TWAS hub - TBC1D30

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0980	0.0290	5.9e-05	0.034	0.032	0.066	0.042	0.059	5.3e-05	8.2e-05	1.8e-08	6.4e-06	1.0e-07
2	GTEx	Liver	0.1900	0.0770	7.8e-03	0.001	NA	-0.011	NA	-0.005	3.0e-01	NA	9.5e-01	NA	4.6e-01
3	NTR	Blood	0.0143	0.0068	5.9e-03	0.000	0.004	0.000	0.004	0.002	4.8e-01	1.7e-02	2.1e-01	1.6e-02	6.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Supplements: Calcium	5.8	6.4	10.7	1.3	-2.6	3.3
Taking other prescription medications	4.5	6.9	15.1	2.0	-1.2	3.9
Number of operations (self-reported)	4.3	6.4	13.3	1.6	-1.8	3.6
Age at last live birth	4.0	5.7	12.8	-3.6	1.0	-1.9
Neuroticism (Nagel 2018)	3.9	9.3	17.0	2.9	1.6	4.1
Worry (Nagel 2018)	3.9	8.2	16.0	2.4	1.6	4.0
Noisy workplace	3.8	4.7	8.1	2.9	-1.0	2.2
Handedness (chirality/laterality): Left-handed	3.8	4.6	5.4	-2.3	2.0	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	3.7	4.9	10.4	1.7	1.1	3.2
Suffer from ‘nerves’	3.7	5.9	12.5	1.7	1.5	3.5
Forced vital capacity (FVC), Best measure	3.6	13.1	34.4	-1.5	1.6	-5.9
Number of self-reported non-cancer illnesses	3.6	6.2	10.5	2.3	-1.7	3.2
Hearing aid user	3.6	4.1	5.9	-2.4	2.2	-1.2
Forced vital capacity (FVC)	3.4	13.2	34.0	-1.7	1.7	-5.8
Worry too long after embarrassment	3.4	5.7	10.1	2.3	1.3	3.2
Had major operations	3.4	4.0	7.1	1.1	-1.9	2.7
Hayfever/allergic rhinitis (self-reported)	3.3	4.4	10.8	1.2	-1.0	3.3
Lung FVC	3.2	16.3	37.1	-3.3	0.9	-6.1
Number of treatments/medications taken	3.2	5.7	13.8	1.5	-0.9	3.7
Ever highly irritable/argumentative for 2 days	3.1	3.7	11.2	0.0	-0.1	3.3
Neuroticism score	2.9	6.0	10.8	2.6	0.8	3.3
Hair/balding pattern: Pattern 3	2.9	4.3	8.7	0.0	-2.9	-2.1
Mouth/teeth dental problems: Loose teeth	2.8	3.4	4.8	-1.7	-1.6	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.1	9.2	-3.0	0.1	-0.3
Depressed Affect (Nagel 2018)	2.6	5.5	10.8	2.1	1.2	3.3
Triglycerides	2.6	4.2	7.8	-1.2	-2.8	-1.8
Medication: Lansoprazole	2.6	2.9	5.9	1.3	1.1	2.4
Exposure to tobacco smoke at home	2.6	2.9	6.0	2.4	-1.6	0.2
Medication: Blood pressure	2.6	4.9	8.7	3.0	-1.2	2.1
Lupus	2.5	3.8	4.6	-2.1	1.5	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.5	8.1	23.2	-1.0	0.2	-4.8
Medication: Amlodipine	2.5	3.5	6.4	1.5	1.3	2.5
Number of children fathered	2.5	2.8	5.1	2.3	-0.2	1.8
Eye problems/disorders: Cataract	2.5	2.9	4.4	1.9	-0.8	2.1
Asthma (self-reported)	2.5	5.1	8.7	2.3	1.1	3.0
Osteoarthritis (self-reported)	2.4	3.1	5.3	1.9	-2.3	0.6
Respiratory disease	2.3	5.1	7.7	2.8	1.0	2.6
Medication: Atenolol	2.3	2.9	5.6	0.2	1.7	2.4
Standing height	2.3	23.0	61.9	-2.3	-1.4	-7.9
Neuroticism	2.2	5.2	7.4	2.4	1.6	2.7
Fed-up feelings	2.2	3.9	5.7	2.2	1.1	2.4
Forced expiratory volume in 1-second (FEV1)	2.2	7.3	20.2	-1.3	0.1	-4.5
Cholesterol lowering medication	2.2	3.2	6.0	1.8	-2.5	0.6
