[Hub]/) : Traits : Forced vital capacity (FVC) : ← →

chr3:157,125,828-159,106,064

Best TWAS P=4.64e-22 · Best GWAS P=4.46e-19 conditioned to 0.00426

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	GTEx	Cells Transformed fibroblasts	RP11-538P18.2	0.10	0.08	enet	10	0.13	5.1e-10	-8.35	9.7	4.6e-22	0.72	0.03	0.97	TRUE
31	GTEx	Lung	RP11-538P18.2	0.16	0.11	enet	17	0.17	6.6e-13	-7.98	9.5	3.3e-21	0.69	0.72	0.28	FALSE
37	GTEx	Ovary	RP11-538P18.2	0.23	0.08	lasso	6	0.13	4.5e-04	-8.35	9.4	5.5e-21	0.76	0.05	0.49	FALSE
36	GTEx	Nerve Tibial	RP11-538P18.2	0.21	0.18	enet	16	0.20	2.1e-14	-8.34	9.3	9.2e-21	0.66	0.34	0.66	FALSE
44	GTEx	Stomach	RSRC1	0.08	0.06	lasso	3	0.07	2.9e-04	-8.66	9.3	1.3e-20	0.73	0.04	0.95	FALSE
7	GTEx	Artery Aorta	RP11-538P18.2	0.11	0.09	lasso	3	0.08	2.9e-05	-8.17	9.3	2.2e-20	0.67	0.03	0.97	FALSE
38	GTEx	Pancreas	RP11-538P18.2	0.14	0.02	lasso	11	0.02	5.3e-02	-7.83	9.2	5.4e-20	0.73	0.15	0.39	FALSE
43	GTEx	Skin Sun Exposed Lower leg	RP11-538P18.2	0.13	0.12	enet	11	0.14	7.8e-12	-8.34	9.1	6.0e-20	0.71	0.13	0.87	FALSE
47	GTEx	Thyroid	RP11-538P18.2	0.14	0.13	lasso	5	0.12	1.2e-09	-8.34	9.1	1.2e-19	0.66	0.27	0.73	FALSE
10	GTEx	Artery Tibial	RP11-538P18.2	0.17	0.14	enet	24	0.21	3.7e-16	-8.34	9.0	3.2e-19	0.69	0.36	0.64	FALSE
3	GTEx	Adipose Subcutaneous	RP11-538P18.2	0.15	0.15	lasso	7	0.18	9.4e-15	-8.35	8.9	3.6e-19	0.59	0.29	0.71	FALSE
34	GTEx	Muscle Skeletal	RP11-538P18.2	0.09	0.08	lasso	2	0.05	1.3e-05	-8.34	8.9	3.7e-19	0.60	0.23	0.77	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	RP11-538P18.2	0.09	0.10	enet	13	0.12	6.8e-07	-7.72	8.9	4.2e-19	0.65	0.39	0.60	FALSE
8	GTEx	Artery Coronary	RP11-538P18.2	0.11	0.16	lasso	4	0.10	3.2e-04	-8.78	8.9	5.4e-19	0.82	0.02	0.97	FALSE
9	GTEx	Artery Tibial	RSRC1	0.13	0.13	lasso	6	0.11	3.5e-09	-8.34	8.8	1.4e-18	0.56	0.34	0.66	FALSE
27	GTEx	Esophagus Muscularis	RSRC1	0.06	0.09	lasso	3	0.10	1.7e-06	-8.78	-8.8	1.7e-18	-0.83	0.02	0.98	FALSE
35	GTEx	Nerve Tibial	RSRC1	0.10	0.15	lasso	3	0.12	9.9e-09	-8.34	8.7	2.6e-18	0.55	0.33	0.67	FALSE
42	GTEx	Skin Sun Exposed Lower leg	RSRC1	0.09	0.09	lasso	2	0.08	4.4e-07	-8.34	8.7	2.7e-18	0.57	0.33	0.66	FALSE
11	GTEx	Brain Cerebellar Hemisphere	RP11-538P18.2	0.17	0.11	lasso	4	0.04	4.1e-02	-8.13	8.7	2.8e-18	0.70	0.03	0.72	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	RSRC1	0.05	0.03	blup	154	0.01	7.9e-03	-7.32	8.7	3.5e-18	0.55	0.18	0.32	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	RSRC1	0.04	0.03	enet	11	0.04	4.5e-09	-8.02	8.6	5.9e-18	0.75	0.02	0.98	FALSE
48	GTEx	Vagina	RP11-538P18.2	0.25	0.19	lasso	3	0.18	6.7e-05	-8.01	8.6	6.8e-18	0.69	0.05	0.69	FALSE
15	GTEx	Breast Mammary Tissue	RP11-538P18.2	0.17	0.14	lasso	6	0.16	1.2e-08	-8.35	8.6	8.1e-18	0.53	0.49	0.51	FALSE
50	YFS	Blood	RSRC1	0.13	0.13	enet	26	0.17	8.8e-54	-8.55	8.6	9.7e-18	0.53	0.07	0.93	FALSE
28	GTEx	Esophagus Muscularis	RP11-538P18.2	0.11	0.16	lasso	5	0.15	1.2e-09	-8.78	-8.5	1.5e-17	-0.81	0.01	0.99	FALSE
45	GTEx	Stomach	RP11-538P18.2	0.06	0.04	lasso	2	0.04	3.4e-03	-8.35	8.5	1.7e-17	0.51	0.09	0.76	FALSE
30	GTEx	Lung	RSRC1	0.09	0.05	enet	12	0.06	3.5e-05	-8.07	8.5	1.8e-17	0.42	0.44	0.52	FALSE
