TWAS hub - ZNF276

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.1980	0.0840	0.00710	0.058	NA	0.133	NA	0.072	0.0130	NA	2.8e-04	NA	0.0065
2	GTEx	Brain Cerebellum	0.1630	0.0730	0.00820	0.057	NA	0.023	NA	0.046	0.0091	NA	7.0e-02	NA	0.0170
3	GTEx	Cells Transformed fibroblasts	0.1320	0.0550	0.00180	0.012	NA	0.017	NA	0.013	0.0390	NA	1.9e-02	NA	0.0340
4	GTEx	Nerve Tibial	0.1408	0.0570	0.00036	0.002	NA	0.014	NA	0.014	0.2100	NA	3.5e-02	NA	0.0330
5	TCGA	Bladder Urothelial Carcinoma	0.0880	0.0540	0.00100	0.017	0.041	0.054	NA	0.026	0.0120	0.00022	2.3e-05	NA	0.0025
6	TCGA	Brain Lower Grade Glioma	0.0435	0.0226	0.00150	0.016	0.012	0.006	NA	0.008	0.0051	0.01300	5.5e-02	NA	0.0420

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Hair Pigment	151.3	4314.2	10816.0	-69.8	-45.6	22.1	43.4	75.8	104.0
Tanning	107.2	1308.2	3956.4	62.9	50.5	6.7	-14.6	-14.0	-29.8
Had menopause	12.8	15.9	27.2	0.1	3.4	4.9	5.2	4.0	4.2
Alcohol drinker status: Previous	6.4	7.3	21.1	2.3	3.0	0.9	0.6	4.6	2.7
Relative age of first facial hair	4.6	9.4	20.1	-1.8	0.0	2.1	3.6	3.9	4.5
Medication for cholesterol	4.5	6.8	17.8	3.0	2.0	-4.2	-0.8	-0.1	-3.1
Medication: Blood pressure	4.4	8.4	24.1	-4.9	-3.0	3.3	0.9	-1.1	2.1
Basal cell carcinoma (self-reported)	3.7	4.5	16.6	-4.1	-2.8	-1.0	0.9	-0.1	0.5
Breast Cancer	3.6	8.8	20.1	1.2	3.1	2.4	4.5	3.2	2.3
Medication: Omeprazole	3.5	4.2	8.5	2.9	2.7	0.7	1.5	2.1	1.5
Eye problems/disorders: Diabetes related eye disease	3.2	3.5	10.6	1.3	0.4	-2.1	-1.1	-1.6	-3.3
Bipolar Disorder (2018)	3.1	5.0	15.4	3.9	2.9	-0.3	-2.1	1.2	0.5
Comparative body size at age 10	3.1	8.5	17.0	1.5	2.5	0.2	4.1	4.1	3.0
Relative age voice broke	3.0	4.6	12.4	0.5	-0.0	0.9	1.7	3.3	3.5
Alzheimer’s Disease (in mother)	2.9	3.4	7.0	2.6	2.4	-1.3	1.2	-0.3	-2.1
Other serious medical condition/disability diagnosed by doctor	2.8	3.7	8.0	2.8	2.8	-0.1	0.8	2.3	0.8
Medication: Atenolol	2.7	3.4	7.0	-1.8	-0.3	2.0	2.0	1.4	2.7
High blood pressure (mother)	2.7	3.8	13.5	-3.7	-2.3	0.7	1.2	-1.4	0.4
Forced vital capacity (FVC)	2.7	10.5	32.1	-2.3	-2.3	-2.2	-2.9	-5.7	-2.7
Number of live births	2.7	3.9	8.4	2.9	2.3	1.7	1.9	1.5	0.8
Hypertension (Self-reported)	2.7	7.6	27.7	-5.3	-2.4	2.3	1.5	-0.2	2.2
Ovarian Cancer	2.6	3.5	7.1	1.9	2.3	0.9	2.7	1.7	1.1
Heel T-Score	2.6	20.5	43.4	-3.0	-2.9	-3.3	-3.0	-6.6	-6.5
High blood pressure	2.6	7.3	22.5	-4.7	-1.9	2.6	1.9	0.4	2.7
Hair/balding pattern: Pattern 3	2.6	3.9	9.8	-3.1	-2.2	-1.4	-0.9	-1.8	-1.7
Osteoarthritis (self-reported)	2.6	3.3	9.7	2.0	3.1	-1.4	0.3	1.8	-0.9
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	7.3	2.5	2.7	-0.1	1.1	2.0	0.7
Bipolar Disorder or Schizophrenia	2.5	6.0	21.9	4.7	2.7	0.1	-1.2	2.1	1.1
Hand grip strength (left)	2.5	6.6	21.9	-2.5	-2.8	-1.0	-1.7	-4.7	-0.3
Supplements: Zinc	2.5	2.7	6.2	0.8	2.2	2.5	0.7	1.1	1.7
Blood clot in the leg (DVT)	2.5	3.2	9.5	-0.8	0.3	-2.0	0.9	-2.1	-3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	3.0	6.9	2.2	2.3	-0.6	0.7	2.6	-0.1
Mineral and other dietary supplements	2.5	3.4	4.6	-2.1	-2.0	-1.1	-1.3	-2.1	-2.1
