Hub : Traits :

Had menopause

123 significantly associated models · 29 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 26592429 28607344 12 1 2.0e-11 1.9e-11 1.00000 100 IFT172
2 4 83635581 85216227 4 1 2.8e-09 6.4e-09 1.00000 100 HELQ
3 5 175611678 177138298 4 1 5.9e-17 1.5e-16 1.00000 100 UIMC1
4 8 37686749 38101003 1 1 5.9e-09 2.1e-09 1.00000 100 EIF4EBP1
5 12 56435412 57844049 1 1 5.8e-11 2.9e-11 1.00000 100 PRIM1
6 12 130579339 131104455 1 1 1.0e-10 1.2e-09 0.16900 95 PIWIL1
7 16 89094243 90172696 4 4 2.5e-09 1.1e-07 1.00000 100 FANCA SPIRE2 ZNF276
8 19 55574907 56099884 2 2 4.2e-10 2.3e-14 0.00047 79 SUV420H2 TMEM150B

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.20 1 0 0.0 0.00 1.0e+00 IFT172
Irritable Bowel Disease (IBD) 1.54 1 0 0.0 0.00 1.0e+00 IFT172
Breast Cancer 5.08 6 0 0.0 0.69 1.3e-01 EIF4EBP1 FANCA HELQ SPIRE2 TMEM150B ZNF276
Fasting Glucose 3.43 1 1 2.2 0.00 1.0e+00 IFT172
Schizophrenia (2014) 2.21 1 0 0.0 0.00 1.0e+00 FANCA
Triglycerides 12.39 1 1 2.2 0.00 1.0e+00 IFT172
Blood Platelet Count 1.38 1 1 2.2 0.00 1.0e+00 IFT172
Blood Red Count 0.61 1 1 2.2 0.00 1.0e+00 PRIM1
Blood White Count 1.41 2 1 2.2 0.00 1.0e+00 IFT172 PRIM1
Heel T-Score 0.94 2 1 2.2 0.00 1.0e+00 FANCA SPIRE2
BMI 0.81 1 0 0.0 0.00 1.0e+00 FANCA
Height 2.03 6 6 13.3 -0.13 7.9e-01 FANCA IFT172 PIWIL1 PRIM1 UIMC1 ZNF276
Waist Hip Ratio (WHR) 1.39 1 1 2.2 0.00 1.0e+00 PRIM1
Systolic Blood Pressure 1.02 2 0 0.0 0.00 1.0e+00 FANCA IFT172
Allergy or Eczema 0.93 1 0 0.0 0.00 1.0e+00 IFT172
Cardiovascular Disease 1.44 1 1 2.2 0.00 1.0e+00 IFT172
Type 2 Diabetes (T2D) (2018) 1.71 1 0 0.0 0.00 1.0e+00 IFT172
Lung FEV1/FVC ratio 0.80 2 0 0.0 0.00 1.0e+00 SUV420H2 TMEM150B
Hair Pigment 40.84 4 4 8.9 0.61 2.7e-01 FANCA IFT172 SPIRE2 ZNF276
Tanning 32.17 4 3 6.7 -0.20 7.5e-01 FANCA IFT172 SPIRE2 ZNF276
Number of treatments/medications taken 1.38 1 0 0.0 0.00 1.0e+00 IFT172
Relative age of first facial hair 2.71 2 0 0.0 0.00 1.0e+00 FANCA ZNF276
Ever used hormone-replacement therapy (HRT) 9.73 7 2 4.4 0.98 5.9e-05 EIF4EBP1 HELQ IFT172 PRIM1 SUV420H2 TMEM150B UIMC1
Impedance of leg (right) 1.00 1 1 2.2 0.00 1.0e+00 PRIM1
Leg fat-free mass (left) 1.67 2 1 2.2 0.00 1.0e+00 IFT172 PRIM1
Trunk fat percentage 1.98 3 0 0.0 -0.58 4.2e-01 FANCA SUV420H2 ZNF276
Bilateral oophorectomy (both ovaries removed) 4.55 2 0 0.0 0.00 1.0e+00 SUV420H2 TMEM150B
Heel bone mineral density (BMD) T-score, automated (left) 1.35 1 0 0.0 0.00 1.0e+00 FANCA
High blood pressure 1.57 1 0 0.0 0.00 1.0e+00 FANCA
Hayfever, allergic rhinitis or eczema 0.96 1 0 0.0 0.00 1.0e+00 IFT172
Sitting height 1.18 3 0 0.0 0.00 1.0e+00 IFT172 PRIM1 ZNF276
