Hub : Traits :

Had menopause

123 significantly associated models · 29 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	26592429	28607344	12	1	2.0e-11	1.9e-11	1.00000	100	IFT172
2	4	83635581	85216227	4	1	2.8e-09	6.4e-09	1.00000	100	HELQ
3	5	175611678	177138298	4	1	5.9e-17	1.5e-16	1.00000	100	UIMC1
4	8	37686749	38101003	1	1	5.9e-09	2.1e-09	1.00000	100	EIF4EBP1
5	12	56435412	57844049	1	1	5.8e-11	2.9e-11	1.00000	100	PRIM1
6	12	130579339	131104455	1	1	1.0e-10	1.2e-09	0.16900	95	PIWIL1
7	16	89094243	90172696	4	4	2.5e-09	1.1e-07	1.00000	100	FANCA SPIRE2 ZNF276
8	19	55574907	56099884	2	2	4.2e-10	2.3e-14	0.00047	79	SUV420H2 TMEM150B

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Hair Pigment	40.84	4	4	8.9	0.61	2.7e-01	FANCA IFT172 SPIRE2 ZNF276
Tanning	32.17	4	3	6.7	-0.20	7.5e-01	FANCA IFT172 SPIRE2 ZNF276
Triglycerides	12.39	1	1	2.2	0.00	1.0e+00	IFT172
Ever used hormone-replacement therapy (HRT)	9.73	7	2	4.4	0.98	5.9e-05	EIF4EBP1 HELQ IFT172 PRIM1 SUV420H2 TMEM150B UIMC1
Breast Cancer	5.08	6	0	0.0	0.69	1.3e-01	EIF4EBP1 FANCA HELQ SPIRE2 TMEM150B ZNF276
Bilateral oophorectomy (both ovaries removed)	4.55	2	0	0.0	0.00	1.0e+00	SUV420H2 TMEM150B
Gout (self-reported)	4.06	1	1	2.2	0.00	1.0e+00	IFT172
Fasting Glucose	3.43	1	1	2.2	0.00	1.0e+00	IFT172
Medication: Allopurinol	2.91	1	1	2.2	0.00	1.0e+00	IFT172
Medication: Paracetamol	2.73	1	0	0.0	0.00	1.0e+00	UIMC1
Relative age of first facial hair	2.71	2	0	0.0	0.00	1.0e+00	FANCA ZNF276
Comparative body size at age 10	2.52	3	0	0.0	0.00	1.0e+00	FANCA UIMC1 ZNF276
Medication: Atorvastatin	2.52	1	0	0.0	0.00	1.0e+00	IFT172
Miserableness	2.31	1	0	0.0	0.00	1.0e+00	FANCA
Medication: Paracetamol	2.31	1	0	0.0	0.00	1.0e+00	UIMC1
Schizophrenia (2014)	2.21	1	0	0.0	0.00	1.0e+00	FANCA
Back pain experienced in last month	2.13	1	0	0.0	0.00	1.0e+00	TMEM150B
Arm fat-free mass (right)	2.06	2	2	4.4	0.00	1.0e+00	IFT172 PRIM1
Height	2.03	6	6	13.3	-0.13	7.9e-01	FANCA IFT172 PIWIL1 PRIM1 UIMC1 ZNF276
High cholesterol (Self-reported)	2.02	1	1	2.2	0.00	1.0e+00	IFT172
Arm fat-free mass (left)	2.01	2	1	2.2	0.00	1.0e+00	IFT172 PRIM1
Trunk fat mass	2.00	2	0	0.0	0.00	1.0e+00	FANCA ZNF276
Trunk fat percentage	1.98	3	0	0.0	-0.58	4.2e-01	FANCA SUV420H2 ZNF276
Medication: Gliclazide	1.98	1	0	0.0	0.00	1.0e+00	SUV420H2
Alcohol drinker status: Previous	1.98	1	0	0.0	0.00	1.0e+00	SPIRE2
Arm predicted mass (left)	1.97	2	1	2.2	0.00	1.0e+00	IFT172 PRIM1
Trunk predicted mass	1.94	2	1	2.2	0.00	1.0e+00	IFT172 PRIM1
Trunk fat-free mass	1.93	2	1	2.2	0.00	1.0e+00	IFT172 PRIM1
Basal metabolic rate	1.91	3	1	2.2	0.00	1.0e+00	IFT172 PRIM1 ZNF276
Arm predicted mass (right)	1.87	2	1	2.2	0.00	1.0e+00	IFT172 PRIM1