Trunk fat percentage	2.4	9.4	21.3	0.5	-0.5	-2.6	-4.4	-2.9	-4.6
Peak expiratory flow (PEF)	2.4	5.7	17.4	-3.0	-1.4	-1.6	-0.8	-4.2	-1.6
Birth weight	2.4	5.2	12.0	1.0	1.5	3.5	1.7	2.4	2.6
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	5.1	1.0	1.8	1.3	0.9	2.2	2.3
Vascular/heart problems diagnosed by doctor	2.4	6.6	20.2	4.5	1.7	-2.5	-1.9	-0.0	-2.6
Ever used hormone-replacement therapy (HRT)	2.3	2.9	5.5	0.7	2.1	1.4	2.0	2.3	1.0
Hand grip strength (right)	2.3	6.4	26.2	-1.2	-1.7	-1.9	-0.2	-5.1	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	2.3	5.2	11.4	-0.1	-0.7	-2.6	-2.2	-3.4	-2.8
Forced expiratory volume in 1-second (FEV1)	2.3	7.7	24.3	-1.9	-1.3	-2.4	-1.5	-4.9	-2.9
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	7.1	-1.0	-2.7	0.1	-2.4	-1.7	0.8
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.9	11.7	-1.0	-2.6	0.2	-3.1	-3.4	-0.5
Alzheimer’s Disease (including proxy)	2.2	3.2	7.2	2.7	2.6	-0.5	1.6	0.5	-1.4
Trunk fat mass	2.2	9.6	22.8	-0.2	-1.1	-2.3	-4.8	-3.5	-4.0
Standing height	2.2	22.0	65.4	-2.5	-4.5	0.1	-6.3	-8.1	-1.0
Knee pain experienced in last month	2.2	3.4	7.9	2.8	2.4	-1.8	-0.2	1.5	-1.0
Financial situation satisfaction	2.2	2.8	13.5	3.7	1.1	-0.5	-0.1	0.9	0.9
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	7.6	-2.8	-2.1	1.3	-0.4	-0.0	1.4
Systolic Blood Pressure	2.0	9.8	21.1	-3.0	-0.1	4.6	2.4	2.8	3.9
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	10.4	0.1	-0.9	-2.4	-2.3	-3.2	-2.3
Medication: Ibuprofen	2.0	2.4	5.6	-0.5	-2.4	-0.5	-2.0	-2.0	0.1
Ever had bowel cancer screening	2.0	2.3	4.2	1.1	1.0	2.0	0.8	2.1	1.6
Mouth/teeth dental problems: Mouth ulcers	2.0	3.3	6.2	1.7	1.9	1.0	0.8	2.5	2.3
Schizophrenia (2014)	1.9	4.1	14.1	3.8	1.8	-0.2	-2.1	1.8	0.2
Cardiovascular Disease	1.9	6.1	18.4	-4.3	-2.9	2.3	0.9	-0.9	1.7
Vitamin and mineral supplements	1.9	2.6	7.1	-0.5	-1.4	-1.3	0.0	-2.2	-2.7
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	4.3	1.8	1.8	1.3	2.0	2.1	1.1
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	4.8	1.9	1.7	0.7	1.0	2.2	1.1
Illnesses of siblings	1.9	2.6	5.6	-1.1	-1.9	-1.1	-1.5	-2.4	-1.4
Forced vital capacity (FVC), Best measure	1.9	6.9	20.9	-2.5	-1.5	-1.3	-2.0	-4.6	-2.4
Body fat percentage	1.9	7.5	17.1	0.4	-0.4	-2.2	-4.1	-2.4	-4.1
Arm fat-free mass (right)	1.9	9.9	21.4	-3.5	-3.6	-1.1	-3.1	-4.6	-1.3
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	6.9	-0.7	0.4	-1.5	1.0	-1.9	-2.6
Heart disease (siblings)	1.9	2.3	5.6	0.4	0.8	2.3	1.3	1.0	2.4
Verbal and Numeric Reasoning (VNR)	1.8	4.4	8.8	-2.9	-3.0	1.1	-0.6	-2.7	-0.7
Height	1.8	34.1	97.8	-0.8	-4.1	-1.5	-8.6	-9.9	-3.7
Medication: Metformin	1.8	2.5	5.4	-1.0	-1.5	-1.6	-1.2	-1.6	-2.3
Severe depression (siblings)	1.8	2.1	7.2	2.7	2.0	-0.0	0.3	0.8	0.8
Past tobacco smoking	1.8	3.3	5.5	-2.3	-1.8	-2.3	-0.0	-1.9	-1.4
Number of children fathered	1.8	2.0	4.5	0.8	2.1	1.5	1.3	1.1	1.4
Eye problems/disorders: None of the above	1.8	2.1	4.6	-2.1	-0.5	1.8	1.9	0.1	0.8
Emphysema/chronic bronchitis	1.8	2.0	5.3	0.9	1.2	-0.7	-1.6	-1.3	-2.3
Whole body fat mass	1.8	7.6	18.7	-0.5	-1.1	-2.0	-4.3	-3.1	-3.5