Impedance of leg (left) 0.92 1 1 2.2 0.00 1.0e+00 PRIM1
Leg predicted mass (left) 1.68 1 1 2.2 0.00 1.0e+00 PRIM1
Trunk fat mass 2.00 2 0 0.0 0.00 1.0e+00 FANCA ZNF276
Waist circumference 1.28 2 0 0.0 0.00 1.0e+00 FANCA ZNF276
Diabetes (self-reported) 1.47 1 0 0.0 0.00 1.0e+00 IFT172
Weight 1.86 3 0 0.0 -1.00 2.0e-03 FANCA PRIM1 ZNF276
Impedance of arm (right) 1.00 1 1 2.2 0.00 1.0e+00 PRIM1
Arm fat percentage (right) 1.03 1 0 0.0 0.00 1.0e+00 FANCA
Trunk fat-free mass 1.93 2 1 2.2 0.00 1.0e+00 IFT172 PRIM1
Hip circumference 1.53 1 0 0.0 0.00 1.0e+00 PRIM1
Alcohol intake versus 10 years previously 1.28 1 0 0.0 0.00 1.0e+00 IFT172
Number of live births 1.55 1 0 0.0 0.00 1.0e+00 SPIRE2
Medication: Cholesterol lowering 1.08 1 0 0.0 0.00 1.0e+00 IFT172
Impedance of arm (left) 0.80 1 1 2.2 0.00 1.0e+00 PRIM1
Arm fat mass (right) 1.24 1 0 0.0 0.00 1.0e+00 FANCA
Trunk predicted mass 1.94 2 1 2.2 0.00 1.0e+00 IFT172 PRIM1
Standing height 1.75 5 3 6.7 -0.11 8.4e-01 FANCA IFT172 PRIM1 UIMC1 ZNF276
Medication: Paracetamol 2.73 1 0 0.0 0.00 1.0e+00 UIMC1
Gout (self-reported) 4.06 1 1 2.2 0.00 1.0e+00 IFT172
Body fat percentage 1.71 2 0 0.0 0.00 1.0e+00 FANCA ZNF276
Leg fat percentage (right) 1.11 1 0 0.0 0.00 1.0e+00 FANCA
Arm fat-free mass (right) 2.06 2 2 4.4 0.00 1.0e+00 IFT172 PRIM1
Comparative body size at age 10 2.52 3 0 0.0 0.00 1.0e+00 FANCA UIMC1 ZNF276
Medication: Allopurinol 2.91 1 1 2.2 0.00 1.0e+00 IFT172
Whole body fat mass 1.68 2 0 0.0 0.00 1.0e+00 FANCA ZNF276
Leg fat mass (right) 1.52 2 0 0.0 0.00 1.0e+00 FANCA ZNF276
Arm predicted mass (right) 1.87 2 1 2.2 0.00 1.0e+00 IFT172 PRIM1
Pulse rate, automated reading 0.89 1 1 2.2 0.00 1.0e+00 IFT172
Alcohol intake frequency. 1.85 1 1 2.2 0.00 1.0e+00 IFT172
Comparative height size at age 10 1.40 4 1 2.2 0.03 9.7e-01 IFT172 PRIM1 UIMC1 ZNF276
Hypertension (Self-reported) 1.48 1 0 0.0 0.00 1.0e+00 FANCA
Whole body fat-free mass 1.84 2 1 2.2 0.00 1.0e+00 IFT172 PRIM1
Leg fat-free mass (right) 1.53 1 1 2.2 0.00 1.0e+00 PRIM1
Diabetes diagnosed by doctor 1.81 1 0 0.0 0.00 1.0e+00 IFT172
Back pain experienced in last month 2.13 1 0 0.0 0.00 1.0e+00 TMEM150B
Medication: Gliclazide 1.98 1 0 0.0 0.00 1.0e+00 SUV420H2
Whole body water mass 1.87 2 1 2.2 0.00 1.0e+00 IFT172 PRIM1
Leg predicted mass (right) 1.55 1 1 2.2 0.00 1.0e+00 PRIM1
Arm fat mass (left) 1.19 1 0 0.0 0.00 1.0e+00 FANCA
Miserableness 2.31 1 0 0.0 0.00 1.0e+00 FANCA
Medication: Blood pressure 1.67 1 0 0.0 0.00 1.0e+00 FANCA
High cholesterol (Self-reported) 2.02 1 1 2.2 0.00 1.0e+00 IFT172
Medication: Paracetamol 2.31 1 0 0.0 0.00 1.0e+00 UIMC1
Medication: Atorvastatin 2.52 1 0 0.0 0.00 1.0e+00 IFT172
