.0	-6.5	7.0e-11	0.64	0.14	0.57	FALSE
15	GTEx	Cells Transformed fibroblasts	HMGN1	0.07	0.03	lasso	4	0.03	2.1e-03	6.3	-6.2	5.4e-10	0.65	0.47	0.20	FALSE
16	GTEx	Colon Transverse	PSMG1	0.23	0.19	lasso	5	0.22	1.4e-10	-6.0	-6.5	7.7e-11	0.82	0.90	0.10	FALSE
17	GTEx	Colon Transverse	BRWD1-IT2	0.28	0.01	enet	41	0.04	8.4e-03	-6.0	5.5	4.4e-08	-0.61	0.04	0.76	FALSE
18	GTEx	Esophagus Mucosa	PSMG1	0.37	0.38	lasso	5	0.37	6.4e-26	6.1	-6.1	9.1e-10	0.59	0.89	0.11	FALSE
19	GTEx	Esophagus Mucosa	HMGN1	0.11	0.08	lasso	4	0.07	2.6e-05	6.2	-6.5	1.1e-10	0.66	0.75	0.17	FALSE
20	GTEx	Esophagus Mucosa	BRWD1-IT2	0.08	0.06	lasso	5	0.06	3.9e-05	5.5	7.0	3.3e-12	-0.88	0.03	0.96	FALSE
21	GTEx	Esophagus Muscularis	PSMG1	0.15	0.10	lasso	4	0.07	3.9e-05	5.4	-5.4	6.3e-08	0.70	0.90	0.08	FALSE
22	GTEx	Heart Atrial Appendage	PSMG1	0.14	0.12	lasso	2	0.10	2.2e-05	5.4	-5.4	6.6e-08	0.70	0.65	0.19	FALSE
23	GTEx	Lung	PSMG1	0.12	0.13	lasso	5	0.12	3.4e-09	5.5	-6.1	1.1e-09	0.78	0.54	0.46	FALSE
24	GTEx	Muscle Skeletal	PSMG1	0.13	0.16	enet	15	0.19	7.1e-18	6.6	-6.8	1.2e-11	0.81	0.44	0.56	FALSE
25	GTEx	Muscle Skeletal	BRWD1-IT2	0.06	0.02	lasso	4	0.01	1.7e-02	6.3	5.9	4.4e-09	-0.74	0.25	0.48	FALSE
26	GTEx	Nerve Tibial	PSMG1	0.27	0.24	lasso	5	0.21	1.6e-14	5.3	-5.2	2.2e-07	0.70	1.00	0.00	FALSE
27	GTEx	Nerve Tibial	BRWD1-IT2	0.11	0.08	lasso	2	0.05	3.0e-04	-6.0	6.0	1.6e-09	-0.87	0.13	0.84	FALSE
28	GTEx	Pancreas	BRWD1-IT2	0.18	0.05	lasso	6	0.02	6.1e-02	-6.1	5.3	1.5e-07	-0.79	0.32	0.48	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	PSMG1	0.26	0.34	lasso	5	0.34	2.1e-19	6.0	-5.5	3.7e-08	0.50	0.91	0.09	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	BRWD1-IT2	0.13	0.09	lasso	3	0.08	2.5e-05	-6.0	6.3	3.1e-10	-0.86	0.03	0.96	FALSE
31	GTEx	Skin Sun Exposed Lower leg	PSMG1	0.32	0.38	lasso	3	0.38	5.5e-33	6.0	-6.0	1.9e-09	0.58	0.92	0.08	FALSE
32	GTEx	Skin Sun Exposed Lower leg	BRWD1	0.09	0.05	lasso	8	0.04	4.9e-04	6.1	-6.0	1.6e-09	0.58	0.07	0.81	FALSE
33	GTEx	Testis	PSMG1	0.30	0.10	lasso	4	0.06	9.5e-04	6.6	-6.2	6.6e-10	0.71	0.19	0.24	FALSE
34	GTEx	Testis	HMGN1	0.21	0.22	lasso	3	0.21	9.7e-10	6.2	-6.6	3.1e-11	0.71	0.63	0.37	FALSE
35	GTEx	Testis	BRWD1-IT2	0.49	0.45	enet	19	0.46	9.0e-23	-5.9	-5.9	3.7e-09	0.86	0.95	0.05	FALSE
36	GTEx	Thyroid	BRWD1-IT2	0.16	0.13	lasso	6	0.14	1.1e-10	-6.0	6.4	1.7e-10	-0.85	0.31	0.69	FALSE
37	GTEx	Vagina	PSMG1	0.40	0.16	lasso	8	0.20	2.1e-05	-6.0	-7.9	2.7e-15	0.74	0.14	0.73	TRUE
38	METSIM	Adipose	HMGN1	0.11	0.13	lasso	5	0.11	9.7e-17	6.3	-6.3	3.6e-10	0.69	0.74	0.26	FALSE
39	METSIM	Adipose	PSMG1	0.05	0.01	bslmm	638	0.02	3.6e-04	-7.4	-6.3	2.3e-10	0.78	0.02	0.98	FALSE
40	YFS	Blood	BRWD1	0.34	0.50	enet	89	0.52	1.3e-202	-6.0	-5.6	2.3e-08	0.85	0.93	0.07	FALSE
41	YFS	Blood	WRB	0.20	0.29	enet	18	0.29	8.4e-95	4.7	5.1	3.0e-07	-0.37	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HMGN1	0.07	0.12	lasso	5	0.09	6.2e-08	6.2	-6.5	1.1e-10	0.68	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	HMGN1	0.04	0.05	lasso	4	0.05	5.9e-10	6.2	-6.5	7.1e-11	0.70	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	PSMG1	0.05	0.09	lasso	4	0.08	1.7e-16	6.1	-6.2	6.0e-10	0.62	0.07	0.93	FALSE
45	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	HMGN1	0.10	0.03	lasso	2	0.04	3.7e-03	5.4	-5.6	2.1e-08	0.57	0.02	0.62	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	HMGN1	0.06	0.03	blup	43	0.05	1.3e-03	6.2	-6.9	3.8e-12	0.62	0.00	0.94	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMG1	0.09	0.05	lasso	2	0.03	6.5e-03	5.3	-5.3	9.0e-08	0.70	0.03	0.33	FALSE