Maternal smoking around birth	2.1	3.1	4.6	2.1	-0.7	2.0
Worrier / anxious feelings	2.1	4.0	6.4	0.7	2.2	2.5
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.3	6.2	2.5	-0.0	2.0
Asthma	2.1	4.1	7.3	2.1	0.8	2.7
Supplements: Fish oil (including cod liver oil)	2.1	2.7	4.0	-2.0	0.6	-2.0
Vascular/heart problems diagnosed by doctor	2.1	5.7	13.1	-2.0	0.1	-3.6
Allergy or Eczema	2.0	5.2	7.7	2.3	-1.7	2.8
Pain all over the body in last month	2.0	2.2	6.1	0.4	-0.6	2.5
Loneliness, isolation	2.0	2.7	4.9	-0.2	1.8	2.2
Guilty feelings	2.0	3.1	6.2	1.4	1.0	2.5
Allergy	1.9	4.5	7.1	-2.5	0.1	-2.7
Medication: Ventolin 100micrograms inhaler	1.9	2.5	5.9	2.4	-0.5	1.1
Long-standing illness, disability or infirmity	1.9	2.9	5.8	1.5	-0.8	2.4
Height	1.8	34.7	93.3	-2.8	-1.7	-9.7
Sensitivity / hurt feelings	1.8	3.1	5.0	2.0	0.4	2.2
Hayfever, allergic rhinitis or eczema	1.8	3.9	6.3	2.0	-1.2	2.5
Trunk predicted mass	1.8	10.1	23.8	-0.6	-2.5	-4.9
Medication: Paracetamol	1.8	3.0	6.1	1.3	1.1	2.5
Emphysema/chronic bronchitis	1.8	2.0	4.2	2.1	1.1	0.8
High blood pressure	1.7	4.8	10.9	1.8	0.5	3.3
Medication: Levothyroxine sodium	1.7	2.9	7.5	0.8	-2.7	0.8
Trunk fat-free mass	1.7	9.9	23.1	-0.4	-2.5	-4.8
Hypothyroidism/myxoedema (self-reported)	1.7	3.4	9.9	0.4	-3.1	0.3
Angina (self-reported)	1.7	2.3	2.7	1.6	-1.3	1.6
Hypertension (Self-reported)	1.7	4.8	10.4	2.0	0.1	3.2
Medication: Gliclazide	1.7	1.9	3.1	1.8	-0.9	1.3
Average weekly champagne plus white wine intake	1.7	2.4	3.5	1.9	-0.5	1.8
Type 2 Diabetes (T2D) (2012)	1.6	1.8	3.1	-0.9	-1.8	-1.3
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	2.1	1.4	-1.4	1.4
Arm predicted mass (right)	1.6	8.4	19.0	-0.4	-2.5	-4.4
Frequency of depressed mood in last 2 weeks	1.5	2.0	5.1	1.0	0.2	2.3
Breastfed as a baby	1.5	1.8	5.0	-0.3	-2.2	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.4	3.5	1.4	1.3	1.9
Arm fat-free mass (right)	1.5	7.8	19.6	-0.3	-1.9	-4.4
Wheeze or whistling in the chest in last year	1.5	2.6	5.5	2.3	0.6	1.5
Osteoporosis (self-reported)	1.5	1.9	4.0	-1.0	-2.0	0.8
Medication: Atorvastatin	1.5	1.9	2.7	1.0	-1.4	1.6
Arm fat-free mass (left)	1.5	7.8	18.6	-0.4	-2.2	-4.3
HbA1C	1.4	1.5	2.0	-1.4	-1.1	1.2
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.1	1.8	-1.4	0.7
Townsend deprivation index at recruitment	1.4	2.0	5.5	-0.1	-2.4	0.6
Stomach or abdominal pain in last month	1.4	1.8	4.7	0.5	0.7	2.2
Gout (self-reported)	1.4	1.9	3.1	1.2	-1.2	1.7
Eye problems/disorders: None of the above	1.4	1.6	2.5	-1.6	1.0	-1.2
Medication: Blood pressure	1.4	2.5	4.8	0.2	1.6	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.0	1.3	1.7	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.1	2.0	0.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	7.1	-1.0	0.7	-2.7
