Hub : Genes

RBM42

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0256	0.0118	0.0160	0.006	0.003	0.001	0.004	0.002	0.0044	0.0240	0.1000	0.017	0.082
2	TCGA	Breast Invasive Carcinoma	0.0296	0.0177	0.0038	0.004	0.006	0.008	NA	0.004	0.0360	0.0150	0.0068	NA	0.042
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0609	0.0350	0.0046	0.006	0.014	0.001	NA	0.012	0.0660	0.0086	0.2200	NA	0.015

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.3	1.7	1.3	1.1	-1.1
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	-0.1	-0.3	-0.0
Depressed Affect (Nagel 2018)	0.5	1.0	2.3	-0.1	-1.5	-0.9
Depression (Nagel 2018)	0.1	0.2	0.4	0.5	0.3	-0.6
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.1	-1.1	0.1	2.0
Neuroticism (Nagel 2018)	0.2	0.5	1.4	0.5	-1.2	0.0
Schizophrenia (2018)	0.5	1.1	1.6	-1.1	-1.3	0.8
Schizophrenia vs Biploar Disorder	0.2	0.3	0.4	-0.5	0.4	0.7
Worry (Nagel 2018)	0.2	0.4	1.1	0.4	0.3	1.0
Alzheimer’s Disease (in mother)	0.6	0.7	0.7	-0.8	-0.8	-0.8
Alzheimer’s Disease (in father)	0.2	0.3	0.8	-0.1	-0.9	0.0
Alzheimer’s Disease (including proxy)	0.9	1.3	1.9	-1.0	-1.4	-1.0
Crohns Disease (2017)	0.5	1.0	2.9	0.4	0.0	1.7
Irritable Bowel Disease (IBD)	0.5	1.1	2.5	0.7	-0.7	1.6
Ulcerative Colitis (UC)	0.3	0.5	1.0	0.2	-0.8	1.0
Major Depression (MDD)	2.5	3.0	4.9	2.0	2.2	-0.4
Reaction Time	0.5	1.0	1.5	-1.2	-1.0	-0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.7	-0.5	0.5	1.3
Breast Cancer	0.2	0.6	0.9	0.5	-0.8	0.9
Ovarian Cancer	0.4	0.5	1.0	-0.1	-1.0	-0.7
Prostate Cancer	0.7	0.9	2.1	1.4	0.1	-0.8
Age at First Birth	0.5	0.7	1.9	-1.4	-0.4	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	2.6	-0.6	0.6	-1.6
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.1	0.0	0.6
Crohns Disease (2012)	0.3	0.4	0.7	0.5	0.6	0.8
Mean Putamen Volume	0.7	0.8	2.3	-0.3	-0.1	-1.5
Fasting Glucose	0.7	0.8	2.1	1.4	0.4	-0.5
HbA1C	0.7	0.8	1.5	0.1	-0.9	1.2
HDL Cholesterol	1.2	2.1	3.8	1.4	0.6	-2.0
LDL Cholesterol	0.3	0.4	0.5	0.6	-0.7	-0.6
Lupus	0.0	0.0	0.1	-0.1	0.2	0.1
Neuroticism (2016)	0.5	0.8	1.4	1.2	0.7	-0.7
Primary Biliary Cirrhosis	1.5	2.1	3.1	-0.7	-1.8	-1.6
Rheumatoid Arthritis	0.3	0.4	0.6	-0.7	0.2	-0.8
Schizophrenia (2014)	0.0	0.1	0.2	0.1	-0.4	0.3
Triglycerides	0.0	0.0	0.1	-0.0	-0.2	0.3
Type 2 Diabetes (T2D) (2012)	1.6	1.8	2.7	-1.1	-1.6	-1.3
Ulcerative Colitis	0.6	0.9	2.1	-0.3	-0.7	1.5
Blood Eosinophil Count	0.3	2.5	7.4	-0.3	-2.7	0.2
Blood Platelet Count	0.2	2.1	2.7	1.6	-1.2	-1.5
Blood Red Count	0.0	0.5	0.8	0.3	-0.9	-0.8
Blood White Count	0.1	0.7	1.1	0.0	-1.0	-1.0
Heel T-Score	0.3	2.1	4.8	-0.1	-1.2	-2.2
BMI	0.4	2.5	7.0	2.6	0.1	-0.8
Height	1.2	22.3	36.0	2.2	5.1	6.0
Waist Hip Ratio (WHR)	0.2	1.0	1.6	0.1	-1.1	-1.2
Systolic Blood Pressure	0.3	1.6	2.9	-0.6	1.7	1.2
