Best TWAS P=2.48e-09 · Best GWAS P=1.05e-07 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | FANCA | 0.08 | 0.03 | lasso | 4 | 0.04 | 4.0e-04 | 5.0 | -5.2 | 2.0e-07 | -0.97 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Nerve Tibial | ZNF276 | 0.14 | 0.00 | lasso | 4 | 0.01 | 3.3e-02 | 4.8 | 5.2 | 1.9e-07 | 0.76 | 0.04 | 0.71 | TRUE |
| 3 | GTEx | Pancreas | GAS8 | 0.19 | 0.08 | lasso | 4 | 0.06 | 1.9e-03 | -4.0 | 5.6 | 1.7e-08 | 0.49 | 0.10 | 0.62 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SPIRE2 | 0.04 | 0.01 | blup | 72 | 0.01 | 3.4e-02 | -4.6 | -5.6 | 2.8e-08 | -0.21 | 0.02 | 0.18 | TRUE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FANCA | 0.15 | 0.16 | enet | 13 | 0.16 | 4.2e-18 | -4.6 | -5.8 | 5.1e-09 | -0.54 | 0.12 | 0.87 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FANCA | 0.09 | 0.06 | enet | 10 | 0.09 | 9.8e-11 | 4.8 | -6.0 | 2.5e-09 | -0.95 | 0.01 | 0.99 | TRUE |
| 7 | The Cancer Genome Atlas | Soft Tissue Sarcoma | FANCA | 0.07 | 0.09 | blup | 81 | 0.08 | 1.2e-05 | 5.0 | -5.3 | 9.2e-08 | -0.96 | 0.01 | 0.98 | TRUE |
| 8 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FANCA | 0.06 | 0.00 | blup | 77 | 0.03 | 3.7e-03 | 5.1 | -5.2 | 1.5e-07 | -0.95 | 0.01 | 0.94 | FALSE |