Average weekly red wine intake	1.4	2.1	5.4	-1.0	-0.2	-2.3
Mood swings	1.4	2.6	4.1	1.6	-1.1	2.0
High cholesterol (Self-reported)	1.4	2.5	5.1	2.3	-1.1	1.1
Arm predicted mass (left)	1.4	7.1	17.0	-0.2	-2.1	-4.1
Alzheimer’s Disease (including proxy)	1.3	1.9	5.8	-0.0	0.1	-2.4
Blood Platelet Count	1.3	15.3	32.4	5.7	3.3	1.6
Glaucoma (self-reported)	1.3	1.6	4.2	-0.4	-2.0	0.6
Age at first live birth	1.3	2.2	3.8	-1.9	1.1	-1.3
Whole body fat-free mass	1.3	7.7	16.9	-0.1	-2.5	-4.1
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.7	1.6	-0.3	1.2
Whole body water mass	1.3	7.5	16.4	-0.1	-2.5	-4.0
Pain type(s) experienced in last month: Hip pain	1.3	1.7	2.7	-0.5	1.4	-1.6
Medication: Paracetamol	1.3	2.1	5.0	0.6	0.9	2.2
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	4.3	2.1	-0.6	-0.7
Ovarian Cancer	1.2	1.6	3.9	2.0	-0.9	-0.3
Fasting Glucose	1.2	1.4	2.8	-1.7	0.3	1.2
Hypothyroidism (self reported)	1.2	2.7	7.4	0.7	-2.7	0.4
Angina	1.2	1.6	2.0	1.4	-0.9	1.3
Sitting height	1.2	8.4	22.0	-1.6	-0.7	-4.7
Pulse rate	1.2	2.0	3.4	0.7	1.8	1.4
Blood clot in the leg (DVT)	1.2	1.6	3.6	1.9	-0.8	-0.6
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	5.2	-0.6	-0.5	-2.3
Exposure to tobacco smoke outside home	1.2	1.6	2.6	-0.2	1.6	-1.4
Medication for cholesterol	1.2	1.8	3.2	-1.8	1.0	-1.1
Miserableness	1.2	2.1	2.6	1.2	-1.5	1.6
Basal metabolic rate	1.2	6.7	14.9	-0.0	-2.3	-3.9
Alzheimer’s Disease (in mother)	1.1	1.2	3.1	0.3	-0.7	-1.8
Coronary Artery Disease (CAD)	1.1	1.3	3.1	1.8	-0.2	0.8
Average weekly spirits intake	1.1	1.3	3.5	-0.5	-1.9	-0.6
Alcohol usually taken with meals	1.1	1.8	3.6	-1.9	-0.2	-1.3
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	3.0	1.1	1.0	1.7
Number of live births	1.1	1.6	3.0	-1.3	0.4	-1.7
Medication for pain relief, constipation, heartburn	1.1	1.8	5.4	0.2	-0.2	-2.3
Overall health rating	1.1	2.4	6.0	0.9	-0.7	2.4
Medication: Aspirin	1.1	1.4	3.8	-1.9	-0.6	0.2
Illnesses of father: High blood pressure	1.1	1.3	2.5	0.4	1.6	1.1
Risk taking	1.1	1.6	3.4	0.9	-0.9	1.8
Age at First Birth	1.0	1.4	4.1	0.1	0.4	-2.0
Cardiovascular Disease	1.0	3.3	5.6	2.1	-0.1	2.4
Hand grip strength (left)	1.0	2.6	7.5	0.5	0.1	-2.7
Ever had hysterectomy (womb removed)	1.0	1.1	2.9	0.5	0.3	1.7
Diabetes (father)	1.0	1.3	2.1	1.4	-0.8	1.0
Diabetes (mother)	1.0	1.2	2.3	0.5	-1.1	-1.5
Illnesses of mother	1.0	1.2	1.6	-1.3	1.0	1.0
Medication: Allopurinol	1.0	1.3	2.7	-0.5	-1.6	0.9
Number of full sisters	1.0	1.2	2.6	-0.7	-0.8	-1.6
Illnesses of father: Heart disease	1.0	1.4	3.4	1.8	0.6	0.6
Medication: Aspirin	1.0	1.3	3.3	-1.8	-0.7	0.2
Medication: Bendroflumethiazide	1.0	1.5	3.8	0.7	0.6	1.9
Medication: Lisinopril	1.0	1.3	3.7	0.4	-0.3	1.9
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.6	1.1	0.1	1.6