Comparative height size at age 10	1.8	10.2	18.3	-3.9	-3.5	0.8	-3.7	-4.3	1.0
Osteoporosis (self-reported)	1.8	2.3	4.0	1.5	1.7	0.9	1.6	2.0	1.1
HbA1C	1.7	1.8	5.5	2.4	2.1	0.6	-0.2	0.3	0.8
Ever had hysterectomy (womb removed)	1.7	1.9	7.2	0.3	0.5	1.6	0.8	1.0	2.7
Time employed in main current job	1.7	2.0	5.5	-0.1	0.4	1.7	-0.5	1.8	2.3
Medication: Amlodipine	1.7	2.4	4.5	-1.6	-0.7	2.1	1.6	1.1	1.7
Arm predicted mass (left)	1.7	8.4	18.4	-3.1	-3.2	-0.8	-3.3	-4.3	-0.5
Coronary Artery Disease (CAD)	1.6	1.9	4.6	0.0	1.2	2.0	2.1	0.4	1.1
Mean Putamen Volume	1.6	1.9	3.9	-0.6	0.2	1.8	0.1	2.0	1.9
Type 2 Diabetes (T2D) (2012)	1.6	1.8	4.1	1.4	0.3	-0.9	-1.7	-0.9	-2.0
Blood Red Count	1.6	15.4	35.5	3.5	1.7	-6.0	2.7	-1.1	-5.8
Had other major operations	1.6	2.0	4.7	0.5	-0.3	-1.7	-2.2	-0.7	-1.8
Weight	1.6	7.8	17.5	-1.6	-2.1	-1.4	-4.2	-4.0	-2.1
Arm predicted mass (right)	1.6	8.3	19.4	-3.2	-3.1	-1.0	-2.7	-4.4	-1.3
Leg fat mass (left)	1.6	6.2	14.7	-1.1	-1.5	-1.6	-3.8	-2.8	-2.9
Fluid intelligence score	1.5	3.1	6.4	-2.4	-2.5	0.1	-0.3	-2.5	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	13.5	-2.1	-1.0	-1.9	-0.8	-3.7	-2.2
Medication: Paracetamol	1.5	2.5	6.6	-0.3	0.0	2.4	0.5	1.4	2.6
Neck or shoulder pain in last month	1.5	2.2	5.9	1.8	1.7	-0.5	0.7	0.4	-2.4
Leg fat mass (right)	1.5	5.8	15.8	-0.9	-1.5	-1.5	-4.0	-2.7	-2.6
Smoking status: Previous	1.5	2.2	3.4	1.6	1.0	1.9	-0.2	1.8	1.8
Diabetes diagnosed by doctor	1.5	2.5	8.9	1.0	0.8	-1.8	-0.6	-1.0	-3.0
Medication: Lisinopril	1.5	2.0	4.6	-1.8	-1.2	1.1	0.3	1.2	2.1
Arm fat-free mass (left)	1.5	7.8	16.5	-3.0	-3.0	-0.9	-3.3	-4.1	-0.4
Unable to work because of sickness or disability	1.5	2.0	4.0	2.0	1.3	0.0	1.8	1.7	-0.1
Supplements: Calcium	1.5	1.7	5.7	2.4	1.4	-1.5	-0.2	0.4	-0.3
Intelligence (Savage-Jansen 2018)	1.4	4.3	10.5	-2.1	-2.9	1.4	-0.8	-3.2	-0.2
Number of treatments/medications taken	1.4	2.5	7.3	0.2	-0.4	1.6	0.3	2.1	2.7
Angina	1.4	1.9	3.5	-0.2	1.6	1.4	1.9	1.0	1.5
Average weekly fortified wine intake	1.4	1.7	5.9	-0.4	-0.5	0.3	1.7	0.7	2.4
Hair/balding pattern: Pattern 4	1.4	3.4	14.4	-3.8	-1.6	0.6	1.5	0.7	0.0
High blood pressure (siblings)	1.4	2.0	6.8	-0.6	1.4	1.1	2.6	1.3	0.1
Medication: Blood pressure	1.4	2.5	6.9	-2.6	-0.5	1.7	2.0	0.7	1.0
Mean time to correctly identify matches	1.4	2.8	8.3	0.1	-0.0	2.9	0.4	2.1	1.9
Handedness (chirality/laterality): Left-handed	1.4	1.7	5.1	-2.3	-1.1	0.8	-1.0	-0.3	1.4
Average weekly champagne plus white wine intake	1.4	2.0	5.9	-2.4	-1.8	-0.2	-0.4	-1.5	0.0
Commuting to job workplace: Cycle	1.4	1.7	5.7	-2.4	-1.4	0.4	-0.8	-1.3	0.3
Crohns Disease (2017)	1.3	2.9	7.9	-0.7	-1.2	2.2	-1.3	0.9	2.8
Prostate Cancer	1.3	1.9	3.0	-0.4	1.6	1.0	1.7	1.7	1.4
Age at First Birth	1.3	1.9	3.7	-1.9	-1.9	-1.6	-0.7	-1.1	0.4
Crohns Disease (2012)	1.3	2.1	4.8	-1.0	-1.7	1.5	-2.2	-0.6	1.2
Neuroticism (2016)	1.3	1.9	6.1	-1.3	-2.5	0.2	-1.7	-0.0	0.7
Ulcerative Colitis	1.3	1.9	4.9	-0.6	0.4	2.2	0.6	1.9	1.6
Neuroticism	1.3	3.1	9.1	-0.4	-0.7	1.3	0.3	3.0	2.6
Multivitamins +/- minerals	1.3	1.7	4.4	-0.5	0.7	2.1	0.3	0.9	2.0
Trunk fat-free mass	1.3	7.2	15.7	-2.5	-3.0	-0.0	-3.4	-4.0	0.6