Whole body water mass	1.87	2	1	2.2	0.00	1.0e+00	IFT172 PRIM1
Weight	1.86	3	0	0.0	-1.00	2.0e-03	FANCA PRIM1 ZNF276
Alcohol intake frequency.	1.85	1	1	2.2	0.00	1.0e+00	IFT172
Whole body fat-free mass	1.84	2	1	2.2	0.00	1.0e+00	IFT172 PRIM1
Diabetes diagnosed by doctor	1.81	1	0	0.0	0.00	1.0e+00	IFT172
Standing height	1.75	5	3	6.7	-0.11	8.4e-01	FANCA IFT172 PRIM1 UIMC1 ZNF276
Type 2 Diabetes (T2D) (2018)	1.71	1	0	0.0	0.00	1.0e+00	IFT172
Body fat percentage	1.71	2	0	0.0	0.00	1.0e+00	FANCA ZNF276
Leg predicted mass (left)	1.68	1	1	2.2	0.00	1.0e+00	PRIM1
Whole body fat mass	1.68	2	0	0.0	0.00	1.0e+00	FANCA ZNF276
Leg fat-free mass (left)	1.67	2	1	2.2	0.00	1.0e+00	IFT172 PRIM1
Medication: Blood pressure	1.67	1	0	0.0	0.00	1.0e+00	FANCA
High blood pressure	1.57	1	0	0.0	0.00	1.0e+00	FANCA
Number of live births	1.55	1	0	0.0	0.00	1.0e+00	SPIRE2
Leg predicted mass (right)	1.55	1	1	2.2	0.00	1.0e+00	PRIM1
Irritable Bowel Disease (IBD)	1.54	1	0	0.0	0.00	1.0e+00	IFT172
Hip circumference	1.53	1	0	0.0	0.00	1.0e+00	PRIM1
Leg fat-free mass (right)	1.53	1	1	2.2	0.00	1.0e+00	PRIM1
Leg fat mass (right)	1.52	2	0	0.0	0.00	1.0e+00	FANCA ZNF276
Vascular/heart problems diagnosed by doctor	1.52	1	0	0.0	0.00	1.0e+00	FANCA
Leg fat mass (left)	1.50	2	0	0.0	0.00	1.0e+00	FANCA ZNF276
Hypertension (Self-reported)	1.48	1	0	0.0	0.00	1.0e+00	FANCA
Diabetes (self-reported)	1.47	1	0	0.0	0.00	1.0e+00	IFT172
Cardiovascular Disease	1.44	1	1	2.2	0.00	1.0e+00	IFT172
Blood White Count	1.41	2	1	2.2	0.00	1.0e+00	IFT172 PRIM1
Comparative height size at age 10	1.40	4	1	2.2	0.03	9.7e-01	IFT172 PRIM1 UIMC1 ZNF276
Waist Hip Ratio (WHR)	1.39	1	1	2.2	0.00	1.0e+00	PRIM1
Blood Platelet Count	1.38	1	1	2.2	0.00	1.0e+00	IFT172
Number of treatments/medications taken	1.38	1	0	0.0	0.00	1.0e+00	IFT172
Heel bone mineral density (BMD) T-score, automated (left)	1.35	1	0	0.0	0.00	1.0e+00	FANCA
Waist circumference	1.28	2	0	0.0	0.00	1.0e+00	FANCA ZNF276
Alcohol intake versus 10 years previously	1.28	1	0	0.0	0.00	1.0e+00	IFT172
Arm fat mass (right)	1.24	1	0	0.0	0.00	1.0e+00	FANCA
Crohns Disease (2017)	1.20	1	0	0.0	0.00	1.0e+00	IFT172
Arm fat mass (left)	1.19	1	0	0.0	0.00	1.0e+00	FANCA
Sitting height	1.18	3	0	0.0	0.00	1.0e+00	IFT172 PRIM1 ZNF276
Leg fat percentage (right)	1.11	1	0	0.0	0.00	1.0e+00	FANCA
Medication: Cholesterol lowering	1.08	1	0	0.0	0.00	1.0e+00	IFT172
Arm fat percentage (right)	1.03	1	0	0.0	0.00	1.0e+00	FANCA
Systolic Blood Pressure	1.02	2	0	0.0	0.00	1.0e+00	FANCA IFT172
Leg fat percentage (left)	1.02	1	0	0.0	0.00	1.0e+00	FANCA
Impedance of leg (right)	1.00	1	1	2.2	0.00	1.0e+00	PRIM1
Impedance of arm (right)	1.00	1	1	2.2	0.00	1.0e+00	PRIM1
Hayfever, allergic rhinitis or eczema	0.96	1	0	0.0	0.00	1.0e+00	IFT172
