Best TWAS P=1.44e-11 · Best GWAS P=3.39e-20 conditioned to 7.43e-24
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LEMD3 | 0.04 | 0.01 | enet | 13 | 0.03 | 7.3e-05 | -6.2 | -5.5 | 3.4e-08 | -0.12 | 0.38 | 0.02 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | LEMD3 | 0.14 | 0.05 | lasso | 8 | 0.05 | 1.1e-03 | -4.8 | -6.1 | 1.3e-09 | -0.11 | 0.46 | 0.03 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | LEMD3 | 0.09 | 0.10 | lasso | 3 | 0.09 | 4.4e-07 | -5.8 | -5.8 | 5.8e-09 | -0.11 | 0.97 | 0.00 | FALSE |
| 4 | GTEx | Esophagus Muscularis | LEMD3 | 0.09 | 0.09 | enet | 7 | 0.09 | 4.3e-06 | -6.2 | -6.0 | 1.6e-09 | -0.12 | 0.98 | 0.00 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | LEMD3 | 0.12 | 0.03 | enet | 12 | 0.06 | 7.5e-04 | -4.8 | -5.4 | 8.1e-08 | -0.10 | 0.34 | 0.03 | FALSE |
| 6 | GTEx | Nerve Tibial | LEMD3 | 0.12 | 0.14 | enet | 13 | 0.16 | 2.0e-11 | -5.8 | -6.8 | 1.4e-11 | -0.12 | 1.00 | 0.00 | TRUE |
| 7 | GTEx | Testis | LEMD3 | 0.15 | 0.15 | lasso | 7 | 0.16 | 1.9e-07 | -4.8 | -5.2 | 2.4e-07 | -0.09 | 0.71 | 0.02 | FALSE |
| 8 | NTR | Blood | TBC1D30 | 0.01 | 0.00 | bslmm | 327 | 0.00 | 1.6e-02 | -1.5 | -5.8 | 5.6e-09 | -0.10 | 0.07 | 0.12 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LEMD3 | 0.02 | 0.02 | blup | 36 | 0.02 | 5.9e-03 | -6.8 | -6.4 | 1.3e-10 | -0.12 | 0.01 | 0.78 | FALSE |