Hip circumference	1.3	5.5	12.0	-1.7	-2.1	-0.5	-3.5	-3.3	-1.6
Angina (self-reported)	1.3	1.8	3.6	-0.5	1.4	1.3	1.9	1.0	1.3
Had major operations	1.3	1.5	4.9	0.0	0.1	-1.4	-1.1	-2.2	-0.9
Medication: Bendroflumethiazide	1.3	2.0	3.9	-1.9	-1.6	2.0	-0.6	-0.6	1.2
Basal metabolic rate	1.3	7.2	16.0	-2.5	-2.7	-0.7	-3.6	-4.0	-0.7
Number of operations (self-reported)	1.3	1.9	4.3	1.1	1.3	-2.1	-1.5	-0.5	-1.1
Schizophrenia (2018)	1.2	2.4	8.8	3.0	1.1	0.4	-0.4	1.7	1.2
Blood White Count	1.2	8.9	20.0	3.3	3.5	-2.8	1.5	-0.1	-4.5
Hearing difficulty/problems: Yes	1.2	1.8	4.0	1.9	-0.5	0.4	-2.0	-0.5	-1.6
Systolic blood pressure, automated reading	1.2	3.6	6.8	-1.5	0.6	2.5	1.2	2.1	2.6
Taking other prescription medications	1.2	1.8	4.1	1.4	1.0	0.6	-0.9	2.0	1.6
Number of incorrect matches in round	1.2	1.9	5.8	0.9	1.4	0.5	-0.6	1.6	2.4
Noisy workplace	1.2	1.5	4.3	-0.2	-0.2	0.7	0.4	2.1	2.0
Trunk predicted mass	1.2	7.0	15.8	-2.4	-2.9	0.1	-3.4	-4.0	0.6
Family relationship satisfaction	1.2	1.4	2.6	-0.8	-1.5	0.2	-1.6	-1.1	1.3
Leg pain on walking	1.2	1.5	3.1	0.3	0.2	-0.6	-1.6	-1.8	-1.7
Medication: Aspirin	1.2	1.6	3.4	-1.9	-1.5	0.5	0.6	-0.2	1.9
Illnesses of father: High blood pressure	1.2	1.5	4.1	-2.0	-1.2	-0.3	0.5	-1.7	0.0
Triglycerides	1.1	1.8	4.2	1.1	0.3	-1.5	-2.1	-1.1	-1.3
Respiratory disease	1.1	2.4	9.2	1.9	-0.9	0.7	-3.0	-0.1	0.5
Medication for hormone replacement therapy	1.1	1.3	3.6	-1.0	0.4	1.9	0.7	0.7	1.4
Waist circumference	1.1	4.2	13.7	-0.4	-1.4	-0.8	-3.7	-2.1	-2.1
Hearing difficulty/problems with background noise	1.1	1.8	5.3	2.3	0.8	1.9	-0.3	1.1	-0.1
Headache pain in last month	1.1	1.8	8.3	-0.0	0.1	2.9	1.2	0.5	1.0
Medication: Ventolin 100micrograms inhaler	1.1	1.4	5.4	0.5	-1.3	0.5	-2.3	-0.7	0.3
Wheeze or whistling in the chest in last year	1.1	1.9	5.0	1.8	-0.7	1.2	-2.2	0.5	0.9
Medication: Aspirin	1.1	1.4	4.6	-1.3	-1.1	0.6	0.8	0.3	2.2
Whole body fat-free mass	1.1	6.3	14.1	-2.6	-2.7	-0.3	-3.1	-3.8	0.1
Mood swings	1.1	2.0	4.3	2.1	1.2	1.0	-1.0	1.8	1.1
Whole body water mass	1.1	6.4	14.6	-2.6	-2.6	-0.5	-3.2	-3.8	-0.0
Leg fat percentage (left)	1.1	4.0	9.5	-0.0	-0.6	-1.4	-3.0	-1.7	-3.1
Rheumatoid Arthritis	1.0	1.3	2.1	0.5	1.4	1.1	-1.4	1.3	1.0
Medication: Co-codamol	1.0	1.2	2.3	0.4	1.0	1.1	0.9	1.5	1.2
Diabetes (mother)	1.0	1.3	4.2	2.1	0.8	-0.2	-1.1	1.3	-0.2
Current tobacco smoking	1.0	1.6	3.0	-0.8	-1.4	0.7	-1.7	-1.6	-0.8
Maternal smoking around birth	1.0	1.5	3.7	-0.4	0.1	-0.5	-1.3	-1.9	-1.8
Diabetes (self-reported)	1.0	1.5	4.7	0.8	1.3	-1.2	0.1	-0.4	-2.2
Pulse rate	1.0	1.7	3.8	-0.1	0.2	-1.9	-0.6	-1.6	-1.9
Depression (self-reported)	1.0	1.2	3.1	1.6	0.3	0.1	0.0	1.8	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.8	2.0	1.0	-1.3	-1.3	-0.1	-0.8
Birth weight of first child	1.0	1.8	5.2	-0.0	-1.0	2.3	-0.5	-0.4	2.1
Pulse wave reflection index	1.0	1.2	4.0	0.4	-0.6	1.2	0.3	2.0	1.1
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.7	0.7	1.6	1.2	-1.5	0.4	-0.3
Leg fat percentage (right)	1.0	3.6	11.5	0.3	-0.6	-1.2	-3.4	-1.5	-2.5