Medication for hormone replacement therapy	0.9	1.0	2.1	0.8	1.4	-0.4
Impedance of leg (right)	0.9	4.3	4.7	-1.9	2.2	-2.1
Leg fat-free mass (left)	0.9	4.6	8.1	0.6	-2.3	-2.8
Had other major operations	0.9	1.1	2.6	0.9	0.3	1.6
Weight	0.9	4.4	7.4	0.6	-2.3	-2.7
Qualifications: A levels/AS levels or equivalent	0.9	1.9	5.5	0.5	0.0	2.4
Birth weight of first child	0.9	1.7	2.3	-1.5	-0.9	-1.4
Peak expiratory flow (PEF)	0.9	2.0	5.3	0.8	-0.3	-2.3
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.9	1.4	-0.8	0.8
High blood pressure (siblings)	0.9	1.2	1.6	0.7	1.3	1.2
Illnesses of siblings: Diabetes	0.9	1.1	2.3	-0.7	-0.8	-1.5
Diabetes diagnosed by doctor	0.9	1.6	3.4	-1.0	-1.8	-0.5
Mineral and other dietary supplements	0.9	1.2	2.0	1.2	-0.4	1.4
Bipolar Disorder (2011)	0.8	0.8	2.1	0.5	-0.3	1.4
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.8	0.2	-1.7	0.2
Impedance of leg (left)	0.8	4.1	4.5	-2.1	2.0	-2.0
Leg predicted mass (left)	0.8	4.3	7.7	0.7	-2.2	-2.8
Waist circumference	0.8	2.8	6.3	0.5	-2.5	-1.3
Hair/balding pattern: Pattern 2	0.8	1.0	2.6	0.4	0.5	1.6
Heart attack	0.8	1.0	1.8	1.1	0.0	1.4
Birth weight	0.8	1.7	4.2	-2.0	-0.0	-1.0
Health satisfaction	0.8	1.0	2.4	0.2	-1.6	0.8
Heart disease (mother)	0.8	1.0	2.7	1.6	-0.4	-0.0
Comparative height size at age 10	0.8	4.7	11.6	-1.4	-0.6	-3.4
Chest pain or discomfort	0.8	1.2	1.7	0.3	1.3	1.3
Family relationship satisfaction	0.8	0.9	1.3	-1.1	-0.5	-1.1
Leg fat-free mass (right)	0.8	4.0	6.5	0.6	-2.3	-2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.3	-0.2	-0.6	1.5
Back pain experienced in last month	0.8	1.1	1.6	1.3	-1.0	0.9
Basal cell carcinoma (self-reported)	0.8	1.0	1.4	-1.2	1.0	-0.7
Depression (Nagel 2018)	0.7	1.1	2.4	0.8	-0.4	1.5
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.0	-1.4	-1.1	-0.8
Medication: Co-codamol	0.7	0.8	1.8	0.6	1.4	0.3
Average weekly fortified wine intake	0.7	0.8	1.6	0.2	-1.3	0.9
Age when periods started (menarche)	0.7	1.6	2.6	-1.0	1.1	-1.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.7	0.9	0.1	1.3
Nervous feelings	0.7	1.2	3.3	0.3	0.6	1.8
Diabetes (self-reported)	0.7	1.1	3.0	-0.4	-1.7	0.5
Illnesses of siblings	0.7	1.0	2.7	-0.1	0.4	-1.6
Supplements: Vitamin C	0.7	0.8	2.0	-0.6	-1.4	0.1
Ever had bowel cancer screening	0.7	0.8	2.0	-1.4	0.4	-0.6
Leg predicted mass (right)	0.7	4.0	6.5	0.7	-2.2	-2.6
Ever smoked	0.7	1.2	2.4	-0.9	-0.6	-1.6
Ulcerative Colitis (UC)	0.6	1.0	2.3	0.8	-0.3	1.5
HDL Cholesterol	0.6	1.1	2.3	1.5	0.8	0.5
LDL Cholesterol	0.6	1.0	1.6	-1.1	-1.2	-0.6
Lung FEV1/FVC ratio	0.6	3.0	8.5	0.3	-2.9	0.7
Medication: Metformin	0.6	0.8	1.7	0.6	-1.3	0.6
Severe depression (siblings)	0.6	0.7	1.8	0.5	0.1	-1.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.5	-0.4	1.2	0.4
Chronic bronchitis/emphysema (father)	0.6	0.7	2.1	1.4	-0.0	-0.2