2	GTEx	Adipose Subcutaneous	RSRC1	0.15	0.17	lasso	4	0.18	9.7e-15	-8.34	8.4	4.8e-17	0.49	0.32	0.68	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	RP11-538P18.2	0.21	0.12	lasso	4	0.12	3.5e-05	-7.32	8.4	6.0e-17	0.60	0.09	0.85	FALSE
4	GTEx	Adipose Visceral Omentum	RSRC1	0.16	0.08	enet	12	0.09	2.5e-05	-7.51	8.3	8.2e-17	0.65	0.04	0.96	FALSE
33	GTEx	Muscle Skeletal	RSRC1	0.11	0.06	lasso	2	0.04	1.5e-04	-8.34	8.3	8.9e-17	0.50	0.30	0.56	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	RSRC1	0.07	0.09	lasso	2	0.06	3.7e-04	-8.34	8.3	1.1e-16	0.54	0.24	0.40	FALSE
16	GTEx	Breast Mammary Tissue (Male)	RSRC1	0.24	0.10	lasso	5	0.19	3.4e-05	-8.34	8.3	1.2e-16	0.51	0.09	0.19	FALSE
14	GTEx	Breast Mammary Tissue	RSRC1	0.14	0.10	lasso	6	0.13	4.9e-07	-8.34	8.2	2.0e-16	0.50	0.40	0.59	FALSE
12	GTEx	Brain Cerebellum	RP11-538P18.2	0.19	0.06	enet	18	0.10	8.0e-04	6.89	8.2	2.6e-16	0.84	0.02	0.94	FALSE
19	GTEx	Breast Mammary Tissue (Female)	RP11-538P18.2	0.20	0.14	enet	13	0.17	9.4e-06	-7.72	8.1	3.8e-16	0.52	0.60	0.16	FALSE
49	METSIM	Adipose	RSRC1	0.14	0.19	blup	532	0.21	6.0e-31	-8.35	8.0	1.1e-15	0.47	0.31	0.69	FALSE
6	GTEx	Artery Aorta	RSRC1	0.09	0.04	lasso	5	0.03	1.4e-02	-8.76	8.0	1.4e-15	0.66	0.02	0.96	FALSE
26	GTEx	Esophagus Mucosa	RP11-538P18.2	0.12	0.10	lasso	5	0.14	1.9e-09	-8.34	7.9	2.0e-15	0.59	0.04	0.96	FALSE
17	GTEx	Breast Mammary Tissue (Male)	RP11-538P18.2	0.30	0.11	lasso	6	0.10	3.3e-03	-8.34	7.8	5.2e-15	0.49	0.05	0.25	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-538P18.2	0.23	0.10	enet	22	0.16	1.2e-08	-7.43	7.8	5.3e-15	0.57	0.05	0.95	FALSE
46	GTEx	Thyroid	RSRC1	0.07	0.04	lasso	7	0.02	8.5e-03	-7.47	7.8	7.0e-15	0.68	0.06	0.93	FALSE
32	GTEx	Lung	RP11-379F4.7	0.05	0.01	lasso	3	0.01	1.2e-01	-7.54	-7.7	9.9e-15	-0.66	0.08	0.58	FALSE
22	GTEx	Colon Transverse	RP11-538P18.2	0.07	0.10	lasso	6	0.08	8.4e-05	-8.35	7.3	3.6e-13	0.37	0.04	0.91	FALSE
39	GTEx	Pituitary	RP11-538P18.2	0.17	0.03	lasso	8	0.03	6.9e-02	-8.35	7.1	1.2e-12	0.38	0.04	0.62	FALSE
13	GTEx	Brain Cortex	RSRC1	0.43	0.02	lasso	7	0.00	2.3e-01	-6.92	6.9	3.7e-12	0.36	0.08	0.06	FALSE
29	GTEx	Heart Atrial Appendage	RP11-379F4.7	0.07	0.09	enet	11	0.01	1.4e-01	-8.78	-6.8	8.3e-12	-0.79	0.02	0.94	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RSRC1	0.04	0.01	bslmm	536	0.01	4.8e-02	-3.69	6.8	1.5e-11	0.51	0.14	0.12	FALSE
25	GTEx	Esophagus Mucosa	MLF1	0.22	0.30	lasso	5	0.28	2.6e-19	6.89	6.7	2.7e-11	0.72	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Colon Adenocarcinoma	MLF1	0.06	0.04	blup	45	0.04	2.0e-03	8.93	6.7	2.8e-11	0.89	0.00	0.86	FALSE
18	GTEx	Breast Mammary Tissue (Female)	RSRC1	0.24	0.05	enet	43	0.13	1.4e-04	-8.17	6.3	2.7e-10	0.47	0.26	0.24	FALSE
24	GTEx	Esophagus Mucosa	RSRC1	0.09	0.02	enet	20	0.04	9.3e-04	-7.51	6.3	2.9e-10	0.44	0.04	0.91	FALSE
21	GTEx	Colon Sigmoid	RP11-538P18.2	0.11	0.05	lasso	8	0.08	7.6e-04	2.87	6.1	9.0e-10	0.49	0.10	0.30	FALSE
55	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GFM1	0.28	0.16	lasso	7	0.14	1.5e-05	6.62	6.0	2.1e-09	0.66	0.00	0.99	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MLF1	0.03	0.00	blup	45	0.01	1.3e-02	-0.82	5.3	1.4e-07	0.31	0.02	0.08	FALSE