Worry too long after embarrassment	1.0	1.6	4.2	-2.1	-1.1	-1.3	0.6	1.5	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	4.6	2.1	1.5	-0.6	0.4	0.8	-0.0
Qualifications: College or University degree	1.0	3.0	7.6	-1.4	-2.0	0.3	-2.0	-2.8	-0.7
Medication: Seretide 50 evohaler	1.0	1.1	2.0	1.0	-1.4	1.2	-1.4	-0.7	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.5	1.3	1.6	-0.9	1.3	0.4	0.6
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	6.2	-0.4	-0.1	-0.4	-0.2	-0.8	-2.5
Arm fat mass (left)	1.0	4.0	9.8	-0.5	-0.3	-1.8	-3.1	-1.8	-2.7
Miserableness	1.0	1.7	3.9	1.6	-0.5	-1.5	-2.0	-1.1	-0.3
Eye problems/disorders: Glaucoma	1.0	1.2	2.9	1.1	1.7	-0.2	0.6	1.0	-1.2
Supplements: Fish oil (including cod liver oil)	1.0	1.3	4.2	1.1	0.6	1.1	0.6	0.9	2.0
Diastolic blood pressure, automated reading	1.0	3.2	7.7	-2.8	-2.4	0.5	-0.9	-1.5	1.6
Neuroticism (Nagel 2018)	0.9	2.2	4.8	-0.8	-1.4	1.1	0.2	2.2	2.1
Schizophrenia vs Biploar Disorder	0.9	1.1	3.1	-1.7	-1.2	0.0	-1.4	-0.7	-0.3
Smoking Status	0.9	2.1	6.9	1.4	0.1	2.6	-1.6	0.3	1.3
Leg fat-free mass (left)	0.9	4.5	9.6	-2.0	-1.8	-0.8	-3.0	-3.1	-0.7
Supplements: Glucosamine	0.9	1.2	3.7	0.7	0.6	0.4	0.2	1.9	1.5
Leg predicted mass (left)	0.9	4.5	10.0	-1.9	-1.8	-0.8	-3.0	-3.2	-0.7
Medication: Ramipril	0.9	1.2	3.0	-1.7	0.6	1.1	1.6	0.0	0.4
Falls in the last year	0.9	1.2	3.1	1.8	1.1	-1.5	0.4	-0.5	-0.4
Asthma	0.9	1.8	5.1	1.2	-0.3	1.5	-2.2	-0.1	1.4
Medication: Lansoprazole	0.9	1.1	2.6	0.5	1.0	-1.0	-1.1	0.6	-1.6
Arm fat mass (right)	0.9	3.7	11.9	-0.5	-0.3	-1.5	-3.5	-1.6	-2.2
Length of working week for main job	0.9	1.0	2.6	-0.6	-0.3	-1.6	-0.5	-0.1	-1.6
Health satisfaction	0.9	1.2	4.2	1.6	0.1	-0.5	-2.1	-0.4	0.3
Alcohol intake frequency.	0.9	2.0	6.4	0.1	1.5	0.5	1.0	2.5	1.5
Suffer from ‘nerves’	0.9	1.4	4.2	0.4	-0.5	0.4	1.3	2.0	1.5
Commuting to job workplace: Car/motor vehicle	0.9	1.1	4.3	2.1	1.1	0.4	0.9	0.3	-0.1
Illnesses of siblings: Diabetes	0.9	1.2	3.5	1.0	0.2	-1.3	-1.9	0.8	-0.0
Arm fat percentage (left)	0.9	3.8	11.3	0.5	0.7	-1.8	-2.7	-0.6	-3.4
Friendships satisfaction	0.9	1.1	4.0	-0.3	-0.8	0.3	-2.0	0.1	1.4
Asthma (self-reported)	0.9	1.7	4.0	1.5	-0.0	1.5	-2.0	0.1	1.4
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.1	1.5	1.4	0.5	0.6	1.2	0.7
Medication: Paracetamol	0.9	1.4	3.2	-0.0	0.1	1.5	1.1	1.3	1.8
Medication: Atorvastatin	0.9	1.2	3.4	-0.6	-1.2	-0.9	-1.8	-0.9	-0.4
Major Depression (MDD)	0.8	1.0	2.2	-1.5	-1.3	-0.4	-1.0	-0.5	0.8
BMI	0.8	4.8	15.0	-0.4	-0.3	-3.9	-2.6	-0.8	-2.5
Diabetes (father)	0.8	1.0	2.0	-0.2	-0.2	-1.2	-1.4	-1.0	-1.3
Impedance of leg (right)	0.8	3.8	8.8	1.3	-1.5	-0.1	-3.0	-2.8	-1.6
Age when periods started (menarche)	0.8	1.8	6.7	0.9	0.3	-1.5	0.6	-0.9	-2.6
Serious illness, injury or assault to yourself	0.8	1.0	3.1	0.6	0.7	1.0	1.8	0.8	0.4
Impedance of leg (left)	0.8	4.1	9.5	1.0	-1.5	-0.3	-2.4	-3.1	-2.5
Nervous feelings	0.8	1.5	5.4	-0.0	-0.1	0.7	-0.3	2.3	1.7
Qualifications: None of the above	0.8	1.8	4.9	0.7	0.7	1.8	1.1	2.2	0.5
Arm fat percentage (right)	0.8	3.3	9.7	0.7	0.8	-1.7	-3.1	-0.3	-2.4
Exposure to tobacco smoke outside home	0.8	1.0	1.8	0.7	0.1	-1.1	-1.4	-0.9	-1.3
