[Hub]/) : Traits : Forced vital capacity (FVC) : ← →

chr12:55,633,142-57,452,308

Best TWAS P=7.33e-09 · Best GWAS P=3.89e-08 conditioned to 0.869

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Brain Cortex	RP11-977G19.11	0.38	0.16	lasso	9	0.12	3.8e-04	5.4	-5.8	7.3e-09	-0.94	0.02	0.90	TRUE
35	GTEx	Thyroid	RP11-977G19.11	0.16	0.11	enet	20	0.13	3.5e-10	5.4	-5.7	1.0e-08	-0.95	0.02	0.98	FALSE
36	NTR	Blood	OBFC2B	0.01	0.00	bslmm	248	0.00	3.6e-02	2.1	-5.7	1.2e-08	-0.68	0.02	0.46	FALSE
8	GTEx	Brain Caudate basal ganglia	RP11-977G19.11	0.31	0.25	lasso	5	0.28	1.2e-08	5.3	-5.6	2.6e-08	-0.94	0.02	0.98	FALSE
22	GTEx	Liver	DGKA	0.33	0.03	lasso	15	0.13	1.4e-04	5.4	5.6	2.8e-08	0.73	0.03	0.71	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	NABP2	0.12	0.12	lasso	4	0.13	2.7e-16	5.3	5.6	2.8e-08	0.96	0.02	0.98	FALSE
39	The Cancer Genome Atlas	Glioblastoma Multiforme	PAN2	0.08	0.04	blup	31	0.03	4.4e-02	5.4	5.5	3.1e-08	0.97	0.01	0.56	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	STAT2	0.02	0.02	blup	21	0.01	9.6e-03	5.4	5.5	3.1e-08	0.98	0.01	0.86	FALSE
18	GTEx	Colon Transverse	RP11-977G19.11	0.18	0.05	lasso	2	0.00	1.9e-01	5.4	-5.5	3.6e-08	-1.00	0.02	0.84	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	IL23A	0.03	0.03	blup	22	0.02	1.8e-03	5.4	5.5	4.0e-08	0.95	0.01	0.82	FALSE
4	GTEx	Adrenal Gland	RP11-977G19.11	0.19	0.16	lasso	15	0.09	3.9e-04	5.4	-5.5	4.1e-08	-1.00	0.02	0.98	FALSE
32	GTEx	Skin Sun Exposed Lower leg	CNPY2	0.10	0.08	lasso	5	0.08	5.9e-07	5.3	5.5	4.7e-08	0.96	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CNPY2	0.06	0.05	lasso	8	0.05	2.3e-06	5.4	-5.5	4.8e-08	-1.00	0.02	0.98	FALSE
9	GTEx	Brain Cerebellum	RP11-977G19.11	0.17	0.19	lasso	14	0.18	5.4e-06	5.3	-5.4	5.3e-08	-0.98	0.02	0.97	FALSE
17	GTEx	Cells Transformed fibroblasts	RP11-977G19.11	0.11	0.07	enet	22	0.05	9.5e-05	5.4	-5.4	5.3e-08	-1.00	0.02	0.98	FALSE
13	GTEx	Brain Nucleus accumbens basal ganglia	RP11-977G19.11	0.30	0.12	lasso	10	0.08	4.6e-03	5.3	-5.4	5.4e-08	-0.98	0.02	0.92	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	COQ10A	0.03	0.03	lasso	2	0.03	9.1e-04	5.4	-5.4	5.6e-08	-1.00	0.01	0.91	FALSE
12	GTEx	Brain Hypothalamus	RP11-977G19.11	0.32	0.20	lasso	6	0.23	4.4e-06	5.4	-5.4	5.9e-08	-0.94	0.02	0.97	FALSE
27	GTEx	Nerve Tibial	RP11-977G19.11	0.15	0.18	enet	23	0.20	7.7e-14	5.4	-5.4	6.0e-08	-1.00	0.02	0.98	FALSE
20	GTEx	Esophagus Mucosa	RP11-977G19.11	0.07	0.09	lasso	1	0.07	1.5e-05	5.4	-5.4	6.1e-08	-1.00	0.02	0.98	FALSE
29	GTEx	Pituitary	RP11-977G19.11	0.47	0.40	lasso	14	0.40	4.5e-11	5.4	-5.4	6.1e-08	-0.96	0.02	0.98	FALSE