Smoking Status	0.5	1.2	2.0	1.2	-1.4	-0.6
Allergy or Eczema	0.2	0.4	0.7	0.6	0.9	-0.3
Cardiovascular Disease	0.6	2.1	4.9	1.1	2.2	-0.2
Hypothyroidism (self reported)	0.4	0.9	1.3	-1.1	1.1	-0.4
Respiratory disease	0.6	1.4	3.5	1.9	-0.5	0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	-0.7	0.8	0.3
Lung FEV1/FVC ratio	0.2	1.2	1.7	0.5	1.3	1.3
Lung FVC	0.0	0.2	0.5	-0.7	-0.2	0.1
Neuroticism	0.1	0.2	0.4	0.5	-0.6	-0.2
Chronotype (morning person)	0.5	1.2	2.2	1.5	1.2	0.2
Hair Pigment	0.0	1.2	3.5	-0.5	-1.9	-0.3
Tanning	0.3	3.8	5.2	1.3	-2.3	-2.1
Hand grip strength (left)	0.8	2.2	6.0	0.4	-0.7	2.5
Number of treatments/medications taken	0.4	0.8	1.3	1.2	0.1	-1.0
Average weekly spirits intake	0.5	0.7	1.9	0.2	-1.4	-0.2
Sensitivity / hurt feelings	0.3	0.5	0.8	0.9	-0.5	-0.6
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.1	0.2	0.1
Hearing difficulty/problems: Yes	0.8	1.3	2.2	1.5	0.2	1.2
Relative age of first facial hair	0.6	1.3	3.2	0.1	0.8	1.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.4	0.8	1.2	0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	-0.2	0.7	-0.2
Ever had hysterectomy (womb removed)	1.6	1.8	5.2	2.3	0.4	-0.1
Systolic blood pressure, automated reading	0.7	2.1	3.4	0.6	1.8	1.6
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.1	1.0	1.8	-0.7
Angina	0.3	0.4	0.6	0.3	0.8	-0.6
Medication for hormone replacement therapy	1.6	1.8	2.9	-0.3	1.7	1.6
Vitamin and mineral supplements	2.4	3.3	7.7	-0.3	-2.8	-1.4
Supplements: Zinc	1.0	1.0	1.8	-0.4	1.3	1.0
Medication: Co-codamol	2.0	2.4	6.4	2.5	0.8	0.3
Medication: Metformin	0.1	0.1	0.3	-0.6	0.1	0.2
Diabetes (father)	0.5	0.6	0.8	-0.9	-0.4	-0.8
Diabetes (mother)	2.6	3.3	8.8	3.0	-1.0	0.4
Severe depression (siblings)	3.1	3.4	10.2	-3.2	-0.1	0.2
Pack years adult smoking proportion	0.2	0.3	0.4	0.7	-0.6	0.2
Impedance of leg (right)	0.1	0.7	1.7	-1.3	-0.2	-0.5
Leg fat-free mass (left)	0.5	2.8	7.1	2.7	0.8	0.8
Trunk fat percentage	0.5	1.9	4.2	2.1	-1.2	0.0
Hand grip strength (right)	1.1	2.9	8.5	-0.3	-0.0	2.9
Townsend deprivation index at recruitment	1.8	2.5	3.0	-1.3	-1.7	-1.6
Current tobacco smoking	0.5	0.8	1.5	1.0	-1.2	-0.1
Average weekly fortified wine intake	1.9	2.2	4.3	-2.1	-1.3	-0.7
Maternal smoking around birth	0.4	0.6	1.2	-0.1	-0.8	1.1
Fed-up feelings	0.5	0.8	2.3	0.4	-1.5	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.4	0.4	-1.0	-1.6
Relative age voice broke	3.3	5.0	8.2	-1.3	2.3	2.9
Taking other prescription medications	1.2	1.8	4.3	0.9	-0.4	-2.1
Age when periods started (menarche)	8.1	19.4	30.1	2.0	5.5	4.9
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.4	1.2	0.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	0.7	-0.1	0.2
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	2.4	-1.4	0.9	-1.5