Hearing difficulty/problems with background noise	0.6	1.0	2.3	-0.6	-0.6	-1.5
Medication: Simvastatin	0.6	0.9	1.5	1.0	-1.2	0.1
Father’s age at death	0.6	0.8	1.5	-0.6	0.6	-1.2
Falls in the last year	0.6	0.8	1.7	-0.5	-1.3	0.6
Length of working week for main job	0.6	0.7	1.6	1.2	-0.2	0.7
Tense / ‘highly strung’	0.6	1.0	2.4	0.6	-0.4	1.5
Number of full brothers	0.6	0.8	1.2	0.4	-1.1	-1.0
Qualifications: College or University degree	0.6	1.8	2.7	0.2	-1.6	1.6
Medication: Omeprazole	0.6	0.7	1.1	-1.0	0.1	1.1
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.7	-0.4	-0.3	-1.3
Friendships satisfaction	0.6	0.7	2.1	-0.4	1.4	0.1
Commuting to job workplace: Public transport	0.6	0.7	1.8	0.5	0.2	1.4
Age started oral contraceptive pill	0.6	0.8	2.0	-1.4	-0.6	0.1
Unable to work because of sickness or disability	0.6	0.8	2.1	-0.1	0.5	1.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.2	-0.9	0.7	1.1
Crohns Disease (2017)	0.5	1.1	1.9	0.1	1.2	1.4
Irritable Bowel Disease (IBD)	0.5	1.2	2.6	0.6	0.8	1.6
Rheumatoid Arthritis	0.5	0.8	1.3	0.9	0.3	1.1
Ulcerative Colitis	0.5	0.8	1.7	0.5	-0.6	1.3
Hair Pigment	0.5	14.8	44.0	-0.6	-0.0	6.6
Hand grip strength (right)	0.5	1.3	3.6	0.4	-0.6	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	0.9	0.9	-0.7	0.9
Supplements: Glucosamine	0.5	0.6	1.3	1.1	0.2	-0.7
High blood pressure (mother)	0.5	0.7	1.6	1.2	0.3	0.7
Body mass index (BMI)	0.5	2.1	3.9	1.4	-2.0	0.6
Depression (self-reported)	0.5	0.7	1.8	-0.4	1.3	0.2
Loud music exposure frequency	0.5	0.5	1.2	-0.2	-0.6	1.1
Pulse wave peak to peak time	0.5	0.6	0.9	-0.8	-0.9	-0.5
Shortness of breath walking on level ground	0.5	0.6	1.3	0.5	-0.2	1.2
Medication: Seretide 50 evohaler	0.5	0.6	1.2	1.1	0.1	0.8
Leg fat mass (right)	0.5	2.0	2.8	0.7	-1.7	-1.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.0	0.3	-1.0	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.3	-0.0	0.1	-1.8
Alcohol drinker status: Previous	0.5	0.5	1.6	0.1	-1.3	0.0
Leg fat mass (left)	0.5	2.0	3.1	0.6	-1.8	-1.6
Bipolar Disorder (2018)	0.4	0.7	1.2	-1.1	0.1	-0.9
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.2	-0.3	-1.5	0.6
Body Mass Index (BMI) (2010)	0.4	0.5	0.9	-0.6	-0.7	0.9
Blood White Count	0.4	3.3	6.9	-1.1	-1.3	-2.6
Systolic Blood Pressure	0.4	1.8	2.7	1.6	1.2	1.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	-0.9	0.2	-0.6
Pack years adult smoking proportion	0.4	0.6	1.2	0.8	-0.0	1.1
Number of incorrect matches in round	0.4	0.6	1.4	-1.2	0.6	0.2
Past tobacco smoking	0.4	0.7	1.9	0.6	0.2	1.4
Financial difficulties in last 2 years	0.4	0.5	0.9	0.9	-0.4	0.7
Arm fat percentage (right)	0.4	1.5	1.9	1.4	-1.3	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.3	1.1	0.3	-0.3
Medication: Cholesterol lowering	0.4	0.6	1.5	0.4	-0.1	1.2
