Best TWAS P=2.21e-15 · Best GWAS P=3.91e-14 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | NOC3L | 0.06 | 0.02 | lasso | 5 | 0.02 | 4.8e-03 | -7.3 | -5.4 | 7.5e-08 | 0.90 | 0.01 | 0.97 | FALSE |
| 2 | GTEx | Artery Coronary | NOC3L | 0.10 | 0.10 | lasso | 3 | 0.10 | 3.5e-04 | -7.2 | -7.0 | 2.0e-12 | 0.97 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | NOC3L | 0.22 | 0.22 | enet | 17 | 0.24 | 8.8e-07 | -7.5 | -6.0 | 2.5e-09 | 0.92 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Brain Hypothalamus | NOC3L | 0.21 | 0.18 | lasso | 3 | 0.12 | 8.5e-04 | -7.3 | -7.2 | 4.6e-13 | 0.98 | 0.02 | 0.83 | TRUE |
| 5 | GTEx | Breast Mammary Tissue (Female) | NOC3L | 0.03 | -0.01 | enet | 2 | -0.01 | 5.9e-01 | -7.3 | -6.9 | 7.0e-12 | 0.98 | 0.02 | 0.43 | FALSE |
| 6 | GTEx | Colon Sigmoid | NOC3L | 0.34 | 0.10 | lasso | 10 | 0.12 | 3.7e-05 | -7.3 | -5.7 | 1.5e-08 | 0.88 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Esophagus Muscularis | NOC3L | 0.11 | 0.10 | lasso | 7 | 0.10 | 1.7e-06 | -3.5 | -6.0 | 1.9e-09 | 0.90 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Heart Atrial Appendage | NOC3L | 0.11 | 0.11 | lasso | 3 | 0.12 | 3.0e-06 | -5.6 | -5.7 | 1.6e-08 | 0.93 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Heart Left Ventricle | NOC3L | 0.11 | 0.07 | lasso | 3 | 0.06 | 2.7e-04 | -7.5 | -7.3 | 2.3e-13 | 1.00 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Nerve Tibial | NOC3L | 0.17 | 0.20 | lasso | 5 | 0.20 | 6.0e-14 | -7.3 | -6.8 | 1.1e-11 | 0.98 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Prostate | NOC3L | 0.21 | 0.07 | enet | 19 | 0.10 | 1.5e-03 | -7.6 | -6.0 | 1.9e-09 | 0.90 | 0.01 | 0.94 | FALSE |
| 12 | GTEx | Skin Not Sun Exposed Suprapubic | NOC3L | 0.32 | 0.21 | enet | 31 | 0.23 | 8.2e-13 | -7.5 | -7.9 | 2.2e-15 | 0.92 | 0.01 | 0.99 | TRUE |
| 13 | GTEx | Skin Sun Exposed Lower leg | NOC3L | 0.13 | 0.15 | lasso | 8 | 0.14 | 8.7e-12 | -7.5 | -7.4 | 1.5e-13 | 1.00 | 0.01 | 0.99 | FALSE |
| 14 | GTEx | Spleen | NOC3L | 0.31 | 0.14 | lasso | 9 | 0.14 | 2.1e-04 | -7.3 | -7.0 | 2.6e-12 | 0.97 | 0.01 | 0.98 | FALSE |
| 15 | GTEx | Uterus | NOC3L | 0.48 | 0.12 | lasso | 5 | 0.26 | 5.1e-06 | -7.0 | -5.2 | 2.3e-07 | 0.72 | 0.02 | 0.94 | FALSE |
| 16 | METSIM | Adipose | NOC3L | 0.10 | 0.10 | lasso | 7 | 0.11 | 3.3e-16 | -7.3 | -5.3 | 1.1e-07 | 0.93 | 0.05 | 0.95 | TRUE |
| 17 | NTR | Blood | NOC3L | 0.02 | 0.02 | lasso | 1 | 0.01 | 5.2e-05 | -7.5 | -7.5 | 6.6e-14 | 0.99 | 0.01 | 0.99 | FALSE |
| 18 | YFS | Blood | NOC3L | 0.09 | 0.14 | enet | 24 | 0.14 | 4.5e-43 | -7.3 | -7.5 | 8.4e-14 | 0.98 | 0.01 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NOC3L | 0.03 | 0.01 | blup | 47 | 0.02 | 2.6e-03 | -6.9 | 7.8 | 6.5e-15 | -0.87 | 0.01 | 0.68 | FALSE |
| 20 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NOC3L | 0.12 | 0.09 | blup | 47 | 0.12 | 1.9e-05 | -7.3 | -5.9 | 4.3e-09 | 0.96 | 0.01 | 0.98 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | NOC3L | 0.02 | 0.01 | blup | 47 | 0.01 | 6.8e-02 | -5.6 | -5.7 | 1.2e-08 | 0.93 | 0.01 | 0.84 | FALSE |