48	The Cancer Genome Atlas	Glioblastoma Multiforme	HMGN1	0.19	0.04	blup	43	0.08	2.1e-03	4.0	-5.6	2.6e-08	0.58	0.01	0.87	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HMGN1	0.08	0.10	lasso	2	0.09	8.7e-11	6.2	-6.2	4.5e-10	0.69	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PSMG1	0.04	0.04	lasso	2	0.03	2.5e-04	5.4	-5.4	6.6e-08	0.70	0.17	0.50	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HMGN1	0.17	0.14	lasso	4	0.14	2.4e-15	6.2	-6.3	2.2e-10	0.68	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSMG1	0.08	0.07	lasso	4	0.06	1.4e-07	-6.1	-6.4	1.3e-10	0.86	0.11	0.89	FALSE
53	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	HMGN1	0.13	0.12	enet	6	0.14	1.9e-08	6.0	-5.7	1.1e-08	0.61	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMG1	0.08	0.06	blup	61	0.06	2.5e-04	5.3	-6.5	1.1e-10	0.74	0.07	0.67	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	BRWD1	0.11	0.03	enet	9	0.03	1.5e-04	-6.6	-5.9	4.6e-09	0.33	0.10	0.31	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	HMGN1	0.14	0.08	blup	43	0.08	3.9e-09	6.2	-6.7	2.6e-11	0.71	0.00	1.00	FALSE
57	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HMGN1	0.12	0.12	enet	7	0.12	1.9e-06	6.0	-6.3	2.8e-10	0.64	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMG1	0.07	0.07	blup	61	0.04	6.3e-03	6.6	-6.5	9.9e-11	0.76	0.01	0.93	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	PSMG1	0.04	0.02	blup	61	0.03	4.8e-04	6.0	-6.6	4.1e-11	0.76	0.03	0.96	FALSE
60	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HMGN1	0.05	0.03	lasso	3	0.03	1.6e-04	5.4	-6.0	2.4e-09	0.61	0.01	0.98	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PSMG1	0.04	0.04	blup	61	0.04	2.1e-05	-6.1	-7.0	3.3e-12	0.82	0.03	0.97	FALSE
62	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HMGN1	0.06	0.05	blup	43	0.02	1.6e-02	6.2	-5.9	3.8e-09	0.40	0.00	0.95	FALSE
63	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PSMG1	0.11	0.10	blup	61	0.08	2.2e-04	6.0	-5.8	8.1e-09	0.74	0.04	0.91	FALSE
64	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HMGN1	0.12	0.13	lasso	4	0.12	2.2e-05	6.0	-6.4	1.2e-10	0.60	0.02	0.96	FALSE
65	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PSMG1	0.07	0.04	blup	61	0.06	1.7e-03	3.9	-6.8	1.1e-11	0.71	0.04	0.83	FALSE
66	The Cancer Genome Atlas	Prostate Adenocarcinoma	HMGN1	0.27	0.06	enet	17	0.10	2.5e-10	6.2	-5.8	5.3e-09	0.54	0.00	1.00	FALSE
67	The Cancer Genome Atlas	Skin Cutaneous Melanoma	WRB	0.12	0.06	blup	48	0.10	1.2e-03	4.0	5.3	1.4e-07	-0.42	0.03	0.19	FALSE
68	The Cancer Genome Atlas	Stomach Adenocarcinoma	BRWD1	0.04	0.02	blup	97	0.03	2.3e-03	5.4	-6.7	1.8e-11	0.63	0.10	0.14	FALSE
69	The Cancer Genome Atlas	Stomach Adenocarcinoma	HMGN1	0.07	0.08	lasso	2	0.06	2.9e-05	6.2	-6.2	4.5e-10	0.69	0.00	1.00	FALSE
70	The Cancer Genome Atlas	Stomach Adenocarcinoma	PSMG1	0.05	0.02	blup	61	0.02	1.4e-02	-6.0	-6.2	6.2e-10	0.83	0.02	0.75	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	HMGN1	0.15	0.21	lasso	4	0.20	9.9e-19	6.2	-6.5	1.0e-10	0.73	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Thyroid Carcinoma	PSMG1	0.03	0.01	blup	61	0.02	9.1e-03	5.4	-6.4	2.1e-10	0.70	0.04	0.36	FALSE
73	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	HMGN1	0.23	0.09	enet	8	0.18	9.6e-06	-5.9	-5.9	3.3e-09	0.77	0.01	0.99	FALSE