Best TWAS P=3.36e-09 · Best GWAS P=1.74e-06 conditioned to 0.428
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | CRIPAK | 0.47 | 0.24 | lasso | 12 | 0.31 | 1.3e-16 | -4.3 | -5.2 | 2.4e-07 | 0.78 | 0.02 | 0.89 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | CRIPAK | 0.27 | 0.00 | lasso | 2 | 0.02 | 9.3e-02 | -4.8 | -5.3 | 1.1e-07 | 0.95 | 0.00 | 0.64 | FALSE |
3 | GTEx | Brain Cortex | CRIPAK | 0.34 | 0.10 | lasso | 6 | 0.18 | 9.5e-06 | -4.3 | -5.6 | 2.6e-08 | 0.73 | 0.01 | 0.70 | FALSE |
4 | GTEx | Brain Hippocampus | CRIPAK | 0.48 | 0.22 | lasso | 4 | 0.23 | 4.0e-06 | -3.5 | -5.2 | 1.7e-07 | 0.63 | 0.03 | 0.28 | FALSE |
5 | GTEx | Brain Hypothalamus | CRIPAK | 0.22 | 0.00 | lasso | 5 | 0.01 | 2.1e-01 | -4.8 | -5.4 | 8.3e-08 | 0.84 | 0.01 | 0.35 | FALSE |
6 | GTEx | Lung | CRIPAK | 0.61 | 0.22 | enet | 46 | 0.41 | 1.1e-33 | -4.3 | -5.2 | 1.7e-07 | 0.76 | 0.02 | 0.88 | FALSE |
7 | GTEx | Uterus | CRIPAK | 0.52 | 0.34 | lasso | 3 | 0.33 | 1.7e-07 | -4.8 | -5.4 | 7.5e-08 | 0.94 | 0.00 | 0.94 | FALSE |
8 | NTR | Blood | CRIPAK | 0.13 | 0.09 | enet | 31 | 0.15 | 1.5e-46 | -4.2 | -5.9 | 3.4e-09 | 0.72 | 0.05 | 0.78 | TRUE |
9 | NTR | Blood | KIAA1530 | 0.19 | 0.04 | blup | 345 | 0.10 | 9.1e-32 | -4.8 | -5.3 | 1.2e-07 | 0.67 | 0.00 | 0.98 | FALSE |
10 | The Cancer Genome Atlas | Soft Tissue Sarcoma | KIAA1530 | 0.08 | 0.03 | enet | 11 | 0.03 | 5.9e-03 | -3.4 | -5.3 | 1.3e-07 | 0.54 | 0.00 | 0.12 | FALSE |
11 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | CRIPAK | 0.57 | 0.07 | enet | 9 | 0.23 | 6.7e-07 | -4.3 | -5.8 | 6.3e-09 | 0.51 | 0.00 | 0.35 | FALSE |