[Hub]/) : Traits : Age when periods started (menarche) :

chr2:60,470,926-62,394,127

Best TWAS P=2.79e-13 · Best GWAS P=3.53e-12 conditioned to 0.0481

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex LOC339803 0.06 0.05 enet 15 0.05 1.8e-06 -6.4 -7.3 2.8e-13 0.80 0.02 0.98 TRUE
2 CommonMind Brain Pre-frontal Cortex PUS10 0.22 0.15 bslmm 364 0.16 6.7e-19 5.8 5.5 3.9e-08 -0.17 0.84 0.16 TRUE
3 GTEx Adipose Subcutaneous PUS10 0.18 0.08 lasso 3 0.08 7.7e-07 5.8 5.6 2.6e-08 -0.23 0.83 0.16 FALSE
4 GTEx Cells Transformed fibroblasts PUS10 0.08 0.05 lasso 6 0.05 1.8e-04 5.8 5.7 1.1e-08 -0.24 0.44 0.36 FALSE
5 GTEx Esophagus Mucosa PUS10 0.10 0.08 lasso 3 0.09 1.1e-06 5.7 5.6 2.6e-08 -0.24 0.80 0.13 FALSE
6 GTEx Heart Atrial Appendage USP34 0.17 0.00 lasso 5 0.01 1.3e-01 -2.6 5.5 3.1e-08 -0.68 0.02 0.77 FALSE
7 GTEx Heart Atrial Appendage PUS10 0.25 0.08 lasso 4 0.04 4.6e-03 5.8 5.5 4.9e-08 -0.19 0.34 0.08 FALSE
8 GTEx Muscle Skeletal AC016747.3 0.07 0.02 lasso 7 0.05 5.5e-06 5.8 5.3 1.5e-07 -0.38 0.61 0.11 FALSE
9 GTEx Testis AC016747.3 0.48 0.63 lasso 7 0.63 3.3e-35 5.8 5.1 2.7e-07 -0.26 0.83 0.17 FALSE
10 ROSMAP Brain Pre-frontal Cortex AC016747.3 0.08 0.04 bslmm 310 0.04 2.9e-06 -6.4 -5.9 3.5e-09 0.74 0.01 0.99 FALSE
11 The Cancer Genome Atlas Breast Invasive Carcinoma PUS10 0.04 0.05 lasso 2 0.05 6.4e-10 5.7 5.8 7.3e-09 -0.24 0.00 1.00 FALSE
12 The Cancer Genome Atlas Glioblastoma Multiforme PUS10 0.38 0.05 blup 64 0.06 5.3e-03 3.8 5.3 1.4e-07 -0.27 0.01 0.79 FALSE
13 The Cancer Genome Atlas Brain Lower Grade Glioma PUS10 0.08 0.07 lasso 1 0.05 1.5e-06 5.8 5.8 5.8e-09 -0.24 0.00 1.00 FALSE
14 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma PUS10 0.14 0.08 blup 64 0.08 3.5e-06 5.3 6.2 7.7e-10 -0.37 0.00 0.99 FALSE
15 The Cancer Genome Atlas Thyroid Carcinoma PUS10 0.04 0.00 blup 64 0.01 2.4e-02 -2.7 5.3 1.5e-07 -0.26 0.01 0.71 FALSE
16 The Cancer Genome Atlas Thyroid Carcinoma USP34 0.03 0.02 blup 106 0.02 3.4e-03 4.0 6.2 6.4e-10 -0.72 0.04 0.46 FALSE