Basal metabolic rate 1.91 3 1 2.2 0.00 1.0e+00 IFT172 PRIM1 ZNF276
Leg fat percentage (left) 1.02 1 0 0.0 0.00 1.0e+00 FANCA
Arm fat-free mass (left) 2.01 2 1 2.2 0.00 1.0e+00 IFT172 PRIM1
Vascular/heart problems diagnosed by doctor 1.52 1 0 0.0 0.00 1.0e+00 FANCA
Alcohol drinker status: Previous 1.98 1 0 0.0 0.00 1.0e+00 SPIRE2
Impedance of whole body 0.91 1 1 2.2 0.00 1.0e+00 PRIM1
Leg fat mass (left) 1.50 2 0 0.0 0.00 1.0e+00 FANCA ZNF276
Arm predicted mass (left) 1.97 2 1 2.2 0.00 1.0e+00 IFT172 PRIM1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 4 0.115 1.3
GTEx Adipose Visceral Omentum 4 0.196 1.3
GTEx Adrenal Gland 1 0.069 1.2
GTEx Artery Aorta 2 0.067 1.2
GTEx Artery Coronary 1 0.085 1.3
GTEx Artery Tibial 4 0.106 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 1 0.050 1.3
GTEx Brain Cortex 1 0.097 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 1 0.070 1.3
GTEx Cells Transformed fibroblasts 5 0.119 1.3
GTEx Colon Sigmoid 1 0.068 1.3
GTEx Colon Transverse 2 0.097 1.4
GTEx Esophagus Gastroesophageal Junction 2 0.138 1.2
GTEx Esophagus Mucosa 2 0.060 1.3
GTEx Esophagus Muscularis 4 0.124 1.3
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.2
GTEx Lung 2 0.070 1.3
GTEx Muscle Skeletal 2 0.069 1.3
GTEx Nerve Tibial 5 0.116 1.3
GTEx Ovary 1 0.110 1.3
GTEx Pancreas 1 0.061 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 1 0.120 1.3
GTEx Skin Not Sun Exposed Suprapubic 1 0.041 1.3
GTEx Skin Sun Exposed Lower leg 4 0.110 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.3
GTEx Testis 6 0.190 1.3
GTEx Thyroid 7 0.175 1.3
GTEx Uterus 0 0.000 1.2
GTEx Vagina 1 0.157 1.4
GTEx Whole Blood 1 0.050 1.2
METSIM Adipose 3 0.065 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 6 0.137 1.2
YFS Blood 5 0.108 1.2
CommonMind Brain Pre-frontal Cortex 7 0.130 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 2 0.121 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 3 0.068 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 2 0.097 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 3 0.110 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 4 0.098 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 5 0.116 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Adenocarcinoma 2 0.068 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 3 0.120 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 2 0.043 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 1 0.094 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.4
The Cancer Genome Atlas Thyroid Carcinoma 3 0.058 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1