Medication: Ibuprofen	0.4	0.5	0.7	0.5	-0.8	0.7
Whole body fat mass	0.4	1.6	2.7	0.5	-1.6	-1.3
Leg pain on walking	0.4	0.4	0.6	0.7	-0.5	0.8
Arm fat percentage (left)	0.4	1.5	2.3	1.5	-1.1	0.9
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	0.8	0.8	0.8	0.9
Alcohol drinker status: Never	0.4	0.4	0.6	-0.8	0.5	-0.7
Myopia	0.4	0.6	1.8	0.2	-1.4	0.2
Impedance of whole body	0.4	2.3	5.2	-1.3	2.3	0.1
Primary Biliary Cirrhosis	0.3	0.4	0.7	-0.7	-0.8	0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	0.5	-0.3	0.9
Current tobacco smoking	0.3	0.5	0.8	-0.4	-0.8	-0.9
Serious illness, injury or assault to yourself	0.3	0.4	1.1	0.3	1.0	-0.1
Trunk fat mass	0.3	1.4	2.5	0.2	-1.6	-1.3
Had menopause	0.3	0.3	0.7	0.2	-0.8	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	0.8	-0.6	-0.9	-0.9
Alcohol intake versus 10 years previously	0.3	0.5	1.2	-0.5	-0.2	1.1
Mouth/teeth dental problems: Dentures	0.3	0.5	1.3	0.2	0.2	-1.1
Prospective memory result	0.3	0.4	1.0	1.0	-0.1	0.5
Lung cancer (father)	0.3	0.4	0.5	-0.3	0.7	-0.7
Pulse wave Arterial Stiffness index	0.3	0.3	0.8	0.4	0.9	-0.2
Impedance of arm (left)	0.3	1.5	3.0	-0.4	1.7	1.2
Arm fat mass (right)	0.3	1.4	3.1	0.8	-1.8	-0.8
Hair/balding pattern: Pattern 4	0.3	0.6	1.2	-1.1	-0.7	0.4
Pulse wave reflection index	0.3	0.3	1.0	0.2	-1.0	0.1
Migraine (self-reported)	0.3	0.4	0.6	0.8	-0.4	0.6
Mean time to correctly identify matches	0.3	0.5	1.0	-0.7	-1.0	-0.1
Alcohol intake frequency.	0.3	0.6	0.7	-0.8	-0.7	0.8
Knee pain experienced in last month	0.3	0.5	1.2	1.1	-0.4	-0.2
Illnesses of father: None of the above (group 1)	0.3	0.4	0.5	-0.7	0.6	-0.5
Arm fat mass (left)	0.3	1.1	2.4	0.8	-1.5	-0.6
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	0.2	-0.1	0.9
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	-0.6	-0.8	0.3
Commuting to job workplace: Cycle	0.3	0.3	0.4	0.5	-0.6	-0.7
Pack years of smoking	0.3	0.4	1.0	0.4	-0.3	1.0
Bipolar Disorder or Schizophrenia	0.2	0.5	0.8	-0.9	0.6	-0.6
Major Depression (MDD)	0.2	0.2	0.2	0.5	-0.4	0.5
Reaction Time	0.2	0.4	0.7	-0.3	-0.6	0.8
Crohns Disease (2012)	0.2	0.3	0.9	0.1	0.3	1.0
Schizophrenia (2014)	0.2	0.5	1.3	-0.5	1.1	-0.4
Blood Red Count	0.2	1.7	4.7	-0.7	-0.1	-2.2
Heel T-Score	0.2	1.3	2.5	1.0	1.6	0.6
Waist Hip Ratio (WHR)	0.2	1.0	1.6	0.2	-1.2	-1.2
Smoking Status	0.2	0.5	1.0	-0.1	-1.0	-0.6
Relative age of first facial hair	0.2	0.4	0.8	-0.7	0.9	-0.1
Systolic blood pressure, automated reading	0.2	0.5	0.7	0.8	0.7	0.6
Supplements: Zinc	0.2	0.2	0.2	-0.5	0.5	-0.4
Relative age voice broke	0.2	0.2	0.7	-0.1	0.8	0.2
Qualifications: None of the above	0.2	0.3	0.7	0.5	0.2	0.8
Mouth/teeth dental problems	0.2	0.3	0.6	-0.8	-0.5	-0.3
Impedance of arm (right)	0.2	0.7	1.4	-0.5	1.2	0.8
Hip circumference	0.2	0.8	1.2	0.7	-1.1	-0.8