Shortness of breath walking on level ground	0.8	1.0	2.2	0.1	-0.9	0.5	-1.5	-1.2	-1.1
Illnesses of father: Heart disease	0.8	1.1	2.6	0.3	1.0	1.4	1.6	0.8	0.6
Illnesses of father: None of the above (group 1)	0.8	1.0	3.1	1.8	0.7	-1.4	-0.3	0.6	0.0
Leg predicted mass (right)	0.8	4.2	9.6	-2.3	-1.8	-0.9	-2.4	-3.1	-0.8
Ever taken oral contraceptive pill	0.8	0.9	2.0	1.0	-0.4	-0.9	-1.4	-1.0	-0.3
Ever smoked	0.8	1.3	5.6	0.6	0.6	2.4	0.8	0.8	0.3
Depression (Nagel 2018)	0.7	1.1	2.9	0.0	-1.1	0.9	-0.1	1.3	1.7
Worry (Nagel 2018)	0.7	1.5	5.4	-0.3	-0.6	0.5	0.7	2.3	1.5
Body Mass Index (BMI) (2010)	0.7	1.0	4.6	-2.1	-0.7	0.7	-0.1	0.1	0.6
Blood Platelet Count	0.7	7.7	23.5	-3.6	-4.8	0.9	-2.3	-1.7	0.9
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.6	0.8	0.9	-0.3	0.7	1.2	1.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.7	-1.2	-1.3	0.7	-0.5	-0.7	0.0
Qualifications: CSEs or equivalent	0.7	0.9	2.4	1.0	1.1	-1.6	0.2	0.3	-0.8
Stomach or abdominal pain in last month	0.7	0.8	2.6	1.2	1.6	0.5	0.4	0.3	-0.7
Medication: Levothyroxine sodium	0.7	1.2	2.8	0.3	1.3	-1.7	-1.1	-0.5	-1.1
Sitting height	0.7	5.3	15.8	-0.2	-1.5	-0.7	-3.6	-4.0	0.0
Impedance of arm (right)	0.7	3.1	11.7	3.4	2.1	0.6	-1.4	0.3	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	4.8	2.2	1.4	0.2	-0.3	0.3	-0.2
Breastfed as a baby	0.7	0.8	3.0	-0.1	0.9	0.6	0.7	1.7	0.6
Glaucoma (self-reported)	0.7	0.8	3.6	0.6	0.5	-0.7	-0.6	-0.0	-1.9
Gout (self-reported)	0.7	0.9	3.6	-0.1	-0.4	-0.4	-1.9	-1.3	-0.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	4.1	0.4	2.0	-1.5	-1.1	-0.3	-0.9
Number of full brothers	0.7	0.8	1.7	0.7	0.5	-1.3	-1.3	-0.7	-0.6
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.3	1.1	1.2	0.9	-0.7	0.8	0.7
Overall health rating	0.7	1.6	4.0	2.0	1.4	-0.2	-1.0	1.4	0.6
Leg fat-free mass (right)	0.7	4.0	8.9	-2.2	-1.8	-0.9	-2.4	-3.0	-0.7
Long-standing illness, disability or infirmity	0.7	1.1	3.5	1.9	1.1	0.5	0.1	1.2	0.2
Smoking status: Current	0.7	1.2	2.7	0.1	-0.9	1.4	-1.6	-1.2	-0.5
Wears glasses or contact lenses	0.7	0.9	1.8	0.4	1.3	0.1	1.2	1.3	-0.3
Irritable Bowel Disease (IBD)	0.6	1.3	3.2	-0.3	-0.5	1.8	-0.7	0.8	1.8
Hypothyroidism (self reported)	0.6	1.5	4.0	0.4	0.6	-2.0	-1.7	-0.8	-0.9
Lung FVC	0.6	3.2	8.1	-1.3	-1.0	-1.4	-0.9	-2.8	-2.3
Mouth/teeth dental problems	0.6	1.0	2.4	1.5	0.6	-0.1	0.6	-1.2	-1.2
Mouth/teeth dental problems: Dentures	0.6	1.0	2.4	-1.1	0.2	-1.4	-0.1	1.5	-0.2
Illnesses of mother	0.6	0.8	3.1	1.7	0.5	-0.7	-0.9	-0.1	-0.1
Migraine (self-reported)	0.6	0.8	2.2	-0.1	0.6	0.3	0.9	-1.2	-1.5
Myopia	0.6	0.9	2.3	0.2	0.4	1.5	1.2	0.8	0.9
Pain experienced in last month	0.6	1.0	2.7	-1.6	-1.6	0.0	0.3	-0.2	0.9
Fasting Glucose	0.5	0.6	1.6	-0.1	-1.0	0.7	-1.3	-0.5	-0.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.3	0.8	0.8	-1.2	-0.4	-0.2	-1.5
Hair/balding pattern: Pattern 2	0.5	0.7	2.2	0.9	-0.3	-0.3	-0.5	-1.5	0.8
Financial difficulties in last 2 years	0.5	0.6	1.3	0.9	0.2	-0.6	1.2	1.1	0.1
Medication: Cholesterol lowering	0.5	0.7	3.0	-0.3	-0.4	-0.9	0.2	-0.3	-1.7
Exposure to tobacco smoke at home	0.5	0.6	1.6	-0.4	-0.3	0.8	-1.2	0.9	-0.2
