TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Forced vital capacity (FVC)
:
←
→
chr3:140,250,247-141,867,638
Best TWAS P=6.2e-24 · Best GWAS P=1.5e-24 conditioned to 1
140.2M
140.4M
140.6M
140.8M
141M
141.2M
141.4M
141.6M
141.8M
0
5
10
15
20
25
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Adipose Subcutaneous
ZBTB38
0.08
0.04
lasso
4
0.03
8.1e-04
10.1
10.1
6.2e-24
0.95
0.01
0.99
TRUE
3
NTR
Blood
ZBTB38
0.03
0.01
lasso
3
0.01
2.2e-05
10.1
7.9
2.1e-15
0.84
0.01
0.99
TRUE
2
GTEx
Colon Transverse
ACPL2
0.15
-0.01
lasso
4
0.00
5.7e-01
5.9
5.8
7.7e-09
0.28
0.05
0.05
TRUE
4
The Cancer Genome Atlas
Soft Tissue Sarcoma
ZBTB38
0.04
0.03
lasso
3
0.04
3.0e-03
4.0
5.3
1.4e-07
0.60
0.05
0.28
FALSE