Qualifications: CSEs or equivalent	1.2	1.5	3.6	1.9	-0.2	-0.9
Serious illness, injury or assault to yourself	1.1	1.3	2.9	-1.7	0.4	0.9
High blood pressure	1.1	3.0	4.5	2.1	2.1	0.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.3	0.1	1.0	-1.1
Multivitamins +/- minerals	2.5	3.2	6.6	-0.5	2.6	1.7
Stomach or abdominal pain in last month	0.4	0.5	0.8	-0.9	0.2	-0.8
Supplements: Glucosamine	1.1	1.5	4.3	0.2	-0.2	2.1
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.2	0.0	1.1	1.5
Medication: Atenolol	0.0	0.1	0.1	0.3	0.1	0.3
Medication: Levothyroxine sodium	0.7	1.2	1.8	-0.9	-1.3	-0.9
Sitting height	0.5	3.2	5.2	2.3	2.0	0.8
Chronic bronchitis/emphysema (father)	0.3	0.4	0.7	0.3	-0.9	-0.6
High blood pressure (mother)	2.0	2.9	6.8	-0.2	2.6	1.4
Body mass index (BMI)	0.7	2.9	7.0	2.6	-1.0	-0.7
Impedance of leg (left)	0.1	0.6	1.7	-1.3	-0.2	0.4
Leg predicted mass (left)	0.5	2.8	7.1	2.7	0.8	0.7
Trunk fat mass	0.5	2.3	6.4	2.5	-0.5	0.5
Waist circumference	0.7	2.6	7.0	2.6	-0.5	0.7
Number of incorrect matches in round	0.6	1.0	1.6	-0.9	-0.8	-1.3
Past tobacco smoking	0.1	0.2	0.5	-0.2	0.7	-0.3
Alcohol usually taken with meals	0.2	0.3	0.4	-0.5	-0.7	0.4
Nervous feelings	0.3	0.6	0.9	0.9	1.0	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	0.2	0.2	0.2
Hearing difficulty/problems with background noise	0.5	0.7	2.0	0.3	0.3	1.4
Hair/balding pattern: Pattern 2	0.0	0.1	0.2	-0.0	0.0	0.4
Had menopause	0.2	0.3	0.7	0.4	-0.2	-0.8
Had other major operations	0.1	0.2	0.2	0.4	-0.5	0.4
Forced vital capacity (FVC)	0.2	0.7	0.9	1.0	0.9	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	-0.0	0.1	-0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	-0.2	0.8	0.4
Qualifications: None of the above	0.4	0.9	2.6	0.4	-0.2	-1.6
Financial difficulties in last 2 years	0.4	0.5	0.8	0.9	0.8	0.5
Mouth/teeth dental problems	0.1	0.2	0.3	0.6	-0.2	-0.5
Heart attack	0.3	0.4	1.1	-0.3	1.0	0.0
Allergy	0.2	0.3	0.6	-0.8	-0.3	0.6
Pain all over the body in last month	0.1	0.2	0.3	0.6	0.1	0.4
Diabetes (self-reported)	0.5	0.8	1.8	-0.7	1.4	0.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.3	-1.1	-0.6	0.5
Medication: Ramipril	2.4	3.1	7.2	0.1	2.7	1.4
Medication: Simvastatin	0.3	0.4	0.7	0.7	-0.8	-0.2
Fluid intelligence score	1.3	2.8	6.7	0.4	1.2	2.6
Illnesses of siblings	0.8	1.1	1.7	-1.3	-0.3	1.3
Neuroticism score	0.2	0.3	0.6	0.6	-0.4	-0.7
Weight	0.9	4.3	12.0	3.5	0.2	0.9
Impedance of arm (right)	0.7	3.2	5.5	-2.4	-1.9	-0.5
Arm fat percentage (right)	0.6	2.2	3.5	1.5	-1.9	-0.9
Trunk fat-free mass	0.7	3.9	5.5	2.4	1.6	2.0
Hip circumference	0.6	2.7	5.8	2.4	0.4	1.5
Time employed in main current job	1.1	1.3	3.2	-0.0	-1.8	0.7
Alcohol intake versus 10 years previously	0.4	0.6	1.2	-0.5	-0.5	-1.1
Father’s age at death	0.2	0.2	0.5	-0.7	0.2	0.3