15	GTEx	Breast Mammary Tissue	RP11-977G19.11	0.11	0.08	lasso	8	0.04	2.5e-03	5.4	-5.4	6.2e-08	-0.98	0.02	0.93	FALSE
16	GTEx	Cells Transformed fibroblasts	PAN2	0.09	0.07	lasso	4	0.05	1.7e-04	5.3	5.4	6.3e-08	0.97	0.02	0.98	FALSE
23	GTEx	Liver	STAT2	0.32	0.17	lasso	13	0.14	9.9e-05	5.3	5.4	6.3e-08	0.97	0.02	0.97	FALSE
28	GTEx	Pancreas	IL23A	0.23	0.01	lasso	13	0.04	1.1e-02	5.3	5.4	6.4e-08	0.97	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	IL23A	0.03	0.04	lasso	7	0.04	2.9e-05	5.4	5.4	6.6e-08	1.00	0.01	0.98	FALSE
6	GTEx	Artery Coronary	RP11-977G19.11	0.24	0.14	lasso	13	0.08	1.2e-03	5.4	-5.4	6.7e-08	-0.96	0.02	0.96	FALSE
31	GTEx	Skin Sun Exposed Lower leg	RP11-977G19.11	0.15	0.09	lasso	11	0.08	1.9e-07	5.4	-5.4	7.3e-08	-0.98	0.02	0.98	FALSE
14	GTEx	Brain Putamen basal ganglia	RP11-973D8.4	0.18	0.21	lasso	1	0.14	4.3e-04	5.4	-5.4	8.0e-08	-0.96	0.02	0.86	FALSE
38	YFS	Blood	CNPY2	0.02	0.02	lasso	1	0.02	5.8e-07	5.4	5.4	8.0e-08	0.95	0.02	0.98	FALSE
21	GTEx	Esophagus Muscularis	RP11-977G19.11	0.12	0.06	lasso	2	0.10	2.2e-06	5.4	-5.4	8.4e-08	-0.83	0.03	0.95	FALSE
25	GTEx	Nerve Tibial	IL23A	0.06	0.08	lasso	10	0.07	1.6e-05	5.3	5.3	8.9e-08	0.98	0.02	0.98	FALSE
30	GTEx	Pituitary	CNPY2	0.32	0.19	lasso	11	0.12	6.8e-04	5.3	5.3	9.0e-08	0.96	0.02	0.93	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PAN2	0.05	0.07	lasso	3	0.06	5.4e-08	5.3	5.3	9.1e-08	0.96	0.02	0.98	FALSE
5	GTEx	Artery Aorta	RP11-977G19.11	0.26	0.28	lasso	14	0.28	5.3e-16	5.3	-5.3	9.1e-08	-0.96	0.02	0.98	FALSE
7	GTEx	Artery Tibial	RP11-977G19.11	0.16	0.18	lasso	12	0.18	6.1e-14	5.3	-5.3	9.1e-08	-0.96	0.02	0.98	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	RP11-977G19.11	0.18	0.14	lasso	13	0.07	2.0e-03	5.3	-5.3	9.1e-08	-0.96	0.02	0.97	FALSE
34	GTEx	Thyroid	IL23A	0.07	0.04	lasso	10	0.00	1.9e-01	5.3	5.3	9.1e-08	0.96	0.02	0.95	FALSE
24	GTEx	Lung	RP11-977G19.11	0.07	0.03	lasso	11	0.04	5.1e-04	5.4	-5.3	1.3e-07	-0.89	0.02	0.97	FALSE
26	GTEx	Nerve Tibial	STAT2	0.08	0.05	lasso	3	0.03	5.0e-03	5.3	-5.3	1.3e-07	-0.97	0.02	0.94	FALSE
3	GTEx	Adipose Subcutaneous	RP11-977G19.11	0.12	0.10	lasso	7	0.09	7.5e-08	5.3	-5.2	1.7e-07	-0.97	0.02	0.98	FALSE
11	GTEx	Brain Frontal Cortex BA9	RP11-977G19.11	0.30	0.34	lasso	5	0.32	3.5e-09	5.4	-5.2	1.7e-07	-0.98	0.02	0.98	FALSE
33	GTEx	Testis	RPS26	0.11	-0.01	enet	29	0.00	2.5e-01	-1.8	-5.2	1.7e-07	-0.57	0.03	0.63	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	COQ10A	0.06	0.02	blup	27	0.02	5.7e-03	5.4	-5.2	2.3e-07	-0.85	0.01	0.58	FALSE