Best TWAS P=5.52e-09 · Best GWAS P=4.25e-09 conditioned to 0.0758
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | SNRPD2 | 0.17 | 0.14 | lasso | 3 | 0.14 | 1.7e-09 | -5.1 | 5.1 | 2.9e-07 | -0.22 | 0.10 | 0.90 | TRUE |
| 2 | GTEx | Skin Sun Exposed Lower leg | SNRPD2 | 0.25 | 0.17 | lasso | 5 | 0.17 | 6.5e-14 | -5.1 | 5.6 | 2.6e-08 | -0.30 | 0.10 | 0.90 | FALSE |
| 3 | GTEx | Testis | DMPK | 0.19 | 0.11 | lasso | 4 | 0.07 | 3.2e-04 | 5.5 | 5.8 | 8.5e-09 | -0.64 | 0.02 | 0.97 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RSPH6A | 0.07 | 0.06 | blup | 50 | 0.05 | 4.9e-04 | 5.5 | -5.8 | 5.5e-09 | 0.74 | 0.02 | 0.94 | TRUE |
| 5 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | SNRPD2 | 0.15 | 0.01 | lasso | 2 | 0.08 | 3.4e-03 | 4.1 | 5.7 | 1.3e-08 | -0.36 | 0.01 | 0.42 | FALSE |