Worrier / anxious feelings	0.6	1.2	3.4	-0.0	-0.2	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.7	0.4	-0.9	-0.6
Falls in the last year	0.2	0.3	0.6	-0.2	-0.6	-0.8
Hair/balding pattern: Pattern 3	0.5	0.7	1.6	0.5	-1.3	0.4
Number of live births	1.4	1.9	4.1	1.0	0.9	-2.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.8	0.9	1.3	0.9
Pulse rate	0.1	0.1	0.2	0.3	-0.4	-0.3
Happiness	0.8	1.0	2.4	-1.6	0.6	0.5
Noisy workplace	0.8	1.0	2.6	1.6	0.3	0.5
Qualifications: A levels/AS levels or equivalent	1.7	3.7	5.8	-2.4	0.1	2.3
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	5.4	0.5	2.3	0.5
Mouth/teeth dental problems: Dentures	0.0	0.1	0.2	-0.3	-0.4	0.1
Asthma	0.3	0.7	1.8	0.4	-1.3	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.4	0.2	0.1
Medication: Cholesterol lowering	0.0	0.1	0.2	-0.0	0.1	0.5
Depression (self-reported)	0.2	0.3	0.4	-0.4	0.5	-0.6
Medication: Lansoprazole	0.5	0.6	0.9	-0.7	-0.6	1.0
Prospective memory result	1.1	1.4	2.8	0.1	-1.7	-1.2
Lung cancer (father)	0.2	0.3	0.7	0.3	-0.3	0.8
Illnesses of mother	1.7	2.1	3.2	-1.8	-1.1	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	4.0	0.3	2.0	1.5
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	-0.5	-0.7	1.1
Impedance of arm (left)	0.5	2.2	4.2	-2.0	-1.6	-0.1
Arm fat mass (right)	0.6	2.3	5.5	2.3	-1.2	-0.3
Trunk predicted mass	0.6	3.7	5.0	2.2	1.5	1.9
Standing height	0.7	7.1	11.8	1.7	2.5	3.4
Length of working week for main job	2.9	3.2	7.6	0.5	-1.4	-2.8
Exposure to tobacco smoke at home	0.5	0.6	0.7	0.8	-0.7	-0.9
Breastfed as a baby	1.5	1.9	4.8	2.2	0.8	0.5
Tense / ‘highly strung’	0.9	1.5	3.5	1.0	1.9	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.0	0.7	1.0	0.5
Hair/balding pattern: Pattern 4	0.5	1.2	3.4	0.3	1.9	0.1
Birth weight of first child	0.3	0.5	0.8	0.5	0.8	0.9
Peak expiratory flow (PEF)	1.2	2.8	5.1	1.1	2.3	1.5
Pulse wave reflection index	0.7	0.9	2.2	-1.5	0.4	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.7	0.5	-0.8	-0.5
Loud music exposure frequency	0.7	0.7	1.6	-0.7	-0.3	1.3
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	5.9	-0.9	-0.2	2.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.8	0.2	0.5	1.7
Blood clot in the leg (DVT)	0.7	0.9	1.5	-1.2	1.2	-0.0
Medication: Paracetamol	0.1	0.2	0.3	0.5	0.2	0.5
Headache pain in last month	0.5	0.9	1.7	-1.3	-0.9	0.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.2	0.3	-0.5	-1.5
Glaucoma (self-reported)	0.9	1.1	2.3	1.5	-0.3	-0.9
Gout (self-reported)	0.1	0.1	0.2	0.1	0.5	-0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.0	-0.3	1.0	-1.0
Medication: Amlodipine	0.3	0.5	0.7	-0.7	-0.5	-0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.8	0.9	0.4	-0.2
Birth weight	0.7	1.4	3.3	0.6	-0.8	-1.8