Age at first live birth	0.5	0.8	3.8	-0.3	-0.4	-2.0	0.5	-0.8	0.0
Chest pain or discomfort	0.5	0.8	3.0	0.9	-0.3	0.6	-1.7	-0.4	-0.4
Supplements: Vitamin C	0.5	0.6	1.2	0.9	1.1	-0.1	0.2	0.9	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.3	0.4	-0.8	-0.3	-1.1	-0.3	1.0
Commuting to job workplace: Walk	0.5	0.6	1.7	-0.4	-1.1	-0.0	-0.5	-1.3	-0.1
Back pain experienced in last month	0.5	0.7	1.4	1.0	0.5	0.4	-1.2	-1.1	-0.2
Breast cancer (self-reported)	0.5	0.6	2.2	0.1	-0.3	-0.6	-0.1	-0.8	-1.5
Mother’s age at death	0.5	0.6	1.6	-1.1	-0.2	0.1	1.3	-0.2	-0.7
Commuting to job workplace: Public transport	0.5	0.6	2.0	-0.7	-0.7	0.6	-0.1	0.6	1.4
Risk taking	0.5	0.7	2.3	1.0	0.6	1.5	-0.3	-0.3	0.4
Ever depressed for a whole week	0.5	0.6	2.1	1.4	-0.0	-0.4	-0.9	0.7	0.6
Cholesterol lowering medication	0.5	0.7	2.7	0.2	0.6	1.6	0.7	0.6	0.7
Impedance of whole body	0.5	2.5	5.0	2.0	0.1	-0.3	-1.5	-2.0	-2.2
Depressed Affect (Nagel 2018)	0.4	0.7	1.4	0.3	-0.8	0.8	-0.8	1.0	1.2
Alzheimer’s Disease (in father)	0.4	0.4	1.0	0.6	0.4	0.7	0.1	1.0	0.5
Reaction Time	0.4	0.9	2.0	-0.0	-0.7	1.2	-0.5	1.4	1.0
Lupus	0.4	0.6	1.5	1.1	-0.3	-0.5	-1.2	0.6	0.7
Primary Biliary Cirrhosis	0.4	0.6	1.9	-0.2	1.4	0.3	0.5	1.1	-0.4
Average weekly spirits intake	0.4	0.5	1.2	-0.5	-0.3	0.8	1.1	0.6	0.5
Fed-up feelings	0.4	0.7	2.2	0.4	0.4	0.0	1.5	1.1	0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.4	0.8	0.7	0.0	-0.2	0.3	-1.2
Chronic bronchitis/emphysema (father)	0.4	0.5	2.3	-0.4	-0.0	1.5	0.6	0.3	0.2
Heart attack	0.4	0.5	1.6	-0.3	0.4	0.8	-0.5	0.2	1.2
Pain all over the body in last month	0.4	0.5	1.7	0.1	1.3	0.1	0.3	1.0	-0.1
Father’s age at death	0.4	0.5	0.7	-0.0	0.8	-0.6	-0.8	-0.6	-0.9
Happiness	0.4	0.5	1.9	1.4	0.2	-0.6	-0.6	0.4	0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.8	-0.9	-1.2	-0.7	-0.3	-1.7	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.3	0.7	-0.0	1.2	-0.4	-0.3	0.8
Impedance of arm (left)	0.4	2.0	5.1	2.3	1.2	0.2	-0.8	-0.9	-1.9
Loud music exposure frequency	0.4	0.5	1.6	1.3	-0.5	-0.4	-0.7	0.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.3	0.5	0.9	-1.5	0.2	-0.1	0.3
Medication for pain relief, constipation, heartburn	0.4	0.7	3.4	-0.5	0.3	-0.1	0.4	-0.6	-1.8
Number of full sisters	0.4	0.5	1.0	-0.8	-1.0	0.9	0.4	0.2	0.5
Age at last live birth	0.4	0.5	0.8	0.2	0.9	-0.6	0.9	-0.4	0.9
Qualifications: nursing, teaching	0.4	0.6	2.6	-1.6	-0.3	-0.2	-0.5	-0.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.6	-0.6	-0.4	-1.1	-0.8	-1.3	-1.1
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.9	-0.7	0.7	0.5	0.6	0.4	0.9
Alcohol drinker status: Never	0.4	0.5	1.4	-0.8	-0.4	-0.0	1.2	1.0	-0.2
Average weekly beer plus cider intake	0.4	0.6	1.6	0.0	-1.3	1.0	-0.5	-0.9	-0.1
Age started oral contraceptive pill	0.4	0.5	1.7	-0.7	-0.0	-1.3	0.9	0.3	0.2
Pack years of smoking	0.4	0.5	1.4	-0.4	0.2	-0.5	-1.1	0.4	-1.2
HDL Cholesterol	0.3	0.5	1.9	0.2	0.5	0.6	1.4	0.3	0.8
LDL Cholesterol	0.3	0.5	1.2	0.4	1.1	0.1	-0.7	-0.1	-0.9
Pack years adult smoking proportion	0.3	0.5	1.4	-0.3	0.0	-0.5	-1.2	0.1	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	0.3	-0.8	0.2	-0.8	0.6	0.8