Time employed in main current job	0.2	0.2	0.3	0.5	-0.3	0.5
Happiness	0.2	0.2	0.4	-0.6	0.4	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.5	0.5	-0.7	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	-0.7	-0.2	0.7
Body fat percentage	0.2	0.7	1.0	1.0	-1.0	-0.0
Smoking status: Previous	0.2	0.3	0.8	-0.4	-0.1	-0.9
Qualifications: nursing, teaching	0.2	0.3	0.4	-0.6	0.5	0.3
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.4	-0.7	-0.4
Breast cancer (self-reported)	0.2	0.2	0.4	0.4	0.6	-0.3
Financial situation satisfaction	0.2	0.3	0.7	-0.4	-0.8	0.1
Average weekly beer plus cider intake	0.2	0.2	0.5	-0.7	-0.1	0.4
Fractured/broken bones in last 5 years	0.2	0.2	0.3	-0.4	0.5	0.6
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.8	-0.9	-0.4	-0.1
Schizophrenia (2018)	0.1	0.2	0.5	-0.2	0.7	-0.1
Schizophrenia vs Biploar Disorder	0.1	0.2	0.5	-0.1	0.7	0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.5	-0.0	-0.1
Mean Putamen Volume	0.1	0.1	0.2	-0.4	-0.1	0.1
Blood Eosinophil Count	0.1	0.7	1.1	1.0	-1.1	0.1
BMI	0.1	0.4	0.6	0.7	-0.4	0.8
Chronotype (morning person)	0.1	0.2	0.5	-0.3	0.4	0.7
Tanning	0.1	0.9	2.2	0.4	0.6	1.5
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.5	-0.0	0.1
Vitamin and mineral supplements	0.1	0.2	0.2	0.5	0.4	-0.4
Trunk fat percentage	0.1	0.5	1.2	0.6	-1.1	-0.1
Multivitamins +/- minerals	0.1	0.1	0.2	-0.1	0.4	0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	-0.2	0.1	0.6
Medication: Ramipril	0.1	0.1	0.2	0.1	-0.2	0.4
Headache pain in last month	0.1	0.2	0.4	0.5	0.0	0.6
Leg fat percentage (right)	0.1	0.5	0.6	0.8	-0.5	-0.7
Comparative body size at age 10	0.1	0.3	0.6	-0.8	-0.3	0.4
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.4	-0.2	-0.4
Pulse rate, automated reading	0.1	0.4	1.0	-0.1	0.4	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.2	-0.0	-0.4
Wears glasses or contact lenses	0.1	0.1	0.4	0.1	0.6	0.1
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.2	0.4	0.3
Mother’s age at death	0.1	0.1	0.2	-0.5	-0.3	0.2
Leg fat percentage (left)	0.1	0.5	0.7	0.8	-0.8	-0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.2	-0.5	0.1
Diastolic blood pressure, automated reading	0.1	0.4	1.0	0.5	0.1	1.0
Pain experienced in last month	0.1	0.2	0.5	-0.2	0.7	-0.3
Heart disease (siblings)	0.1	0.1	0.2	-0.2	-0.5	-0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.0	0.0	0.1	0.1	0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	0.5	0.1	0.0
Qualifications: CSEs or equivalent	0.0	0.0	0.0	0.1	0.1	-0.1
Fluid intelligence score	0.0	0.1	0.1	-0.4	0.0	0.2
Smoking status: Current	0.0	0.1	0.1	0.0	-0.3	-0.3
Irritability	0.0	0.0	0.1	0.0	0.3	-0.0
Ever depressed for a whole week	0.0	0.0	0.1	-0.0	-0.0	-0.4

Hub : Genes

TBC1D30

Models

Trait associations