Chronic bronchitis/emphysema (mother)	2.5	2.9	4.8	2.2	-1.5	-1.2
High blood pressure (siblings)	1.2	1.7	2.9	1.4	0.6	-1.7
Forced vital capacity (FVC), Best measure	0.4	1.4	2.1	0.6	1.5	1.3
Body fat percentage	0.5	2.0	4.6	2.1	-1.1	-0.5
Leg fat percentage (right)	0.9	3.2	7.0	2.7	-1.0	-1.2
Arm fat-free mass (right)	1.0	5.2	9.6	3.1	1.9	1.6
Exposure to tobacco smoke outside home	0.9	1.2	3.5	-0.1	-1.9	0.3
Comparative body size at age 10	0.3	0.9	2.0	-0.3	-0.7	-1.4
Number of full brothers	0.7	0.9	1.9	-0.4	1.4	-0.7
Worry too long after embarrassment	0.2	0.3	0.5	0.5	0.7	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	-0.6	-0.4	0.9
Wheeze or whistling in the chest in last year	0.6	1.0	2.0	1.4	0.6	0.9
Number of children fathered	0.4	0.4	1.3	0.1	0.0	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	4.9	-2.2	0.4	0.1
Age at first live birth	2.8	4.9	9.1	-2.2	0.9	3.0
Pulse wave peak to peak time	0.6	0.7	0.8	0.7	0.9	-0.9
Health satisfaction	0.6	0.8	2.0	1.4	0.5	0.5
Shortness of breath walking on level ground	1.7	2.0	4.2	2.0	-1.1	0.8
Qualifications: College or University degree	3.4	10.6	15.6	-3.4	2.1	4.0
Eye problems/disorders: None of the above	1.0	1.2	2.4	-0.6	-0.8	-1.6
Mouth/teeth dental problems: Loose teeth	1.3	1.6	2.5	1.6	-1.0	-1.1
Emphysema/chronic bronchitis	0.1	0.2	0.4	0.6	0.1	0.3
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	-0.5	-0.7	0.5
Neck or shoulder pain in last month	0.9	1.3	3.7	0.5	1.9	-0.1
Medication: Blood pressure	0.7	1.2	2.8	-0.1	1.0	1.7
Angina (self-reported)	0.4	0.5	1.1	0.3	1.1	-0.4
Migraine (self-reported)	0.8	1.0	1.7	-0.8	-1.3	-0.8
Medication: Ibuprofen	0.3	0.4	0.6	-0.6	0.4	0.8
Medication: Allopurinol	0.1	0.2	0.2	-0.3	-0.5	-0.4
Medication: Omeprazole	1.4	1.7	4.0	0.3	2.0	1.0
Medication: Seretide 50 evohaler	1.4	1.7	2.9	-1.1	1.7	1.0
Mean time to correctly identify matches	0.5	1.0	1.6	-1.1	-0.4	-1.3
Heart disease (mother)	2.1	2.6	3.4	1.1	1.8	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.4	-0.5	0.7	1.2
Whole body fat mass	0.6	2.6	7.4	2.7	-0.5	-0.2
Leg fat mass (right)	0.9	3.5	9.5	3.1	-0.4	-0.9
Arm predicted mass (right)	0.9	4.8	8.6	2.9	1.9	1.5
Pulse rate, automated reading	0.7	2.4	3.1	1.8	-1.0	-1.7
Alcohol intake frequency.	1.1	2.5	5.0	2.2	1.4	-0.8
Comparative height size at age 10	0.1	0.3	0.8	0.1	-0.2	-0.9
Number of full sisters	3.2	3.9	9.3	-1.2	-1.1	-3.0
Suffer from ‘nerves’	0.1	0.2	0.4	0.1	0.7	0.2
Overall health rating	0.5	1.0	1.8	1.4	-0.0	-1.1
Chest pain or discomfort	1.0	1.4	2.3	0.3	1.4	1.5
Had major operations	1.4	1.6	3.1	-0.6	1.7	1.2
Age at last live birth	3.1	4.4	6.2	-2.4	1.1	2.5
Family relationship satisfaction	0.1	0.1	0.2	0.2	0.5	0.2
Leg pain on walking	0.7	0.8	1.7	1.3	0.4	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	2.8	1.7	0.4	-1.7
