Best TWAS P=1.93e-11 · Best GWAS P=2.11e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | GTEx | Whole Blood | SHKBP1 | 0.12 | 0.09 | lasso | 3 | 0.07 | 3.7e-07 | 6.7 | 6.7 | 1.9e-11 | 1.00 | 0.00 | 1.00 | TRUE |
| 9 | The Cancer Genome Atlas | Rectum Adenocarcinoma | GSK3A | 0.15 | 0.10 | lasso | 7 | 0.09 | 4.0e-03 | -6.5 | -6.5 | 8.8e-11 | -0.09 | 0.00 | 0.55 | TRUE |
| 5 | NTR | Blood | SHKBP1 | 0.05 | 0.04 | enet | 18 | 0.04 | 3.1e-13 | 6.7 | 6.4 | 1.4e-10 | 0.88 | 0.00 | 1.00 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | LTBP4 | 0.09 | 0.05 | lasso | 9 | 0.04 | 3.9e-06 | 6.5 | -6.4 | 1.6e-10 | -0.90 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Lung | SHKBP1 | 0.12 | 0.12 | enet | 20 | 0.09 | 1.8e-07 | 6.7 | 6.0 | 2.3e-09 | 0.89 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DEDD2 | 0.02 | 0.02 | lasso | 1 | 0.01 | 3.1e-02 | -5.8 | 5.8 | 6.0e-09 | 0.09 | 0.02 | 0.88 | FALSE |
| 3 | GTEx | Testis | GRIK5 | 0.41 | 0.24 | lasso | 10 | 0.24 | 7.9e-11 | -5.8 | 5.7 | 1.4e-08 | 0.08 | 0.03 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LTBP4 | 0.01 | 0.00 | blup | 54 | 0.01 | 2.0e-02 | 4.1 | -5.5 | 4.5e-08 | -0.77 | 0.02 | 0.37 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZNF574 | 0.02 | 0.01 | lasso | 2 | 0.02 | 1.1e-04 | 2.7 | -5.2 | 2.4e-07 | -0.05 | 0.01 | 0.34 | FALSE |