Body mass index (BMI)	0.3	1.4	3.3	-0.3	-0.1	-1.5	-1.6	-0.5	-1.8
Allergy	0.3	0.6	2.9	-0.2	0.3	0.1	1.7	0.8	0.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	0.5	0.8	0.8	-0.4	0.6	0.8
Prospective memory result	0.3	0.4	1.6	0.3	0.2	-0.3	0.0	1.3	0.7
Pulse wave Arterial Stiffness index	0.3	0.3	0.8	-0.3	-0.6	-0.9	-0.9	-0.0	-0.1
Medication: Allopurinol	0.3	0.4	1.6	-0.4	-0.0	-0.0	-1.2	-0.4	-0.5
Heart disease (mother)	0.3	0.3	0.7	-0.8	-0.2	0.8	0.6	-0.1	0.4
Average weekly red wine intake	0.3	0.4	1.6	1.3	0.3	0.4	-0.3	-0.6	0.3
Eye problems/disorders: Cataract	0.3	0.3	1.4	1.2	-0.1	-0.5	-0.2	0.4	-0.0
Medication: Gliclazide	0.3	0.3	0.8	-0.2	-0.4	-0.5	-0.8	-0.1	-0.9
Guilty feelings	0.3	0.4	2.1	-0.5	-0.1	-0.2	0.1	1.4	0.1
Hearing aid user	0.3	0.4	1.0	0.9	0.3	-0.1	0.1	1.0	0.4
High cholesterol (Self-reported)	0.3	0.5	1.2	0.3	0.7	0.8	0.7	-0.2	-1.1
Irritability	0.3	0.6	1.1	-0.3	-0.7	1.0	1.1	-0.6	0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	-0.5	0.3	0.6	-0.7	-0.1	1.1
Ulcerative Colitis (UC)	0.2	0.3	1.1	0.2	0.3	1.0	0.2	0.6	-0.3
Waist Hip Ratio (WHR)	0.2	1.0	3.7	1.9	-0.3	0.0	-1.5	-0.2	-0.5
Lung FEV1/FVC ratio	0.2	1.2	2.0	0.5	1.0	-1.3	1.2	-0.7	-1.4
Sensitivity / hurt feelings	0.2	0.4	1.2	-0.9	-0.2	0.3	0.4	1.1	0.2
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.2	0.6	0.5	0.6	0.6	0.8
Alcohol usually taken with meals	0.2	0.3	0.7	-0.8	0.1	-0.3	-0.7	-0.6	-0.2
Medication: Simvastatin	0.2	0.3	0.7	0.5	0.6	0.2	0.6	-0.3	-0.9
Neuroticism score	0.2	0.5	2.2	-0.3	-0.4	0.1	0.2	1.5	0.7
Lung cancer (father)	0.2	0.3	0.9	0.4	-0.5	0.6	-0.1	-0.9	0.1
Tense / ‘highly strung’	0.2	0.3	1.1	0.5	0.0	-0.1	0.1	1.1	0.6
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.2	1.1	-0.1	0.1	-0.1	0.1	0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	0.9	0.2	-0.7	-0.8	-0.3	0.4
Pulse wave peak to peak time	0.2	0.2	0.6	0.1	0.4	0.8	0.4	-0.5	0.0
Pulse rate, automated reading	0.2	0.6	2.0	0.4	0.2	-1.4	0.8	0.3	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	-0.5	-0.6	-0.6	0.3	-0.6	-0.1
Loneliness, isolation	0.2	0.3	0.8	-0.9	-0.4	-0.9	0.2	-0.2	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.6	0.6	-0.0	0.4	0.5	0.5
Number of self-reported non-cancer illnesses	0.2	0.3	0.9	0.5	1.0	0.6	-0.6	0.4	0.0
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.7	-0.4	0.4	0.9	0.6	0.4	-0.0
Fractured/broken bones in last 5 years	0.2	0.2	0.8	0.3	0.4	0.5	-0.1	-0.9	0.4
Bipolar Disorder (2011)	0.1	0.1	0.3	0.0	0.0	0.0	0.0	0.5	-0.3
Blood Eosinophil Count	0.1	0.9	3.6	-0.1	-1.2	-0.0	-1.9	-0.8	-0.0
Allergy or Eczema	0.1	0.4	0.8	0.3	0.2	0.5	-0.9	0.5	0.8
Chronotype (morning person)	0.1	0.3	0.6	0.4	0.3	-0.1	0.7	0.8	0.4
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.4	0.3	-0.4	0.0	-0.3	0.1	0.7
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	0.3	0.5	0.7	-0.1	0.7	0.6
Alcohol intake versus 10 years previously	0.1	0.1	0.6	-0.0	0.2	-0.2	-0.8	0.3	-0.0
Worrier / anxious feelings	0.1	0.2	0.5	-0.7	0.0	0.4	0.5	0.6	-0.5

Hub : Genes

ZNF276

Models

Trait associations