Best TWAS P=2.79e-13 · Best GWAS P=3.53e-12 conditioned to 0.0481
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC339803 | 0.06 | 0.05 | enet | 15 | 0.05 | 1.8e-06 | -6.4 | -7.3 | 2.8e-13 | 0.80 | 0.02 | 0.98 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PUS10 | 0.22 | 0.15 | bslmm | 364 | 0.16 | 6.7e-19 | 5.8 | 5.5 | 3.9e-08 | -0.17 | 0.84 | 0.16 | TRUE |
| 3 | GTEx | Adipose Subcutaneous | PUS10 | 0.18 | 0.08 | lasso | 3 | 0.08 | 7.7e-07 | 5.8 | 5.6 | 2.6e-08 | -0.23 | 0.83 | 0.16 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | PUS10 | 0.08 | 0.05 | lasso | 6 | 0.05 | 1.8e-04 | 5.8 | 5.7 | 1.1e-08 | -0.24 | 0.44 | 0.36 | FALSE |
| 5 | GTEx | Esophagus Mucosa | PUS10 | 0.10 | 0.08 | lasso | 3 | 0.09 | 1.1e-06 | 5.7 | 5.6 | 2.6e-08 | -0.24 | 0.80 | 0.13 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | USP34 | 0.17 | 0.00 | lasso | 5 | 0.01 | 1.3e-01 | -2.6 | 5.5 | 3.1e-08 | -0.68 | 0.02 | 0.77 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | PUS10 | 0.25 | 0.08 | lasso | 4 | 0.04 | 4.6e-03 | 5.8 | 5.5 | 4.9e-08 | -0.19 | 0.34 | 0.08 | FALSE |
| 8 | GTEx | Muscle Skeletal | AC016747.3 | 0.07 | 0.02 | lasso | 7 | 0.05 | 5.5e-06 | 5.8 | 5.3 | 1.5e-07 | -0.38 | 0.61 | 0.11 | FALSE |
| 9 | GTEx | Testis | AC016747.3 | 0.48 | 0.63 | lasso | 7 | 0.63 | 3.3e-35 | 5.8 | 5.1 | 2.7e-07 | -0.26 | 0.83 | 0.17 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | AC016747.3 | 0.08 | 0.04 | bslmm | 310 | 0.04 | 2.9e-06 | -6.4 | -5.9 | 3.5e-09 | 0.74 | 0.01 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PUS10 | 0.04 | 0.05 | lasso | 2 | 0.05 | 6.4e-10 | 5.7 | 5.8 | 7.3e-09 | -0.24 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Glioblastoma Multiforme | PUS10 | 0.38 | 0.05 | blup | 64 | 0.06 | 5.3e-03 | 3.8 | 5.3 | 1.4e-07 | -0.27 | 0.01 | 0.79 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PUS10 | 0.08 | 0.07 | lasso | 1 | 0.05 | 1.5e-06 | 5.8 | 5.8 | 5.8e-09 | -0.24 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PUS10 | 0.14 | 0.08 | blup | 64 | 0.08 | 3.5e-06 | 5.3 | 6.2 | 7.7e-10 | -0.37 | 0.00 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | PUS10 | 0.04 | 0.00 | blup | 64 | 0.01 | 2.4e-02 | -2.7 | 5.3 | 1.5e-07 | -0.26 | 0.01 | 0.71 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | USP34 | 0.03 | 0.02 | blup | 106 | 0.02 | 3.4e-03 | 4.0 | 6.2 | 6.4e-10 | -0.72 | 0.04 | 0.46 | FALSE |