Commuting to job workplace: Car/motor vehicle	4.1	4.7	9.4	3.1	2.1	0.2
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	4.7	0.0	-2.2	-0.8
Medication: Aspirin	1.0	1.4	2.3	0.8	1.5	-1.1
Supplements: Vitamin C	2.1	2.5	5.7	0.4	2.4	1.3
Knee pain experienced in last month	0.2	0.2	0.7	0.8	0.2	-0.1
Hypertension (Self-reported)	0.9	2.6	4.0	1.9	2.0	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	1.6	-1.2	1.2	0.6
Illnesses of father: Heart disease	0.8	1.2	2.9	-0.5	-1.7	0.5
Illnesses of siblings: Diabetes	0.4	0.5	1.4	-0.0	-0.4	1.2
Smoking status: Previous	0.2	0.3	0.6	-0.4	-0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.2	0.0	0.3	1.1
Whole body fat-free mass	0.6	3.5	6.8	2.6	1.3	1.5
Leg fat-free mass (right)	0.6	3.0	6.6	2.6	0.9	1.3
Arm fat percentage (left)	0.5	2.0	3.3	1.8	-1.5	-0.6
Average weekly red wine intake	1.2	1.8	3.7	1.3	0.2	1.9
Handedness (chirality/laterality): Left-handed	1.8	2.1	3.3	1.8	-1.7	-0.5
Mood swings	0.6	1.1	1.6	-0.6	-1.3	-1.1
Loneliness, isolation	0.6	0.9	2.3	0.4	0.3	-1.5
Long-standing illness, disability or infirmity	0.4	0.6	1.4	0.5	1.2	-0.4
Ever had bowel cancer screening	0.8	0.9	1.9	0.8	1.4	0.3
Diabetes diagnosed by doctor	0.7	1.2	2.1	-0.5	1.4	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.7	-0.8	0.6	0.6
Friendships satisfaction	0.4	0.5	1.0	-0.2	-0.5	-1.0
Qualifications: nursing, teaching	0.2	0.3	0.5	-0.7	0.3	0.5
Commuting to job workplace: Walk	0.9	1.0	2.7	-0.6	-0.2	-1.6
Eye problems/disorders: Cataract	0.6	0.7	1.5	-0.8	-0.2	1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	1.5	-1.1	1.2	-0.9
Medication for cholesterol	0.3	0.4	0.8	-0.6	-0.3	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	4.2	2.0	0.3	-0.6
Back pain experienced in last month	0.1	0.1	0.1	0.3	0.4	-0.2
Mineral and other dietary supplements	0.6	0.8	2.1	-0.6	0.3	-1.4
Breast cancer (self-reported)	0.7	0.8	1.0	-0.8	0.9	1.0
Asthma (self-reported)	0.3	0.6	1.0	0.8	-1.0	0.3
Osteoporosis (self-reported)	0.8	1.0	1.7	-0.4	-1.1	-1.3
Osteoarthritis (self-reported)	0.2	0.3	0.7	-0.2	0.9	0.3
Medication: Aspirin	0.8	1.0	1.6	0.7	1.3	-0.9
Medication: Gliclazide	0.1	0.1	0.2	0.1	0.3	-0.4
Illnesses of father: None of the above (group 1)	0.8	1.0	2.1	0.4	1.4	0.9
Smoking status: Current	0.6	0.9	1.5	0.9	-1.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.8	-0.2	1.4	0.5
Whole body water mass	0.6	3.4	6.5	2.5	1.2	1.4
Leg predicted mass (right)	0.5	2.9	6.3	2.5	0.9	1.3
Arm fat mass (left)	0.6	2.4	6.7	2.6	-0.6	0.0
Number of self-reported non-cancer illnesses	0.0	0.1	0.2	0.0	0.5	-0.1
Average weekly champagne plus white wine intake	0.5	0.7	0.9	0.9	1.0	0.7
Miserableness	0.8	1.3	3.7	-0.2	-1.9	-0.5
Guilty feelings	0.7	1.1	2.0	1.0	-0.6	-1.4