Heel T-Score	0.94	2	1	2.2	0.00	1.0e+00	FANCA SPIRE2
Allergy or Eczema	0.93	1	0	0.0	0.00	1.0e+00	IFT172
Impedance of leg (left)	0.92	1	1	2.2	0.00	1.0e+00	PRIM1
Impedance of whole body	0.91	1	1	2.2	0.00	1.0e+00	PRIM1
Pulse rate, automated reading	0.89	1	1	2.2	0.00	1.0e+00	IFT172
BMI	0.81	1	0	0.0	0.00	1.0e+00	FANCA
Lung FEV1/FVC ratio	0.80	2	0	0.0	0.00	1.0e+00	SUV420H2 TMEM150B
Impedance of arm (left)	0.80	1	1	2.2	0.00	1.0e+00	PRIM1
Blood Red Count	0.61	1	1	2.2	0.00	1.0e+00	PRIM1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Colon Transverse	2	0.097	1.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
GTEx	Vagina	1	0.157	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.4
GTEx	Adipose Subcutaneous	4	0.115	1.3
GTEx	Adipose Visceral Omentum	4	0.196	1.3
GTEx	Artery Coronary	1	0.085	1.3
GTEx	Artery Tibial	4	0.106	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cerebellum	1	0.050	1.3
GTEx	Brain Cortex	1	0.097	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	1	0.070	1.3
GTEx	Cells Transformed fibroblasts	5	0.119	1.3
GTEx	Colon Sigmoid	1	0.068	1.3
GTEx	Esophagus Mucosa	2	0.060	1.3
GTEx	Esophagus Muscularis	4	0.124	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Lung	2	0.070	1.3
GTEx	Muscle Skeletal	2	0.069	1.3
GTEx	Nerve Tibial	5	0.116	1.3
GTEx	Ovary	1	0.110	1.3
GTEx	Pancreas	1	0.061	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Prostate	1	0.120	1.3
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.3
GTEx	Skin Sun Exposed Lower leg	4	0.110	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	6	0.190	1.3
GTEx	Thyroid	7	0.175	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.121	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	3	0.110	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	3	0.120	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
GTEx	Adrenal Gland	1	0.069	1.2
GTEx	Artery Aorta	2	0.067	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	2	0.138	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Whole Blood	1	0.050	1.2
METSIM	Adipose	3	0.065	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	6	0.137	1.2
YFS	Blood	5	0.108	1.2
CommonMind	Brain Pre-frontal Cortex	7	0.130	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	3	0.068	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	2	0.097	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	4	0.098	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	5	0.116	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	2	0.068	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	1	0.094	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	3	0.058	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1