Wears glasses or contact lenses	0.5	0.6	1.0	-1.0	0.6	0.7
Ever taken oral contraceptive pill	1.1	1.2	2.6	-1.6	-0.8	0.6
Hearing aid user	0.3	0.3	0.8	-0.0	0.9	0.5
Mother’s age at death	1.5	1.9	3.1	0.1	1.6	1.8
Financial situation satisfaction	0.5	0.6	1.2	-1.1	-0.4	-0.8
Tinnitus: Yes, now most or all of the time	2.0	2.4	3.6	0.5	1.9	1.8
Commuting to job workplace: Public transport	3.8	4.5	11.4	-3.4	-0.5	-1.4
Eye problems/disorders: Glaucoma	1.3	1.6	4.4	2.1	-0.0	-0.5
Medication: Blood pressure	0.4	0.7	1.0	1.0	0.3	-1.0
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.3	-0.4	-0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.3	0.6	-0.5	0.5
High cholesterol (Self-reported)	0.3	0.5	1.0	-0.5	-0.3	-1.0
Medication: Bendroflumethiazide	0.2	0.3	0.5	0.7	0.6	-0.3
Medication: Paracetamol	0.3	0.5	1.1	1.1	0.4	-0.3
Medication: Lisinopril	0.8	1.0	2.2	1.5	0.4	-0.8
Medication: Atorvastatin	0.8	1.0	1.5	-1.2	0.7	-1.0
Illnesses of father: High blood pressure	0.8	1.0	1.8	-0.4	1.1	1.3
Alcohol drinker status: Never	0.8	0.9	1.2	1.0	1.1	0.7
Ever smoked	0.4	0.6	1.2	0.9	-1.1	-0.1
Basal metabolic rate	0.6	3.5	7.9	2.8	0.9	1.3
Leg fat percentage (left)	0.8	2.7	6.9	2.6	-1.0	-0.6
Arm fat-free mass (left)	0.8	4.0	8.1	2.9	1.4	1.3
Number of operations (self-reported)	0.8	1.2	2.4	0.5	1.6	1.0
Average weekly beer plus cider intake	0.5	0.7	1.2	1.1	-1.0	-0.1
Irritability	0.5	0.8	1.8	-0.7	-1.3	-0.5
Risk taking	0.3	0.5	1.3	0.4	1.2	0.1
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.0	-0.5	1.7	-1.1
Fractured/broken bones in last 5 years	0.7	0.9	1.6	-0.9	1.3	-0.7
Age started oral contraceptive pill	1.7	2.1	4.1	-1.1	2.0	1.0
Diastolic blood pressure, automated reading	0.5	1.5	4.4	2.1	-0.4	-0.3
Ever depressed for a whole week	0.3	0.4	1.0	-1.0	0.2	0.1
Unable to work because of sickness or disability	0.4	0.6	1.7	1.3	0.1	-0.2
Commuting to job workplace: Cycle	0.5	0.7	1.9	-0.3	-1.4	0.1
Myopia	0.7	1.1	2.5	-0.9	0.1	1.6
Vascular/heart problems diagnosed by doctor	0.9	2.5	3.7	-1.9	-1.9	-0.4
Cholesterol lowering medication	1.0	1.5	2.9	1.1	-0.7	-1.7
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	4.1	0.7	2.0	0.4
Pain experienced in last month	0.3	0.5	1.2	0.2	-1.1	-0.6
Supplements: Calcium	0.1	0.1	0.3	0.0	-0.6	-0.1
Basal cell carcinoma (self-reported)	0.0	0.1	0.1	0.1	0.4	0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.1	-0.5	1.0	-0.0
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.0	-1.4	1.3	0.2
Heart disease (siblings)	1.4	1.7	2.6	1.6	0.1	-1.6
Alcohol drinker status: Previous	1.3	1.5	4.2	2.0	0.5	-0.4
Pack years of smoking	0.1	0.2	0.5	0.7	-0.3	-0.1
Impedance of whole body	0.3	1.5	3.7	-1.9	-0.9	0.0
Leg fat mass (left)	0.9	3.4	9.8	3.1	-0.4	-0.5
Arm predicted mass (left)	0.8	4.2	8.0	2.8	1.7	1.3